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Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation.
Autophagy is a conserved intracellular degradation pathway essential for protein homeostasis, survival and development. Defects in autophagic pathways have been connected to a variety of human diseases, including cancer and...
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Lidia Wrobel, Farah H Siddiqi, Sandra M Hill, Sung Min Son, Cansu Karabiyik, Hyunjeong Kim, David C Rubinsztein
Jan 19, 2021
The mechanistic target of rapamycin complex 2 (mTORC2) controls cell metabolism and survival in response to environmental inputs. Dysregulation of mTORC2 signaling has been linked to diverse human diseases, including cancer and...
RICTOR USP9X growth factor signaling mTORC2 Mechanistic Target of Rapamycin Complex 2 posttranslational modification ubiquitin-specific protease 9X Animals Cell Line Tumor Female Gene Expression Regulation Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Intercellular Signaling Peptides and Proteins Male Mechanistic Target of Rapamycin Complex 2 Mice Mice Inbred C57BL Protein Binding Protein Processing Post-Translational Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction Ubiquitin Thiolesterase Ubiquitination
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Lidia Wrobel, Sandra M Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W Bürli, David C Rubinsztein
Aug 16, 2022
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Lidia Wrobel, Sandra M Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W Bürli, David C Rubinsztein
Jul 16, 2022
Investigation of Mechanical Loss Components and Heat Transfer in an Axial-Flux PM Machine
This paper investigates components of mechanical loss together with heat transfer effects in an axial-flux permanent-magnet motor. The mechanical loss components generated within electrical machines are well known; however...
Investigation of Mechanical Loss Components and Heat Transfer in an Axial-Flux PM Machine
This paper investigates components of mechanical loss together with heat transfer effects in an axial-flux permanent-magnet motor. The mechanical loss components generated within electrical machines are well known; however...
Female university students' preferences for different types of sexual relationships
BACKGROUND: Gender-based violence among young women is a growing problem worldwide. The consequences of this victimization have been well reported in the scientific literature, among which negative health outcomes stand out. The...
Chronic Illnesses, Vulnerability, and Uncertainty
The goal of this chapter is to describe some of the recent challenges that modern medicine is facing using patient-centered medicine as a theoretical frame of reference. First, the work will describe the origin, the development...
Published by: IGI Global Scientific Publishing
In Vitro Influence of Mycophenolic Acid on Selected Parameters of Stimulated Peripheral Canine Lymphocytes.
Mycophenolic acid (MPA) is an active metabolite of mycophenolate mofetil, a new immunosuppressive drug effective in the treatment of canine autoimmune diseases. The impact of MPA on immunity is ambiguous and its influence on the...
Symptom appraisal in uncertainty
Lauren C. Heathcote, Nele Loecher, Pamela Simon, Sheri Spunt, Abbie Jordan, Perri Tutelman, Sarah Cunningham, Lidia Schapira, Laura Simons
Dec 31, 2021
Objective: Somatic symptoms capture attention, demand interpretation, and promote health behaviors. Symptom appraisal is particularly impactful within uncertain health contexts such as cancer survivorship. Yet, little is known...
Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.
Paloma Navarro Negredo, James R Edgar, Antoni G Wrobel, Nathan R Zaccai, Robin Antrobus, David J Owen, Margaret S Robinson
Sep 11, 2018
Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. To find acidic cluster sorting machinery, we performed a gene-trap...
Adaptor Protein Complex 1 Adaptor Protein Complex mu Subunits CRISPR-Cas Systems Clathrin-Coated Vesicles Flow Cytometry Gene Knockdown Techniques Genotype HEK293 Cells HIV-1 HeLa Cells Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Models Molecular Mutation Phenotype Protein Binding Protein Interaction Domains and Motifs Protein Transport Structure-Activity Relationship Time Factors Transfection nef Gene Products Human Immunodeficiency Virus
Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.
Regulated phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) by the endoplasmic reticulum (ER) stress-activated protein kinase PERK modulates protein synthesis and couples the...
Nest desertion is not predicted by cuckoldry in the Eurasian penduline tit
Rene E Van Dijk, Lidia A Mészáros, Marco Velde, T Székely, A Pogány, J Szabad, Jan Komdeur
Sep 01, 2010
Engagement in extra-pair copulations is an example of the abundant conflicting interests between males and females over reproduction. Potential benefits for females and the risk of cuckoldry for males are expected to have...
Nest desertion is not predicted by cuckoldry in the Eurasian penduline tit
Rene E Van Dijk, Lidia A Mészáros, Marco Velde, T Székely, A Pogány, J Szabad, Jan Komdeur
Sep 01, 2010
Engagement in extra-pair copulations is an example of the abundant conflicting interests between males and females over reproduction. Potential benefits for females and the risk of cuckoldry for males are expected to have...
Symptom appraisal in uncertainty
Lauren C. Heathcote, Nele Loecher, Pamela Simon, Sheri Spunt, Abbie Jordan, Perri Tutelman, Sarah Cunningham, Lidia Schapira, Laura Simons
Dec 31, 2021
Objective: Somatic symptoms capture attention, demand interpretation, and promote health behaviors. Symptom appraisal is particularly impactful within uncertain health contexts such as cancer survivorship. Yet, little is known...
GPVI surface expression and signalling pathway activation are increased in platelets from obese patients
María N Barrachina, Aurelio M Sueiro, Irene Izquierdo, Lidia Hermida-Nogueira, Esteban Guitián, Felipe F Casanueva, Richard W Farndale, Masaaki Moroi, Stephanie M Jung, María Pardo, Ángel García
Jan 30, 2019
Drug targets GPVI signalling obesity platelets Proteomics SFK-Mediated signalling pathways Adolescent Adult Blood Platelets Body Mass Index Case-Control Studies Female Humans Male obesity Phospholipase C gamma Phosphorylation Platelet Activation Platelet Aggregation Platelet Membrane Glycoproteins Signal Transduction Up-Regulation Young Adult
Breaking the electrical barrier between copper and carbon nanotubes.
Karolina Z Milowska, Mahdi Ghorbani-Asl, Marek Burda, Lidia Wolanicka, Nordin Ćatić, Paul D Bristowe, Krzysztof KK Koziol
Nov 20, 2018
Improving the interface between copper and carbon nanotubes (CNTs) offers a straightforward strategy for the effective manufacturing and utilisation of Cu-CNT composite material that could be used in various industries including...
Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an "HHT-like" syndrome in children.
Joshua Hodgson, Lidia Ruiz-Llorente, Jamie McDonald, Oliver Quarrell, Kelechi Ugonna, James Bentham, Rebecca Mason, Jennifer Martin, David Moore, Katie Bergstrom, Pinar Bayrak-Toydemir, Whitney Wooderchak-Donahue, Nicholas Morrell, Robin Condliffe, Carmelo Bernabeu, Paul Upton
Mar 23, 2021
BACKGROUND: Disrupted endothelial BMP9/10 signaling may contribute to the pathophysiology of both hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH), yet loss of circulating BMP9 has not been...
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