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Sensory Feedback for Upper-Limb Prostheses
Leen Jabban, Sigrid Dupan, Dingguo Zhang, Ben Ainsworth, Kianoush Nazarpour, Benjamin Metcalfe
Mar 15, 2022
The addition of sensory feedback to upper-limb prostheses has been shown to improve control, increase embodiment, and reduce phantom limb pain. However, most commercial prostheses do not incorporate sensory feedback due to...
Licenses Control embodiment phantom limb pain prostheses sensory feedback Translation user needs /dk/atira/pure/subjectarea/asjc/2700/2724 name=Internal Medicine /dk/atira/pure/subjectarea/asjc/2800/2800 name=General Neuroscience /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2742 name=Rehabilitation
Sensory Feedback for Upper-Limb Prostheses
Leen Jabban, Sigrid Dupan, Dingguo Zhang, Ben Ainsworth, Kianoush Nazarpour, Benjamin Metcalfe
Mar 15, 2022
The addition of sensory feedback to upper-limb prostheses has been shown to improve control, increase embodiment, and reduce phantom limb pain. However, most commercial prostheses do not incorporate sensory feedback due to...
Licenses Control embodiment phantom limb pain prostheses sensory feedback Translation user needs /dk/atira/pure/subjectarea/asjc/2700/2724 name=Internal Medicine /dk/atira/pure/subjectarea/asjc/2800/2800 name=General Neuroscience /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2742 name=Rehabilitation
Epilepsia partialis continua complicated by disseminated tuberculosis and hemophagocytic lymphohistiocytosis
Gashirai K Mbizvo, Isabel C Lentell, Clifford Leen, Huw Roddie, Christopher P Derry, Susan E Duncan, Kristiina Rannikmäe
Jun 23, 2020
BACKGROUND: We describe a patient copresenting with epilepsia partialis continua, tuberculosis, and hemophagocytic lymphohistiocytosis. To our knowledge, this is the first documented case of this triad. CASE PRESENTATION: A...
Structure-based identification of dual ligands at the A2AR and PDE10A with anti-proliferative effects in lung cancer cell-lines.
Leen Kalash, Ian Winfield, Dewi Safitri, Marcel Bermudez, Sabrina Carvalho, Robert Glen, Graham Ladds, Andreas Bender
Apr 23, 2021
Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A2A receptor (A2AR) and phosphodiesterase 10A (PDE10A), are differentially...
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Liliane Chung, Dalan Bailey, Eoin N Leen, Edward P Emmott, Yasmin Chaudhry, Lisa O Roberts, Stephen Curry, Nicolas Locker, Ian G Goodfellow
Jul 09, 2014
Eukaryotic Translation Initiation Factor 4E (eIF4E) Norovirus Plus-stranded RNA Virus Translation Translation Initiation Factor VPg Virus eIF4G Base Sequence Chromatography Affinity DNA Primers Eukaryotic Initiation Factor-4G Genome Viral Norovirus Polymerase Chain Reaction Protein Binding Protein Biosynthesis Proteomics Viral Proteins
Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space.
Leen Kalash, Joel Cresser-Brown, Johnny Habchi, Connor Morgan, David J Miller, Robert C Glen, Rudolf K Allemann, Andreas Bender
Nov 13, 2018
Dimeric calpains constitute a promising therapeutic target for many diseases such as cardiovascular, neurodegenerative and ischaemic disease. The discovery of selective calpain inhibitors, however, has been extremely...
Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters.
Natalia Mateu, Sarah L Kidd, Leen Kalash, Hannah F Sore, Andrew Madin, Andreas Bender, David R Spring
Sep 05, 2018
Structure‐based identification of dual ligands at the A 2A R and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
Leen Kalash, Ian Winfield, Dewi Safitri, Marcel Bermudez, Sabrina Carvalho, Robert Glen, Graham Ladds, Andreas Bender
Mar 03, 2021
Abstract: Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A2A receptor (A2AR) and phosphodiesterase 10A (PDE10A), are...
Lectins in Cervical Screening.
Anita WW Lim, André A Neves, Sarah Lam Shang Leen, Pierre Lao-Sirieix, Elizabeth Bird-Lieberman, Naveena Singh, Michael Sheaff, Tony Hollingworth, Kevin Brindle, Peter Sasieni
Aug 10, 2020
Cervical screening in low-resource settings remains an unmet need. Lectins are naturally occurring sugar-binding glycoproteins whose binding patterns change as cancer develops. Lectins discriminate between dysplasia and normal...
Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.
Leen Kalash, Cristina Val, Jhonny Azuaje, María I Loza, Fredrik Svensson, AZEDINE Zoufir, Lewis Mervin, Graham Ladds, José Brea, Robert Glen, Eddy Sotelo, Andreas Bender
Mar 07, 2018
Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in...
