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Results: 42
Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling.
Barbara Bernardim, Lavinia Dunsmore, He Li, Brad Hocking, Reyes Nuñez-Franco, Claudio D Navo, Gonzalo Jiménez-Osés, Antonio CB Burtoloso, Gonçalo JL Bernardes
May 11, 2020
The chemistry of diazo compounds has generated a huge breadth of applications in the field of organic synthesis. Their versatility combined with their tunable reactivity, stability, and chemoselectivity makes diazo compounds...
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
Jean B Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A Aprile, Marta C Marques, Leonardo A Rosado, Omar Boutureira, Thomas B Steinbrecher, Woody Sherman, Francisco Corzana, Hernán Terenzi, Gonçalo JL Bernardes
Nov 13, 2017
"Nish" Rumboldt
Douglas Dunsmore
Nov 19, 2013
This paper deals with the life and work of Ignatius "Nish" Rumboldt, a formidable force in the development of the choral art in Newfoundland and Labrador. Data has been gathered through the examination of journal and...
Published by: Faculty of Education
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination.
Lavinia Dunsmore, Claudio D Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R Ruivo, Tiago Rodrigues, Filipa P da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Aug 01, 2022
Natural products that contain ortho-quinones show great potential as anticancer agents but have been largely discarded from clinical development because their redox-cycling behaviour results in general systemic toxicity. Here we...
"Nish" Rumboldt
Douglas Dunsmore
Nov 19, 2013
This paper deals with the life and work of Ignatius "Nish" Rumboldt, a formidable force in the development of the choral art in Newfoundland and Labrador. Data has been gathered through the examination of journal and...
Published by: Faculty of Education
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination.
Lavinia Dunsmore, Claudio D Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R Ruivo, Tiago Rodrigues, Filipa P da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Goncalo Lopes Bernardes
Jul 05, 2022
Natural products that contain ortho-quinones show great potential as anticancer agents but have been largely discarded from clinical development because their redox-cycling behaviour results in general systemic toxicity. Here we...
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells.
Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S Bailey
Oct 11, 2021
We have used three established human glioblastoma (GBM) cell lines-U87MG, A172, and T98G-as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase...
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells.
Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S Bailey
Sep 08, 2021
We have used three established human glioblastoma (GBM) cell lines-U87MG, A172, and T98G-as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase...
Published by: Cancers
Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells
Vladimir Shapovalov, Liliya Kopanitsa, Lavinia-Lorena Pruteanu, Graham Ladds, David S. Bailey
Jul 28, 2021
We have used three established human glioblastoma (GBM) cell lines—U87MG, A172, and T98G—as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase...
Developments in toxicogenomics
Benjamin Alexander-Dann, Lavinia Lorena Pruteanu, Erin Oerton, Nitin Sharma, Ioana Berindan-Neagoe, Dezső Módos, Andreas Bender
Sep 05, 2018
Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light.
Normal optic nerve axons exhibit a temperature dependence, previously explained by a membrane potential hyperpolarization on warming. We now report that near infra-red laser light, delivered via a fibre optic light guide, also...
Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells
Lavinia-Lorena Pruteanu, Liliya Kopanitsa, Dezső Módos, Edgars Kletnieks, Elena Samarova, Andreas Bender, Leonardo Dario Gomez, David Stanley Bailey
Sep 18, 2020
Pathway analysis is an informative method for comparing and contrasting drug-induced gene expression in cellular systems. Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with...
Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells.
Lavinia-Lorena Pruteanu, Liliya Kopanitsa, Dezső Módos, Edgars Kletnieks, Elena Samarova, Andreas Bender, Leonardo Dario Gomez, David Stanley Bailey
Nov 30, 2020
Pathway analysis is an informative method for comparing and contrasting drug-induced gene expression in cellular systems. Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with...
Apoptosis Biological Products Cell Line Tumor Cell Proliferation Chromones Combined Modality Therapy Dietary Supplements Drug Synergism Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Glioblastoma Humans Morpholines Phosphoinositide-3 Kinase Inhibitors Xanthophylls
Exploring the Factors Influencing the Use of Communication and Collaboration Applications
Over the recent years, online communication and collaboration applications have been extensively used in teaching, learning, and research. The aim of the present study is to evaluate the attitudes and perceptions of higher...
