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Results: 18
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation.
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C Marioni, Carolina Guibentif, Berthold Göttgens
Aug 11, 2021
Background
Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here we...
Published by: Genome biology
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C. Marioni, Carolina Guibentif, Berthold Göttgens
Oct 28, 2021
Abstract: Background: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here...
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation.
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C Marioni, Carolina Guibentif, Berthold Göttgens
Jun 23, 2021
BACKGROUND: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here we apply...
Erythropoiesis Gastrulation Gata1 RNA velocity Animals Cell Differentiation Datasets as Topic Embryo Mammalian Erythroid Cells Erythropoiesis Fetus GATA1 Transcription Factor Gastrula Gene Expression Regulation Developmental Humans Kinetics Liver Mice Organogenesis Proto-Oncogene Proteins Single-Cell Analysis Trans-Activators Transcriptional Activation
Diverse Routes toward Early Somites in the Mouse Embryo.
Carolina Guibentif, Jonathan A Griffiths, Ivan Imaz-Rosshandler, Shila Ghazanfar, Jennifer Nichols, Valerie Wilson, Berthold Göttgens, John C Marioni
Nov 03, 2020
Brachyury cell fate regulation developmental trajectories neuromesodermal progenitors Somites Animals Body Patterning Cell Differentiation Cell Line Chimera Embryo Mammalian Female Fetal Proteins Gene Expression Profiling Gene Expression Regulation Developmental Germ Cells Heterozygote Male Mesoderm Mice Mice Inbred C57BL SOXB1 Transcription Factors Single-Cell Analysis Somites T-Box Domain Proteins Transcriptome
Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation
Melania Barile, Ivan Imaz-Rosshandler, Isabella Inzani, Shila Ghazanfar, Jennifer Nichols, John C. Marioni, Carolina Guibentif, Berthold Göttgens
Jul 07, 2021
Abstract: Background: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here...
Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Aurora Perez-Cornago, Francesca L Crowe, Paul N Appleby, Kathryn E Bradbury, Angela M Wood, Marianne Uhre Jakobsen, Laura Johnson, Carlotta Sacerdote, Marinka Steur, Elisabete Weiderpass, Anne Mette L Würtz, Tilman Kühn, Verena Katzke, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Giovanna Masala, Rosario Tumino, Salvatore Panico, Ivonne Sluijs, Guri Skeie, Liher Imaz, Dafina Petrova, J Ramón Quirós, Sandra Milena Colorado Yohar, Paula Jakszyn, Olle Melander, Emily Sonestedt, Jonas Andersson, Maria Wennberg, Dagfinn Aune, Elio Riboli, Matthias B Schulze, Emanuele Di Angelantonio, Nicholas J Wareham, John Danesh, Nita G Forouhi, Adam S Butterworth, Timothy J Key
May 07, 2021
BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of...
The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors.
GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells
Susana R Solorzano, Ivan Imaz-Rosshandler, Ignacio Camacho-Arroyo, Pilar García-Tobilla, Gustavo Morales-Montor, Patricia Salazar, Ma Leticia Arena-Ortiz, Mauricio Rodríguez-Dorantes
Sep 20, 2018
In prostate cancer (PCa), neuroendocrine cells (NE) have been associated with the progression of the disease due to the secretion of neuropeptides that are capable of diffusing and influence surrounding cells. The GABAergic...
Machine learning-selected variables associated with CD4 T cell recovery under antiretroviral therapy in very advanced HIV infection
Abstract
Background
A considerable portion of the HIV pandemic is composed of people under antiretroviral therapy, many of whom get a late diagnosis. Patients...
Dámaris P Romero-Rodríguez, Carlos Ramírez, Iván Imaz-Rosshandler, Christopher E Ormsby, Amy Peralta-Prado, Gustavo Olvera-García, Fernanda Cervantes, Daniela Würsch-Molina, Jessica Romero-Rodríguez, Wei Jiang, Gustavo Reyes-Terán, Enrique Espinosa
Apr 23, 2021
Machine learning-selected variables associated with CD4 T cell recovery under antiretroviral therapy in very advanced HIV infection
Dámaris P. Romero-Rodríguez, Carlos Ramírez, Iván Imaz-Rosshandler, Christopher E. Ormsby, Amy Peralta-Prado, Gustavo Olvera-García, Fernanda Cervantes, Daniela Würsch-Molina, Jessica Romero-Rodríguez, Wei Jiang, Gustavo Reyes-Terán, Enrique Espinosa
Jun 06, 2020
Abstract: Background: A considerable portion of the HIV pandemic is composed of people under antiretroviral therapy, many of whom get a late diagnosis. Patients starting antiretroviral therapy (ART) at a very advanced stage of...
