Search
Results: 112
Long term azathioprine maintenance therapy in ANCA-associated vasculitis
Anoek AE de Joode, Jan Stephan F Sanders, Xavier Puéchal, Loic P Guillevin, Thomas F Hiemstra, Oliver Flossmann, Nils Rasmussen, Kerstin Westman, David R Jayne, Coen A Stegeman
Sep 10, 2018
OBJECTIVE: We studied whether in ANCA-associated vasculitis patients, duration of AZA maintenance influenced relapse rate during long-term follow-up. METHODS: Three hundred and eighty newly diagnosed ANCA-associated vasculitis...
ANCA EUVAS FVSG PR3 Azathioprine Granulomatosis with polyangiitis long-term follow-up Maintenance Vasculitis Adult Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Azathioprine Disease-Free Survival Female Follow-Up Studies Granulomatosis with polyangiitis Humans Immunosuppressive Agents Kidney Diseases Maintenance Chemotherapy Male Microscopic Polyangiitis Middle Aged Myeloblastin Peroxidase Recurrence Time Factors Young Adult
Randomised controlled trial of prolonged treatment in the remission phase of ANCA-associated vasculitis.
Alexandre Karras, Christian Pagnoux, Marion Haubitz, Kirsten de Groot, Xavier Puechal, Jan Willem Cohen Tervaert, Mårten Segelmark, Loic Guillevin, David Jayne, European Vasculitis Society
Feb 27, 2020
OBJECTIVES: A prospective randomised trial to compare two different durations of maintenance immunosuppressive therapy for the prevention of relapse in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV)....
ANCA Azathioprine maintenance therapy Relapse Vasculitis Adult Aged Anti-Inflammatory Agents Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Azathioprine Creatinine cyclophosphamide Female Glomerular Filtration Rate Humans Immunosuppressive Agents Kidney Failure Chronic Maintenance Chemotherapy Male Middle Aged Prednisolone Prospective Studies Remission Induction Secondary Prevention Survival Rate Time Factors
Identification of novel epithelial ovarian cancer loci in women of African ancestry.
Ani Manichaikul, Lauren C Peres, Xin-Qun Wang, Mollie E Barnard, Deanna Chyn, Xin Sheng, Zhaohui Du, Jonathan Tyrer, Joseph Dennis, Ann G Schwartz, Michele L Cote, Edward Peters, Patricia G Moorman, Melissa Bondy, Jill S Barnholtz-Sloan, Paul Terry, Anthony J Alberg, Elisa V Bandera, Ellen Funkhouser, Anna H Wu, Celeste Leigh Pearce, Malcom Pike, Veronica Wendy Setiawan, Christopher A Haiman, African American Breast Cancer Consortium (AABC), African Ancestry Prostate Cancer Consortium (AAPC), Julie R Palmer, Loic Lemarchand, Lynne R Wilkens, Andrew Berchuck, Jennifer A Doherty, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Beth Y Karlan, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Kate Lawrenson, Simon Gayther, Thomas A Sellers, Paul Pharoah, Joellen M Schildkraut, African American Cancer Epidemiology Study (AACES) and the Ovarian Cancer Association Consortium (OCAC)
Aug 20, 2019
Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC...
African ancestry eQTLs Gene Expression Genome wide association study ovarian cancer Black or African American Aldo-Keto Reductase Family 1 Member C3 Antigens Neoplasm Black People Breast Neoplasms Carcinoma Ovarian Epithelial Female Follistatin Genetic Predisposition to Disease Genome-Wide Association Study Humans Neoplasm Proteins Polymorphism Single Nucleotide United States White People
Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site.
Willy MJM Bogers, Susan W Barnett, Herman Oostermeijer, Ivonne G Nieuwenhuis, Niels Beenhakker, Daniella Mortier, Petra Mooij, Gerrit Koopman, Edmund Remarque, Gregoire Martin, Rachel Pei-Jen Lai, Antu K Dey, Yide Sun, Brian Burke, Guido Ferrari, David Montefiori, Loic Martin, David Davis, Indresh Srivastava, Jonathan L Heeney
Aug 17, 2017
B-cell responses CD4 mimetic CD4 occluded T-cell responses human immunodeficiency virus nonhuman primates vaccines AIDS Vaccines Animals Antibodies Neutralizing Antibody-Dependent Cell Cytotoxicity B-Lymphocytes Binding Sites Antibody CD4 Antigens HIV Antibodies HIV-1 Macaca mulatta T-Lymphocytes Helper-Inducer Vaccination env Gene Products Human Immunodeficiency Virus
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma
Franck Morschhauser, Martin J. S. Dyer, Harriet S. Walter, Alexey V. Danilov, Loic Ysebaert, Daniel James Hodson, Christopher Fegan, Simon A. Rule, John Radford, Guillaume Cartron, Krimo Bouabdallah, Andrew John Davies, Stephen Spurgeon, Nishanthan Rajakumaraswamy, Biao Li, Rita Humeniuk, Xi Huang, Pankaj Bhargava, Juliane M. Jürgensmeier, Gilles Salles
Jul 07, 2021
Funder: Gilead Sciences (Gilead); doi: https://doi.org/10.13039/100005564
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma.
