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Results: 33
Structure-Function Studies on Human Epithelial Cystic Fibrosis Chloride Channels Expressed in Xenopus Laevis Oocytes
Laszlo Csanady
Jan 01, 0001
The cystic fibrosis transmembrane conductance regulator (CFTR) Cl" channel is an ATP-binding cassette protein, comprising two transmembrane domains, two nucleotide binding domains (NBD1, NBD2) and a regulatory (R) domain....
Published by: Rockefeller University
Martingale defocusing and transience of a self-interacting random walk
Suppose that (X,Y,Z) is a random walk in Z3 that moves in the following way: on the first visit to a vertex only Z changes by ±1 equally likely, while on later visits to the same vertex (X,Y) performs a two-dimensional random...
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Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.
Identifying distinct anatomical structures within the brain and developing genetic tools to target them are fundamental steps for understanding brain function. We hypothesize that enhancer expression patterns can be used to...
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ZEITLUPE Promotes ABA-Induced Stomatal Closure in Arabidopsis and Populus.
Plants balance water availability with gas exchange and photosynthesis by controlling stomatal aperture. This control is regulated in part by the circadian clock, but it remains unclear how signalling pathways of daily rhythms...
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Structural Study of Disease Relevant ABC Transporters-Cystic Fibrosis Transmembrane Conductance Regulator and ABCA4
Fangyu Liu
Jan 01, 0001
ATP-binding cassette (ABC) transporters are primary transporters that utilize the energy from ATP binding and hydrolysis to transport substrates across membrane against their concentration gradients [1]. Structurally, canonical...
Published by: Rockefeller University
Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy.
Walter Paul Weber, Jane Shaw, Andrea Pusic, Lynda Wyld, Monica Morrow, Tari King, Zoltán Mátrai, Jörg Heil, Florian Fitzal, Shelley Potter, Isabel T Rubio, Maria-Joao Cardoso, Oreste Davide Gentilini, Viviana Galimberti, Virgilio Sacchini, Emiel JT Rutgers, John Benson, Tanir M Allweis, Martin Haug, Regis R Paulinelli, Tibor Kovacs, Yves Harder, Bahadir M Gulluoglu, Eduardo Gonzalez, Andree Faridi, Elisabeth Elder, Peter Dubsky, Jens-Uwe Blohmer, Vesna Bjelic-Radisic, Mitchel Barry, Susanne Dieroff Hay, Kimberly Bowles, James French, Roland Reitsamer, Rupert Koller, Peter Schrenk, Daniela Kauer-Dorner, Jorge Biazus, Fabricio Brenelli, Jaime Letzkus, Ramon Saccilotto, Sarianna Joukainen, Susanna Kauhanen, Ulla Karhunen-Enckell, Juergen Hoffmann, Ulrich Kneser, Thorsten Kühn, Michalis Kontos, Ekaterini Christina Tampaki, Moshe Carmon, Tal Hadar, Giuseppe Catanuto, Carlos A Garcia-Etienne, Linetta Koppert, Pedro F Gouveia, Jakob Lagergren, Tor Svensjö, Nadia Maggi, Elisabeth A Kappos, Fabienne D Schwab, Liliana Castrezana, Daniel Steffens, Janna Krol, Christoph Tausch, Andreas Günthert, Michael Knauer, Maria C Katapodi, Susanne Bucher, Nik Hauser, Christian Kurzeder, Rosine Mucklow, Pelagia G Tsoutsou, Atakan Sezer, Güldeniz Karadeniz Çakmak, Hasan Karanlik, Patricia Fairbrother, Laszlo Romics, Giacomo Montagna, Cicero Urban, Melanie Walker, Silvia C Formenti, Guenther Gruber, Frank Zimmermann, Daniel Rudolf Zwahlen, Sherko Kuemmel, Mahmoud El-Tamer, Marie Jeanne Vrancken Peeters, Orit Kaidar-Person, Michael Gnant, Philip Poortmans, Jana de Boniface
May 09, 2022
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Report on the sixth blind test of organic crystal structure prediction methods.
