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Results: 152
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
Luis B Barreiro, Olivier Neyrolles, Chantal L Babb, Ludovic Tailleux, Hélène Quach, Ken McElreavey, Paul D van Helden, Eileen G Hoal, Brigitte Gicquel, Lluis Quintana-Murci
Apr 16, 2018
BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic...
Adult Black People Case-Control Studies Cell Adhesion Molecules Dendritic Cells Female Genetic Predisposition to Disease Humans Lectins C-Type Male Middle Aged Mycobacterium tuberculosis Phylogeny Polymorphism Single Nucleotide Promoter Regions Genetic Receptors Cell Surface Risk Factors South Africa Tuberculosis Pulmonary
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Petar Scepanovic, Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson Byrd, Christian Hammer, Cécile Alanio, Jacob Bergstedt, Etienne Patin, Mathilde Touvier, Olivier Lantz, Matthew L Albert, Darragh Duffy, Lluis Quintana-Murci, Jacques Fellay, Milieu Intérieur Consortium
Feb 07, 2020
BACKGROUND: The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu...
Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels
Michael D. Morgan, Etienne Patin, Bernd Jagla, Milena Hasan, Lluís Quintana-Murci, John C. Marioni
Mar 25, 2020
Identifying the factors that shape protein expression variability in complex multi-cellular organisms has primarily focused on promoter architecture and regulation of single-cell expression in cis. However, this targeted...
Disentangling α and β relaxation in orientationally disordered crystals with theory and experiments.
We use a microscopically motivated generalized Langevin equation (GLE) approach to link the vibrational density of states (VDOS) to the dielectric response of orientational glasses (OGs). The dielectric function calculated based...
Cavity solitons in a microring dimer with gain and loss
We address a pair of vertically coupled microring resonators with gain and loss pumped by a single-frequency field. Coupling between microrings results in a twofold splitting of the single microring resonance that increases...
NAFlex
Adam Hospital, Ignacio Faustino, Rosana Collepardo-Guevara, Carlos González, Josep Lluis Gelpí, Modesto Orozco
Mar 25, 2021
We present NAFlex, a new web tool to study the flexibility of nucleic acids, either isolated or bound to other molecules. The server allows the user to incorporate structures from protein data banks, completing gaps and removing...
Cavity solitons in a microring dimer with gain and loss
We address a pair of vertically coupled microring resonators with gain and loss pumped by a single-frequency field. Coupling between microrings results in a twofold splitting of the single microring resonance that increases...
Refractory lupus nephritis
Andreas Kronbichler, Biljana Brezina, Philipp Gauckler, Luis F Quintana, David RW Jayne
May 13, 2019
Refractory lupus nephritis indicates an inadequate response to lupus nephritis therapy. It implies persisting or worsening disease activity despite therapy, but the definition is complicated by the parameters of response...
A Systematic Review and Meta-Analysis of Discrepancies Between Logged and Self-Reported Digital Media Use
Douglas Parry, Brit Davidson, Craig Sewall, Jacob Fisher, Hannah Mieczkowski, Dan Quintana
Nov 30, 2021
There is widespread public and academic interest in understanding the uses and effects of digital media. Scholars primarily use self-report measures of the quantity or duration of media use as proxies for more objective...
Anxiety and depression among medical doctors in Catalonia, Italy, and the UK during the COVID-19 pandemic.
Climent Quintana-Domeque, Ines Lee, Anwen Zhang, Eugenio Proto, Michele Battisti, Antonia Ho
Jan 06, 2022
Healthcare workers have had the longest and most direct exposure to COVID-19 and consequently may suffer from poor mental health. We conducted one of the first repeated multi-country analysis of the mental wellbeing of medical...
Hereditary sensory and autonomic neuropathy in a family of mixed breed dogs associated with a novel RETREG1 variant.
Rodrigo Gutierrez-Quintana, Cathryn Mellersh, Annette Wessmann, Maria Ortega, Jacques Penderis, Samuel Sharpe, Eleanor Freeman, Lynn Stevenson, Louise Burmeister
Aug 23, 2021
BACKGROUND: Hereditary sensory and autonomic neuropathies (HSANs) are a group of genetic disorders affecting the peripheral nervous system. Two different associated variants have been identified in dogs: 1 in Border Collies and...