Franck Morschhauser, Martin JS Dyer, Harriet S Walter, Alexey V Danilov, Loic Ysebaert, Daniel James Hodson, Christopher Fegan, Simon A Rule, John Radford, Guillaume Cartron, Krimo Bouabdallah, Andrew John Davies, Stephen Spurgeon, Nishanthan Rajakumaraswamy, Biao Li, Rita Humeniuk, Xi Huang, Pankaj Bhargava, Juliane M Jürgensmeier, Gilles Salles
Dec 04, 2020
B-cell receptor (BCR) signaling pathway inhibitors (including Bruton’s tyrosine kinase [BTK] inhibitors, and phosphatidylinositol-3 kinase inhibitors [PI3Ki]) have shown clinical efficacy in non-Hodgkin lymphoma (NHL). However...
A New Comprehensive Colorectal Cancer Risk Prediction Model Incorporating Family History, Personal Characteristics, and Environmental Factors.
Yingye Zheng, Xinwei Hua, Aung K Win, Robert J Macinnis, Steven Gallinger, Loic Le Marchand, Noralane M Lindor, John A Baron, John L Hopper, James G Dowty, Antonis C Antoniou, Jiayin Zheng, Mark A Jenkins, Polly A Newcomb
Feb 28, 2020
PURPOSE: Reducing colorectal cancer incidence and mortality through early detection would improve efficacy if targeted. We developed a colorectal cancer risk prediction model incorporating personal, family, genetic, and...
Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.
Delores J Grant, Ani Manichaikul, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Lauren C Peres, Edward S Peters, Ann G Schwartz, Paul D Terry, Xin-Qun Wang, Temitope O Keku, Cathrine Hoyo, Andrew Berchuck, Dale P Sandler, Jack A Taylor, Katie M O'Brien, Digna R Velez Edwards, Todd L Edwards, Alicia Beeghly-Fadiel, Nicolas Wentzensen, Celeste Leigh Pearce, Anna H Wu, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Joseph H Rothstein, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Mary Anne Rossing, Jennifer A Doherty, Thomas A Sellers, Jennifer B Permuth-Way, Alvaro N Monteiro, Douglas A Levine, Veronica Wendy Setiawan, Christopher A Haiman, Loic Lemarchand, Lynne R Wilkens, Beth Y Karlan, Usha Menon, Susan Ramus, Simon Gayther, Aleksandra Gentry-Maharaj, Kathryn L Terry, Daniel W Cramer, Ellen L Goode, Melissa C Larson, Scott H Kaufmann, Rikki Cannioto, Kunle Odunsi, John L Etter, Ruea-Yea Huang, Marcus Q Bernardini, Alicia A Tone, Taymaa May, Marc T Goodman, Pamela J Thompson, Michael E Carney, Shelley S Tworoger, Elizabeth M Poole, Diether Lambrechts, Ignace Vergote, Adriaan Vanderstichele, Els Van Nieuwenhuysen, Hoda Anton-Culver, Argyrios Ziogas, James D Brenton, Line Bjorge, Helga B Salvensen, Lambertus A Kiemeney, Leon FAG Massuger, Tanja Pejovic, Amanda Bruegl, Melissa Moffitt, Linda Cook, Nhu D Le, Angela Brooks-Wilson, Linda E Kelemen, Paul DP Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Anna DeFazio, Catherine J Kennedy, Joellen M Schildkraut
Sep 17, 2019
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso, Oscar Lao, Esther Molina-Montes, Isabel Adoración Martín-Antoniano, Paulina Gómez-Rubio, Rita Lawlor, Alfredo Carrato, Manuel Hidalgo, Mar Iglesias, Xavier Molero, Matthias Löhr, Christopher Michalski, José Perea, Michael O’Rorke, Victor Manuel Barberà, Adonina Tardón, Antoni Farré, Luís Muñoz-Bellvís, Tanja Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Thomas Gress, William Greenhalf, Linda Sharp, Luís Arnes, Lluís Cecchini, Joaquim Balsells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Mirari Márquez, Josefina Mora, Damian O’Driscoll, Aldo Scarpa, Weimin Ye, Jingru Yu, Montserrat García-Closas, Manolis Kogevinas, Nathaniel Rothman, Debra T Silverman, Demetrius Albanes, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Federico Canzian, Margaret Du, Steve Gallinger, J Michael Gaziano, Phyllis J Goodman, Marc Gunter, Loic Lemarchand, Donghui Li, Rachael E Neale, Ulrika Peters, Gloria M Petersen, Harvey A Risch, Maria José Sánchez, Xiao-Ou Shu, Mark D Thornquist, Kala Visvanathan, Wei Zheng, Stephen J Chanock, Douglas Easton, Brian M Wolpin, Rachael Z Stolzenberg-Solomon, Alison P Klein, Laufey T Amundadottir, Marc A Marti-Renom, Francisco X Real, Núria Malats
Feb 01, 2021
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.
Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso, Oscar Lao, Esther Molina-Montes, Isabel Adoración Martín-Antoniano, Paulina Gómez-Rubio, Rita Lawlor, Alfredo Carrato, Manuel Hidalgo, Mar Iglesias, Xavier Molero, Matthias Löhr, Christopher Michalski, José Perea, Michael O'Rorke, Victor Manuel Barberà, Adonina Tardón, Antoni Farré, Luís Muñoz-Bellvís, Tanja Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Thomas Gress, William Greenhalf, Linda Sharp, Luís Arnes, Lluís Cecchini, Joaquim Balsells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Mirari Márquez, Josefina Mora, Damian O'Driscoll, Aldo Scarpa, Weimin Ye, Jingru Yu, PanGenEU Investigators, Montserrat García-Closas, Manolis Kogevinas, Nathaniel Rothman, Debra T Silverman, SBC/EPICURO Investigators, Demetrius Albanes, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Federico Canzian, Margaret Du, Steve Gallinger, J Michael Gaziano, Phyllis J Goodman, Marc Gunter, Loic Lemarchand, Donghui Li, Rachael E Neale, Ulrika Peters, Gloria M Petersen, Harvey A Risch, Maria José Sánchez, Xiao-Ou Shu, Mark D Thornquist, Kala Visvanathan, Wei Zheng, Stephen J Chanock, Douglas Easton, Brian M Wolpin, Rachael Z Stolzenberg-Solomon, Alison P Klein, Laufey T Amundadottir, Marc A Marti-Renom, Francisco X Real, Núria Malats
Dec 16, 2020
BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the...
3D genomic structure genetic susceptibility Genome-wide association analysis Local indices of genome spatial autocorrelation Pancreatic cancer risk Biomarkers Tumor Cell Line Tumor Computer Simulation Gene Regulatory Networks Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Linkage Disequilibrium Pancreatic Neoplasms Reproducibility of Results Signal Transduction
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.
Anja Rudolph, Peter A Fasching, Sabine Behrens, Ursula Eilber, Manjeet K Bolla, Qin Wang, Deborah Thompson, Kamila Czene, Judith S Brand, Jingmei Li, Christopher Scott, V Shane Pankratz, Kathleen Brandt, Emily Hallberg, Janet E Olson, Adam Lee, Matthias W Beckmann, Arif B Ekici, Lothar Haeberle, Gertraud Maskarinec, Loic Le Marchand, Fredrick Schumacher, Roger L Milne, Julia A Knight, Carmel Apicella, Melissa C Southey, Miroslav K Kapuscinski, John L Hopper, Irene L Andrulis, Graham G Giles, Christopher A Haiman, Kay-Tee Khaw, Robert Luben, Per Hall, Paul DP Pharoah, Fergus J Couch, Douglas F Easton, Isabel dos-Santos-Silva, Celine Vachon, Jenny Chang-Claude
Sep 03, 2015
Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk
Celine M Vachon, Christopher G Scott, Rulla M Tamimi, Deborah J Thompson, Peter A Fasching, Jennifer Stone, Melissa C Southey, Stacey Winham, Sara Lindström, Jenna Lilyquist, Graham G Giles, Roger L Milne, Robert J Macinnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, Mikael Eriksson, Peter Kraft, Robert Luben, Nick Wareham, Janet E Olson, Aaron Norman, Eric C Polley, Gertraud Maskarinec, Loic Le Marchand, Christopher A Haiman, John L Hopper, Fergus J Couch, Douglas F Easton, Per Hall, Nilanjan Chatterjee, Montse Garcia-Closas
May 28, 2019
breast cancer risk Breast Density genetic variation polygenic risk score Risk models Adult Aged Algorithms Biomarkers Tumor Body Mass Index Breast Density Breast Neoplasms Case-Control Studies Female Humans Middle Aged Models Biological Multifactorial Inheritance Odds Ratio Polymorphism Single Nucleotide Risk Assessment Risk Factors
Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.
