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Real-Time Assessment of Health-Care Requirements During the Zika Virus Epidemic in Martinique.
Alessio Andronico, Frédérique Dorléans, Jean-Louis Fergé, Henrik Salje, Frédéric Ghawché, Aissatou Signate, Elise Daudens-Vaysse, Laure Baudouin, Timothée Dub, Maite Aubry, Van-Mai Cao-Lormeau, Martine Ledrans, Harold Noel, Henri-Pierre Mallet, Arnaud Fontanet, André Cabié, Simon Cauchemez
Feb 15, 2021
The spread of Zika virus in the Americas has been associated with a surge in Guillain-Barré syndrome (GBS) cases. Given the severity of GBS, territories affected by Zika virus need to plan health-care resources to manage GBS...
Weather, Land and Crops in the Indus Village Model
Andreas Angourakis, Jennifer Bates, Jean-Philippe Baudouin, Alena Giesche, Joanna R Walker, M Cemre Ustunkaya, Nathan Wright, Ravindra Nath Singh, Cameron Petrie
May 02, 2022
The start and end of the urban phase of the Indus civilization (IC; c. 2500 to 1900 BC) are often linked with climate change, specifically regarding trends in the intensity of summer and winter precipitation and its effect on...
The Reflexive Mind in Doris Lessing’s Landlocked > Poem and Novel
Dr Anne-Laure Brevet
Apr 23, 2021
Doris Lessing’s poem “Landlocked” was published on December, 20th 1946 in the daily newspaper New Rhodesia and remains little known as it was not included in the 1959 Fourteen Poems collection. Plausibly, one of the reasons for...
A national survey of the diagnosis and management of suspected ventilator-associated pneumonia.
Emma Browne, Thomas P Hellyer, Simon V Baudouin, Andrew Conway Morris, Vanessa Linnett, Danny F McAuley, Gavin D Perkins, A John Simpson
Jun 26, 2020
BACKGROUND: Ventilator-associated pneumonia (VAP) affects up to 20% of patients admitted to intensive care units (ICU). It is associated with increased morbidity, mortality and healthcare costs. Despite published guidelines...
The Evolution of Sox Gene Repertoires and Regulation of Segmentation in Arachnids.
Luis Baudouin-Gonzalez, Anna Schoenauer, Amber Harper, Grace Blakeley, Michael Seiter, Saad Arif, Lauren Sumner-Rooney, Steven Russell, Prashant P Sharma, Alistair P McGregor
Mar 10, 2021
The Sox family of transcription factors regulates many processes during metazoan development, including stem cell maintenance and nervous system specification. Characterizing the repertoires and roles of these genes can...
Low-noise, high-brightness, tunable source of picosecond pulsed light in the near-infrared and visible
We have built a flexible source of picosecond pulsed light in both the near-infrared and visible spectral regions. A photonic crystal fiber (PCF) was pumped with a pulsed 1064 nm fiber laser to generate four-wave mixing (FWM)...
Error rate on the director's task is influenced by the need to take another's perspective but not the type of perspective.
Adults are prone to responding erroneously to another's instructions based on what they themselves see and not what the other person sees. Previous studies have indicated that in instruction-following tasks participants make...
Low-noise, high-brightness, tunable source of picosecond pulsed light in the near-infrared and visible
We have built a flexible source of picosecond pulsed light in both the near-infrared and visible spectral regions. A photonic crystal fiber (PCF) was pumped with a pulsed 1064 nm fiber laser to generate four-wave mixing (FWM)...
Neoadjuvant trials in early breast cancer
Helena Earl, Elena Provenzano, Jean Abraham, Janet Dunn, Anne-Laure Vallier, Ioannis Gounaris, Louise Hiller
Sep 29, 2016
BACKGROUND: Neoadjuvant breast cancer trials are important for speeding up the introduction of new treatments for patients with early breast cancer and for the highly productive translational research which they facilitate....
Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses.
John D Widdrington, Aurora Gomez-Duran, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V Baudouin, Anthony J Rostron, Penny E Lovat, Patrick F Chinnery, A John Simpson
Nov 16, 2018
Nutrient sensing and acquisition in fungi
Fungal pathogens destroy our crops and cause hazardous human infections, therefore threatening our health and food security. The ability of fungal pathogens to sense and respond to dynamic host microenvironments enables the...
A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
Felipe Serrano, William George Bernard, Alessandra Granata, Dharini Iyer, Ben Steventon, Matthew Kim, Ludovic Vallier, Laure Gambardella, Sanjay Sinha
Dec 10, 2018
The neural crest (NC) is a transient multipotent cell population present during embryonic development. The NC can give rise to multiple cell types and is involved in a number of different diseases. Therefore, the development of...
Treacher Collins syndrome DIFFERENTIATION Disease Modeling Human pluripotent stem cells Neural Crest Adaptor Proteins Signal Transducing Animals Benzamides Cell Death Cell Differentiation Cell Movement Cellular Reprogramming Techniques Chick Embryo Dioxoles Fibroblast Growth Factor 2 Humans Mandibulofacial Dysostosis Neural Crest Neural Stem Cells Nuclear Proteins Phosphoproteins Pluripotent Stem Cells SOXE Transcription Factors Transcription Factor AP-2 Transcription Factors Twist-Related Protein 1
Introduction of glucan synthase into the cytosol in wheat endosperm causes massive maltose accumulation and represses starch synthesis.
