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Green Algorithms
Climate change is profoundly affecting nearly all aspects of life on earth, including human societies, economies, and health. Various human activities are responsible for significant greenhouse gas (GHG) emissions, including...
Tangent-space optimization for interactive animation control
Character animation tools are based on a keyframing metaphor where artists pose characters at selected keyframes and the software automatically interpolates the frames inbetween. Although the quality of the interpolation...
A new benchmark problem for electromagnetic modelling of superconductors
Mark Ainslie, Francesco Grilli, Loïc Quéval, Enric Pardo, Fernando Perez-Mendez, Ratu Mataira, Antonio Morandi, Asef Ghabeli, Chris Bumby, Roberto Brambilla
Sep 03, 2020
Abstract: The high-T c superconducting (HTS) dynamo is a promising device that can inject large DC supercurrents into a closed superconducting circuit. This is particularly attractive to energise HTS coils in NMR/MRI magnets and...
A new benchmark problem for electromagnetic modelling of superconductors
Mark Ainslie, Francesco Grilli, Loïc Quéval, Enric Pardo, Fernando Perez-Mendez, Ratu Mataira, Antonio Morandi, Asef Ghabeli, Chris Bumby, Roberto Brambilla
Sep 03, 2020
Abstract: The high-T c superconducting (HTS) dynamo is a promising device that can inject large DC supercurrents into a closed superconducting circuit. This is particularly attractive to energise HTS coils in NMR/MRI magnets and...
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.
Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S Benke, Jennifer L Bragg-Gresham, Mickaël Canouil, Tanguy Corre, Harald Grallert, Aaron Isaacs, Zoltan Kutalik, Jari Lahti, Letizia Marullo, Carola Marzi, Laura J Rasmussen-Torvik, Ghislain Rocheleau, Rico Rueedi, Chiara Scapoli, Niek Verweij, Nicole Vogelzangs, Sara M Willems, Loïc Yengo, Stephan JL Bakker, John Beilby, Jennie Hui, Eero Kajantie, Martina Müller-Nurasyid, Wolfgang Rathmann, Beverley Balkau, Sven Bergmann, Johan G Eriksson, Jose C Florez, Philippe Froguel, Tamara Harris, Joseph Hung, Alan L James, Maryam Kavousi, Iva Miljkovic, Arthur W Musk, Lyle J Palmer, Annette Peters, Ronan Roussel, Pim van der Harst, Cornelia M van Duijn, Peter Vollenweider, Inês Barroso, Inga Prokopenko, Josée Dupuis, James B Meigs, Nabila Bouatia-Naji
Jul 18, 2019
Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development...
Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS)
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Tania Capeloa, Justine A Van de Velde, Donatienne d'Hose, Sara G Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P Duhoux, Michael P Murphy, Paolo E Porporato, Bernard Gallez, Pierre Sonveaux
Nov 16, 2022
At diagnosis, about 35% of pancreatic cancers are at the locally invasive yet premetastatic stage. Surgical resection is not a treatment option, leaving patients with a largely incurable disease that often evolves to the...
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Position paper
Xavier Bossuyt, Jan-Willem Cohen Tervaert, Yoshihiro Arimura, Daniel Blockmans, Luis Felipe Flores-Suárez, Loïc Guillevin, Bernhard Hellmich, David Jayne, J Charles Jennette, Cees GM Kallenberg, Sergey Moiseev, Pavel Novikov, Antonella Radice, Judith Anne Savige, Renato Alberto Sinico, Ulrich Specks, Pieter van Paassen, Ming-Hui Zhao, Niels Rasmussen, Jan Damoiseaux, Elena Csernok
Feb 24, 2020
Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic...
Superconducting motors for aircraft propulsion
Francesco Grilli, Tara Benkel, Jens H¨anisch, Mayraluna Lao, Thomas Reis, Eva Berberich, Simon Wolfst¨adter, Christian Schneider, Paul Miller, Chloe Palmer, Bartek Glowacki, Vicente Climente-Alarcon, Anis Smara, Lukasz Tomkow, Johannes Teigelk¨otter, Alexander Stock, Johannes Bu¨del, Loïc Jeunesse, Martin Staempflin, Guillaume Delautre, Baptiste Zimmermann, Ruud van der Woude, Ana Perez, Sergey Samoilenkov, Alexander Molodyk, Enric Pardo, Milan Kapolka, Shuo Li, Anang Dadhich
Jul 31, 2020
Abstract: The European Union-funded Advanced Superconducting Motor Experimental Demonstrator (ASuMED) project started in May 2017 with the purpose of demonstrating the benefits of a new, fully superconducting motor for reaching...
Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer.
