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Letter from Herbert Gasser, 1939
Markus Library
Jan 01, 0001
Letter from Herbert Gasser to Dr. Leonor Michaelis, June 5th, 1939
Published by: Rockefeller University
Genetic variation regulates the activation and specificity of Restriction-Modification systems in Neisseria gonorrhoeae
ABSTRACT Restriction-Modification systems (RMS) are one of the main mechanisms of defence against foreign DNA invasion and can have an important role in the regulation of gene expression. The obligate human pathogen Neisseria...
Genetic variation regulates the activation and specificity of Restriction-Modification systems in Neisseria gonorrhoeae.
Restriction-Modification systems (RMS) are one of the main mechanisms of defence against foreign DNA invasion and can have an important role in the regulation of gene expression. The obligate human pathogen Neisseria gonorrhoeae...
Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.
Sophia David, Leonor Sánchez-Busó, Simon R Harris, Pekka Marttinen, Christophe Rusniok, Carmen Buchrieser, Timothy G Harrison, Julian Parkhill
Oct 23, 2019
Legionella pneumophila is an environmental bacterium and the causative agent of Legionnaires' disease. Previous genomic studies have shown that recombination accounts for a high proportion (>96%) of diversity within several...
Mirnovo
Dimitrios M Vitsios, Elissavet Kentepozidou, Leonor Quintais, Elia Benito-Gutiérrez, Stijn van Dongen, Matthew P Davis, Anton J Enright
Jan 24, 2018
The discovery of microRNAs (miRNAs) remains an important problem, particularly given the growth of high-throughput sequencing, cell sorting and single cell biology. While a large number of miRNAs have already been annotated...
Exploring ways to respond to rising obesity and diabetes in the Caribbean using a system dynamics model.
Leonor Guariguata, Leandro Garcia, Natasha Sobers, Trevor S Ferguson, James Woodcock, T Alafia Samuels, Cornelia Guell, Nigel Unwin
May 19, 2022
Diabetes and obesity present a high and increasing burden of disease in the Caribbean that have failed to respond to prevention policies and interventions. These conditions are the result of a complex system of drivers and...
Using Group Model Building to Describe the System Driving Unhealthy Eating and Identify Intervention Points
Leonor Guariguata, Etiënne Aja Rouwette, Madhuvanti M Murphy, Arlette Saint Ville, Leith L Dunn, Gordon M Hickey, Waneisha Jones, T Alafia Samuels, Nigel Unwin
Jan 17, 2020
Many Small Island Developing States of the Caribbean experience a triple burden of malnutrition with high rates of obesity, undernutrition in children, and iron deficiency anemia in women of reproductive age, driven by an...
Caribbean NCDs agricultural development food sovereignty group model building small islands Systems science unhealthy diet Adolescent Caribbean Region Child Child Nutrition Disorders Child Preschool Diet Feeding Behavior Female Humans Jamaica Male Nutrition Policy Policy Making Saint Kitts and Nevis Saint Vincent and the Grenadines stakeholder participation Systems Analysis Young Adult
Systems science for developing policy to improve physical activity, the Caribbean.
Leonor Guariguata, Nigel Unwin, Leandro Garcia, James Woodcock, T Alafia Samuels, Cornelia Guell
Nov 08, 2021
The World Health Organization (WHO) Global Action Plan on Physical Activity recommends adopting a systems approach to implementing and tailoring actions according to local contexts. We held group model-building workshops with...
Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ42 toxicity.
Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth
Aug 14, 2022
Mitochondria-ER contact sites (MERCs) orchestrate many important cellular functions including regulating mitochondrial quality control through mitophagy and mediating mitochondrial calcium uptake. Here, we identify and...
Exploring ways to respond to rising obesity and diabetes in the Caribbean using a system dynamics model.
Leonor Guariguata, Leandro Garcia, Natasha Sobers, Trevor S Ferguson, James Woodcock, T Alafia Samuels, Cornelia Guell, Nigel Unwin
Apr 17, 2023
Diabetes and obesity present a high and increasing burden of disease in the Caribbean that have failed to respond to prevention policies and interventions. These conditions are the result of a complex system of drivers and...
