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Results: 325
Characterizing Tightness of LP Relaxations by Forbidding Signed Minors
Adrian Weller
Jun 09, 2016
We consider binary pairwise graphical models and provide an exact characterization (necessary and sufficient conditions observing signs of potentials) of tightness for the LP relaxation on the triplet-consistent polytope of the...
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes
Jakie Guertin, Yannick Kaiser, Hasanga Manikpurage, Nicolas Perrot, Raphaëlle Bourgeois, Christian Couture, Nicholas J Wareham, Yohan Bossé, Philippe Pibarot, Erik SG Stroes, Patrick Mathieu, Marie-Annick Clavel, Sébastien Thériault, S Matthijs Boekholdt, Benoit J Arsenault
Jul 26, 2021
BACKGROUND: Elevated Lp(a) (Lipoprotein(a)) levels are associated with coronary artery disease (CAD), ischemic stroke (IS), and calcific aortic valve stenosis (CAVS). Studies investigating the association between Lp(a) levels...
apoB/apoA-I Ratio and Lp(a) Associations With Aortic Valve Stenosis Incidence
Kang H Zheng, Benoit J Arsenault, Yannick Kaiser, Kay-Tee Khaw, Nicholas J Wareham, Erik SG Stroes, S Matthijs Boekholdt
Aug 21, 2019
Background Apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio and lipoprotein(a) (Lp[a]) are associated with aortic valve stenosis (AVS) disease progression. Clinical characteristics such as age, sex, and presence of...
aortic valve stenosis apoB/apoA‐I ratio lipids and lipoproteins lipoprotein(a) low‐density lipoprotein cholesterol Adult Aged aortic valve stenosis Apolipoprotein A-I Apolipoproteins B Cholesterol LDL Comorbidity Coronary Artery Disease Female Humans Incidence lipoprotein(a) Longitudinal Studies Male Middle Aged Prospective Studies United Kingdom
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
Performance of the ImmuView and BinaxNOW assays for the detection of urine and cerebrospinal fluid Streptococcus pneumoniae and Legionella pneumophila serogroup 1 antigen in patients with Legionnaires' disease or pneumococcal pneumonia and meningitis.
The performances of the ImmuView Streptococcus pneumoniae (Sp) and Legionella pneumophila (Lp) urinary antigen test were compared to that of the BinaxNOW Sp and Lp assays, using frozen urine from 166 patients with Legionnaires'...
Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target
JM Gregson, DF Freitag, P Surendran, NO Stitziel, R Chowdhury, S Burgess, S Kaptoge, P Gao, JR Staley, P Willeit, SF Nielsen, M Caslake, S Trompet, LM Polfus, K Kuulasmaa, J Kontto, M Perola, S Blankenberg, G Veronesi, F Gianfagna, S Männistö, A Kimura, H Lin, DF Reilly, M Gorski, V Mijatovic, CKDGen consortium, PB Munroe, GB Ehret, International Consortium for Blood Pressure, A Thompson, M Uria-Nickelsen, A Malarstig, A Dehghan, CHARGE inflammation working group, TF Vogt, T Sasaoka, F Takeuchi, N Kato, Y Yamada, F Kee, M Müller-Nurasyid, J Ferrières, D Arveiler, P Amouyel, V Salomaa, E Boerwinkle, SG Thompson, I Ford, J Wouter Jukema, N Sattar, CJ Packard, AA Shafi Majumder, DS Alam, P Deloukas, H Schunkert, NJ Samani, S Kathiresan, MICAD Exome consortium, BG Nordestgaard, D Saleheen, JM Howson, E Di Angelantonio, AS Butterworth, J Danesh, EPIC-CVD consortium and the CHD Exome+ consortium
Mar 23, 2017
Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk
Benoit J Arsenault, William Pelletier, Yannick Kaiser, Nicolas Perrot, Christian Couture, Kay-Tee Khaw, Nicholas J Wareham, Yohan Bossé, Philippe Pibarot, Erik SG Stroes, Patrick Mathieu, Sébastien Thériault, S Matthijs Boekholdt
Mar 31, 2020
IMPORTANCE: Elevated lipoprotein(a) (Lp[a]) levels are associated with atherosclerotic cardiovascular diseases. The association between high Lp(a) levels and human longevity phenotypes is, however, controversial. OBJECTIVE: To...
Cardiovascular disease risk associated with elevated lipoprotein(a) attenuates at low low-density lipoprotein cholesterol levels in a primary prevention setting.
