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Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension.
Ivana Nikolic, Lai-Ming Yung, Peiran Yang, Rajeev Malhotra, Samuel D Paskin-Flerlage, Teresa Dinter, Geoffrey A Bocobo, Kathleen E Tumelty, Anthony J Faugno, Luca Troncone, Megan E McNeil, Xiuli Huang, Kathryn R Coser, Carol SC Lai, Paul D Upton, Marie Jose Goumans, Roham T Zamanian, C Gregory Elliott, Arthur Lee, Wei Zheng, Stephen P Berasi, Christine Huard, Nicholas W Morrell, Raymond T Chung, Richard W Channick, Kari E Roberts, Paul B Yu
Dec 04, 2018
RATIONALE: BMP9 (bone morphogenetic protein 9) is a circulating endothelial quiescence factor with protective effects in pulmonary arterial hypertension (PAH). Loss-of-function mutations in BMP9, its receptors, and downstream...
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
Lu Long, Mark L Ormiston, Xudong Yang, Mark Southwood, Stefan Gräf, Rajiv D Machado, Matthias Mueller, Bernd Kinzel, Lai Ming Yung, Janine M Wilkinson, Stephen D Moore, Kylie M Drake, Micheala A Aldred, Paul B Yu, Paul D Upton, Nicholas W Morrell
Jan 23, 2018
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH). However, selective targeting of this...
aging Animals Apoptosis Bone Morphogenetic Protein Receptors Type II Cell Membrane Permeability Densitometry Endothelial Cells Gene Expression Profiling Gene Knock-In Techniques Growth Differentiation Factor 2 Heart Ventricles Humans Hypertension Pulmonary Immunoblotting JNK Mitogen-Activated Protein Kinases Male Mice Inbred C57BL Monocrotaline Phosphorylation Pulmonary Artery Rats Rats Sprague-Dawley Systole Transcription Genetic
Design, dynamic simulation and construction of a hybrid HTS SMES (high-temperature superconducting magnetic energy storage systems) for Chinese power grid
High-temperature superconducting magnetic energy storage systems (HTS SMES) are an emerging technology with fast response and large power capacities which can address the challenges of growing power systems and ensure a reliable...
NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma.
Moinul Haque, Jing Li, Yung-Hsing Huang, Meaad Almowaled, Carter J Barger, Adam R Karpf, Peng Wang, Will Chen, Suzanne D Turner, Raymond Lai
Aug 13, 2019
Forkhead Box M1 (FOXM1) is an oncogenic transcription factor implicated in the pathogenesis of solid and hematologic cancers. In this study, we examined the significance of FOXM1 in NPM-ALK-positive anaplastic large cell...
Design, dynamic simulation and construction of a hybrid HTS SMES (high-temperature superconducting magnetic energy storage systems) for Chinese power grid
High-temperature superconducting magnetic energy storage systems (HTS SMES) are an emerging technology with fast response and large power capacities which can address the challenges of growing power systems and ensure a reliable...
A Prospective Randomized Controlled Trial Comparing the Efficacy of Fascia Iliaca Compartment Block Versus Local Anesthetic Infiltration After Hip Arthroscopic Surgery.
PURPOSE: To compare the efficacy of fascia iliaca compartment block (FICB) with local anesthetic infiltration (LAI) of the arthroscopy portals for pain control after hip arthroscopy. METHODS: A prospective single-blinded...
Early intervention for incipient insanity
Hang Sze Chau, Wai Sun Chong, Josephine Grace Wing San Wong, Gabriel Bing Kei Hung, Simon Sai Yu Lui, Sherry Kit Wa Chan, Wing Chung Chang, Christy Lai Ming Hui, Edwin Ho Ming Lee, Patrick D McGorry, Peter B Jones, Eric Yu Hai Chen
May 11, 2016
Stratosphere-troposphere coupling in the Earth system
A Ming
Jun 04, 2015
This is the author accepted manuscript. The final version is available at http://onlinelibrary.wiley.com/doi/10.1002/wea.2517/abstract.
Adipose tissue responses to breaking sitting in men and women with central adiposity
Purpose Breaking prolonged sitting reduces postprandial glucose and insulin concentrations and influences skeletal muscle molecular signaling pathways, but it is unknown whether breaking sitting also affects adipose tissue....
Revisiting the Water-Use Efficiency Performance for Microelectronics Manufacturing Facilities
Semiconductors are enabling technologies that drive today’s information economy by producing a broad spectrum of microelectronic consumer products including computers, flat-panel displays, sensors, storage devices, and lighting...
Water reuse Water reclamation Industrial water use Semiconductors Wafer fabrication Fabs Green manufacturing Water Resource Management
Published by: Digital Commons @ Texas A&M University-San Antonio
Revisiting the Water-Use Efficiency Performance for Microelectronics Manufacturing Facilities
Semiconductors are enabling technologies that drive today’s information economy by producing a broad spectrum of microelectronic consumer products including computers, flat-panel displays, sensors, storage devices, and lighting...
Water reuse Water reclamation Industrial water use Semiconductors Wafer fabrication Fabs Green manufacturing Water Resource Management
Published by: Digital Commons @ Texas A&M University-San Antonio
Mitochondrial - Endoplasmic reticulum interactions in the trophoblast
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.
Endoplasmic reticulum (ER) stress is a common factor in the pathophysiology of diverse human diseases that are characterised by contrasting cellular behaviours, from proliferation in cancer to apoptosis in neurodegenerative...
Designed beta-hairpins inhibit LDH5 oligomerization and enzymatic activity
Lactate dehydrogenase 5 (LDH5) is overexpressed in aggressive and metastatic tumors and is an attractive target for anticancer therapy. Small molecule drugs have been developed to target the substrate and/or the cofactor sites...
Analysis of Delays in Processing Times in an Ophthalmology Clinic
Kai Yung Natalie Lui
Jan 01, 0001
Efficiency is an important component of any medical practice. It facilitates quality care, reduction in wait time, patient and staff satisfaction, and decreased cost. The purpose of this study was to identify bottlenecks in the...
Lean thinking patient flow opthamology optometry eye clinic patient processing time patient waiting time Analytical, Diagnostic and Therapeutic Techniques and Equipment health information technology Ophthalmology Quality Improvement
Published by: Harrisburg University of Science and Technology
Designed beta-hairpins inhibit LDH5 oligomerization and enzymatic activity
Lactate dehydrogenase 5 (LDH5) is overexpressed in aggressive and metastatic tumors and is an attractive target for anticancer therapy. Small molecule drugs have been developed to target the substrate and/or the cofactor sites...
Development of a sensitive multiplexed open circuit potential system for the detection of prostate cancer biomarkers
We report the development of a sensitive label-free, cost-effective detection system with simultaneous multi-channel measurement of open circuit potential (OCP) variations for the detection of prostate specific antigen (PSA)....
Development of a sensitive multiplexed open circuit potential system for the detection of prostate cancer biomarkers
We report the development of a sensitive label-free, cost-effective detection system with simultaneous multi-channel measurement of open circuit potential (OCP) variations for the detection of prostate specific antigen (PSA)....
Revisiting the Water-Use Efficiency Performance for Microelectronics Manufacturing Facilities
Semiconductors are enabling technologies that drive today’s information economy by producing a broad spectrum of microelectronic consumer products including computers, flat-panel displays, sensors, storage devices, and lighting...
Water reuse Water reclamation Industrial water use Semiconductors Wafer fabrication Fabs Green manufacturing Water Resource Management
Published by: Digital Commons @ Texas A&M University-San Antonio
Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss.
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