Anthony M Reilly, Richard I Cooper, Claire S Adjiman, Saswata Bhattacharya, A Daniel Boese, Jan Gerit Brandenburg, Peter J Bygrave, Rita Bylsma, Josh E Campbell, Roberto Car, David H Case, Renu Chadha, Jason C Cole, Katherine Cosburn, Herma M Cuppen, Farren Curtis, Graeme M Day, Robert A DiStasio, Alexander Dzyabchenko, Bouke P van Eijck, Dennis M Elking, Joost A van den Ende, Julio C Facelli, Marta B Ferraro, Laszlo Fusti-Molnar, Christina Anna Gatsiou, Thomas S Gee, René de Gelder, Luca M Ghiringhelli, Hitoshi Goto, Stefan Grimme, Rui Guo, Detlef WM Hofmann, Johannes Hoja, Rebecca K Hylton, Luca Iuzzolino, Wojciech Jankiewicz, Daniël T de Jong, John Kendrick, Niek JJ de Klerk, Hsin Yu Ko, Liudmila N Kuleshova, Xiayue Li, Sanjaya Lohani, Frank JJ Leusen, Albert M Lund, Jian Lv, Yanming Ma, Noa Marom, Artëm E Masunov, Patrick McCabe, David P McMahon, Hugo Meekes, Michael P Metz, Alston J Misquitta, Sharmarke Mohamed, Bartomeu Monserrat, Richard J Needs, Marcus A Neumann, Jonas Nyman, Shigeaki Obata, Harald Oberhofer, Artem R Oganov, Anita M Orendt, Gabriel I Pagola, Constantinos C Pantelides, Chris J Pickard, Rafal Podeszwa, Louise S Price, Sarah L Price, Angeles Pulido, Murray G Read, Karsten Reuter, Elia Schneider, Christoph Schober, Gregory P Shields, Pawanpreet Singh, Isaac J Sugden, Krzysztof Szalewicz, Christopher R Taylor, Alexandre Tkatchenko, Mark E Tuckerman, Francesca Vacarro, Manolis Vasileiadis, Alvaro Vazquez-Mayagoitia, Leslie Vogt, Yanchao Wang, Rona E Watson, Gilles A de Wijs, Jack Yang, Qiang Zhu, Colin R Groom
May 16, 2016
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Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
Thanos P. Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C. Fitzgerald, Paola Scaffidi, Francesca D. Ciccarelli, Ayesha Noorani, Paul A. W. Edwards, Rachael Fels Elliott, Nicola Grehan, Barbara Nutzinger, Caitriona Hughes, Elwira Fidziukiewicz, Jan Bornschein, Shona MacRae, Jason Crawte, Alex Northrop, Gianmarco Contino, Xiaodun Li, Rachel de la Rue, Annalise Katz-Summercorn, Sujath Abbas, Daniel Loureda, Maria O’Donovan, Ahmad Miremadi, Shalini Malhotra, Monika Tripathi, Simon Tavaré, Andy G. Lynch, Matthew Eldridge, Maria Secrier, Lawrence Bower, Ginny Devonshire, Sriganesh Jammula, Jim Davies, Charles Crichton, Nick Carroll, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Stephen J. Hayes, Yeng Ang, Andrew Sharrocks, Shaun R. Preston, Sarah Oakes, Izhar Bagwan, Vicki Save, Richard J. E. Skipworth, Ted R. Hupp, J. Robert O’Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Timothy J. Underwood, Robert C. Walker, Ben L. Grace, Hugh Barr, Neil Shepherd, Oliver Old, James Gossage, Andrew Davies, Fuju Chang, Janine Zylstra, Ula Mahadeva, Vicky Goh, Grant Sanders, Richard Berrisford, Catherine Harden, Mike Lewis, Ed Cheong, Bhaskar Kumar, Simon L. Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Laszlo Igali, Michael Scott, Sharmila Sothi, Sari Suortamo, Suzy Lishman, George B. Hanna, Christopher J. Peters, Krishna Moorthy, Anna Grabowska, Richard Turkington, Damian McManus, David Khoo, Will Fickling
Jul 14, 2020
Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning...