A Systematic Review and Meta-Analysis of Discrepancies Between Logged and Self-Reported Digital Media Use
Douglas Parry, Brit Davidson, Craig Sewall, Jacob Fisher, Hannah Mieczkowski, Dan Quintana
Nov 30, 2021
There is widespread public and academic interest in understanding the uses and effects of digital media. Scholars primarily use self-report measures of the quantity or duration of media use as proxies for more objective...
ANCA associated vasculitis
ANCA associated vasculitis is a serious, very often recurrent disease that despite the current standard treatment with high-dose glucocorticoids and either cyclophosphamide or rituximab, patients have a nine-fold increased...
The effect of increasing Women's autonomy on primary and repeated caesarean sections in Brazil.
Caesarean section (C-section) rates continue to rise globally. Yet, there is little consensus about the key determinants of rising C-section rates and the sources of variation in C-section rates across the world. While...
Severe conservation risks of roads on apex predators
Abstract The global expansion of road networks threatens apex predator conservation and ecosystem functioning. This occurs through wildlife-vehicle collisions, habitat loss and fragmentation...
Itxaso Quintana, Edgar F Cifuentes, Jeffrey A Dunnink, María Ariza, Daniela Martínez-Medina, Felipe M Fantacini, Bibek R Shrestha, Freddie-Jeanne Richard
Feb 21, 2022
Anxiety and depression among medical doctors in Catalonia, Italy, and the UK during the COVID-19 pandemic.
Climent Quintana-Domeque, Ines Lee, Anwen Zhang, Eugenio Proto, Michele Battisti, Antonia Ho
Nov 02, 2021
Healthcare workers have had the longest and most direct exposure to COVID-19 and consequently may suffer from poor mental health. We conducted one of the first repeated multi-country analysis of the mental wellbeing of medical...
The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp.
Elena Fernández Álvaro, Phat Voong Vinh, Cristina de Cozar, David R Willé, Beatriz Urones, Alvaro Cortés, Alan Price, Nhu Tran Do Hoang, Tuyen Ha Thanh, Molly McCloskey, Shareef Shaheen, Denise Dayao, Amanda Martinot, Jaime de Mercado, Pablo Castañeda, Adolfo García-Perez, Benson Singa, Patricia Pavlinac, Judd Walson, Maria Santos Martínez-Martínez, Samuel LM Arnold, Saul Tzipori, Lluis Ballell Pages, Stephen Baker
Apr 19, 2022
BACKGROUND: Diarrhoea remains one of the leading causes of childhood mortality globally. Recent epidemiological studies conducted in low-middle income countries (LMICs) identified Shigella spp. as the first and second most...
Severe conservation risks of roads on apex predators.
Itxaso Quintana, Edgar F Cifuentes, Jeffrey A Dunnink, María Ariza, Daniela Martínez-Medina, Felipe M Fantacini, Bibek R Shrestha, Freddie-Jeanne Richard
Mar 28, 2022
The global expansion of road networks threatens apex predator conservation and ecosystem functioning. This occurs through wildlife-vehicle collisions, habitat loss and fragmentation, reduced genetic connectivity and increased...
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Feb 04, 2019
Systematic Assessment of the Accuracy of Subunit Counting in Biomolecular Complexes Using Automated Single-Molecule Brightness Analysis.
John SH Danial, Yuri Quintana, Uris Ros, Raed Shalaby, Eleonora G Margheritis, Sabrina Chumpen Ramirez, Christian Ungermann, Ana J Garcia-Saez, Katia Cosentino
Feb 19, 2022
Analysis of single-molecule brightness allows subunit counting of high-order oligomeric biomolecular complexes. Although the theory behind the method has been extensively assessed, systematic analysis of the experimental...
Self-Directed/Community-Supported Learning
MOOC designers seeking to address evolving ambitions of MOOCs to support workforce development confront a fundamental design dilemma: on the one hand, the self-paced nature of online learning is efficient for busy learners...
Instructional Design Education Educational Technologies Media and Communications Computer Science and Information Technology
Published by: IGI Global Scientific Publishing
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