Lectins in Cervical Screening
Anita WW Lim, André A. Neves, Sarah Lam Shang Leen, Pierre Lao-Sirieix, Elizabeth Bird-Lieberman, Naveena Singh, Michael Sheaff, Tony Hollingworth, Kevin Brindle, Peter Sasieni
Jul 17, 2020
Cervical screening in low-resource settings remains an unmet need. Lectins are naturally occurring sugar-binding glycoproteins whose binding patterns change as cancer develops. Lectins discriminate between dysplasia and normal...
Seasonal drivers of understorey temperature buffering in temperate deciduous forests across Europe.
Florian Zellweger, David Coomes, Jonathan Lenoir, Leen Depauw, Sybryn L Maes, Monika Wulf, Keith J Kirby, Jörg Brunet, Martin Kopecký, František Máliš, Wolfgang Schmidt, Steffi Heinrichs, Jan den Ouden, Bogdan Jaroszewicz, Gauthier Buyse, Fabien Spicher, Kris Verheyen, Pieter De Frenne
Jan 29, 2020
Aim:Forest understorey microclimates are often buffered against extreme heat or cold, with important implications for the organisms living in these environments. We quantified seasonal effects of understorey microclimate...
Seasonal drivers of understorey temperature buffering in temperate deciduous forests across Europe.
Florian Zellweger, David Coomes, Jonathan Lenoir, Leen Depauw, Sybryn L Maes, Monika Wulf, Keith J Kirby, Jörg Brunet, Martin Kopecký, František Máliš, Wolfgang Schmidt, Steffi Heinrichs, Jan den Ouden, Bogdan Jaroszewicz, Gauthier Buyse, Fabien Spicher, Kris Verheyen, Pieter De Frenne
Aug 01, 2019
Long-term life history predicts current gut microbiome in a population-based cohort study
Jiyeon Si, Jorge F Vázquez-Castellanos, Ann C Gregory, Lindsey Decommer, Leen Rymenans, Sebastian Proost, Javier Centelles Lodeiro, Martin Weger, Marlene Notdurfter, Christoph Leitner, Peter Santer, Gregorio Rungger, Johann Willeit, Peter Willeit, Raimund Pechlaner, Felix Grabherr, Stefan Kiechl, Herbert Tilg, Jeroen Raes
Oct 24, 2022
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation
Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata‐Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
Oct 07, 2021
Published by: The EMBO journal
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen AA Nollen
Nov 25, 2021
While aggregation-prone proteins are known to accelerate aging and cause age-related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG-4, SERF1A, and SERF2 have...
MOAG-4 SERF Amyloid protein aggregation protein quality control Amino Acid Sequence Amyloid Amyloidogenic Proteins Animals Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Gene Expression Regulation HEK293 Cells Humans Hydrophobic and Hydrophilic Interactions Intracellular Signaling Peptides and Proteins Nerve Tissue Proteins Peptides Protein Aggregates Protein Array Analysis Protein Binding Signal Transduction Static Electricity ALPHA-SYNUCLEIN
A Classification of Motivation and Behavior Change Techniques Used in Self-Determination Theory-Based Interventions in Health Contexts
Pedro J. Teixeira, Marta M. Marques, Marlene N. Silva, Jennifer Brunet, Joan Duda, Leen Haerens, Jennifer La Guardia, Magnus Lindwall, Chris Lonsdale, David Markland, Susan Michie, Arlen C. Moller, Nikos Ntoumanis, Heather Patrick, Johnmarshall Reeve, Richard M. Ryan, Simon Sebire, Martyn Standage, Maarten Vansteenkiste, Netta Weinstein, Karin Weman-Josefsson, Geoffrey C. Williams, Martin S. Hagger
Dec 31, 2020
While evidence suggests that interventions based on self-determination theory have efficacy in motivating adoption and maintenance of health-related behaviors, and in promoting adaptive psychological outcomes, the motivational...
A Classification of Motivation and Behavior Change Techniques Used in Self-Determination Theory-Based Interventions in Health Contexts
Pedro J. Teixeira, Marta M. Marques, Marlene N. Silva, Jennifer Brunet, Joan Duda, Leen Haerens, Jennifer La Guardia, Magnus Lindwall, Chris Lonsdale, David Markland, Susan Michie, Arlen C. Moller, Nikos Ntoumanis, Heather Patrick, Johnmarshall Reeve, Richard M. Ryan, Simon Sebire, Martyn Standage, Maarten Vansteenkiste, Netta Weinstein, Karin Weman-Josefsson, Geoffrey C. Williams, Martin S. Hagger
Dec 31, 2020
While evidence suggests that interventions based on self-determination theory have efficacy in motivating adoption and maintenance of health-related behaviors, and in promoting adaptive psychological outcomes, the motivational...
Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
Ferry Hagen, Paulo C Ceresini, Itzhack Polacheck, Hansong Ma, Filip Van Nieuwerburgh, Toni Gabaldón, Sarah Kagan, E Rhiannon Pursall, Hans L Hoogveld, Leo JJ van Iersel, Gunnar W Klau, Steven M Kelk, Leen Stougie, Karen H Bartlett, Kerstin Voelz, Leszek P Pryszcz, Elizabeth Castañeda, Marcia Lazera, Wieland Meyer, Dieter Deforce, Jacques F Meis, Robin C May, Corné HW Klaassen, Teun Boekhout
Oct 22, 2019
Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy...
Animals Brazil British Columbia Cells Cultured Cryptococcosis Cryptococcus gattii Disease Outbreaks Genes Fungal Humans Likelihood Functions MACROPHAGES Mice Mice Inbred BALB C Molecular Sequence Data Multilocus Sequence Typing Mycological Typing Techniques Northwestern United States Phylogeny Polymorphism Restriction Fragment Length Trees Tropical Climate Virulence
A classification system for teachers’ motivational behaviors recommended in self-determination theory interventions.
Asghar Ahmadi, Michael Noetel, Philip David Parker, Richard M. Ryan, Nikos Ntoumanis, Johnmarshall Reeve, Mark R. Beauchamp, Theresa Dicke, Alexander Yeung, Malek Ahmadi, Kimberley Bartholomew, Thomas K. F. Chiu, Thomas Curran, Gokce Erturan, Barbara Flunger, Christina Frederick, John Mark Froiland, David González-Cutre, Leen Haerens, Lucas Matias Jeno, Andre Koka, Christa Krijgsman, Jody Langdon, Rhiannon Lee White, David Litalien, David Lubans, John Mahoney, Ma Jenina N. Nalipay, Erika Patall, Dana Perlman, Eleanor Quested, Sascha Schneider, Martyn Standage, Kim Stroet, Damien Tessier, Cecilie Thogersen-Ntoumani, Henri Tilga, Diego Vasconcellos, Chris Lonsdale
May 18, 2023
Teachers’ behavior is a key factor that influences students’ motivation. Many theoretical models have tried to explain this influence, with one of the most thoroughly researched being self-determination theory (SDT). We used...
A classification system for teachers’ motivational behaviors recommended in self-determination theory interventions.
Asghar Ahmadi, Michael Noetel, Philip David Parker, Richard M. Ryan, Nikos Ntoumanis, Johnmarshall Reeve, Mark R. Beauchamp, Theresa Dicke, Alexander Yeung, Malek Ahmadi, Kimberley Bartholomew, Thomas K. F. Chiu, Thomas Curran, Gokce Erturan, Barbara Flunger, Christina Frederick, John Mark Froiland, David González-Cutre, Leen Haerens, Lucas Matias Jeno, Andre Koka, Christa Krijgsman, Jody Langdon, Rhiannon Lee White, David Litalien, David Lubans, John Mahoney, Ma Jenina N. Nalipay, Erika Patall, Dana Perlman, Eleanor Quested, Sascha Schneider, Martyn Standage, Kim Stroet, Damien Tessier, Cecilie Thogersen-Ntoumani, Henri Tilga, Diego Vasconcellos, Chris Lonsdale
May 18, 2023
Teachers’ behavior is a key factor that influences students’ motivation. Many theoretical models have tried to explain this influence, with one of the most thoroughly researched being self-determination theory (SDT). We used...
Imaging biomarker roadmap for cancer studies.
James PB O'Connor, Eric O Aboagye, Judith E Adams, Hugo JWL Aerts, Sally F Barrington, Ambros J Beer, Ronald Boellaard, Sarah E Bohndiek, Michael Brady, Gina Brown, David L Buckley, Thomas L Chenevert, Laurence P Clarke, Sandra Collette, Gary J Cook, Nandita M deSouza, John C Dickson, Caroline Dive, Jeffrey L Evelhoch, Corinne Faivre-Finn, Ferdia A Gallagher, Fiona J Gilbert, Robert J Gillies, Vicky Goh, John R Griffiths, Ashley M Groves, Steve Halligan, Adrian L Harris, David J Hawkes, Otto S Hoekstra, Erich P Huang, Brian F Hutton, Edward F Jackson, Gordon C Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O Leach, Ting-Yim Lee, Edward L Leen, Jason S Lewis, Yan Liu, Mark F Lythgoe, Prakash Manoharan, Ross J Maxwell, Kenneth A Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R Padhani, Geoff JM Parker, Mike Partridge, Arvind P Pathak, Andrew C Peet, Shonit Punwani, Andrew R Reynolds, Simon P Robinson, Lalitha K Shankar, Ricky A Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C Sullivan, Stuart A Taylor, Paul S Tofts, Gillian M Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J Williams, Paul Workman, Thomas E Yankeelov, Kevin M Brindle, Lisa M McShane, Alan Jackson, John C Waterton
Dec 14, 2016
Predicting and elucidating the etiology of fatty liver disease
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra JM Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline WJ Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks
Jun 09, 2020
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help...
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