An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development.
Martha V Koerner,
Kashyap Chhatbar,
Shaun Webb,
Justyna Cholewa-Waclaw,
Jim Selfridge,
Dina De Sousa,
Bill Skarnes,
Barry Rosen,
Mark Thomas,
Joanna Bottomley,
Ramiro Ramires-Solis,
Christopher Lelliott,
David J Adams,
Adrian Bird
Feb 08, 2021
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for...