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Results: 45
Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.
Competition between movement plans increases motor variability
Fluorescent reporters for functional analysis in rice leaves.
Fluorescent reporters have facilitated non-invasive imaging in multiple plant species and thus allowed the analysis of processes ranging from gene expression and protein localization to cellular patterning. However, in rice, a...
Published by: Plant direct
Behavioural therapy for smoking cessation
Rosemary Hiscock, Susan Murray, Leonie S. Brose, Andy McEwen, Jo Leonardi Bee, Fiona Dobbie, Linda Bauld
Nov 01, 2013
Background:
Disadvantaged smokers are less likely to be successful when trying to stop smoking than more affluent smokers. In the UK, NHS Stop Smoking Services (SSS) provide a range of pharmacotherapy and behavioural...
Disadvantaged smokers are less likely to be successful when trying to stop smoking than more affluent smokers. In the UK, NHS Stop Smoking Services (SSS) provide a range of pharmacotherapy and behavioural...
Chloroplast development in green plant tissues
Lee Cackett, Leonie H Luginbuehl, Tina B Schreier, Enrique Lopez-Juez, Julian M Hibberd
Nov 02, 2021
Chloroplasts are best known for their role in photosynthesis, but they also allow nitrogen and sulphur assimilation, amino acid, fatty acid, nucleotide and hormone synthesis. How chloroplasts develop is therefore relevant to...
Behavioural therapy for smoking cessation
Rosemary Hiscock, Susan Murray, Leonie S. Brose, Andy McEwen, Jo Leonardi Bee, Fiona Dobbie, Linda Bauld
Nov 01, 2013
Background:
Disadvantaged smokers are less likely to be successful when trying to stop smoking than more affluent smokers. In the UK, NHS Stop Smoking Services (SSS) provide a range of pharmacotherapy and behavioural...
Disadvantaged smokers are less likely to be successful when trying to stop smoking than more affluent smokers. In the UK, NHS Stop Smoking Services (SSS) provide a range of pharmacotherapy and behavioural...
Gut microbiome composition is similar between pregnant women with excess body fat with healthy and less healthy dietary intake patterns.
Hannah O'Connor, Sherly Li, Allison Hodge, Leonie Callaway, Harold David Mclntyre, Helen Barrett, Shelley A Wilkinson, Marloes Dekker Nitert
Jan 04, 2023
BACKGROUND: Dietary composition influences the composition of the gut microbiota in healthy adults. Little is known about the effect of dietary patterns on gut microbiota composition in pregnancy. This cross-sectional study...
Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.
Alish B Palmos, Vincent Millischer, David K Menon, Timothy R Nicholson, Leonie S Taams, Benedict Michael, Geraint Sunderland, Michael J Griffiths, COVID Clinical Neuroscience Study Consortium, Christopher Hübel, Gerome Breen
Mar 03, 2022
Acute, but not longer-term, exposure to environmental enrichment attenuates Pavlovian cue-evoked conditioned approach and Fos expression in the prefrontal cortex in mice.
Gabriella Margetts-Smith, Anastasia I Macnaghten, Leonie S Brebner, Joseph J Ziminski, Meike C Sieburg, Jeffrey W Grimm, Hans S Crombag, Eisuke Koya
Apr 27, 2021
Evaluation of the Perioperative and Postoperative Course of Surgery for Pineal Germinoma in the SIOP CNS GCT 96 Trial.
Ehab Shabo, Thomas Czech, James C Nicholson, Conor Mallucci, Carmine Mottolese, Gianluca Piatelli, Didier Frappaz, Matthew Jonathan Murray, Cecile Faure-Conter, Maria Luisa Garrè, Sevgi Sarikaya-Seiwert, Leonie Weinhold, Hannes Haberl, Gabriele Calaminus
Jul 22, 2022
BACKGROUND: CNS germinoma, being marker-negative, are mainly diagnosed by histological examination. These tumors predominantly appear in the suprasellar and/or pineal region. In contrast to the suprasellar region, where biopsy...
Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes
Sampurna Chakrabarti, Zoe Hore, Luke A Pattison, Sylvine Lalnunhlimi, Charity N Bhebhe, Gerard Callejo, David C Bulmer, Leonie S Taams, Franziska Denk, Ewan St John Smith
Apr 14, 2020
Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors.