The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke
Tammy YN Tong, Paul N Appleby, Timothy J Key, Christina C Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Verena Katzke, Tilman Kühn, Heiner Boeing, Anna Karakatsani, Eleni Peppa, Antonia Trichopoulou, Elisabete Weiderpass, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Jolanda MA Boer, WM Monique Verschuren, J Ramón Quirós, Antonio Agudo, Miguel Rodríguez-Barranco, Liher Imaz, María-Dolores Chirlaque, Conchi Moreno-Iribas, Gunnar Engström, Emily Sonestedt, Marcus Lind, Julia Otten, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Nicholas J Wareham, Fumiaki Imamura, Nita G Forouhi, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, Aurora Perez-Cornago
Jan 13, 2020
Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease
Marinka Steur, Laura Johnson, Stephen J Sharp, Fumiaki Imamura, Ivonne Sluijs, Timothy J Key, Angela Wood, Rajiv Chowdhury, Marcela Guevara, Marianne U Jakobsen, Ingegerd Johansson, Albert Koulman, Kim Overvad, Maria-José Sánchez, Yvonne T van der Schouw, Antonia Trichopoulou, Elisabete Weiderpass, Maria Wennberg, Ju-Sheng Zheng, Heiner Boeing, Jolanda MA Boer, Marie-Christine Boutron-Ruault, Ulrika Ericson, Alicia K Heath, Inge Huybrechts, Liher Imaz, Rudolf Kaaks, Vittorio Krogh, Tilman Kühn, Cecilie Kyrø, Giovanna Masala, Olle Melander, Conchi Moreno-Iribas, Salvatore Panico, José R Quirós, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Carmen Santiuste, Guri Skeie, Anne Tjønneland, Rosario Tumino, WM Monique Verschuren, Raul Zamora-Ros, Christina C Dahm, Aurora Perez-Cornago, Matthias B Schulze, Tammy YN Tong, Elio Riboli, Nicholas J Wareham, John Danesh, Adam S Butterworth, Nita G Forouhi
Jul 01, 2021
Multi-omics profiling of mouse gastrulation at single-cell resolution.
Ricard Argelaguet, Stephen J Clark, Hisham Mohammed, L Carine Stapel, Christel Krueger, Chantriolnt-Andreas Kapourani, Ivan Imaz-Rosshandler, Tim Lohoff, Yunlong Xiang, Courtney W Hanna, Sebastien Smallwood, Ximena Ibarra-Soria, Florian Buettner, Guido Sanguinetti, Wei Xie, Felix Krueger, Berthold Göttgens, Peter J Rugg-Gunn, Gavin Kelsey, Wendy Dean, Jennifer Nichols, Oliver Stegle, John C Marioni, Wolf Reik
Oct 29, 2019
Animals Cell Differentiation Cell Lineage Chromatin DNA Methylation Demethylation Embryoid Bodies Endoderm Enhancer Elements Genetic Epigenesis Genetic epigenome Erythropoiesis Factor Analysis Statistical Gastrula Gastrulation Gene Expression Regulation Developmental Mesoderm Mice Pluripotent Stem Cells RNA Single-Cell Analysis Time Factors Zinc Fingers
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
Chen Li, Svetlana Stoma, Luca A Lotta, Sophie Warner, Eva Albrecht, Alessandra Allione, Pascal P Arp, Linda Broer, Jessica L Buxton, Alexessander Da Silva Couto Alves, Joris Deelen, Iryna O Fedko, Scott D Gordon, Tao Jiang, Robert Karlsson, Nicola Kerrison, Taylor K Loe, Massimo Mangino, Yuri Milaneschi, Benjamin Miraglio, Natalia Pervjakova, Alessia Russo, Ida Surakka, Ashley van der Spek, Josine E Verhoeven, Najaf Amin, Marian Beekman, Alexandra I Blakemore, Federico Canzian, Stephen E Hamby, Jouke-Jan Hottenga, Peter D Jones, Pekka Jousilahti, Reedik Mägi, Sarah E Medland, Grant W Montgomery, Dale R Nyholt, Markus Perola, Kirsi H Pietiläinen, Veikko Salomaa, Elina Sillanpää, H Eka Suchiman, Diana van Heemst, Gonneke Willemsen, Antonio Agudo, Heiner Boeing, Dorret I Boomsma, Maria-Dolores Chirlaque, Guy Fagherazzi, Pietro Ferrari, Paul Franks, Christian Gieger, Johan Gunnar Eriksson, Marc Gunter, Sara Hägg, Iiris Hovatta, Liher Imaz, Jaakko Kaprio, Rudolf Kaaks, Timothy Key, Vittorio Krogh, Nicholas G Martin, Olle Melander, Andres Metspalu, Concha Moreno, N Charlotte Onland-Moret, Peter Nilsson, Ken K Ong, Kim Overvad, Domenico Palli, Salvatore Panico, Nancy L Pedersen, Brenda WJH Penninx, J Ramón Quirós, Marjo Riitta Jarvelin, Miguel Rodríguez-Barranco, Robert A Scott, Gianluca Severi, P Eline Slagboom, Tim D Spector, Anne Tjonneland, Antonia Trichopoulou, Rosario Tumino, André G Uitterlinden, Yvonne T van der Schouw, Cornelia M van Duijn, Elisabete Weiderpass, Eros Lazzerini Denchi, Giuseppe Matullo, Adam S Butterworth, John Danesh, Nilesh J Samani, Nicholas J Wareham, Christopher P Nelson, Claudia Langenberg, Veryan Codd
Feb 21, 2020
Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Jeroen R Huyghe, Tabitha A Harrison, Stephanie A Bien, Heather Hampel, Jane C Figueiredo, Stephanie L Schmit, David V Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A Baron, Amanda J Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M Levine, Vittorio Perduca, Aurora Perez-Cornago, Lori C Sakoda, Fredrick R Schumacher, Martha L Slattery, Amanda E Toland, Fränzel JB van Duijnhoven, Bethany Van Guelpen, Antonio Agudo, Demetrius Albanes, M Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Barbara L Banbury, Michael C Bassik, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Juergen Boehm, Heiner Boeing, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D Buchanan, Andrea Burnett-Hartman, Bette J Caan, Peter T Campbell, Prudence R Carr, Antoni Castells, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Keith R Curtis, Albert de la Chapelle, Douglas F Easton, Dallas R English, Edith JM Feskens, Manish Gala, Steven J Gallinger, W James Gauderman, Graham G Giles, Phyllis J Goodman, William M Grady, John S Grove, Andrea Gsur, Marc J Gunter, Robert W Haile, Jochen Hampe, Michael Hoffmeister, John L Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J Hudson, Mazda Jenab, Mark A Jenkins, Amit D Joshi, Temitope O Keku, Charles Kooperberg, Tilman Kühn, Sébastien Küry, Loic Le Marchand, Flavio Lejbkowicz, Christopher I Li, Li Li, Wolfgang Lieb, Annika Lindblom, Noralane M Lindor, Satu Männistö, Sanford D Markowitz, Roger L Milne, Lorena Moreno, Neil Murphy, Rami Nassir, Kenneth Offit, Shuji Ogino, Salvatore Panico, Patrick S Parfrey, Rachel Pearlman, Paul DP Pharoah, Amanda I Phipps, Elizabeth A Platz, John D Potter, Ross L Prentice, Lihong Qi, Leon Raskin, Gad Rennert, Hedy S Rennert, Elio Riboli, Clemens Schafmayer, Robert E Schoen, Daniela Seminara, Mingyang Song, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Antonia Trichopoulou, Cornelia M Ulrich, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J Weinstein, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Goncalo R Abecasis, Deborah A Nickerson, Peter C Scacheri, Anshul Kundaje, Graham Casey, Stephen B Gruber, Li Hsu, Victor Moreno, Richard B Hayes, Polly A Newcomb, Ulrike Peters
Mar 02, 2021
OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and...
CANCER GENETICS cancer susceptibility colon carcinogenesis colorectal cancer GENETIC POLYMORPHISMS Adult Age Distribution Age of Onset Aged Aged 80 and over Alleles Case-Control Studies Cecum Colon Colon Ascending Colon Descending Colon Sigmoid Colon Transverse Colonic Neoplasms Female Genetic Heterogeneity Genome-Wide Association Study Genotype Humans Male Middle Aged Polymorphism Single Nucleotide Rectal Neoplasms Risk Factors White People Young Adult
Milk intake and incident stroke and CHD in populations of European descent
LET Vissers, I Sluijs, S Burgess, NG Forouhi, H Freisling, F Imamura, TK Nilsson, F Renström, E Weiderpass, K Aleksandrova, CC Dahm, A Perez-Cornago, MB Schulze, TYN Tong, D Aune, C Bonet, JMA Boer, H Boeing, MD Chirlaque, MI Conchi, L Imaz, S Jäger, V Krogh, C Kyrø, G Masala, O Melander, K Overvad, S Panico, MJ Sánches, E Sonestedt, A Tjønneland, I Tzoulaki, WMM Verschuren, E Riboli, NJ Wareham, J Danesh, AS Butterworth, YT van der Schouw
Oct 28, 2021
Higher milk intake has been associated with a lower stroke risk, but not with risk of CHD. Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with...
Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.
Andrej Ćorović, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R Jayne, Stephen P Hoole, Patrick A Calvert, Andrew F Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Fiona J Gilbert, Marc R Dweck, David E Newby, Zahi A Fayad, Gary Reynolds, Ann W Morgan, Eric O Aboagye, Anthony P Davenport, Helle F Jørgensen, Ziad Mallat, Martin R Bennett, James E Peters, James HF Rudd, Justin C Mason, Jason M Tarkin
Feb 25, 2023
BACKGROUND: Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. OBJECTIVES: We aimed to investigate somatostatin receptor 2 (SST2) as a novel...
Takayasu arteritis Atherosclerosis Giant Cell Arteritis Inflammation Molecular Imaging somatostatin receptor Humans Receptors Somatostatin Prospective Studies Fluorodeoxyglucose F18 Inflammation Positron-Emission Tomography Magnetic Resonance Imaging Takayasu arteritis Coronary Vessels Atherosclerosis Myocardial Infarction Giant Cell Arteritis Radiopharmaceuticals