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Results: 99
Mild cognitive impairment with Lewy bodies
Paul C Donaghy, Joanna Ciafone, Rory Durcan, Calum A Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M Allan, John T O'Brien, John-Paul Taylor, Alan J Thomas
Aug 03, 2020
BACKGROUND: Recently published diagnostic criteria for mild cognitive impairment with Lewy bodies (MCI-LB) include five neuropsychiatric supportive features (non-visual hallucinations, systematised delusions, apathy, anxiety and...
In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies.
Julia Schumacher, John-Paul Taylor, Calum A Hamilton, Michael Firbank, Ruth A Cromarty, Paul C Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T O'Brien, Alan J Thomas
May 10, 2021
OBJECTIVES: To investigate in vivo degeneration of the cholinergic system in mild cognitive impairment with Lewy bodies (MCI-LB), we studied nucleus basalis of Meynert (NBM) volumes from structural MR images and its relation to...
Does adiposity mediate the relationship between physical activity and biological risk factors in youth?
BACKGROUND/OBJECTIVES: To model the association between accumulating 60 daily minutes of moderate-to-vigorous physical activity and a composite score of biological risk factors into a direct and an indirect effect, using...
Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies.
Julia Schumacher, John-Paul Taylor, Calum A Hamilton, Michael Firbank, Ruth A Cromarty, Paul C Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T O'Brien, Alan J Thomas
Sep 21, 2020
OBJECTIVES: To investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer's disease (MCI-AD) and (2) its utility as a potential...
Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer's disease.
Eleanor King, John Tiernan O'Brien, Paul Donaghy, Christopher Morris, Nicola Barnett, Kirsty Olsen, Carmen Martin-Ruiz, John Paul Taylor, Alan J Thomas
Apr 16, 2019
UNLABELLED: ABSTRACTObjectives and design:To Investigate the peripheral inflammatory profile in patients with mild cognitive impairment (MCI) from three subgroups - probable Lewy body disease (probable MCI-LB), possible Lewy...
Alzheimer’s disease CRP Lewy Body Disease Cytokines Inflammation mild cognitive impairment Aged Alzheimer Disease Cognitive Dysfunction Correlation of Data Cytokines Disease Progression Early Medical Intervention Female Humans Inflammation Lewy Body Disease Male Memory Disorders Middle Aged Motor Skills
Stress, health and quality of life of female migrant domestic workers in Singapore
Abstract
Background: There is a global increase in migrant workers. In Singapore, there are over 230,000 migrant domestic workers (MDWs). Female MDWs may experience high levels of stress and social isolation, which may...
Humans Cross-Sectional Studies Mental Health Quality of life Work Schedule Tolerance Adult Middle Aged Transients and Migrants Housekeeping Workload Singapore Female Male
Published by: BMC women's health
Mild cognitive impairment with Lewy bodies
Michael J Firbank, John T O'Brien, Rory Durcan, Louise M Allan, Sally Barker, Joanna Ciafone, Paul C Donaghy, Calum A Hamilton, Sarah Lawley, Jim Lloyd, Gemma Roberts, John-Paul Taylor, Alan J Thomas
Oct 12, 2020
OBJECTIVE: To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. METHODS: We obtained...
Resource-Aware Least Busy (RALB) Strategy for Load Balancing in Containerized Cloud Systems
Containers are a key technology in modern cloud environments. They provide a lightweight manner to package and deploy service applications compared to virtual machines, with an isolated processing approach. The state-of-the-art...
Published by: IGI Global Scientific Publishing
Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease.
Calum A Hamilton, Fiona E Matthews, Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Ian G McKeith, Alan J Thomas
Apr 14, 2020
BACKGROUND: Mild cognitive impairment (MCI) may gradually worsen to dementia, but often remains stable for extended periods of time. Little is known about the predictors of decline to help explain this variation. We aimed to...
