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Results: 18
Olfactory sniffing signals consciousness in unresponsive patients with brain injuries.
Anat Arzi, Liron Rozenkrantz, Lior Gorodisky, Danit Rozenkrantz, Yael Holtzman, Aharon Ravia, Tristan A Bekinschtein, Tatyana Galperin, Ben-Zion Krimchansky, Gal Cohen, Anna Oksamitni, Elena Aidinoff, Yaron Sacher, Noam Sobel
May 06, 2020
After severe brain injury, it can be difficult to determine the state of consciousness of a patient, to determine whether the patient is unresponsive or perhaps minimally conscious1, and to predict whether they will recover....
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics.
Human cytomegalovirus (HCMV) is an important pathogen in immunocompromised individuals and neonates, and a paradigm for viral immune evasion. We previously developed a quantitative proteomic approach that identified 133 proteins...
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes
Abstract: Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical...
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes.
Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical monocytes play the...
Published by: Scientific reports
The rise and fall of viticulture in the Late Antique Negev Highlands reconstructed from archaeobotanical and ceramic data.
Daniel Fuks, Guy Bar-Oz, Yotam Tepper, Tali Erickson-Gini, Dafna Langgut, Lior Weissbrod, Ehud Weiss
Aug 16, 2021
The international scope of the Mediterranean wine trade in Late Antiquity raises important questions concerning sustainability in an ancient international economy and offers a valuable historical precedent to modern...
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist.
Lior Soday, Yongxu Lu, Jonas D Albarnaz, Colin TR Davies, Robin Antrobus, Geoffrey L Smith, Michael P Weekes
Apr 16, 2019
Histone deacetylase host-pathogen interaction Immune Evasion innate immunity interferon Poxvirus quantitative proteomics restriction factor systems virology tandem mass tag Cytomegalovirus Down-Regulation Gene Expression Regulation Viral Herpesvirus 1 Human Histone Deacetylases Host-Pathogen Interactions Humans Immune Evasion Interferons Membrane Proteins Proteasome Endopeptidase Complex Proteolysis Proteomics Time Factors Vaccinia vaccinia virus Viral Proteins
Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
Georgia Cook, Katherine Brown, Pengcheng Shang, Yanhua Li, Lior Soday, Adam Dinan, Charlotte Tumescheit, Adrian Mockett, Ying Fang, Andrew Firth, Ian Brierley
Apr 11, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus which causes significant economic losses to the swine industry worldwide. Here, we use ribosome profiling (RiboSeq) and parallel RNA sequencing...
PRRSV RNA sequencing arterivirus Chromosomes Gene Expression Gene Expression Regulation infectious disease microbiology nidovirus porcine reproductive programmed ribosomal frameshifting respiratory syndrome virus ribosome profiling subgenomic mRNAs Transcriptome translatome Animals Codon Frameshifting Ribosomal Gene Expression Profiling Porcine respiratory and reproductive syndrome virus Ribosomes Swine Transcriptome
Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon
Lior Soday, Martin Potts, Leah M. Hunter, Benjamin J. Ravenhill, Jack W. Houghton, James C. Williamson, Robin Antrobus, Mark R. Wills, Nicholas J. Matheson, Michael P. Weekes
Feb 22, 2021
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the...
Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon.
Lior Soday, Martin Potts, Leah M Hunter, Benjamin J Ravenhill, Jack W Houghton, James C Williamson, Robin Antrobus, Mark R Wills, Nicholas J Matheson, Michael P Weekes
Feb 24, 2021
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the...
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions.
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 29, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions.
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 06, 2020
Computational Biology host-pathogen interaction human human cytomegalovirus Immune Evasion infectious disease microbiology Protein-Protein Interaction Proteomics Systems Biology systems virology Virus Adaptor Proteins Signal Transducing Cytomegalovirus Cytomegalovirus Infections Gene Expression Regulation Viral Host-Pathogen Interactions Humans Oncogene Proteins Proteomics RNA Splicing RNA Messenger Viral Proteins Virus Replication
The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Michal Meir, Yaron Galanty, Lior Kashani, Michael Blank, Rami Khosravi, María Jesús Fernández-Ávila, Andrés Cruz-García, Ayelet Star, Lea Shochot, Yann Thomas, Lisa J Garrett, Daniel A Chamovitz, David M Bodine, Thimo Kurz, Pablo Huertas, Yael Ziv, Yosef Shiloh
Jun 01, 2015
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 15, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.
