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Results: 87777
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Family lifestyle dynamics and childhood obesity
Abstract
Background
The prevalence of childhood obesity has been increasing but the causes are not fully understood. Recent public health interventions and guidance aiming to reduce childhood obesity have focused on the whole...
Gene-lifestyle interaction and type 2 diabetes
Claudia Langenberg, Stephen J Sharp, Paul W Franks, Robert A Scott, Panos Deloukas, Nita G Forouhi, Philippe Froguel, Leif C Groop, Torben Hansen, Luigi Palla, Oluf Pedersen, Matthias B Schulze, Maria-Jose Tormo, Eleanor Wheeler, Claudia Agnoli, Larraitz Arriola, Aurelio Barricarte, Heiner Boeing, Geraldine M Clarke, Françoise Clavel-Chapelon, Eric J Duell, Guy Fagherazzi, Rudolf Kaaks, Nicola D Kerrison, Timothy J Key, Kay Tee Khaw, Janine Kröger, Martin Lajous, Andrew P Morris, Carmen Navarro, Peter M Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, María-José Sánchez, Nadia Slimani, Annemieke MW Spijkerman, Rosario Tumino, Daphne L van der A, Yvonne T van der Schouw, Inês Barroso, Mark I McCarthy, Elio Riboli, Nicholas J Wareham
Nov 08, 2018
BACKGROUND: Understanding of the genetic basis of type 2 diabetes (T2D) has progressed rapidly, but the interactions between common genetic variants and lifestyle risk factors have not been systematically investigated in studies...
The international study of childhood obesity, lifestyle and the environment (ISCOLE)
Peter T Katzmarzyk, Tiago V Barreira, Stephanie T Broyles, Catherine M Champagne, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, William D Johnson, Rebecca Kuriyan, Anura Kurpad, Estelle V Lambert, Carol Maher, José Maia, Victor Matsudo, Tim Olds, Vincent Onywera, Olga L Sarmiento, Martyn Standage, Mark S Tremblay, Catrine Tudor-Locke, Pei Zhao, Timothy S Church
Jan 01, 0001
The primary aim of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE) was to determine the relationships between lifestyle behaviours and obesity in a multi-national study of children, and to...
The international study of childhood obesity, lifestyle and the environment (ISCOLE)
Peter T Katzmarzyk, Tiago V Barreira, Stephanie T Broyles, Catherine M Champagne, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, William D Johnson, Rebecca Kuriyan, Anura Kurpad, Estelle V Lambert, Carol Maher, José Maia, Victor Matsudo, Tim Olds, Vincent Onywera, Olga L Sarmiento, Martyn Standage, Mark S Tremblay, Catrine Tudor-Locke, Pei Zhao, Timothy S Church
Jan 01, 0001
The primary aim of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE) was to determine the relationships between lifestyle behaviours and obesity in a multi-national study of children, and to...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle
Loes CA Rutten-Jacobs, Susanna C Larsson, Rainer Malik, Kristiina Rannikmäe, MEGASTROKE Consortium, International Stroke Genetics Consortium, Cathie L Sudlow, Martin Dichgans, Hugh S Markus, Matthew Traylor
Dec 03, 2018
OBJECTIVE: To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. DESIGN: Prospective population based cohort study. SETTING: UK Biobank Study, UK. PARTICIPANTS: 306 473 men and women...
Adult Aged cerebral hemorrhage Exercise Female Genetic Predisposition to Disease Healthy lifestyle Humans Incidence Male Middle Aged Multifactorial Inheritance Myocardial Infarction Patient Compliance Polymorphism Single Nucleotide Prospective Studies Risk Factors stroke Subarachnoid Hemorrhage United Kingdom
Pediatric Obesity-Assessment, Treatment, and Prevention
Dennis M Styne, Silva A Arslanian, Ellen L Connor, Ismaa Sadaf Farooqi, M Hassan Murad, Janet H Silverstein, Jack A Yanovski
Aug 02, 2019
Cosponsoring Associations: The European Society of Endocrinology and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the assessment...