Vincenzo Prato, Francisco J Taberner, James RF Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A Heppenstall, Ewan S Smith, Stefan G Lechner
Mar 02, 2018
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical...
CHRNA3 MIA NGF Piezo2 Hyperalgesia inflammatory pain mechanically insensitive nociceptor Mechanotransduction Nerve Growth Factor silent nociceptor Animals Biomechanical Phenomena Evoked Potentials Somatosensory Ganglia Spinal Gene Expression Regulation Hyperalgesia Ion Channels Mechanotransduction Cellular Mice Mice Transgenic Nerve Growth Factor Nociceptors Pain Patch-Clamp Techniques Primary Cell Culture Receptors Nicotinic
Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN)
Heather A O'Mahen, Paul G Ramchandani, Dorothy X King, Leonie Lee-Carbon, Esther L Wilkinson, Chloe Thompson-Booth, Jennifer Ericksen, Jeannette Milgrom, Jacqueline Dunkley-Bent, Sarah L Halligan, Pasco Fearon
Mar 21, 2022
BACKGROUND: We investigated the acceptability and feasibility of a new brief intervention for maternal prenatal anxiety within maternity services in London and Exeter, UK. METHODS: One hundred fourteen pregnant individuals...
Adapting and testing a brief intervention to reduce maternal anxiety during pregnancy (ACORN)
Heather A O'Mahen, Paul Ramchandani, Dorothy X King, Leonie Lee-Carbon, Esther L Wilkinson, Chloe Thompson-Booth, Jennifer Ericksen, Jeannette Milgrom, Jacqueline Dunkley-Bent, Sarah L Halligan, Pasco Fearon
Feb 17, 2022
BACKGROUND: We investigated the acceptability and feasibility of a new brief intervention for maternal prenatal anxiety within maternity services in London and Exeter, UK. METHODS: One hundred fourteen pregnant individuals...
Evaluation of the Perioperative and Postoperative Course of Surgery for Pineal Germinoma in the SIOP CNS GCT 96 Trial.
Ehab Shabo, Thomas Czech, James C Nicholson, Conor Mallucci, Carmine Mottolese, Gianluca Piatelli, Didier Frappaz, Matthew Jonathan Murray, Cecile Faure-Conter, Maria Luisa Garrè, Sevgi Sarikaya-Seiwert, Leonie Weinhold, Hannes Haberl, Gabriele Calaminus
Sep 02, 2022
Background: CNS germinoma, being marker-negative, are mainly diagnosed by histological examination. These tumors predominantly appear in the suprasellar and/or pineal region. In contrast to the suprasellar region, where biopsy...
Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2.
Xin-Ran Li, Jongho Sun, Doris Albinsky, Darius Zarrabian, Raphaella Hull, Tak Lee, Edwin Jarratt-Barnham, Chai Hao Chiu, Amy Jacobsen, Eleni Soumpourou, Alessio Albanese, Wouter Kohlen, Leonie H Luginbuehl, Bruno Guillotin, Tom Lawrensen, Hui Lin, Jeremy Murray, Emma Wallington, Wendy Harwood, Jeongmin Choi, Uta Paszkowski, Giles ED Oldroyd
Oct 28, 2022
Many plants associate with arbuscular mycorrhizal fungi for nutrient acquisition, while legumes also associate with nitrogen-fixing rhizobial bacteria. Both associations rely on symbiosis signaling and here we show that cereals...
Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer.
Alacoque L Browne, Sara Charmsaz, Damir Varešlija, Ailis Fagan, Nicola Cosgrove, Sinéad Cocchiglia, Siobhan Purcell, Elspeth Ward, Fiona Bane, Lance Hudson, Arnold D Hill, Jason S Carroll, Aisling M Redmond, Leonie S Young
Feb 22, 2019
Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and...
Animals Antineoplastic Agents Hormonal Breast Neoplasms Chromatin Assembly and Disassembly Drug Resistance Neoplasm Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Humans MCF-7 Cells Mice Mice Inbred NOD Mice SCID Microarray Analysis Nuclear Receptor Coactivator 1 Transcriptional Activation Transcriptome Tumor Cells Cultured
Research priorities for neuroimmunology
Georgina MacKenzie, Sumithra Subramaniam, Lindsey J Caldwell, Denise Fitzgerald, Neil A Harrison, Soyon Hong, Sarosh R Irani, Golam M Khandaker, Adrian Liston, Veronique E Miron, Valeria Mondelli, B Paul Morgan, Carmine Pariante, Divya K Shah, Leonie S Taams, Jessica L Teeling, Rachel Upthegrove
Jan 07, 2022
Neuroimmunology in the broadest sense is the study of interactions between the nervous and the immune systems. These interactions play important roles in health from supporting neural development, homeostasis and plasticity to...
Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2.
Xin-Ran Li, Jongho Sun, Doris Albinsky, Darius Zarrabian, Raphaella Hull, Tak Lee, Edwin Jarratt-Barnham, Chai Hao Chiu, Amy Jacobsen, Eleni Soumpourou, Alessio Albanese, Wouter Kohlen, Leonie H Luginbuehl, Bruno Guillotin, Tom Lawrensen, Hui Lin, Jeremy Murray, Emma Wallington, Wendy Harwood, Jeongmin Choi, Uta Paszkowski, Giles ED Oldroyd
Nov 28, 2022
Many plants associate with arbuscular mycorrhizal fungi for nutrient acquisition, while legumes also associate with nitrogen-fixing rhizobial bacteria. Both associations rely on symbiosis signaling and here we show that cereals...
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
Ferdinand von Meyenn, Mario Iurlaro, Ehsan Habibi, Ning Qing Liu, Ali Salehzadeh-Yazdi, Fátima Santos, Edoardo Petrini, Inês Milagre, Miao Yu, Zhenqing Xie, Leonie I Kroeze, Tatyana B Nesterova, Joop H Jansen, Hehuang Xie, Chuan He, Wolf Reik, Hendrik G Stunnenberg
Jun 24, 2019
Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a...
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Max TB Clabbers, Susannah Holmes, Timothy W Muusse, Parimala R Vajjhala, Sara J Thygesen, Alpeshkumar K Malde, Dominic JB Hunter, Tristan I Croll, Leonie Flueckiger, Jeffrey D Nanson, Md Habibur Rahaman, Andrew Aquila, Mark S Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
May 06, 2021
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of...
Crystallography Dimerization HEK293 Cells Humans Membrane Glycoproteins Models Molecular Molecular Dynamics Simulation Mutation Myeloid Differentiation Factor 88 Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Domains Receptors Interleukin-1 Recombinant Proteins Signal Transduction Toll-Like Receptor 4
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic
Charlotte Thibeault, Barbara Mühlemann, Elisa T Helbig, Mirja Mittermaier, Tilman Lingscheid, Pinkus Tober-Lau, Lil A Meyer-Arndt, Leonie Meiners, Paula Stubbemann, Sascha S Haenel, Laure Bosquillon de Jarcy, Lena Lippert, Moritz Pfeiffer, Miriam S Stegemann, Robert Roehle, Janine Wiebach, Stefan Hippenstiel, Thomas Zoller, Holger Müller-Redetzky, Alexander Uhrig, Felix Balzer, Christof von Kalle, Norbert Suttorp, Terry C Jones, Christian Drosten, Martin Witzenrath, Leif E Sander, Pa-COVID study Group, Victor M Corman, Florian Kurth
Jul 28, 2021
Artificial respiration COVID-19 Nucleic Acid Testing Coronavirus disease 2019 (COVID-19) Mechanical ventilation prospective study Respiratory Distress Syndrome Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Symptom Assessment Viral concentration covid-19 Cohort Studies Germany Hospitalization Humans Hypertension Kinetics Prospective Studies Respiration Artificial Risk Factors SARS-CoV-2 Tertiary Care Centers Time Factors Viral Load Virus Shedding
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Max T B Clabbers, Susannah Holmes, Timothy W Muusse, Parimala R Vajjhala, Sara J Thygesen, Alpeshkumar K Malde, Dominic J B Hunter, Tristan I Croll, Leonie Flueckiger, Jeffrey D Nanson, Md Habibur Rahaman, Andrew Aquila, Mark S Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
Jun 11, 2021
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation...
Humans Membrane Glycoproteins Receptors Interleukin-1 Recombinant Proteins Crystallography Signal Transduction Dimerization Mutation Models Molecular Toll-Like Receptor 4 Myeloid Differentiation Factor 88 Molecular Dynamics Simulation HEK293 Cells Protein Conformation alpha-Helical Protein Domains Protein Conformation beta-Strand
Published by: Nature Communications
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