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Testing the T-loop Model of Telomeric End Protection
Leonid Alexeevich Timashev
Jan 01, 0001
Telomeres are the key structures that protect the ends of linear chromosomes. Although they are often thought about in the context of cellular aging, their most important role is actually to protect the end of the DNA from being...
Published by: Rockefeller University
Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Australian Pancreatic Cancer Genome Initiative, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders
Jan 31, 2017
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy...
Mechanistic studies of the rhodium NHC catalyzed hydrodefluorination of polyfluorotoluenes
Leonid Schwartsburd, Mary F. Mahon, Rebecca C. Poulten, Mark R. Warren, Michael K. Whittlesey
Nov 10, 2014
The six-membered-ring NHC complexes Rh(6-NHC)(PPh3)2H (6-NHC = 6-iPr (1), 6-Et (2), 6-Me (3)) have been employed in the catalytic hydrodefluorination (HDF) of...
Mechanistic studies of the rhodium NHC catalyzed hydrodefluorination of polyfluorotoluenes
Leonid Schwartsburd, Mary F. Mahon, Rebecca C. Poulten, Mark R. Warren, Michael K. Whittlesey
Nov 10, 2014
The six-membered-ring NHC complexes Rh(6-NHC)(PPh3)2H (6-NHC = 6-iPr (1), 6-Et (2), 6-Me (3)) have been employed in the catalytic hydrodefluorination (HDF) of...
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q Doe
Sep 24, 2022
Insulin Signaling Intermediate neural progenitor Neuroblast quiescence Single cell RNA-sequencing Temporal transcription factor Animals Cell Lineage Drosophila Drosophila Proteins Drosophila melanogaster Gene Expression Gene Expression Regulation Developmental Larva Neural Stem Cells Sequence Analysis RNA
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages.
Marc Corrales, Benjamin T Cocanougher, Andrea B Kohn, Jason D Wittenbach, Xi S Long, Andrew Lemire, Albert Cardona, Robert H Singer, Leonid L Moroz, Marta Zlatic
Aug 25, 2022
Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complete gene expression...
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages.
Marc Corrales, Benjamin T Cocanougher, Andrea B Kohn, Jason D Wittenbach, Xi S Long, Andrew Lemire, Albert Cardona, Robert H Singer, Leonid L Moroz, Marta Zlatic
Oct 27, 2022
Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complete gene expression...
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages
Marc Corrales, Benjamin T. Cocanougher, Andrea B. Kohn, Jason D. Wittenbach, Xi S. Long, Andrew Lemire, Albert Cardona, Robert H. Singer, Leonid L. Moroz, Marta Zlatic
Oct 26, 2022
Abstract: Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complete gene...
Published by: BioMed Central
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q Doe
Aug 24, 2022
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints. We...
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Aug 20, 2020
Abstract: Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection...
Autoantibody specificities and type I interferon pathway activation in Idiopathic Inflammatory Myopathies
Autoantibody specificities and type I interferon pathway activation in Idiopathic Inflammatory Myopathies
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians.
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T Galea, Mercedes Becerra, Sergey Nejentsev, Peter A Nigrovic, D Branch Moody, Megan B Murray, Soumya Raychaudhuri
Oct 22, 2019
Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5-15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection, presumably...
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Jan 27, 2021
Peering into the dark (ages) with low-frequency space interferometers
Léon V E Koopmans, Rennan Barkana, Mark Bentum, Gianni Bernardi, Albert-Jan Boonstra, Judd Bowman, Jack Burns, Xuelei Chen, Abhirup Datta, Heino Falcke, Anastasia Fialkov, Bharat Gehlot, Leonid Gurvits, Vibor Jelić, Marc Klein-Wolt, Joseph Lazio, Daan Meerburg, Garrelt Mellema, Florent Mertens, Andrei Mesinger, André Offringa, Jonathan Pritchard, Benoit Semelin, Ravi Subrahmanyan, Joseph Silk, Cathryn Trott, Harish Vedantham, Licia Verde, Saleem Zaroubi, Philippe Zarka
Oct 18, 2021
The Dark Ages and Cosmic Dawn are largely unexplored windows on the infant Universe (z ~ 200-10). Observations of the redshifted 21-cm line of neutral hydrogen can provide valuable new insight into fundamental physics and...