Genetic basis of lacunar stroke
Matthew Traylor, Elodie Persyn, Liisa Tomppo, Sofia Klasson, Vida Abedi, Mark K Bakker, Nuria Torres, Linxin Li, Steven Bell, Loes Rutten-Jacobs, Daniel J Tozer, Christoph J Griessenauer, Yanfei Zhang, Annie Pedersen, Pankaj Sharma, Jordi Jimenez-Conde, Tatjana Rundek, Raji P Grewal, Arne Lindgren, James F Meschia, Veikko Salomaa, Aki Havulinna, Christina Kourkoulis, Katherine Crawford, Sandro Marini, Braxton D Mitchell, Steven J Kittner, Jonathan Rosand, Martin Dichgans, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, Ramin Zand, Ynte Ruigrok, Natalia Rost, Robin Lemmens, Peter M Rothwell, Christopher D Anderson, Joanna Wardlaw, Cathryn M Lewis, Hugh S Markus, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group Helsinki Stroke, National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network, UK DNA Lacunar Stroke Study Investigators, International Stroke Genetics Consortium
Apr 01, 2021
BACKGROUND: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. METHODS: We did a...
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
Modifiable lifestyle factors and severe COVID-19 risk
BACKGROUND: Lifestyle factors including obesity and smoking are suggested to be correlated with increased risk of COVID-19 severe illness or related death. However, whether these relationships are causal is not well known;...
Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts.
Louise Brunkwall, Yan Chen, George Hindy, Gull Rukh, Ulrika Ericson, Inês Barroso, Ingegerd Johansson, Paul W Franks, Marju Orho-Melander, Frida Renström
Jul 26, 2019
BACKGROUND: The consumption of sugar-sweetened beverages (SSBs), which has increased substantially during the last decades, has been associated with obesity and weight gain. OBJECTIVE: Common genetic susceptibility to obesity...
BMI Sweden Gene-lifestyle interaction genetic risk score Sugar-sweetened beverage Beverages Body Mass Index Carbonated Beverages Cohort Studies Confounding Factors Epidemiologic Cross-Sectional Studies Diet Records Dietary Carbohydrates Female Fruit and Vegetable Juices Genetic Association Studies Genetic Loci Genetic Predisposition to Disease Humans Male Middle Aged Nutrigenomics Nutrition Surveys obesity Overweight Polymorphism Single Nucleotide Prospective Studies Self Report Sweden
Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants.
Jing Dong, Matthew F Buas, Puya Gharahkhani, Bradley J Kendall, Lynn Onstad, Shanshan Zhao, Lesley A Anderson, Anna H Wu, Weimin Ye, Nigel C Bird, Leslie Bernstein, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Paul D Pharoah, Harvey A Risch, Prasad G Iyer, Brian J Reid, Laura J Hardie, Jesper Lagergren, Nicholas J Shaheen, Douglas A Corley, Rebecca C Fitzgerald, Stomach and Oesophageal Cancer Study (SOCS) consortium, David C Whiteman, Thomas L Vaughan, Aaron P Thrift
Feb 23, 2018
BACKGROUND & AIMS: We developed comprehensive models to determine risk of Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC) based on genetic and non-genetic factors. METHODS: We used pooled data from 3288 patients with...
BEACON Environmental Exposures neoplasm SNP Adenocarcinoma Area Under Curve Australia Barrett Esophagus Case-Control Studies Databases Factual Decision Support Techniques Esophageal Neoplasms Europe Female Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Humans Life Style Logistic Models Male Middle Aged Models Genetic molecular epidemiology Multifactorial Inheritance North America Odds Ratio Phenotype Polymorphism Single Nucleotide Predictive Value of Tests ROC Curve Risk Assessment Risk Factors
A community-based motivational personalised lifestyle intervention to reduce BMI in obese adolescents
Deborah Christie, Lee Duncan Hudson, Sanjay Kinra, Ian Chi Kei Wong, Irwin Nazareth, Tim J Cole, Ulla Sovio, John Gregson, Anthony S Kessel, Anne Mathiot, Stephen Morris, Monica Panca, Silvia Costa, Rebecca Holt, Russell M Viner
Dec 04, 2017
OBJECTIVE: Approximately 7% of children and young people aged 5-15 years in the UK have obesity at a level likely to be associated with comorbidities. The majority of multicomponent lifestyle programmes have limited...
The response to receiving phenotypic and genetic coronary heart disease risk scores and lifestyle advice – a qualitative study
Abstract
Background
Individuals routinely receive information about their risk of coronary heart disease (CHD) based on traditional risk factors as part of their primary care. We...