Xiaoliang Wang, James Y Dai, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stéphane Bézieau, Hermann Brenner, Daniel D Buchanan, Katja Butterbach, Bette Caan, Graham Casey, Peter T Campbell, Andrew T Chan, Zhengyi Chen, Jenny Chang-Claude, Michelle Cotterchio, Douglas F Easton, Graham G Giles, Edward Giovannucci, William M Grady, Michael Hoffmeister, John L Hopper, Li Hsu, Mark A Jenkins, Amit D Joshi, Johanna W Lampe, Susanna C Larsson, Flavio Lejbkowicz, Li Li, Annika Lindblom, Loic Le Marchand, Vicente Martin, Roger L Milne, Victor Moreno, Polly A Newcomb, Kenneth Offitt, Shuji Ogino, Paul DP Pharoah, Mila Pinchev, John D Potter, Hedy S Rennert, Gad Rennert, Walid Saliba, Clemens Schafmayer, Robert E Schoen, Petra Schrotz-King, Martha L Slattery, Mingyang Song, Christa Stegmaier, Stephanie J Weinstein, Alicja Wolk, Michael O Woods, Anna H Wu, Stephen B Gruber, Ulrike Peters, Emily White
Dec 11, 2018
Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.
Naomi Walsh, Han Zhang, Paula L Hyland, Qi Yang, Evelina Mocci, Mingfeng Zhang, Erica J Childs, Irene Collins, Zhaoming Wang, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Federico Canzian, Eric J Duell, Steven Gallinger, Graham G Giles, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Rayjean J Hung, Charles Kooperberg, Robert C Kurtz, Núria Malats, Loic Lemarchand, Rachel E Neale, Sara H Olson, Ghislaine Scelo, Xiao O Shu, Stephen K Van Den Eeden, Kala Visvanathan, Emily White, Wei Zheng, PanScan and PanC4 consortia, Demetrius Albanes, Gabriella Andreotti, Ana Babic, William R Bamlet, Sonja I Berndt, Ayelet Borgida, Marie-Christine Boutron-Ruault, Lauren Brais, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Kari G Chaffee, Stephen Chanock, Sean Cleary, Michelle Cotterchio, Lenka Foretova, Charles Fuchs, J Michael M Gaziano, Edward Giovannucci, Michael Goggins, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Vladimir Janout, Eric A Klein, Robert C Kurtz, Daniel Laheru, I-Min Lee, Lingeng Lu, Núria Malats, Satu Mannisto, Roger L Milne, Ann L Oberg, Irene Orlow, Alpa V Patel, Ulrike Peters, Miquel Porta, Francisco X Real, Nathaniel Rothman, Howard D Sesso, Gianluca Severi, Debra Silverman, Oliver Strobel, Malin Sund, Mark D Thornquist, Geoffrey S Tobias, Jean Wactawski-Wende, Nick Wareham, Elisabete Weiderpass, Nicolas Wentzensen, William Wheeler, Herbert Yu, Anne Zeleniuch-Jacquotte, Peter Kraft, Donghui Li, Eric J Jacobs, Gloria M Petersen, Brian M Wolpin, Harvey A Risch, Laufey T Amundadottir, Kai Yu, Alison P Klein, Rachael Z Stolzenberg-Solomon
Feb 04, 2019
Prediction and clinical utility of a contralateral breast cancer risk model.
Daniele Giardiello, Ewout W Steyerberg, Michael Hauptmann, Muriel A Adank, Delal Akdeniz, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M Dunning, Douglas F Easton, Diana M Eccles, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A Haiman, Per Hall, Ute Hamann, John L Hopper, Agnes Jager, Anna Jakubowska, Audrey Jung, Renske Keeman, Iris Kramer, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubiński, Mehdi Manoochehri, Luigi Mariani, Heli Nevanlinna, Hester SA Oldenburg, Saskia Pelders, Paul DP Pharoah, Mitul Shah, Sabine Siesling, Vincent THBM Smit, Melissa C Southey, William J Tapper, Rob AEM Tollenaar, Alexandra J van den Broek, Carolien HM van Deurzen, Flora E van Leeuwen, Chantal Van Ongeval, Laura J Van't Veer, Qin Wang, Camilla Wendt, Pieter J Westenend, Maartje J Hooning, Marjanka K Schmidt
Jan 20, 2020
BACKGROUND: Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop and validate a CBC risk...