Published by: IGI Global Scientific Publishing
Increased development of radiographic hip osteoarthritis in individuals with high bone mass
April Hartley, Sarah A Hardcastle, Monika Frysz, Jon Parkinson, Lavinia Paternoster, Eugene McCloskey, Kenneth ES Poole, Muhammad K Javaid, Mo Aye, Katie Moss, Martin Williams, Jon H Tobias, Celia L Gregson
Feb 01, 2021
BACKGROUND: Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral sclerosis)....
Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.
Lavinia Ferrante di Ruffano, Yemisi Takwoingi, Jacqueline Dinnes, Naomi Chuchu, Susan E Bayliss, Clare Davenport, Rubeta N Matin, Kathie Godfrey, Colette O'Sullivan, Abha Gulati, Sue Ann Chan, Alana Durack, Susan O'Connell, Matthew D Gardiner, Jeffrey Bamber, Jonathan J Deeks, Hywel C Williams, Cochrane Skin Cancer Diagnostic Test Accuracy Group
Feb 15, 2019
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers...
Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults.
Jacqueline Dinnes, Jonathan J Deeks, Naomi Chuchu, Lavinia Ferrante di Ruffano, Rubeta N Matin, David R Thomson, Kai Yuen Wong, Roger Benjamin Aldridge, Rachel Abbott, Monica Fawzy, Susan E Bayliss, Matthew J Grainge, Yemisi Takwoingi, Clare Davenport, Kathie Godfrey, Fiona M Walter, Hywel C Williams, Cochrane Skin Cancer Diagnostic Test Accuracy Group
Nov 28, 2018
Visual inspection for diagnosing cutaneous melanoma in adults.
Jacqueline Dinnes, Jonathan J Deeks, Matthew J Grainge, Naomi Chuchu, Lavinia Ferrante di Ruffano, Rubeta N Matin, David R Thomson, Kai Yuen Wong, Roger Benjamin Aldridge, Rachel Abbott, Monica Fawzy, Susan E Bayliss, Yemisi Takwoingi, Clare Davenport, Kathie Godfrey, Fiona M Walter, Hywel C Williams, Cochrane Skin Cancer Diagnostic Test Accuracy Group
Nov 27, 2018
Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines.
Lavinia-Lorena Pruteanu, Cornelia Braicu, Dezső Módos, Maria-Ancuţa Jurj, Lajos-Zsolt Raduly, Oana Zănoagă, Lorand Magdo, Roxana Cojocneanu, Sergiu Paşca, Cristian Moldovan, Alin Iulian Moldovan, Adrian Bogdan Ţigu, Eugen Gurzău, Lorentz Jäntschi, Andreas Bender, Ioana Berindan-Neagoe
Jun 14, 2022
Triple negative breast cancer (TNBC) is currently associated with a lack of treatment options. Arsenic derivatives have shown antitumoral activity both in vitro and in vivo; however, their mode of action is not completely...
Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines.
Lavinia-Lorena Pruteanu, Cornelia Braicu, Dezső Módos, Maria-Ancuţa Jurj, Lajos-Zsolt Raduly, Oana Zănoagă, Lorand Magdo, Roxana Cojocneanu, Sergiu Paşca, Cristian Moldovan, Alin Iulian Moldovan, Adrian Bogdan Ţigu, Eugen Gurzău, Lorentz Jäntschi, Andreas Bender, Ioana Berindan-Neagoe
Apr 27, 2022
Triple negative breast cancer (TNBC) is currently associated with a lack of treatment options. Arsenic derivatives have shown antitumoral activity both in vitro and in vivo; however, their mode of action is not completely...
Representative Sequencing
Kevin Litchfield, Stacey Stanislaw, Lavinia Spain, Lisa L Gallegos, Andrew Rowan, Desiree Schnidrig, Heidi Rosenbaum, Alexandre Harle, Lewis Au, Samantha M Hill, Zayd Tippu, Jennifer Thomas, Lisa Thompson, Hang Xu, Stuart Horswell, Aoune Barhoumi, Carol Jones, Katherine F Leith, Daniel L Burgess, Thomas BK Watkins, Emilia Lim, Nicolai J Birkbak, Philippe Lamy, Iver Nordentoft, Lars Dyrskjøt, Lisa Pickering, Stephen Hazell, Mariam Jamal-Hanjani, PEACE consortium, James Larkin, Charles Swanton, Nelson R Alexander, Samra Turajlic
May 13, 2020
Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias is inherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mm biopsy), which...