Tina B Schreier, Brendan Fahy, Laure C David, Hamad Siddiqui, Roger Castells-Graells, Alison M Smith
May 05, 2021
We expressed a bacterial glucan synthase (Agrobacterium GlgA) in the cytosol of developing endosperm cells in wheat grains, to discover whether it could generate a glucan from cytosolic ADP-glucose. Transgenic lines had high...
Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells.
Emmanuel Than-Trong, Bahareh Kiani, Nicolas Dray, Sara Ortica, Benjamin Simons, Steffen Rulands, Alessandro Alunni, Laure Bally-Cuif
Jan 20, 2021
The cellular basis and extent of neural stem cell (NSC) self-renewal in adult vertebrates, and their heterogeneity, remain controversial. To explore the functional behavior and dynamics of individual NSCs, we combined genetic...
Adjuvant trastuzumab duration trials in HER2 positive breast cancer - what results would be practice-changing? Persephone investigator questionnaire prior to primary endpoint results.
Louise Hiller, Janet A Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L Howe, David A Cameron, David Miles, Andrew M Wardley, Helena Earl
Jul 16, 2018
Humans Breast Neoplasms Receptor ErbB-2 Treatment Outcome Chemotherapy Adjuvant Perception Female Cardiotoxicity Surveys and Questionnaires Trastuzumab Antineoplastic Agents Immunological
Published by: BMC cancer
Mitochondrial DNA depletion induces innate immune dysfunction rescued by interferon-γ
JD Widdrington, A Gomez-Duran, JS Steyn, A Pyle, M-H Ruchaud-Sparagano, J Scott, SV Baudouin, AJ Rostron, J Simpson, PF Chinnery FMedSci
Aug 08, 2017
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune...
Nutrient sensing and acquisition in fungi
Fungal pathogens destroy our crops and cause hazardous human infections, therefore threatening our health and food security. The ability of fungal pathogens to sense and respond to dynamic host microenvironments enables the...
Response of the human gut and saliva microbiome to urbanization in Cameroon.
Ana Lokmer, Sophie Aflalo, Norbert Amougou, Sophie Lafosse, Alain Froment, Francis Ekwin Tabe, Mathilde Poyet, Mathieu Groussin, Rihlat Said-Mohamed, Laure Ségurel
May 18, 2020
Urban populations from highly industrialized countries are characterized by a lower gut bacterial diversity as well as by changes in composition compared to rural populations from less industrialized countries. To unveil the...
Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.
Lawrence R Shiow, Geraldine Favrais, Lucas Schirmer, Anne-Laure Schang, Sara Cipriani, Christian Andres, Jaclyn N Wright, Hiroko Nobuta, Bobbi Fleiss, Pierre Gressens, David H Rowitch
Dec 12, 2017
Inflammation is a major risk factor for neonatal white matter injury (NWMI), which is associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest of oligodendrocyte progenitor...
Cox2 astrocyte cerebral palsy Neuroinflammation oligodendrocyte prostaglandin white matter Animals Animals Newborn Astrocytes Cells Cultured Cyclooxygenase 2 Dinoprostone Female Fetus Gene Expression Regulation Developmental Glial Fibrillary Acidic Protein Humans Interleukin-1beta L-Lactate Dehydrogenase Male Mice Mice Inbred C57BL Mice Transgenic Oligodendroglia Rats Signal Transduction Spatial Memory white matter
Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation.
Johannes Bargehr, Lucinda Low, Christine Cheung, William G Bernard, Dharini Iyer, Martin R Bennett, Laure Gambardella, Sanjay Sinha
Feb 25, 2016
Embryological origin Endothelial Cells Lineage specific Network formation Smooth muscle cells Cell Differentiation Cell Lineage Cells Cultured Coculture Techniques Embryonic Stem Cells Human Umbilical Vein Endothelial Cells Humans Muscle Smooth Vascular Myocytes Smooth Muscle Neovascularization Physiologic
Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats.
Paul John Cocker, Jean-Yves Rotge, Marie-Laure Daniel, Aude Belin-Rauscent, David Belin
Feb 14, 2019
Patient involvement in outcome measures for psoriatic arthritis
William Tillett, Ade Adebajo, Mel Brooke, Willemina Campbell, Laura C Coates, Oliver FitzGerald, Laure Gossec, Philip Helliwell, Sarah Hewlett, Jana James, Patricia Minnock, Aisling Reast, Dennis O'Sullivan, Maarten de Wit, Neil McHugh
May 01, 2014
Psoriatic arthritis (PsA) is a heterogeneous inflammatory arthritis with a varied clinical phenotype. There has been considerable international collaboration over recent years to develop and prioritise appropriate disease...
The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish.
Ewa Bielczyk-Maczyńska, Laure Lam Hung, Lauren Ferreira, Tobias Fleischmann, Félix Weis, Antonio Fernández-Pevida, Steven A Harvey, Neha Wali, Alan J Warren, Inês Barroso, Derek L Stemple, Ana Cvejic
Oct 28, 2015
Upper limits on the extent of seafloor anoxia during the PETM from uranium isotopes.
Matthew O Clarkson, Timothy M Lenton, Morten B Andersen, Marie-Laure Bagard, Alexander J Dickson, Derek Vance
Jan 15, 2021
The Paleocene Eocene Thermal Maximum (PETM) represents a major carbon cycle and climate perturbation that was associated with ocean de-oxygenation, in a qualitatively similar manner to the more extensive Mesozoic Oceanic Anoxic...
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