Brca Mutation Carriers Clinical Decision-Making Contralateral breast cancer Risk prediction model Area Under Curve BRCA1 Protein BRCA2 Protein Breast Neoplasms Clinical Decision-Making Disease Management Disease Susceptibility Female Germ-Line Mutation Humans Neoplasms Second Primary Netherlands Prognosis Proportional Hazards Models Risk Assessment Risk Factors
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Sonja Neumeyer, Barbara L Banbury, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Stephanie A Bien, Dan D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Graham Casey, Andrew T Chan, Stephen J Chanock, James Y Dai, Steven Gallinger, Edward L Giovannucci, Graham G Giles, William M Grady, Jochen Hampe, Michael Hoffmeister, John L Hopper, Li Hsu, Mark A Jenkins, Amit Joshi, Susanna C Larsson, Loic Le Marchand, Annika Lindblom, Victor Moreno, Mathieu Lemire, Li Li, Yi Lin, Kenneth Offit, Polly A Newcomb, Paul D Pharaoh, John D Potter, Lihong Qi, Gad Rennert, Clemens Schafmayer, Robert E Schoen, Martha L Slattery, Mingyang Song, Cornelia M Ulrich, Aung K Win, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Stephen B Gruber, Hermann Brenner, Ulrike Peters, Jenny Chang-Claude
Jul 13, 2018
BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on...
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
Momoko Horikoshi, Lorenzo Pasquali, Steven Wiltshire, Jeroen R Huyghe, Anubha Mahajan, Jennifer L Asimit, Teresa Ferreira, Adam E Locke, Neil R Robertson, Xu Wang, Xueling Sim, Hayato Fujita, Kazuo Hara, Robin Young, Weihua Zhang, Sungkyoung Choi, Han Chen, Ismeet Kaur, Fumihiko Takeuchi, Pierre Fontanillas, Dorothée Thuillier, Loic Yengo, Jennifer E Below, Claudia HT Tam, Ying Wu, Gonçalo Abecasis, David Altshuler, Graeme I Bell, John Blangero, Noél P Burtt, Ravindranath Duggirala, Jose C Florez, Craig L Hanis, Mark Seielstad, Gil Atzmon, Juliana CN Chan, Ronald CW Ma, Philippe Froguel, James G Wilson, Dwaipayan Bharadwaj, Josee Dupuis, James B Meigs, Yoon Shin Cho, Taesung Park, Jaspal S Kooner, John C Chambers, Danish Saleheen, Takashi Kadowaki, E Shyong Tai, Karen L Mohlke, Nancy J Cox, Jorge Ferrer, Eleftheria Zeggini, Norihiro Kato, Yik Ying Teo, Michael Boehnke, Mark I McCarthy, Andrew P Morris, T2D-GENES Consortium
Aug 15, 2018
To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook...
Black or African American Alleles Asian People Chromosome Mapping Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p18 Diabetes mellitus Type 2 Female Genetic Association Studies Genetic Predisposition to Disease Humans KCNQ1 Potassium Channel Linkage Disequilibrium Male Polymorphism Single Nucleotide RNA-Binding Proteins Regulatory Elements Transcriptional White People tRNA Methyltransferases
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Alison P Klein, Brian M Wolpin, Harvey A Risch, Rachael Z Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J Childs, Jason W Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A Arslan, Ana Babic, William R Bamlet, Laura Beane-Freeman, Sonja I Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G Chaffee, Charles C Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J Michael M Gaziano, Maria Gazouli, Graham G Giles, Edward Giovannucci, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Eric J Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H Kulke, Juozas Kupcinskas, Robert J Kurtz, Daniel Laheru, Stefano Landi, Rita T Lawlor, I-Min Lee, Loic Lemarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L Milne, Beatrice Mohelníková-Duchoňová, Rachel E Neale, John P Neoptolemos, Ann L Oberg, Sara H Olson, Irene Orlow, Claudio Pasquali, Alpa V Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X Real, Nathaniel Rothman, Ghislaine Scelo, Howard D Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D Thornquist, Geoffrey S Tobias, Stephen K Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M Petersen, Laufey T Amundadottir
Jul 31, 2018
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040...
