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The River Lech—a Cyborg
Jens Soentgen
Jan 07, 2019
What is a river? Wikipedia describes a river as “a natural, linear body of water that flows over land surfaces.” This definition, however, is only an external and geometric definition; I would like to present an alternative. My...
Published by: Memorial University of Newfoundland
The River Lech—a Cyborg
Jens Soentgen
Jan 07, 2019
What is a river? Wikipedia describes a river as “a natural, linear body of water that flows over land surfaces.” This definition, however, is only an external and geometric definition; I would like to present an alternative. My...
Published by: Memorial University of Newfoundland
Heterogeneous Expression of Proangiogenic and Coagulation Proteins in Gliomas of Different Histopathological Grade.
Marek Z Wojtukiewicz, Marta Mysliwiec, Elwira Matuszewska, Stanislaw Sulkowski, Lech Zimnoch, Barbara Politynska, Anna M Wojtukiewicz, Stephanie C Tucker, Kenneth V Honn
Apr 14, 2021
Brain gliomas are characterized by remarkably intense invasive growth and the ability to create new blood vessels. Angiogenesis is a key process in the progression of these tumors. Coagulation and fibrinolysis factors play a...
Imbalance in Coagulation/Fibrinolysis Inhibitors Resulting in Extravascular Thrombin Generation in Gliomas of Varying Levels of Malignancy
Marek Z. Wojtukiewicz, Marta Mysliwiec, Elwira Matuszewska, Stanislaw Sulkowski, Lech Zimnoch, Barbara Politynska, Anna M. Wojtukiewicz, Stephanie C. Tucker, Kenneth V. Honn
Apr 30, 2021
Neoplastic processes are integrally related to disturbances in the mechanisms regulating hemostatic processes. Brain tumors, including gliomas, are neoplasms associated with a significantly increased risk of thromboembolic...
Imbalance in Coagulation/Fibrinolysis Inhibitors Resulting in Extravascular Thrombin Generation in Gliomas of Varying Levels of Malignancy.
Marek Z Wojtukiewicz, Marta Mysliwiec, Elwira Matuszewska, Stanislaw Sulkowski, Lech Zimnoch, Barbara Politynska, Anna M Wojtukiewicz, Stephanie C Tucker, Kenneth V Honn
Jun 04, 2021
Neoplastic processes are integrally related to disturbances in the mechanisms regulating hemostatic processes. Brain tumors, including gliomas, are neoplasms associated with a significantly increased risk of thromboembolic...
F1+2 PAI-1 PC PS TFPI TFPI-2 blood coagulation/fibrinolysis inhibitors glial tumors gliomas Hemostasis Thrombomodulin Blood Coagulation Factors Brain Neoplasms Female Gene Expression Regulation Neoplastic glioma Glycoproteins Humans Male Neoplasm Grading Plasminogen Activator Inhibitor 1 Protein C Protein S Thrombin Thrombomodulin
Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.
Xiaoqiang Qi, François Loiseau, Wee Lee Chan, Yahui Yan, Zhenquan Wei, Lech-Gustav Milroy, Rebecca M Myers, Steven V Ley, Randy J Read, Robin W Carrell, Aiwu Zhou
Aug 20, 2020
The release of hormones from thyroxine-binding globulin (TBG) and corticosteroid-binding globulin (CBG) is regulated by movement of the reactive center loop in and out of the β-sheet A of the molecule. To investigate how these...
Umbralisib, a Dual PI3Kδ/CK1ε Inhibitor in Patients With Relapsed or Refractory Indolent Lymphoma.
Nathan H Fowler, Felipe Samaniego, Wojciech Jurczak, Nilanjan Ghosh, Enrico Derenzini, James A Reeves, Wanda Knopińska-Posłuszny, Chan Y Cheah, Tycel Phillips, Ewa Lech-Maranda, Bruce D Cheson, Paolo F Caimi, Sebastian Grosicki, Lori A Leslie, Julio C Chavez, Gustavo Fonseca, Sunil Babu, Daniel J Hodson, Spencer H Shao, John M Burke, Jeff P Sharman, Jennie Y Law, John M Pagel, Hari P Miskin, Peter Sportelli, Owen A O'Connor, Michael S Weiss, Pier Luigi Zinzani
Mar 18, 2021
PURPOSE: Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown activity in relapsed or refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). PI3K inhibitors have been hampered by poor long-term tolerability and toxicity...