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew JS Furness, Kevin Litchfield, Kroopa Joshi, Rachel Rosenthal, Ehsan Ghorani, Isabelle Solomon, Marta H Lesko, Nora Ruef, Claire Roddie, Jake Y Henry, Lavinia Spain, Assma Ben Aissa, Andrew Georgiou, Yien Ning Sophia Wong, Myles Smith, Dirk Strauss, Andrew Hayes, David Nicol, Tim O'Brien, Linda Mårtensson, Anne Ljungars, Ingrid Teige, Björn Frendéus, TRACERx Melanoma, TRACERx Renal, TRACERx Lung consortia, Martin Pule, Teresa Marafioti, Martin Gore, James Larkin, Samra Turajlic, Charles Swanton, Karl S Peggs, Sergio A Quezada
Jun 29, 2018
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo...
CTLA-4 Fc-gamma receptors IgG subclass antibody-dependent cell-mediated cytotoxicity immune checkpoints immune regulatory antibodies ipilimumab regulatory T cell depletion tremelimumab tumor immunotherapy Animals Antibodies Monoclonal Antibodies Monoclonal Humanized Antineoplastic Agents Immunological CTLA-4 Antigen Cell Line Tumor Female Humans Ipilimumab Melanoma Mice Polymorphism Single Nucleotide Receptors IgG T-Lymphocytes Regulatory Treatment Outcome Xenograft Model Antitumor Assays
Association of alcohol consumption with allergic disease and asthma
Tea Skaaby, Tuomas O Kilpeläinen, Amy E Taylor, Yuvaraj Mahendran, Andrew Wong, Tarunveer S Ahluwalia, Lavinia Paternoster, Stella Trompet, David J Stott, Claudia Flexeder, Ang Zhou, Guy Brusselle, Ayesha Sajjad, Lies Lahousse, Henning Tiemeier, Christian Theil Have, Betina H Thuesen, Line Lund Kårhus, Line Tang Møllehave, Katja Biering Leth-Møller, Daniel Mønsted Shabanzadeh, Arturo Gonzalez-Quintela, Chris Power, Elina Hyppönen, Diana Kuh, Rebecca Hardy, Thomas Meitinger, J Wouter Jukema, Uwe Völker, Matthias Nauck, Henry Völzke, Nele Friedrich, Tobias N Bonten, Raymond Noordam, Dennis O Mook-Kanamori, Janne S Tolstrup, Christian Taube, Annette Peters, Harald Grallert, Konstantin Strauch, Holger Schulz, Niels Grarup, Torben Hansen, Oluf Pedersen, Stephen Burgess, Marcus R Munafò, Allan Linneberg
Nov 19, 2018
AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and...
Alcohol allergic disease allergic sensitization Asthma hay fever Mendelian randomization Adolescent Aged 80 and over Alcohol Dehydrogenase Alcohol Drinking Asthma Denmark Female Genotype Humans Hypersensitivity Immunoglobulin E Male Mendelian Randomization Analysis Respiratory Function Tests Rhinitis Allergic Seasonal Young Adult
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer
Thomas J Mitchell, Samra Turajlic, Andrew Rowan, David Nicol, James HR Farmery, Tim O'Brien, Inigo Martincorena, Patrick Tarpey, Nicos Angelopoulos, Lucy R Yates, Adam P Butler, Keiran Raine, Grant D Stewart, Ben Challacombe, Archana Fernando, Jose I Lopez, Steve Hazell, Ashish Chandra, Simon Chowdhury, Sarah Rudman, Aspasia Soultati, Gordon Stamp, Nicos Fotiadis, Lisa Pickering, Lewis Au, Lavinia Spain, Joanna Lynch, Mark Stares, Jon Teague, Francesco Maura, David C Wedge, Stuart Horswell, Tim Chambers, Kevin Litchfield, Hang Xu, Aengus Stewart, Reza Elaidi, Stéphane Oudard, Nicholas McGranahan, Istvan Csabai, Martin Gore, P Andrew Futreal, James Larkin, Andy G Lynch, Zoltan Szallasi, Charles Swanton, Peter J Campbell, TRACERx Renal Consortium
Jul 16, 2018
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear...
Cancer evolution Chromothripsis clear cell renal cell carcinoma 5' Untranslated Regions Adult Aged Aged 80 and over Carcinoma Renal Cell Chromosomes Human Pair 3 Chromosomes Human Pair 5 Disease Progression Female Gene Dosage Genome Human Humans Kidney Neoplasms Male Middle Aged Mutation Prospective Studies Telomerase Von Hippel-Lindau Tumor Suppressor Protein
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