Carcinoma Pancreatic Ductal Databases Genetic Genetic Predisposition to Disease Genome-Wide Association Study Hepatocyte Nuclear Factor 1-beta Hepatocyte Nuclear Factor 4 Humans Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Pancreatic Neoplasms Polymorphism Single Nucleotide Proteins Repressor Proteins Tensins
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
Jennifer Stone, Deborah J Thompson, Isabel Dos Santos Silva, Christopher Scott, Rulla M Tamimi, Sara Lindstrom, Peter Kraft, Aditi Hazra, Jingmei Li, Louise Eriksson, Kamila Czene, Per Hall, Matt Jensen, Julie Cunningham, Janet E Olson, Kristen Purrington, Fergus J Couch, Judith Brown, Jean Leyland, Ruth Ml Warren, Robert N Luben, Kay-Tee Khaw, Paula Smith, Nicholas J Wareham, Sebastian M Jud, Katharina Heusinger, Matthias W Beckmann, Julie A Douglas, Kaanan P Shah, Heang-Ping Chan, Mark A Helvie, Loic Le Marchand, Laurence N Kolonel, Christy Woolcott, Gertraud Maskarinec, Christopher Haiman, Graham G Giles, Laura Baglietto, Kavitha Krishnan, Melissa C Southey, Carmel Apicella, Irene L Andrulis, Julia A Knight, Giske Ursin, Grethe I Grenaker Alnaes, Vessela N Kristensen, Anne-Lise Borresen-Dale, Inger Torhild Gram, Manjeet K Bolla, Qin Wang, Kyriaki Michailidou, Joe Dennis, Jacques Simard, Paul Pharoah, Alison M Dunning, Douglas F Easton, Peter A Fasching, V Shane Pankratz, John L Hopper, Celine M Vachon
May 20, 2015
Telomere structure and maintenance gene variants and risk of five cancer types.
Sara Karami, Younghun Han, Mala Pande, Iona Cheng, James Rudd, Brandon L Pierce, Ellen L Nutter, Fredrick R Schumacher, Zsofia Kote-Jarai, Sara Lindstrom, John S Witte, Shenying Fang, Jiali Han, Peter Kraft, David J Hunter, Fengju Song, Rayjean J Hung, James McKay, Stephen B Gruber, Stephen J Chanock, Angela Risch, Hongbing Shen, Christopher A Haiman, Lisa Boardman, Cornelia M Ulrich, Graham Casey, Ulrike Peters, Ali Amin Al Olama, Andrew Berchuck, Sonja I Berndt, Stephane Bezieau, Paul Brennan, Hermann Brenner, Louise Brinton, Neil Caporaso, Andrew T Chan, Jenny Chang-Claude, David C Christiani, Julie M Cunningham, Douglas Easton, Rosalind A Eeles, Timothy Eisen, Manish Gala, Steven J Gallinger, Simon A Gayther, Ellen L Goode, Henrik Grönberg, Brian E Henderson, Richard Houlston, Amit D Joshi, Sébastien Küry, Mari T Landi, Loic Le Marchand, Kenneth Muir, Polly A Newcomb, Jenny Permuth-Wey, Paul Pharoah, Catherine Phelan, John D Potter, Susan J Ramus, Harvey Risch, Joellen Schildkraut, Martha L Slattery, Honglin Song, Nicolas Wentzensen, Emily White, Fredrik Wiklund, Brent W Zanke, Thomas A Sellers, Wei Zheng, Nilanjan Chatterjee, Christopher I Amos, Jennifer A Doherty, DRIVE, ELLIPSE, FOCI, and TRICL GECCO and the GAME-ON Network: CORECT
Aug 16, 2016
GWAS Breast Cancer cancer risk colorectal cancer Lung cancer Meta-Analysis ovarian cancer prostate cancer telomere maintenance telomere structure Alleles Case-Control Studies Genetic Association Studies Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Linkage Disequilibrium Neoplasms Odds Ratio Polymorphism Single Nucleotide risk Telomerase Telomere Telomere Homeostasis White People
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
Mariaelisa Graff, Robert A Scott, Anne E Justice, Kristin L Young, Mary F Feitosa, Llilda Barata, Thomas W Winkler, Audrey Y Chu, Anubha Mahajan, David Hadley, Luting Xue, Tsegaselassie Workalemahu, Nancy L Heard-Costa, Marcel den Hoed, Tarunveer S Ahluwalia, Qibin Qi, Julius S Ngwa, Frida Renström, Lydia Quaye, John D Eicher, James E Hayes, Marilyn Cornelis, Zoltan Kutalik, Elise Lim, Jian'an Luan, Jennifer E Huffman, Weihua Zhang, Wei Zhao, Paula J Griffin, Toomas Haller, Shafqat Ahmad, Pedro M Marques-Vidal, Stephanie Bien, Loic Yengo, Alexander Teumer, Albert Vernon Smith, Meena Kumari, Marie Neergaard Harder, Johanne Marie Justesen, Marcus E Kleber, Mette Hollensted, Kurt Lohman, Natalia V Rivera, John B Whitfield, Jing Hua Zhao, Heather M Stringham, Leo-Pekka Lyytikäinen, Charlotte