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
Rachel M Freathy, M Geoffrey Hayes, Margrit Urbanek, Lynn P Lowe, Hoon Lee, Christine Ackerman, Timothy M Frayling, Nancy J Cox, David B Dunger, Alan R Dyer, Andrew T Hattersley, Boyd E Metzger, William L Lowe, HAPO Study Cooperative Research Group
Feb 21, 2020
OBJECTIVE: Common genetic variants in GCK and TCF7L2 are associated with higher fasting glucose and type 2 diabetes in nonpregnant populations. However, their associations with glucose levels from oral glucose tolerance tests...
Birth Weight Female genetic variation Genotype Germinal Center Kinases Humans Hyperglycemia Infant Newborn Polymorphism Single Nucleotide Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy in Diabetics Protein Serine-Threonine Kinases TCF Transcription Factors Transcription Factor 7-Like 2 Protein White People
Possible mechanism and mode of action of Al-Hijama (Wet Cupping Therapy) to Manage Non Communicable Lifestyle Diseases–An appraisal
Lifestyle diseases or diseases of longevity has reached alarming proportions among Indians in recent era due to rapid economic development, stress full life and increasing westernization of lifestyle. There is an extensive...
Published by: IJHS Medical Association
Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models.
Farideh Jalali-Najafabadi, Michael Stadler, Nick Dand, Deepak Jadon, Mehreen Soomro, Pauline Ho, Helen Marzo-Ortega, Philip Helliwell, Eleanor Korendowych, Michael A Simpson, Jonathan Packham, Catherine H Smith, Jonathan N Barker, Neil McHugh, Richard B Warren, Anne Barton, John Bowes, BADBIR Study Group, BSTOP Study Group
Dec 15, 2021
In view of the growth of clinical risk prediction models using genetic data, there is an increasing need for studies that use appropriate methods to select the optimum number of features from a large number of genetic variants...
Possible mechanism and mode of action of Al-Hijama (Wet Cupping Therapy) to Manage Non Communicable Lifestyle Diseases–An appraisal
Lifestyle diseases or diseases of longevity has reached alarming proportions among Indians in recent era due to rapid economic development, stress full life and increasing westernization of lifestyle. There is an extensive...
Published by: IJHS Medical Association
Physical Activity in the Prevention of Childhood Obesity
Justyna Wyszyńska, Susanne Ring-Dimitriou, David Thivel, Daniel Weghuber, Adamos Hadjipanayis, Zachi Grossman, Robert Ross-Russell, Katarzyna Dereń, Artur Mazur
Nov 19, 2020
Obesity affects an increasing number of children and adolescents. Physical activity (PA) is a significant factor in the prevention of excessive body mass in the pediatric population. A significant percentage of pediatric...
Frailty, lifestyle, genetics and dementia risk.
OBJECTIVE: To optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics. METHODS: We explored relationships between frailty index, healthy lifestyle...
Patterns of gray matter atrophy in genetic frontotemporal dementia
David M Cash, Martina Bocchetta, David L Thomas, Katrina M Dick, John C van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Martin N Rossor, Sebastien Ourselin, Jonathan D Rohrer, GENFI, Genetic FTD Initiative
Feb 05, 2018
Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms of genetic FTD...
Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models.
Farideh Jalali-Najafabadi, Michael Stadler, Nick Dand, Deepak Jadon, Mehreen Soomro, Pauline Ho, Helen Marzo-Ortega, Philip Helliwell, Eleanor Korendowych, Michael A Simpson, Jonathan Packham, Catherine H Smith, Jonathan N Barker, Neil McHugh, Richard B Warren, Anne Barton, John Bowes, BADBIR Study Group, BSTOP Study Group
Jan 28, 2022
In view of the growth of clinical risk prediction models using genetic data, there is an increasing need for studies that use appropriate methods to select the optimum number of features from a large number of genetic variants...
The epidemiological transition and the global childhood obesity epidemic
OBJECTIVES:
Childhood obesity is now recognized as a global public health issue. Social patterning of obesity, consistent with the theory of epidemiologic transition, has not been well described in children, and the...
Childhood obesity is now recognized as a global public health issue. Social patterning of obesity, consistent with the theory of epidemiologic transition, has not been well described in children, and the...
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