Published by: PLOS global public health
ARIBA
Martin Hunt, Alison E Mather, Leonor Sánchez-Busó, Andrew J Page, Julian Parkhill, Jacqueline A Keane, Simon R Harris
May 25, 2018
Antimicrobial resistance (AMR) is one of the major threats to human and animal health worldwide, yet few high-throughput tools exist to analyse and predict the resistance of a bacterial isolate from sequencing data. Here we...
A Systematic Scoping Review of the Impacts of Community Food Production Initiatives in Kenya, Cameroon, and South Africa.
Gráinne B Hutton, Anna Brugulat-Panés, Divya Bhagtani, Camille Mba Maadjhou, Jack M Birch, Hueyjong Shih, Kufre Okop, Monica Muti, Pamela Wadende, Lambed Tatah, Ebele Mogo, Leonor Guariguata, Nigel Unwin
Mar 26, 2021
BACKGROUND: Even before the COVID-19 pandemic, one in two people in Africa were food insecure. The burden of malnutrition remains high (e.g. childhood stunting, anaemia in women of reproductive age) or are increasing (e.g....
MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni.
Anna V Protasio, Stijn van Dongen, Julie Collins, Leonor Quintais, Diogo M Ribeiro, Florian Sessler, Martin Hunt, Gabriel Rinaldi, James J Collins, Anton J Enright, Matthew Berriman
Jan 22, 2018
Schistosomes are parasitic helminths that cause schistosomiasis, a disease affecting circa 200 million people, primarily in underprivileged regions of the world. Schistosoma mansoni is the most experimentally tractable...
Deployable extrusion bioprinting of compartmental tumoroids with cancer associated fibroblasts for immune cell interactions.
Corrado Mazzaglia, Yaqi Sheng, Leonor Nunes Rodrigues, Iek Man Lei, Jacqueline D Shields, Yan Yan Shery Huang
Jan 31, 2023
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F Rogan, Adam Dinan, Andrew E Firth, Byron Andrews, Alexander J Whitworth, Schraga Schwartz, Alan J Warren, Michal Minczuk
Mar 21, 2022
Many cellular processes, including ribosome biogenesis, are regulated through post-transcriptional RNA modifications. Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'-O-methylation is limited...
An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes
Maria C R Medeiros, Ana Mestre, Pedro Inácio, Sanaz Asgarif, Inês M. Araújo, Peter C. Hubbard, Zélia Velez, M. Leonor Cancela, Paulo R F Rocha, Dago M. De Leeuw, Fabio Biscarini, Henrique L. Gomes
Sep 01, 2016
An electrical method to measure extracellular bioelectrical activity in vitro is presented. This method exploits the Helmholtz capacitive double-layer established at the electrode surface. Small extracellular voltage...
Bioelectrical signals Displacement current Electrical double-layer Extracellular electrodes intercellular signaling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/1700/1711 name=Signal Processing /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch.
Silvia Argimón, Corin A Yeats, Richard J Goater, Khalil Abudahab, Benjamin Taylor, Anthony Underwood, Leonor Sánchez-Busó, Vanessa K Wong, Zoe A Dyson, Satheesh Nair, Se Eun Park, Florian Marks, Andrew J Page, Jacqueline A Keane, Stephen Baker, Kathryn E Holt, Gordon Dougan, David M Aanensen
Jul 12, 2021
As whole-genome sequencing capacity becomes increasingly decentralized, there is a growing opportunity for collaboration and the sharing of surveillance data within and between countries to inform typhoid control policies. This...
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.
Violeta Heras, Susana Sangiao-Alvarellos, Maria Manfredi-Lozano, María J Sanchez-Tapia, Francisco Ruiz-Pino, Juan Roa, Maribel Lara-Chica, Rosario Morrugares-Carmona, Nathalie Jouy, Ana P Abreu, Vincent Prevot, Denise Belsham, Maria J Vazquez, Marco A Calzado, Leonor Pinilla, Francisco Gaytan, Ana C Latronico, Ursula B Kaiser, Juan M Castellano, Manuel Tena-Sempere
Jan 20, 2020
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular...
