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Results: 79
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Feb 04, 2019
Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Cristina Porcheri, Ohad Golan, Fernando J Calero-Nieto, Roshana Thambyrajah, Cristina Ruiz-Herguido, Xiaonan Wang, Francesca Catto, Yolanda Guillén, Roshani Sinha, Jessica González, Sarah J Kinston, Samanta A Mariani, Antonio Maglitto, Chris S Vink, Elaine Dzierzak, Pierre Charbord, Bertie Göttgens, Lluis Espinosa, David Sprinzak, Anna Bigas
Feb 21, 2020
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.
Brochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
Juliel Espinosa
Jan 01, 0001
The intestinal microbiota consists of diverse bacterial species and their effectors that play key roles in regulating human health. Interestingly, cell wall, or peptidoglycan, fragments from commensal and pathogenic bacteria can...
Published by: Rockefeller University
Disentangling α and β relaxation in orientationally disordered crystals with theory and experiments.
We use a microscopically motivated generalized Langevin equation (GLE) approach to link the vibrational density of states (VDOS) to the dielectric response of orientational glasses (OGs). The dielectric function calculated based...
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it.
Cavity solitons in a microring dimer with gain and loss
We address a pair of vertically coupled microring resonators with gain and loss pumped by a single-frequency field. Coupling between microrings results in a twofold splitting of the single microring resonance that increases...
NAFlex
Adam Hospital, Ignacio Faustino, Rosana Collepardo-Guevara, Carlos González, Josep Lluis Gelpí, Modesto Orozco
Mar 25, 2021
We present NAFlex, a new web tool to study the flexibility of nucleic acids, either isolated or bound to other molecules. The server allows the user to incorporate structures from protein data banks, completing gaps and removing...
MRSA carrying mecC in captive mara.
WGS methicillin resistance wildlife zoo Animals Animals Zoo Anti-Bacterial Agents DNA Bacterial Denmark Genes Bacterial Genome Bacterial Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Polymerase Chain Reaction Rodentia Sequence Analysis DNA Staphylococcal Infections Virulence Factors
Cavity solitons in a microring dimer with gain and loss
We address a pair of vertically coupled microring resonators with gain and loss pumped by a single-frequency field. Coupling between microrings results in a twofold splitting of the single microring resonance that increases...
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid–Liquid Phase Separation
Proteins containing intrinsically disordered regions (IDRs) are ubiquitous within biomolecular condensates, which are liquid-like compartments within cells formed through liquid−liquid phase separation (LLPS). The sequence of...
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates.
Biomolecular condensates formed by the process of liquid-liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions. Upon maturation, the...
Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components
Ignacio Sanchez-Burgos, Jorge R. Espinosa, Jerelle A. Joseph, Rosana Collepardo-Guevara
Feb 15, 2021
Biomolecular condensates, which assemble via the process of liquid–liquid phase separation (LLPS), are multicomponent compartments found ubiquitously inside cells. Experiments and simulations have shown that biomolecular...
Role of Salt, Pressure, and Water Activity on Homogeneous Ice Nucleation.
Jorge R Espinosa, Guiomar D Soria, Jorge Ramirez, Chantal Valeriani, Carlos Vega, Eduardo Sanz
Dec 19, 2019
Pure water can be substantially supercooled below the melting temperature without transforming into ice. The achievable supercooling can be enhanced by adding solutes or by applying hydrostatic pressure. Avoiding ice formation...
Published by: J Phys Chem Lett
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid-Liquid Phase Separation.
Proteins containing intrinsically disordered regions (IDRs) are ubiquitous within biomolecular condensates, which are liquid-like compartments within cells formed through liquid-liquid phase separation (LLPS). The sequence of...
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Petar Scepanovic, Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson Byrd, Christian Hammer, Cécile Alanio, Jacob Bergstedt, Etienne Patin, Mathilde Touvier, Olivier Lantz, Matthew L Albert, Darragh Duffy, Lluis Quintana-Murci, Jacques Fellay, Milieu Intérieur Consortium
Feb 07, 2020
BACKGROUND: The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu...
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
Luis B Barreiro, Olivier Neyrolles, Chantal L Babb, Ludovic Tailleux, Hélène Quach, Ken McElreavey, Paul D van Helden, Eileen G Hoal, Brigitte Gicquel, Lluis Quintana-Murci
Apr 16, 2018
BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic...
Adult Black People Case-Control Studies Cell Adhesion Molecules Dendritic Cells Female Genetic Predisposition to Disease Humans Lectins C-Type Male Middle Aged Mycobacterium tuberculosis Phylogeny Polymorphism Single Nucleotide Promoter Regions Genetic Receptors Cell Surface Risk Factors South Africa Tuberculosis Pulmonary
Information Technology/Systems Adoption in the Public Sector
State government has been moving from manual and paper-based processes to digital services. However, digital divide, declining trust in technology, and low IT/IS adoption rates by public sector employees are important challenges...
Published by: IGI Global Scientific Publishing
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