Rutger Verbeek, Renate M Hoogeveen, Anne Langsted, Lotte CA Stiekema, Simone L Verweij, G Kees Hovingh, Nicholas J Wareham, Kay-Tee Khaw, S Matthijs Boekholdt, Børge G Nordestgaard, Erik SG Stroes
Apr 05, 2019
AIMS: Lipoprotein(a) (Lp(a)) elevation is a causal risk factor for cardiovascular disease (CVD). It has however been suggested that elevated Lp(a) causes CVD mainly in individuals with high low-density lipoprotein cholesterol...
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans
Nicolas Perrot, Sébastien Thériault, Sidwell Rigade, Hao Yu Chen, Christian Dina, Andreas Martinsson, S Matthijs Boekholdt, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, James C Engert, Nicholas J Wareham, Marie-Annick Clavel, Philippe Pibarot, J Gustav Smith, Jean Jacques Schott, Patrick Mathieu, Yohan Bossé, George Thanassoulis, Benoit J Arsenault
Jul 08, 2020
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and...
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.
Nicolas Perrot, Sébastien Thériault, Sidwell Rigade, Hao Yu Chen, Christian Dina, Andreas Martinsson, S Matthijs Boekholdt, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, James C Engert, Nicholas J Wareham, Marie-Annick Clavel, Philippe Pibarot, J Gustav Smith, Jean Jacques Schott, Patrick Mathieu, Yohan Bossé, George Thanassoulis, Benoit J Arsenault
Jul 14, 2020
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and...
Aortic stenosis Coronary Artery Disease 1-Alkyl-2-acetylglycerophosphocholine Esterase Aged Aged 80 and over Aortic Valve aortic valve stenosis Biomarkers Calcinosis Case-Control Studies Europe Female Genetic Association Studies Genetic Predisposition to Disease Humans Male Meta-Analysis as Topic Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Up-Regulation
Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
Sadam Yaseen, Gregory Demopulos, Thomas Dudler, Munehisa Yabuki, Christi L Wood, W Jason Cummings, Larry W Tjoelker, Teizo Fujita, Steven Sacks, Peter Garred, Peter Andrew, Robert B Sim, Peter J Lachmann, Russell Wallis, Nicholas Lynch, Wilhelm J Schwaeble
Aug 05, 2019
All 3 activation pathways of complement-the classic pathway (CP), the alternative pathway, and the lectin pathway (LP)- converge into a common central event: the cleavage and activation of the abundant third complement...
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins
Youssif M. Ali, Matteo Ferrari, Nicholas J. Lynch, Sadam Yaseen, Thomas Dudler, Sasha Gragerov, Gregory Demopulos, Jonathan L. Heeney, Wilhelm J. Schwaeble
Jul 28, 2021
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction...
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies
Stephen Burgess, Brian A Ference, James R Staley, Daniel F Freitag, Amy M Mason, Sune F Nielsen, Peter Willeit, Robin Young, Praveen Surendran, Savita Karthikeyan, Thomas R Bolton, James E Peters, Pia R Kamstrup, Anne Tybjaerg-Hansen, Marianne Benn, Anne Langsted, Peter Schnohr, Signe Vedel-Krogh, Camilla J Kobylecki, Ian Ford, Chris Packard, Stella Trompet, J Wouter Jukema, Naveed Sattar, Emanuele Di Angelantonio, Danish Saleheen, Joanna MM Howson, Børge G Nordestgaard, Adam S Butterworth, John Danesh, European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium
Sep 27, 2018
IMPORTANCE: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25%...
Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role.
D Mercurio, M Oggioni, S Fumagalli, NJ Lynch, S Roscher, D Minuta, C Perego, S Ippati, R Wallis, WJ Schwaeble, M-G De Simoni
Dec 14, 2020
The lectin pathway (LP) of complement activation is believed to contribute to brain inflammation. The study aims to identify the key components of the LP contributing to TBI outcome as possible novel pharmacological targets. We...
Complement cascade Lectin pathway MBL-associated serine protease Neuroinflammation Neurological deficits Pharmacological target Traumatic brain injury Animals Brain Brain Injuries Traumatic Collectins Complement C4b Complement Pathway Mannose-Binding Lectin Gene Deletion Inflammation Lectins Mannose-Binding Lectin Mannose-Binding Protein-Associated Serine Proteases Mice Mice Knockout Prognosis Recovery of Function
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans
Nicolas Perrot, Sébastien Thériault, Sidwell Rigade, Hao Yu Chen, Christian Dina, Andreas Martinsson, S Matthijs Boekholdt, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, James C Engert, Nicholas J Wareham, Marie-Annick Clavel, Philippe Pibarot, J Gustav Smith, Jean Jacques Schott, Patrick Mathieu, Yohan Bossé, George Thanassoulis, Benoit J Arsenault
Jul 10, 2020
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and...
Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk
Julian C van Capelleveen, Sang-Rok Lee, Rutger Verbeek, John JP Kastelein, Nicholas J Wareham, Erik SG Stroes, G Kees Hovingh, Kay-Tee Khaw, S Matthijs Boekholdt, Joseph L Witztum, Sotirios Tsimikas
Jul 01, 2019
BACKGROUND: Plasma apolipoprotein C-III (apoC-III) levels are associated with coronary artery disease (CAD) risk. OBJECTIVE: To assess whether lipoprotein-associated apoC-III levels predict risk of CAD events. METHODS: apoC-III...
CBT repackaged or a novel treatment? The Lightning Process® compared with specialist medical care for paediatric Chronic Fatigue Syndrome.
Emma Anderson, Maria Loades, Jennifer Starbuck, Phil Parker, Fiona Finch, Rebecca Barnes, Lucy Beasant, Esther Crawley
Dec 31, 2021
Rationale
UK specialist medical care (SMC) for paediatric Chronic Fatigue Syndrome (CFS/ME) includes behavioural approaches (Graded Exercise Therapy; Activity Management) and Cognitive Behavioural Therapy for fatigue...
UK specialist medical care (SMC) for paediatric Chronic Fatigue Syndrome (CFS/ME) includes behavioural approaches (Graded Exercise Therapy; Activity Management) and Cognitive Behavioural Therapy for fatigue...
Lipoprotein(a) and incident type-2 diabetes
Ellie Paige, Katya L Masconi, Sotirios Tsimikas, Florian Kronenberg, Peter Santer, Siegfried Weger, Johann Willeit, Stefan Kiechl, Peter Willeit
May 05, 2017
AIMS: We aimed to (1) assess the association between lipoprotein(a) [Lp(a)] concentration and incident type-2 diabetes in the Bruneck study, a prospective population-based study, and (2) combine findings with evidence from...
CBT repackaged or a novel treatment? The Lightning Process® compared with specialist medical care for paediatric Chronic Fatigue Syndrome.
Emma Anderson, Maria Loades, Jennifer Starbuck, Phil Parker, Fiona Finch, Rebecca Barnes, Lucy Beasant, Esther Crawley
Dec 31, 2021
Rationale
UK specialist medical care (SMC) for paediatric Chronic Fatigue Syndrome (CFS/ME) includes behavioural approaches (Graded Exercise Therapy; Activity Management) and Cognitive Behavioural Therapy for fatigue...
UK specialist medical care (SMC) for paediatric Chronic Fatigue Syndrome (CFS/ME) includes behavioural approaches (Graded Exercise Therapy; Activity Management) and Cognitive Behavioural Therapy for fatigue...
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins.
Youssif M Ali, Matteo Ferrari, Nicholas J Lynch, Sadam Yaseen, Thomas Dudler, Sasha Gragerov, Gregory Demopulos, Jonathan L Heeney, Wilhelm J Schwaeble
Sep 13, 2021
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction...
covid-19 SARS-CoV-2 Complement system innate immunity Lectin pathway Adult Aged Aged 80 and over Asian People Biomarkers covid-19 Cohort Studies Complement Activation Complement System Proteins Female Humans Lectins Male Middle Aged Renal Insufficiency Chronic SARS-CoV-2 Severity of Illness Index Spike Glycoprotein Coronavirus White People
Impact of International Monetary Fund programs on child health
Parental education is located at the center of global efforts to improve child health. In a developing-country context, the International Monetary Fund (IMF) plays a crucial role in determining how governments allocate scarce...
Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.
Nicolas Perrot, Sébastien Thériault, Christian Dina, Hao Yu Chen, S Matthijs Boekholdt, Sidwell Rigade, Audrey-Anne Després, Anthony Poulin, Romain Capoulade, Thierry Le Tourneau, David Messika-Zeitoun, Mikaël Trottier, Michel Tessier, Jean Guimond, Maxime Nadeau, James C Engert, Kay-Tee Khaw, Nicholas J Wareham, Marc R Dweck, Patrick Mathieu, Philippe Pibarot, Jean-Jacques Schott, George Thanassoulis, Marie-Annick Clavel, Yohan Bossé, Benoit J Arsenault
Jun 20, 2019
IMPORTANCE: Genetic variants at the LPA locus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those...
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