Huppertz, Gonneke Willemsen, Wouter J Peyrot, Ying Wu, Kati Kristiansson, Ayse Demirkan, Myriam Fornage, Maija Hassinen, Lawrence F Bielak, Gemma Cadby, Toshiko Tanaka, Reedik Mägi, Peter J van der Most, Anne U Jackson, Jennifer L Bragg-Gresham, Veronique Vitart, Jonathan Marten, Pau Navarro, Claire Bellis, Dorota Pasko, Åsa Johansson, Søren Snitker, Yu-Ching Cheng, Joel Eriksson, Unhee Lim, Mette Aadahl, Linda S Adair, Najaf Amin, Beverley Balkau, Juha Auvinen, John Beilby, Richard N Bergman, Sven Bergmann, Alain G Bertoni, John Blangero, Amélie Bonnefond, Lori L Bonnycastle, Judith B Borja, Søren Brage, Fabio Busonero, Steve Buyske, Harry Campbell, Peter S Chines, Francis S Collins, Tanguy Corre, George Davey Smith, Graciela E Delgado, Nicole Dueker, Marcus Dörr, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Jessica D Faul, Mao Fu, Kristine Færch, Christian Gieger, Sven Gläser, Jian Gong, Penny Gordon-Larsen, Harald Grallert, Tanja B Grammer, Niels Grarup, Gerard van Grootheest, Kennet Harald, Nicholas D Hastie, Aki S Havulinna, Dena Hernandez, Lucia Hindorff, Lynne J Hocking, Oddgeir L Holmens, Christina Holzapfel, Jouke Jan Hottenga, Jie Huang, Tao Huang, Jennie Hui, Cornelia Huth, Nina Hutri-Kähönen, Alan L James, John-Olov Jansson, Min A Jhun, Markus Juonala, Leena Kinnunen, Heikki A Koistinen, Ivana Kolcic, Pirjo Komulainen, Johanna Kuusisto, Kirsti Kvaløy, Mika Kähönen, Timo A Lakka, Lenore J Launer, Benjamin Lehne, Cecilia M Lindgren, Mattias Lorentzon, Robert Luben, Michel Marre, Yuri Milaneschi, Keri L Monda, Grant W Montgomery, Marleen HM De Moor, Antonella Mulas, Martina Müller-Nurasyid, AW Musk, Reija Männikkö, Satu Männistö, Narisu Narisu, Matthias Nauck, Jennifer A Nettleton, Ilja M Nolte, Albertine J Oldehinkel, Matthias Olden, Ken K Ong, Sandosh Padmanabhan, Lavinia Paternoster, Jeremiah Perez, Markus Perola, Annette Peters, Ulrike Peters, Patricia A Peyser, Inga Prokopenko, Hannu Puolijoki, Olli T Raitakari, Tuomo Rankinen, Laura J Rasmussen-Torvik, Rajesh Rawal, Paul M Ridker, Lynda M Rose, Igor Rudan, Cinzia Sarti, Mark A Sarzynski, Kai Savonen, William R Scott, Serena Sanna, Alan R Shuldiner, Steve Sidney, Günther Silbernagel, Blair H Smith, Jennifer A Smith, Harold Snieder, Alena Stančáková, Barbara Sternfeld, Amy J Swift, Tuija Tammelin, Sian-Tsung Tan, Barbara Thorand, Dorothée Thuillier, Liesbeth Vandenput, Henrik Vestergaard, Jana V van Vliet-Ostaptchouk, Marie-Claude Vohl, Uwe Völker, Gérard Waeber, Mark Walker, Sarah Wild, Andrew Wong, Alan F Wright, M Carola Zillikens, Niha Zubair, Christopher A Haiman, Loic Lemarchand, Ulf Gyllensten, Claes Ohlsson, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Louis Pérusse, James F Wilson, Caroline Hayward, Ozren Polasek, Francesco Cucca, Kristian Hveem, Catharina A Hartman, Anke Tönjes, Stefania Bandinelli, Lyle J Palmer, Sharon LR Kardia, Rainer Rauramaa, Thorkild IA Sørensen, Jaakko Tuomilehto, Veikko Salomaa, Brenda WJH Penninx, Eco JC de Geus, Dorret I Boomsma, Terho Lehtimäki, Massimo Mangino, Markku Laakso, Claude Bouchard, Nicholas G Martin, Diana Kuh, Yongmei Liu, Allan Linneberg, Winfried März, Konstantin Strauch, Mika Kivimäki, Tamara B Harris, Vilmundur Gudnason, Henry Völzke, Lu Qi, Marjo-Riitta Järvelin, John C Chambers, Jaspal S Kooner, Philippe Froguel, Charles Kooperberg, Peter Vollenweider, Göran Hallmans, Torben Hansen, Oluf Pedersen, Andres Metspalu, Nicholas J Wareham, Claudia Langenberg, David R Weir, David J Porteous, Eric Boerwinkle, Daniel I Chasman, CHARGE consortium, EPIC-InterAct Consortium, PAGE Consortium, Gonçalo R Abecasis, Inês Barroso, Mark I McCarthy, Timothy M Frayling, Jeffrey R O'Connell, Cornelia M van Duijn, Michael Boehnke, Iris M Heid, Karen L Mohlke, David P Strachan, Caroline S Fox, Ching-Ti Liu, Joel N Hirschhorn, Robert J Klein, Andrew D Johnson, Ingrid B Borecki, Paul W Franks, Kari E North, L Adrienne Cupples, Ruth JF Loos, Tuomas O Kilpeläinen
Aug 16, 2017
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and...
GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.
Maxine M Chen, Tracy A O'Mara, Deborah J Thompson, Jodie N Painter, Australian National Endometrial Cancer Study Group (ANECS), John Attia, Amanda Black, Louise Brinton, Stephen Chanock, Chu Chen, Timothy Ht Cheng, Linda S Cook, Marta Crous-Bou, Jennifer Doherty, Christine M Friedenreich, Montserrat Garcia-Closas, Mia M Gaudet, Maggie Gorman, Christopher Haiman, Susan E Hankinson, Patricia Hartge, Brian E Henderson, Shirley Hodgson, Elizabeth G Holliday, Pamela L Horn-Ross, David J Hunter, Loic Le Marchand, Xiaolin Liang, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M Magliocco, Lynn Martin, Mark McEvoy, National Study of Endometrial Cancer Genetics Group (NSECG), Sara H Olson, Irene Orlow, Loreall Pooler, Jennifer Prescott, Radhai Rastogi, Timothy R Rebbeck, Harvey Risch, Carlotta Sacerdote, Frederick Schumacher, Veronica Wendy Setiawan, Rodney J Scott, Xin Sheng, Xiao-Ou Shu, Constance Turman, David Van Den Berg, Zhaoming Wang, Noel S Weiss, Nicholas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P Yang, Herbert Yu, Wei Zheng, Paul DP Pharoah, Alison M Dunning, Ian Tomlinson, Douglas F Easton, Peter Kraft, Amanda B Spurdle, Immaculata De Vivo
Apr 15, 2016
Prediction and clinical utility of a contralateral breast cancer risk model.
Daniele Giardiello, Ewout W Steyerberg, Michael Hauptmann, Muriel A Adank, Delal Akdeniz, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M Dunning, Douglas F Easton, Diana M Eccles, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A Haiman, Per Hall, Ute Hamann, John L Hopper, Agnes Jager, Anna Jakubowska, Audrey Jung, Renske Keeman, Iris Kramer, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubiński, Mehdi Manoochehri, Luigi Mariani, Heli Nevanlinna, Hester S A Oldenburg, Saskia Pelders, Paul D P Pharoah, Mitul Shah, Sabine Siesling, Vincent T H B M Smit, Melissa C Southey, William J Tapper, Rob A E M Tollenaar, Alexandra J van den Broek, Carolien H M van Deurzen, Flora E van Leeuwen, Chantal Van Ongeval, Laura J Van't Veer, Qin Wang, Camilla Wendt, Pieter J Westenend, Maartje J Hooning, Marjanka K Schmidt
Jan 27, 2020
BACKGROUND:Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop and validate a CBC risk...
Genetic determinants of telomere length and risk of common cancers
Chenan Zhang, Jennifer A Doherty, Stephen Burgess, Rayjean J Hung, Sara Lindström, Peter Kraft, Jian Gong, Christopher I Amos, Thomas A Sellers, Alvaro NA Monteiro, Georgia Chenevix-Trench, Heike Bickeböller, Angela Risch, Paul Brennan, James D Mckay, Richard S Houlston, Maria Teresa Landi, Maria N Timofeeva, Yufei Wang, Joachim Heinrich, Zsofia Kote-Jarai, Rosalind A Eeles, Ken Muir, Fredrik Wiklund, Henrik Grönberg, Sonja I Berndt, Stephen J Chanock, Fredrick Schumacher, Christopher A Haiman, Brian E Henderson, Ali Amin Al Olama, Irene L Andrulis, John L Hopper, Jenny Chang-Claude, Esther M John, Kathleen E Malone, Marilie D Gammon, Giske Ursin, Alice S Whittemore, David J Hunter, Stephen B Gruber, Julia A Knight, Lifang Hou, Loic Le Marchand, Polly A Newcomb, Thomas J Hudson, Andrew T Chan, Li Li, Michael O Woods, Habibul Ahsan, Brandon L Pierce, DRIVE, ELLIPSE, FOCI, and TRICL GECCO and GAME-ON Network: CORECT
Jul 13, 2015
|
|< |
< |
1 |