Katie Nightingale, Kai-Min Lin, Benjamin J Ravenhill, Colin Davies, Luis Nobre, Ceri A Fielding, Eva Ruckova, Alice Fletcher-Etherington, Lior Soday, Hester Nichols, Daniel Sugrue, Eddie CY Wang, Pablo Moreno, Yagnesh Umrania, Edward L Huttlin, Robin Antrobus, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Peter Tomasec, Michael P Weekes
Nov 05, 2018
host-pathogen interaction Immune Evasion innate immunity lysosome Proteasome protein degradation pulsed SILAC quantitative proteomics restriction factor tandem mass tag Cytomegalovirus Cytomegalovirus Infections DNA-Binding Proteins Humans Immune Evasion Protein Stability Proteins Proteomics Transcription Factors Viral Proteins
Expert appraisal of criteria for assessing gaming disorder
Jesús Castro-Calvo, Daniel L King, Dan J Stein, Matthias Brand, Lior Carmi, Samuel R Chamberlain, Zsolt Demetrovics, Naomi A Fineberg, Hans-Jürgen Rumpf, Murat Yücel, Sophia Achab, Atul Ambekar, Norharlina Bahar, Alexander Blaszczynski, Henrietta Bowden-Jones, Xavier Carbonell, Elda Mei Lo Chan, Chih-Hung Ko, Philippe de Timary, Magali Dufour, Marie Grall-Bronnec, Hae Kook Lee, Susumu Higuchi, Susana Jimenez-Murcia, Orsolya Király, Daria J Kuss, Jiang Long, Astrid Müller, Stefano Pallanti, Marc N Potenza, Afarin Rahimi-Movaghar, John B Saunders, Adriano Schimmenti, Seung-Yup Lee, Kristiana Siste, Daniel T Spritzer, Vladan Starcevic, Aviv M Weinstein, Klaus Wölfling, Joël Billieux
Aug 02, 2021
BACKGROUND AND AIMS: Following the recognition of 'internet gaming disorder' (IGD) as a condition requiring further study by the DSM-5, 'gaming disorder' (GD) was officially included as a diagnostic entity by the World Health...
Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
Kelly L Bolton, Ryan N Ptashkin, Teng Gao, Lior Braunstein, Sean M Devlin, Daniel Kelly, Minal Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine C Coombs, Nicole M Caltabellotta, Mike Walsh, Kenneth Offit, Zsofia Stadler, Diana Mandelker, Jessica Schulman, Akshar Patel, John Philip, Elsa Bernard, Gunes Gundem, Juan E Arango Ossa, Max Levine, Juan S Medina Martinez, Noushin Farnoud, Dominik Glodzik, Sonya Li, Mark E Robson, Choonsik Lee, Paul DP Pharoah, Konrad H Stopsack, Barbara Spitzer, Simon Mantha, James Fagin, Laura Boucai, Christopher J Gibson, Benjamin L Ebert, Andrew L Young, Todd Druley, Koichi Takahashi, Nancy Gillis, Markus Ball, Eric Padron, David M Hyman, Jose Baselga, Larry Norton, Stuart Gardos, Virginia M Klimek, Howard Scher, Dean Bajorin, Eder Paraiso, Ryma Benayed, Maria E Arcila, Marc Ladanyi, David B Solit, Michael F Berger, Martin Tallman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Luis A Diaz, Ross L Levine, Lindsay M Morton, Ahmet Zehir, Elli Papaemmanuil
Jun 02, 2021
Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal...
Humans Neoplasms Leukemia Myeloid Neoplasms Second Primary Cell Transformation Neoplastic Antineoplastic Agents Cohort Studies Mutation Models Biological Adolescent Adult Aged Aged 80 and over Middle Aged Child Child Preschool Infant Infant Newborn Female Male Young Adult selection Genetic Genetic Fitness Clonal Evolution clonal hematopoiesis