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Giovanni Canestrini’s models of Leonardo da Vinci’s friction experiments
IM Hutchings
Feb 16, 2017
Among the exhibits at the 2016 Leonardo da Vinci exhibition at the Science Museum, London, was one that purported to illustrate Leonardo’s experiments on friction. The models involved were the work of Giovanni Canestrini...
Review: Torres Cacoullos and Travis. 2018. Bilingualism in the Community: Code-switching and Grammars in Contact. Cambridge
Li Nguyen
Sep 10, 2019
Torres Cacoullos and Travis's ‘Bilingualism in the Community: Code-switching and Grammars in Contact’ is a comprehensive study of language contact in New Mexico – a well-established bilingual community in the Southwest of the...
Dual mode imaging in mid infrared with thermal signal reconstruction for innovative diagnostics of the "Monocromo" by Leonardo da Vinci.
Dual mode imaging in the mid infrared band, a joint use of thermography and quasi-thermal reflectography, was recently proposed as a full field diagnostic tool in cultural heritage. Here we discuss for the first time, to the...
Mind the Gap
The way organelles are viewed by cell biologists is quickly changing. For many years, these cellular entities were thought to be unique and singular structures that performed specific roles. However, in recent decades...
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian YH Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A Malagon, Patricia Valerio, Marcos F Fondevila, Johan Fernø, Maria M Malagon, Raian Contreras, Paul Pfluger, Jens C Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Sep 10, 2018
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide...
Alzheimer’s and Parkinson’s Diseases Predict Different COVID-19 Outcomes
In December 2019, a coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began infecting humans, causing a novel disease, coronavirus disease 19 (COVID-19). This was first described in the Wuhan province of...
Links between air pollution and COVID-19 in England.
Marco Travaglio, Yizhou Yu, Rebeka Popovic, Liza Selley, Nuno Santos Leal, Luis Miguel Martins
Feb 26, 2021
In December 2019, a novel disease, coronavirus disease 19 (COVID-19), emerged in Wuhan, People's Republic of China. COVID-19 is caused by a novel coronavirus (SARS-CoV-2) presumed to have jumped species from another mammal to...
Android-IoT Malware Classification and Detection Approach Using Deep URL Features Analysis
Currently, malware attacks pose a high risk to compromise the security of Android-IoT apps. These threats have the potential to steal critical information, causing economic, social, and financial harm. Because of their constant...
Published by: IGI Global Scientific Publishing
Evolution of protein complexes by duplication of homomeric interactions.
BACKGROUND: Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins...
3D complex
Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data...
Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner.
Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L Torres-Leal, Brian YH Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Apr 26, 2021
Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuin homologs of the yeast Sir2 gene that has emerged as an important player in the regulation of energy metabolism in peripheral tissues. However, its role in the hypothalamus...
Management Support Model for Information Technology Outsourcing
This study deals with the problem of outsourcing management, presenting a structure to support decision-making on effective information-technology outsourcing and highlighting the advantages and disadvantages that must be...
Published by: IGI Global Scientific Publishing
Leonardo da Vinci's studies of friction
IM Hutchings
Apr 28, 2016
Paracetamol Is Associated with a Lower Risk of COVID-19 Infection and Decreased ACE2 Protein Expression
Ibuprofen is a common over-the-counter drug taken for pain relief. However, recent studies have raised concerns about its potential toxic effect with coronavirus disease 2019 (COVID-19), which is caused by severe acute...
Alzheimer's and Parkinson's Diseases Predict Different COVID-19 Outcomes
In December 2019, a coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began infecting humans, causing a novel disease, coronavirus disease 19 (COVID-19). This was first described in the Wuhan province of...
Oriented Type I Collagen - A Review on Artificial Alignment Strategies
Collagen is the most abundant protein in the human body and serves many functions, from mechanical stability and elasticity in tendons and bone, to optical properties, such as transparency and a fine tuned refractive index in...
Published by: IGI Global Scientific Publishing
Distinct responses of human peripheral blood cells to different misfolded protein oligomers.
Magdalena Leal-Lasarte, Benedetta Mannini, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson, Cintia Roodveldt, David Pozo
Jun 21, 2021
Th1/Th17 Tregs Immunoregulation neurodegeneration peripheral immunity protein misfolding diseases Adult CD4-Positive T-Lymphocytes Cell Differentiation Cells Cultured Cytokines Humans Leukocytes Mononuclear Lymphocyte Activation Middle Aged Protein Folding Proteostasis Deficiencies T-Lymphocytes Regulatory Th1 Cells Th17 Cells
Estimates of running ground reaction force parameters from motion analysis
We compared running mechanics parameters determined from ground reaction force (GRF) measurements with estimated forces obtained from double differentiation of kinematic (K) data from motion analysis in a broad spectrum of...
Focus U-Net
BACKGROUND: Colonoscopy remains the gold-standard screening for colorectal cancer. However, significant miss rates for polyps have been reported, particularly when there are multiple small adenomas. This presents an opportunity...
Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in lymphangioleiomyomatosis.
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare multisystem disease almost exclusively affecting women which causes loss of lung function, lymphatic abnormalities and angiomyolipomas. LAM occurs sporadically and in people...
Planetary health and health education in Brazil
Walter Leal Filho, José Baltazar Salgueirinho Osório de Andrade Guerra, Ana Regina de Aguiar Dutra, Maria Gabriela Mendonça Peixoto, Jefferson Traebert, Gustavo J Nagy
Jan 26, 2023
Brazil has the world's fifth-largest population and seventh-largest economy. However, it also has many inequalities, especially in health education, which impacts health sector services. Thus, this article aims to describe the...
Introduction to the Special Issue on the Utility of Transdiagnostic Approaches for Developing Novel Interventions for Substance and Behavioural Addictions.
It is widely established that certain psychoactive substances (e.g., alcohol, cocaine) affect brain reward pathways including dopamine, opioid, and glutamatergic neurochemical systems (Kalivas & Volkow, 2005). These biological...
Recent advances of HCI in decision-making tasks for optimized clinical workflows and precision medicine.
The ever-increasing amount of biomedical data is enabling new large-scale studies, even though ad hoc computational solutions are required. The most recent Machine Learning (ML) and Artificial Intelligence (AI) techniques have...
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