Aung Ko Win, Mark A Jenkins, James G Dowty, Antonis C Antoniou, Andrew Lee, Graham G Giles, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Dennis J Ahnen, Stephen N Thibodeau, Graham Casey, Steven Gallinger, Loïc Le Marchand, Robert W Haile, John D Potter, Yingye Zheng, Noralane M Lindor, Polly A Newcomb, John L Hopper, Robert J Macinnis
Jan 25, 2017
Superconducting motors for aircraft propulsion
Francesco Grilli, Tara Benkel, Jens H¨anisch, Mayraluna Lao, Thomas Reis, Eva Berberich, Simon Wolfst¨adter, Christian Schneider, Paul Miller, Chloe Palmer, Bartek Glowacki, Vicente Climente-Alarcon, Anis Smara, Lukasz Tomkow, Johannes Teigelk¨otter, Alexander Stock, Johannes Bu¨del, Loïc Jeunesse, Martin Staempflin, Guillaume Delautre, Baptiste Zimmermann, Ruud van der Woude, Ana Perez, Sergey Samoilenkov, Alexander Molodyk, Enric Pardo, Milan Kapolka, Shuo Li, Anang Dadhich
Jul 31, 2020
Abstract: The European Union-funded Advanced Superconducting Motor Experimental Demonstrator (ASuMED) project started in May 2017 with the purpose of demonstrating the benefits of a new, fully superconducting motor for reaching...
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
James J Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér, Mark Alan Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, Pascal N Timshel, Raymond K Walters, Emily A Willoughby, Loïc Yengo, 23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium, Maris Alver, Yanchun Bao, David W Clark, Felix R Day, Nicholas A Furlotte, Peter K Joshi, Kathryn E Kemper, Aaron Kleinman, Claudia Langenberg, Reedik Mägi, Joey W Trampush, Shefali Setia Verma, Yang Wu, Max Lam, Jing Hua Zhao, Zhili Zheng, Jason D Boardman, Harry Campbell, Jeremy Freese, Kathleen Mullan Harris, Caroline Hayward, Pamela Herd, Meena Kumari, Todd Lencz, Jian'an Luan, Anil K Malhotra, Andres Metspalu, Lili Milani, Ken K Ong, John RB Perry, David J Porteous, Marylyn D Ritchie, Melissa C Smart, Blair H Smith, Joyce Y Tung, Nicholas J Wareham, James F Wilson, Jonathan P Beauchamp, Dalton C Conley, Tõnu Esko, Steven F Lehrer, Patrik KE Magnusson, Sven Oskarsson, Tune H Pers, Matthew R Robinson, Kevin Thom, Chelsea Watson, Christopher F Chabris, Michelle N Meyer, David I Laibson, Jian Yang, Magnus Johannesson, Philipp D Koellinger, Patrick Turley, Peter M Visscher, Daniel J Benjamin, David Cesarini
Oct 03, 2018
Associations between exploratory dietary patterns and incident type 2 diabetes
Franziska Jannasch, Stefan Dietrich, Tom RP Bishop, Matthew Pearce, Anouar Fanidi, Gráinne O'Donoghue, Donal O'Gorman, Pedro Marques-Vidal, Peter Vollenweider, Maira Bes-Rastrollo, Liisa Byberg, Alicja Wolk, Maryam Hashemian, Reza Malekzadeh, Hossein Poustchi, Vivian C Luft, Sheila M Alvim de Matos, Jihye Kim, Mi Kyung Kim, Yeonjung Kim, Dalia Stern, Martin Lajous, Dianna J Magliano, Jonathan E Shaw, Tasnime Akbaraly, Mika Kivimaki, Gertraud Maskarinec, Loïc Le Marchand, Miguel Ángel Martínez-González, Sabita S Soedamah-Muthu, EPIC-InterAct Consortium, Nicholas J Wareham, Nita G Forouhi, Matthias B Schulze
Sep 10, 2022
Superconducting motors for aircraft propulsion
Francesco Grilli, Tara Benkel, Jens Hänisch, Mayraluna Lao, Thomas Reis, Eva Berberich, Simon Wolfstädter, Christian Schneider, Paul Miller, Chloe Palmer, Bartek Glowacki, Vicente Climente-Alarcon, Anis Smara, Lukasz Tomkow, Johannes Teigelkötter, Alexander Stock, Johannes Büdel, Loïc Jeunesse, Martin Staempflin, Guillaume Delautre, Baptiste Zimmermann, Ruud van der Woude, Ana Perez, Sergey Samoilenkov, Alexander Molodyk, Enric Pardo, Milan Kapolka, Shuo Li, Anang Dadhich
Jul 28, 2021
Abstract: The European Union-funded Advanced Superconducting Motor Experimental Demonstrator (ASuMED) project started in May 2017 with the purpose of demonstrating the benefits of a new, fully superconducting motor for reaching...
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.
Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard Mr Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Jörg Epplen, Loïc Guillevin, David RW Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A Little, Davide Martorana, Frank Moosig, Thomas Neumann, Sophie Ohlsson, Stefanie Quickert, Giuseppe A Ramirez, Barbara Rewerska, Georg Schett, Renato A Sinico, Wojciech Szczeklik, Vladimir Tesar, Damjan Vukcevic, European Vasculitis Genetics Consortium, Benjamin Terrier, Richard A Watts, Augusto Vaglio, Julia U Holle, Chris Wallace, Kenneth GC Smith
Jul 05, 2019
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.
Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard M R Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Jörg Epplen, Loïc Guillevin, David R W Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A Little, Davide Martorana, Frank Moosig, Thomas Neumann, Sophie Ohlsson, Stefanie Quickert, Giuseppe A Ramirez, Barbara Rewerska, Georg Schett, Renato A Sinico, Wojciech Szczeklik, Vladimir Tesar, Damjan Vukcevic, Benjamin Terrier, Richard A Watts, Augusto Vaglio, Julia U Holle, Chris Wallace, Kenneth G C Smith
Dec 14, 2019
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a...
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R Robertson, Jason M Torres, N William Rayner, Anthony J Payne, Valgerdur Steinthorsdottir, Robert A Scott, Niels Grarup, James P Cook, Ellen M Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F Bielak, Jennifer E Below, Donald W Bowden, John Campbell Chambers, Young Jin Kim, Maggie CY Ng, Lauren E Petty, Xueling Sim, Weihua Zhang, Amanda J Bennett, Jette Bork-Jensen, Chad M Brummett, Mickaël Canouil, Kai-Uwe Ec Kardt, Krista Fischer, Sharon LR Kardia, Florian Kronenberg, Kristi Läll, Ching-Ti Liu, Adam E Locke, Jian'an Luan, Ioanna Ntalla, Vibe Nylander, Sebastian Schönherr, Claudia Schurmann, Loïc Yengo, Erwin P Bottinger, Ivan Brandslund, Cramer Christensen, George Dedoussis, Jose C Florez, Ian Ford, Oscar H Franco, Timothy M Frayling, Vilmantas Giedraitis, Sophie Hackinger, Andrew T Hattersley, Christian Herder, M Arfan Ikram, Martin Ingelsson, Marit E Jørgensen, Torben Jørgensen, Jennifer Kriebel, Johanna Kuusisto, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Valeriya Lyssenko, Vasiliki Mamakou, Thomas Meitinger, Karen L Mohlke, Andrew D Morris, Girish Nadkarni, James S Pankow, Annette Peters, Naveed Sattar, Alena Stančáková, Konstantin Strauch, Kent D Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Daniel R Witte, Josée Dupuis, Patricia A Peyser, Eleftheria Zeggini, Ruth JF Loos, Philippe Froguel, Erik Ingelsson, Lars Lind, Leif Groop, Markku Laakso, Francis S Collins, J Wouter Jukema, Colin NA Palmer, Harald Grallert, Andres Metspalu, Abbas Dehghan, Anna Köttgen, Goncalo R Abecasis, James B Meigs, Jerome I Rotter, Jonathan Marchini, Oluf Pedersen, Torben Hansen, Claudia Langenberg, Nicholas J Wareham, Kari Stefansson, Anna L Gloyn, Andrew P Morris, Michael Boehnke, Mark I McCarthy
Sep 08, 2018
Body Mass Index Case-Control Studies Chromosome Mapping Diabetes mellitus Type 2 Epigenesis Genetic Female Gene Frequency Genetic Loci Genetic Predisposition to Disease Genome Human Genome-Wide Association Study High-Throughput Screening Assays Humans Islets of Langerhans Linkage Disequilibrium Male Meta-Analysis as Topic Polymorphism Single Nucleotide Sex Factors White People
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
Momoko Horikoshi, Lorenzo Pasquali, Steven Wiltshire, Jeroen R Huyghe, Anubha Mahajan, Jennifer L Asimit, Teresa Ferreira, Adam E Locke, Neil R Robertson, Xu Wang, Xueling Sim, Hayato Fujita, Kazuo Hara, Robin Young, Weihua Zhang, Sungkyoung Choi, Han Chen, Ismeet Kaur, Fumihiko Takeuchi, Pierre Fontanillas, Dorothée Thuillier, Loic Yengo, Jennifer E Below, Claudia HT Tam, Ying Wu, Gonçalo Abecasis, David Altshuler, Graeme I Bell, John Blangero, Noél P Burtt, Ravindranath Duggirala, Jose C Florez, Craig L Hanis, Mark Seielstad, Gil Atzmon, Juliana CN Chan, Ronald CW Ma, Philippe Froguel, James G Wilson, Dwaipayan Bharadwaj, Josee Dupuis, James B Meigs, Yoon Shin Cho, Taesung Park, Jaspal S Kooner, John C Chambers, Danish Saleheen, Takashi Kadowaki, E Shyong Tai, Karen L Mohlke, Nancy J Cox, Jorge Ferrer, Eleftheria Zeggini, Norihiro Kato, Yik Ying Teo, Michael Boehnke, Mark I McCarthy, Andrew P Morris, T2D-GENES Consortium
Aug 15, 2018
To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook...
Black or African American Alleles Asian People Chromosome Mapping Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p18 Diabetes mellitus Type 2 Female Genetic Association Studies Genetic Predisposition to Disease Humans KCNQ1 Potassium Channel Linkage Disequilibrium Male Polymorphism Single Nucleotide RNA-Binding Proteins Regulatory Elements Transcriptional White People tRNA Methyltransferases
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