Published by: Experimental astronomy
Peering into the dark (ages) with low-frequency space interferometers
Léon VE Koopmans, Rennan Barkana, Mark Bentum, Gianni Bernardi, Albert-Jan Boonstra, Judd Bowman, Jack Burns, Xuelei Chen, Abhirup Datta, Heino Falcke, Anastasia Fialkov, Bharat Gehlot, Leonid Gurvits, Vibor Jelić, Marc Klein-Wolt, Joseph Lazio, Daan Meerburg, Garrelt Mellema, Florent Mertens, Andrei Mesinger, André Offringa, Jonathan Pritchard, Benoit Semelin, Ravi Subrahmanyan, Joseph Silk, Cathryn Trott, Harish Vedantham, Licia Verde, Saleem Zaroubi, Philippe Zarka
Oct 22, 2021
The Dark Ages and Cosmic Dawn are largely unexplored windows on the infant Universe (z ~ 200-10). Observations of the redshifted 21-cm line of neutral hydrogen can provide valuable new insight into fundamental physics and...
Copy number, linkage disequilibrium and disease association in the FCGR locus.
Heather A Niederer, Lisa C Willcocks, Tim F Rayner, Wanling Yang, Yu Lung Lau, Thomas N Williams, J Anthony G Scott, Britta C Urban, Norbert Peshu, Sarah J Dunstan, Tran Tinh Hien, Nguyen Hoan Phu, Leonid Padyukov, Iva Gunnarsson, Elisabet Svenungsson, Caroline O Savage, Richard A Watts, Paul A Lyons, David G Clayton, Kenneth GC Smith
Sep 05, 2018
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcgammaRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including...
Alleles Asian People Black People Chi-Square Distribution China GPI-Linked Proteins Gene Dosage Gene Frequency Genetic Predisposition to Disease Genotype Humans Kenya Linkage Disequilibrium Lupus Erythematosus Systemic Polymorphism Single Nucleotide Receptors IgG Sweden United Kingdom Vietnam White People
Understanding the effectiveness of government interventions against the resurgence of COVID-19 in Europe
Mrinank Sharma, Sören Mindermann, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Janvi Ahuja, Jonas B. Sandbrink, Joshua Teperowski Monrad, George Altman, Gurpreet Dhaliwal, Lukas Finnveden, Alexander John Norman, Sebastian B. Oehm, Julia Fabienne Sandkühler, Laurence Aitchison, Tomáš Gavenčiak, Thomas Mellan, Jan Kulveit, Leonid Chindelevitch, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Jan Markus Brauner
Oct 05, 2021
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance
Timothy M Walker, Paolo Miotto, Claudio U Köser, Philip W Fowler, Jeff Knaggs, Zamin Iqbal, Martin Hunt, Leonid Chindelevitch, Maha Farhat, Daniela Maria Cirillo, Iñaki Comas, James Posey, Shaheed V Omar, Timothy EA Peto, Anita Suresh, Swapna Uplekar, Sacha Laurent, Rebecca E Colman, Carl-Michael Nathanson, Matteo Zignol, Ann Sarah Walker, CRyPTIC Consortium, Seq&Treat Consortium, Derrick W Crook, Nazir Ismail, Timothy C Rodwell
May 09, 2022
BACKGROUND: Molecular diagnostics are considered the most promising route to achieving rapid, universal drug susceptibility testing for Mycobacterium tuberculosiscomplex (MTBC). We aimed to generate a WHO endorsed catalogue of...