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Breast cancer management pathways during the COVID-19 pandemic
Rajiv V. Dave, Baek Kim, Alona Courtney, Rachel O’Connell, Tim Rattay, Vicky P. Taxiarchi, Jamie J. Kirkham, Elizabeth M. Camacho, Patricia Fairbrother, Nisha Sharma, Christopher W. J. Cartlidge, Kieran Horgan, Stuart A. McIntosh, Daniel R. Leff, Raghavan Vidya, Chris Holcombe, Ellen Copson, Charlotte E. Coles, Ramsey I. Cutress, Ashu Gandhi, Cliona C. Kirwan, Amit Agrawal, John Benson, Parto Forouhi, Primeera Wignarajah, Anu Shrotri, Arjun Kattakayam, Jarin Louis Noronha, Lee Martin, Mohamed Lafi, Rob Hardy, Khalid Amin, Abdalla Saad Abdalla AL-Zawi, Mohamed Elamass, Ali Salih, Firas Eddin Bachir Alkistawi, Anna Heeney, Arnold D. K. Hill, Colm Power, Michael J. Allen, Ashok Chouhan, Rathi Rathinaezhil, Samy Shaheed, Charles Zammit, Gillian Clayton, Sascha Dua, Simon Smith, Tasha Gandamihardja, Chloe Williams, Donna Egbeare, Eleri Davies, Helen M. Sweetland, Sharat Chopra, Sumit Goyal, Dalia Elfadl, Dheer Singh Rana, Eliana Kalakouti, Musa Barkeji, Rajiv Vashisht, Ralia Bunza, Saung Hnin Phyu, Ciaran Hollywood, Iman Azmy, Julia Massey, Anita Hargreaves, Claudia Harding-Mackean, Jane Ooi, Joanna Seward, Helen Mathers, Norah Scally, Reem Salman, Hyunjin Shin, Jane Turner, Lubna Noor, Sanjay Joshi, Sarah Horne, Wail Al Sarakbi, Peter Liptay-Wagner, Rosamond Jacklin, Sankaran Chandrasekharan, Simon Marsh, Sunita Saha, Christopher Wilson, Claire Louise Rutherford, Julie Doughty, Laszlo Romics, Sheila Stallard, Anushka Chaudhry, Jennifer Peck, Nathan Coombs, Samantha K. Williams, Simon Hawkins, Ashutosh Kothari, Hisham Hamed, Urvashi Jain, Ian Daltrey, Nick Abbott, Russell Mullen, Dorin Dumitru, Eiman Khalifa, Masuma Sarker, M. Bilal Elahi, Raouef Ahmed Bichoo, Anzors Gvaramadze, Dinesh Thekkinkattil, Jibril Jibril, Demetrios Hadjiminas, Edward R. C. St John, Henry Douglas Robb, Katy Hogben, Nur Amalina Che Bakri, Paul Thiruchelvam, Georgios Exarchos, Ragheed Al-Mufti, Caroline Mortimer, Evangelos Mallidis, Georgios Karagiannidis, Hussein Tuffaha, Inga Peerlink, Rajive Nair, Lydia Prusty, Amtul Sami, Alex Knight, Duraisamy Ravichandran, Katharine Kirkpatrick, Ruth James, Deepika Akolekar, Disha Mehta, Ellora Barua, Hannah Knowles, Haresh Devalia, Karina Cox, Mohsin Dani, Ritchie Chalmers, Anjana Satpathy, Edel Quinn, Gerard Byrne, James Harvey, John Murphy, Lyndsey Highton, Mohammad Amir Sharif, Nicola Barnes, Nikitas Dimopoulos, Richard Johnson, Sumohan Chatterjee, Hiba Fatayer, Vinod Mathen, Amanda Taylor, Rachel Soulsby, Adam Walsh, Amanda Thorne, Jasper Gill, Louise Merker, Adam Critchley, Andrew Pieri, Henry Cain, Jane Ralph, Loraine Kalra, Robert Thomas, Ian Young, Lucy R. Khan, Beatrix Elsberger, Elizabeth Smyth, Gordon Urquhart, Mairi Fuller, Yazan Masannat, Ada Chrysafi, Muhammad Salman, El-Rasheed Abdalla, Katalin Zechmeister, Maged Hussien, Mina M. G. Youssef, Angeline Tanhueco, Reginald Salvador, Sharon Wallace, Simon Pain, Ajay Sahu, Alice Chambers, Alice Moody, Isabella Dash, James Cook, Jeremy Batt, Michelle Mullan, Mike Shere, Nicholas Gallegos, Rachel Ainsworth, Sasi Govindarajulu, Shelley