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SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function.
Silvia Marchiano, Tien-Ying Hsiang, Akshita Khanna, Ty Higashi, Leanne S Whitmore, Johannes Bargehr, Hongorzul Davaapil, Jean Chang, Elise Smith, Lay Ping Ong, Maria Colzani, Hans Reinecke, Xiulan Yang, Lil Pabon, Sanjay Sinha, Behzad Najafian, Nathan J Sniadecki, Alessandro Bertero, Michael Gale, Charles E Murry
Feb 26, 2021
COVID-19 patients often develop severe cardiovascular complications, but it remains unclear if these are caused directly by viral infection or are secondary to a systemic response. Here, we examine the cardiac tropism of...
covid-19 SARS-CoV-2 arrhythmias and heart failure cardiac infection cardiovascular disease hESC-CMs hPSC-CMs human pluripotent stem cell-derived cardiomyocytes viral myocarditis covid-19 Cells Cultured Humans Induced Pluripotent Stem Cells Myocytes Cardiac RNA Splicing RNA Messenger SARS-CoV-2 Virus Internalization
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic
Charlotte Thibeault, Barbara Mühlemann, Elisa T Helbig, Mirja Mittermaier, Tilman Lingscheid, Pinkus Tober-Lau, Lil A Meyer-Arndt, Leonie Meiners, Paula Stubbemann, Sascha S Haenel, Laure Bosquillon de Jarcy, Lena Lippert, Moritz Pfeiffer, Miriam S Stegemann, Robert Roehle, Janine Wiebach, Stefan Hippenstiel, Thomas Zoller, Holger Müller-Redetzky, Alexander Uhrig, Felix Balzer, Christof von Kalle, Norbert Suttorp, Terry C Jones, Christian Drosten, Martin Witzenrath, Leif E Sander, Pa-COVID study Group, Victor M Corman, Florian Kurth
Jul 28, 2021
Artificial respiration COVID-19 Nucleic Acid Testing Coronavirus disease 2019 (COVID-19) Mechanical ventilation prospective study Respiratory Distress Syndrome Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Symptom Assessment Viral concentration covid-19 Cohort Studies Germany Hospitalization Humans Hypertension Kinetics Prospective Studies Respiration Artificial Risk Factors SARS-CoV-2 Tertiary Care Centers Time Factors Viral Load Virus Shedding