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Jan 20, 2021
Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo, Dominik Szabó, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M Chiariello, Ibai Irastorza-Azcarate, Christoph J Thieme, Thomas M Sparks, Sílvia Carvalho, Luca Fiorillo, Francesco Musella, Ehsan Irani, Elena Torlai Triglia, Aleksandra A Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J Paul, Vedran Franke, Rieke Kempfer, Altuna Akalin, Sarah A Teichmann, Georg Dechant, Mark A Ungless, Mario Nicodemi, Lonnie Welch, Gonçalo Castelo-Branco, Ana Pombo
Jan 07, 2022
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems such...
Understanding the effectiveness of government interventions against the resurgence of COVID-19 in Europe.
Mrinank Sharma, Sören Mindermann, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Janvi Ahuja, Jonas B Sandbrink, Joshua Teperowski Monrad, George Altman, Gurpreet Dhaliwal, Lukas Finnveden, Alexander John Norman, Sebastian B Oehm, Julia Fabienne Sandkühler, Laurence Aitchison, Tomáš Gavenčiak, Thomas Mellan, Jan Kulveit, Leonid Chindelevitch, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Jan Markus Brauner
Nov 06, 2021
European governments use non-pharmaceutical interventions (NPIs) to control resurging waves of COVID-19. However, they only have outdated estimates for how effective individual NPIs were in the first wave. We estimate the...
Cell-type specialization is encoded by specific chromatin topologies.
Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea-Redondo, Dominik Szabó, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M Chiariello, Ibai Irastorza-Azcarate, Christoph J Thieme, Thomas M Sparks, Sílvia Carvalho, Luca Fiorillo, Francesco Musella, Ehsan Irani, Elena Torlai Triglia, Aleksandra A Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J Paul, Vedran Franke, Rieke Kempfer, Altuna Akalin, Sarah Teichmann, Georg Dechant, Mark A Ungless, Mario Nicodemi, Lonnie Welch, Gonçalo Castelo-Branco, Ana Pombo
Nov 24, 2021
The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems such...
Understanding the effectiveness of government interventions against the resurgence of COVID-19 in Europe.
Mrinank Sharma, Sören Mindermann, Charlie Rogers-Smith, Gavin Leech, Benedict Snodin, Janvi Ahuja, Jonas B Sandbrink, Joshua Teperowski Monrad, George Altman, Gurpreet Dhaliwal, Lukas Finnveden, Alexander John Norman, Sebastian B Oehm, Julia Fabienne Sandkühler, Laurence Aitchison, Tomáš Gavenčiak, Thomas Mellan, Jan Kulveit, Leonid Chindelevitch, Seth Flaxman, Yarin Gal, Swapnil Mishra, Samir Bhatt, Jan Markus Brauner
Dec 15, 2021
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Steve Eyre, John Bowes, Dorothée Diogo, Annette Lee, Anne Barton, Paul Martin, Alexandra Zhernakova, Eli Stahl, Sebastien Viatte, Kate McAllister, Christopher I Amos, Leonid Padyukov, Rene EM Toes, Tom WJ Huizinga, Cisca Wijmenga, Gosia Trynka, Lude Franke, Harm-Jan Westra, Lars Alfredsson, Xinli Hu, Cynthia Sandor, Paul IW de Bakker, Sonia Davila, Chiea Chuen Khor, Khai Koon Heng, Robert Andrews, Sarah Edkins, Sarah E Hunt, Cordelia Langford, Deborah Symmons, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Wellcome Trust Case Control Consortium, Pat Concannon, Suna Onengut-Gumuscu, Stephen S Rich, Panos Deloukas, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Ärlsetig, Javier Martin, Solbritt Rantapää-Dahlqvist, Robert M Plenge, Soumya Raychaudhuri, Lars Klareskog, Peter K Gregersen, Jane Worthington
May 28, 2021
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European...
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