Potter, Zenon Rayter, Kate E. Williams, Maria Bramley, Mohammed Absar, Nabila Nasir, Rami Tabbakh, Bernadette Pereira, Jasdeep Gahir, Karen Bosch, Oladapo Fafemi, Nader Touqan, Georgette Oni, Hazem Khout, Kristjan Asgeirsson, Lisa Whisker, Rachel Xue Ning Lee, Robert Macmillan, Stephen McCulley, Tuabin Rasheed, Asha Adwani, Ashvina Segaran, David Dodwell, Dennis Remoundos, Gael MacLean, Giulio Cuffolo, Michael Douek, Pankaj Roy, Toral Gathani, Erum Najeeb, Claudiu Simonca, Maria Verroiotou, Sa’ed Ramzi, Stephanie C. Jenkins, Vallipuran Gopalan, Sarah Barker, Ciara McGoldrick, Gareth W. Irwin, Peter Mallon, Samantha A. Sloan, Abbas Imran, Giuseppina Mondani, Iain Brown, Imran Abbas, Mona Sulieman, Philip Drew, Polly King, Rachel Elizabeth English, Anita Sharma, Charlotte Ives, Douglas Ferguson, George Boundouki, James Bentley, Jenny Banks, Julie Dunn, Rachel Tillett, Sisse Olsen, Anne Tansley, Emma de Sousa, Geraldine Mitchell, Ian Whitehead, Julia Henderson, Matthew Rowland, Mysore Chandrashekar, Raja Eid, Elizabeth Clayton, Farrokh Pakzad, Jonathan D. Horsnell, Matthew Hague, Polly Partlett, Tracey Irvine, Charlotte Kallaway, Katherine Fairhurst, Christiana Laban, Jamie McIntosh, Nicola Laurence, Richard Sutton, Anup Sharma, Dibyesh Banerjee, Nadine Betambeau, Sabrina Bezzaa, Sonia Bathla, Atanu Ray, Leena Chagla, Tamara Kiernan, Brian Hogan, Channegowda Navin, Emma MacInnes, Philip Turton, Raj Achuthan, Venla Kantola, Shireen Mckenzie, Helen Dent, Caroline Pogson, Shamaela Waheed, Tania S. de Silva, Usama Suleiman, Lucie Jones, Ruvinder Athwal, Simon Harries, Catherine Krzyzanowska, Abeera Abbas, Anna R. Hurley, Gerald Gui, Jennifer E. Rusby, Katherine Krupa, Kathryn E. Harborough, Nicola Roche, Peter A. Barry, Rebekah Law, William H. Allum, Cheryl Lobo, Eleni Ntakomyti, Joanna Franks, Massimiliano Cariati, Neill Patani, Noyko Stanilov, Petros Charalampoudis, Zarghuna Taraki, Kat McEvoy, Mohamed Razick Sait, Stuart Robertson, Bashar Zeidan, David Rew, Fayyaz Mazari, Louise Alder, Vasileios Sakellariou, Ahmed Hamad, Amit Goyal, Amtul Carmichael, Carol-Ann Courtney, David Mark Sibbering, Emanuele Garreffa, Kwok-Leung Cheung, Susan Williams-Jones, Yasmin Wahedna, Aonghus Ansari, Frances Kenny, Kalliope Valassiadou, Kelly Lambert, Jaroslaw Krupa, Mini V. Sardar, Monika Kaushik, Sheila Shokuhi, Simon Pilgrm, Walid Sasi, Penelope McManus, Rishikesh Parmeshwar, Santosh Somasundaram, Manoj Gowda, Sadaf Jafferbhoy, Sankaran Narayanan, Sekhar Marla, Soni Soumian, Ngee-Ming Goh, Jamie Vatish, Tin Aung Sein, Ennio Agabiti, Joseph Maalo, Kelvin Chong, Lee-Min Lai, Mohamed Elkorety, Sherif Monib, Simon Thomson, Youhana Mikhael, Bahar Mirshekar-Syahkal, Jane Aitken, Mina Girgis, Dibendu Betal, Fabio Rapisarda, Lorna Cook, Olubunmi Odofin, Riccardo Bonomi, Stacy Wardle, Wendy Sotheran, Irene Athanasiou, Jonathan Lund, Maria Callaghan, Rajaram Burrah, Raman Vinayagam, Karen James, Shabbir Poonawala, Brian Isgar, Pilar Matey, Senthurun Mylvaganam, Carl Podesta, Tapan Sircar, Fathi Salem, Zaid Al-Ishaq
Jun 10, 2021
Abstract: Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions....
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