Alzheimer's Disease dementia with Lewy bodies latent class mixture modelling longitudinal decline mild cognitive impairment Aged Aged 80 and over Alzheimer Disease Cognitive Dysfunction Disease Progression England Female Humans latent class analysis Lewy Bodies Lewy Body Disease Longitudinal Studies Male Middle Aged Prospective Studies
Drones, Swarms, and Becoming-Insect
LB Wilcox
Apr 10, 2017
Insects and ‘the swarm’ as metaphors and objects of research have inspired works in the genres of science fiction and horror; social and political theorists; and the development of war-fighting technologies such as ‘drone...
Associations between organized sports participation and objectively measured physical activity, sedentary time and weight status in youth
Objectives
The purpose of this study was to examine whether participation in organized sports is related to achieving physical activity recommendations, body mass index (BMI), objectively measured PA intensity and time spent...
Phylogeography of Lyme borreliosis-group spirochetes and methicillin-resistant <em>Staphylococcus aureus</em>
Multilocus sequence typing (MLST) and multilocus sequence analysis (MLSA) have revolutionized understanding the global epidemiology of many medically relevant bacteria utilizing a number, mostly seven, of housekeeping genes. A...
N-heterocyclic carbene adducts of molybdenum tetra-carboxylate complexes
Treatment of the quadruply bonded dimolybdenum complexes [Mo2(μ-O2CCF3)4] (1), [Mo2(μ-O2CCH3)4] (2) and [Mo2(μ-O2CBut)4] (3) with the N-heterocyclic carbenes (NHCs), L (La = IPr, Lb =IMes, Lc = IiPr2Me2 and Ld = IEt2Me2)...
Thermodynamics of CuPt nanoalloys.
The control of structural and chemical transitions in bimetallic nanoalloys at finite temperatures is one of the challenges for their use in advanced applications. Comparing Nested Sampling and Molecular Dynamics simulations, we...
Nested sampling for materials
Abstract
We review the materials science applications of the nested sampling (NS) method, which was originally conceived for calculating the evidence in...
N-heterocyclic carbene adducts of molybdenum tetra-carboxylate complexes
Treatment of the quadruply bonded dimolybdenum complexes [Mo2(μ-O2CCF3)4] (1), [Mo2(μ-O2CCH3)4] (2) and [Mo2(μ-O2CBut)4] (3) with the N-heterocyclic carbenes (NHCs), L (La = IPr, Lb =IMes, Lc = IiPr2Me2 and Ld = IEt2Me2)...
Phylogeography of Lyme borreliosis-group spirochetes and methicillin-resistant <em>Staphylococcus aureus</em>
Multilocus sequence typing (MLST) and multilocus sequence analysis (MLSA) have revolutionized understanding the global epidemiology of many medically relevant bacteria utilizing a number, mostly seven, of housekeeping genes. A...
Prospective longitudinal evaluation of cytokines in mild cognitive impairment due to AD and Lewy body disease.
Alan J Thomas, Calum A Hamilton, Paul C Donaghy, Carmen Martin-Ruiz, Chris M Morris, Nicola Barnett, Kirsty Olsen, John-Paul Taylor, John T O'Brien
Jun 18, 2020
OBJECTIVES: We conducted a prospective longitudinal study of plasma cytokines during the Mild Cognitive Impairment (MCI) stage of Lewy body disease and Alzheimer's disease, hypothesizing that cytokine levels would decrease over...
The limits of planned obsolescence for conspicuous durable goods
An extensive body of literature argues for the benefits of planned obsolescence, the strategy of designing products with low durability to induce repeat purchases from the consumers and allow the firm to sell a larger volume....
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation.
Lasse Reimer, Hjalte Gram, Nanna Møller Jensen, Cristine Betzer, Li Yang, Lorrain Jin, Min Shi, Driss Boudeffa, Giuliana Fusco, Alfonso De Simone, Deniz Kirik, Hilal A Lashuel, Jing Zhang, Poul Henning Jensen
Mar 02, 2023
Aggregated α-synuclein (α-syn) accumulates in the neuronal Lewy body (LB) inclusions in Parkinson's disease (PD) and LB dementia. Yet, under nonpathological conditions, monomeric α-syn is hypothesized to exist in an equilibrium...
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