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F Rogan, Adam Dinan, Andrew Firth, Byron Andrews, Alex Whitworth, Schraga Schwartz, Alan Warren, Michal Minczuk
Feb 17, 2022
An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes
Maria C R Medeiros, Ana Mestre, Pedro Inácio, Sanaz Asgarif, Inês M. Araújo, Peter C. Hubbard, Zélia Velez, M. Leonor Cancela, Paulo R F Rocha, Dago M. De Leeuw, Fabio Biscarini, Henrique L. Gomes
Sep 01, 2016
An electrical method to measure extracellular bioelectrical activity in vitro is presented. This method exploits the Helmholtz capacitive double-layer established at the electrode surface. Small extracellular voltage...
Bioelectrical signals Displacement current Electrical double-layer Extracellular electrodes intercellular signaling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/1700/1711 name=Signal Processing /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Making Waves
Lian Lundy, Despo Fatta-Kassinos, Jaroslav Slobodnik, Popi Karaolia, Lubos Cirka, Norbert Kreuzinger, Sara Castiglioni, Lubertus Bijlsma, Valeria Dulio, Geneviève Deviller, Foon Yin Lai, Nikiforos Alygizakis, Manuela Barneo, Jose Antonio Baz-Lomba, Frederic Béen, Marianna Cíchová, Kelly Conde-Pérez, Adrian Covaci, Erica Donner, Andrej Ficek, Francis Hassard, Annelie Hedström, Félix Hernandez, Veronika Janská, Kristen Jellison, Jan Hofman, Kelly Hill, Pei Ying Hong, Barbara Kasprzyk-Hordern, Stoimir Kolarević, Jan Krahulec, Dimitra Lambropoulou, Rosa de Llanos, Tomáš Mackuľak, Lorena Martinez-García, Francisco Martínez, Gertjan Medema, Adrienn Micsinai, Mette Myrmel, Mohammed Nasser, Harald Niederstätter, Leonor Nozal, Herbert Oberacher, Věra Očenášková, Leslie Ogorzaly, Dimitrios Papadopoulos, Beatriz Peinado, Tarja Pitkänen, Margarita Poza, Soraya Rumbo-Feal, Maria Blanca Sánchez, Anna J. Székely, Andrea Soltysova, Nikolaos S. Thomaidis, Juan Vallejo, Alexander van Nuijs, Vassie Ware, Maria Viklander
Jul 01, 2021
The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. Over the subsequent months, the potential for wastewater surveillance to contribute to COVID-19 mitigation programmes has been the focus of...
/dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2300/2302 name=Ecological Modelling /dk/atira/pure/subjectarea/asjc/2300/2312 name=Water Science and Technology /dk/atira/pure/subjectarea/asjc/2300/2311 name=Waste Management and Disposal /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Genome-wide epistasis and co-selection study using mutual information.
Johan Pensar, Santeri Puranen, Brian Arnold, Neil MacAlasdair, Juri Kuronen, Gerry Tonkin-Hill, Maiju Pesonen, Yingying Xu, Aleksi Sipola, Leonor Sánchez-Busó, John A Lees, Claire Chewapreecha, Stephen D Bentley, Simon R Harris, Julian Parkhill, Nicholas J Croucher, Jukka Corander
Aug 20, 2019
Covariance-based discovery of polymorphisms under co-selective pressure or epistasis has received considerable recent attention in population genomics. Both statistical modeling of the population level covariation of alleles...
Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana.
Isaac Darko Otchere, Andries J van Tonder, Adwoa Asante-Poku, Leonor Sánchez-Busó, Mireia Coscollá, Stephen Osei-Wusu, Prince Asare, Samuel Yaw Aboagye, Samuel Acquah Ekuban, Abdallah Iddrisu Yahayah, Audrey Forson, Akosua Baddoo, Clement Laryea, Julian Parkhill, Simon R Harris, Sebastien Gagneux, Dorothy Yeboah-Manu
Jul 25, 2019
BACKGROUND: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M. bovis strains with hyper-virulence, MDR-TB and disseminated disease makes it...
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