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Results: 12
Beyond online participant crowdsourcing
Charlotte R. Pennington, Andrew J. Jones, Loukia Tzavella, Christopher D Chambers, Katherine S Button
Aug 31, 2022
Participant crowdsourcing platforms (e.g., MTurk, Prolific) offer numerous advantages to addiction science, permitting access to hard-to-reach populations and enhancing the feasibility of complex experimental, longitudinal...
Beyond online participant crowdsourcing
Charlotte R. Pennington, Andrew J. Jones, Loukia Tzavella, Christopher D Chambers, Katherine S Button
Aug 31, 2022
Participant crowdsourcing platforms (e.g., MTurk, Prolific) offer numerous advantages to addiction science, permitting access to hard-to-reach populations and enhancing the feasibility of complex experimental, longitudinal...
Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications.
The liver, lung, pancreas, and digestive tract all originate from the endoderm germ layer, and these vital organs are subject to many life-threatening diseases affecting millions of patients. However, primary cells from...
Cell cycle regulators control mesoderm specification in human pluripotent stem cells.
Loukia Yiangou, Rodrigo A Grandy, Anna Osnato, Daniel Ortmann, Sanjay Sinha, Ludovic Vallier
Sep 25, 2019
RB transcriptional corepressor 1 (RB1) Cell Cycle cyclin-dependent kinase (CDK) DIFFERENTIATION embryo development Gene Expression Mesoderm Pluripotency signaling Stem Cells tissue regeneration Cell Cycle Cell Differentiation Cell Lineage Cyclin-Dependent Kinases Human Embryonic Stem Cells Humans MAP Kinase Signaling System Mesoderm Protein Kinase Inhibitors Retinoblastoma Binding Proteins Ubiquitin-Protein Ligases
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers.
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M Trigg, John A Williams, Joao Pereira, Megan L Cavanagh, Suzanne D Turner, Georgios V Gkoutos, Loukia Tsaprouni
Aug 06, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Mark A Smith, Loukia Katsouri, Samuel Virtue, Agharul I Choudhury, Antonio Vidal-Puig, Michael LJ Ashford, Dominic J Withers
Oct 09, 2020
Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated...
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M. Trigg, John A. Williams, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner, Georgios V. Gkoutos, Loukia Tsaprouni
Aug 11, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics.
Loukia Yiangou, Rodrigo A Grandy, Carola M Morell, Rute A Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G Bernard, Daniel Ortmann, Davis J McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Jan 07, 2019
The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells
Leila Jahangiri, Tala Ishola, Perla Pucci, Ricky M. Trigg, Joao Pereira, John A. Williams, Megan L. Cavanagh, Georgios V. Gkoutos, Loukia Tsaprouni, Suzanne D. Turner
Mar 12, 2021
Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) and may account for...
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency.
Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C Hubner, Igor Ruiz de Los Mozos, Christoph Sadée, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G Stunnenberg, Sasha Mendjan, Ludovic Vallier
May 15, 2018
Activins Adenosine Animals Cell Cycle Proteins Cell Differentiation Epigenesis Genetic Humans Methylation Methyltransferases Multiprotein Complexes Nanog Homeobox Protein Nodal Protein Nuclear Proteins Pluripotent Stem Cells Protein Binding RNA Splicing Factors RNA Messenger Signal Transduction Smad2 Protein Smad3 Protein Transcriptome Transforming Growth Factor beta
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Sarah J Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q Du, David J Adams, Brian JP Huntly
Apr 06, 2018
Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We demonstrate that...
Acetylation Animals CREB-Binding Protein Cell Proliferation Cell Self Renewal Cell Transformation Neoplastic Cells Cultured DNA Damage Epigenesis Genetic Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Histones Lymphangiogenesis Lymphoid Progenitor Cells Lymphoma lymphopoiesis Methylation Mice Mice Inbred C57BL Mice Knockout Mutation Neoplastic Stem Cells Phenotype Signal Transduction Time Factors Transcription Genetic Tumor Suppressor Protein p53
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, Yuanfang Guan, Thomas Yu, Jaewoo Kang, Minji Jeon, Russ Wolfinger, Tin Nguyen, Mikhail Zaslavskiy, In Sock Jang, Zara Ghazoui, Mehmet Eren Ahsen, Robert Vogel, Elias Chaibub Neto, Thea Norman, Eric K. Y. Tang, Mathew J. Garnett, Giovanni Y. Di Veroli, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R. Dry, Julio Saez-Rodriguez, Jordi Abante, Barbara Schmitz Abecassis, Nanne Aben, Delasa Aghamirzaie, Tero Aittokallio, Farida S. Akhtari, Bissan Al-Lazikani, Tanvir Alam, Amin Allam, Chad Allen, Mariana Pelicano de Almeida, Doaa Altarawy, Vinicius Alves, Alicia Amadoz, Benedict Anchang, Albert A. Antolin, Jeremy R. Ash, Victoria Romeo Aznar, Wail Ba-alawi, Moeen Bagheri, Vladimir Bajic, Gordon Ball, Pedro J. Ballester, Delora Baptista, Christopher Bare, Mathilde Bateson, Andreas Bender, Denis Bertrand, Bhagya Wijayawardena, Keith A. Boroevich, Evert Bosdriesz, Salim Bougouffa, Gergana Bounova, Thomas Brouwer, Barbara Bryant, Manuel Calaza, Alberto Calderone, Stefano Calza, Stephen Capuzzi, Jose Carbonell-Caballero, Daniel Carlin, Hannah Carter, Luisa Castagnoli, Remzi Celebi, Gianni Cesareni, Hyeokyoon Chang, Guocai Chen, Haoran Chen, Huiyuan Chen, Lijun Cheng, Ariel Chernomoretz, Davide Chicco, Kwang-Hyun Cho, Sunghwan Cho, Daeseon Choi, Jaejoon Choi, Kwanghun Choi, Minsoo Choi, Martine De Cock, Elizabeth Coker, Isidro Cortes-Ciriano, Miklós Cserzö, Cankut Cubuk, Christina Curtis, Dries Van Daele, Cuong C. Dang, Tjeerd Dijkstra, Joaquin Dopazo, Sorin Draghici, Anastasios Drosou, Michel Dumontier, Friederike Ehrhart, Fatma-Elzahraa Eid, Mahmoud ElHefnawi, Haitham Elmarakeby, Bo van Engelen, Hatice Billur Engin, Iwan de Esch, Chris Evelo, Andre O. Falcao, Sherif Farag, Carlos Fernandez-Lozano, Kathleen Fisch, Asmund Flobak, Chiara Fornari, Amir B. K. Foroushani, Donatien Chedom Fotso, Denis Fourches, Stephen Friend, Arnoldo Frigessi, Feng Gao, Xiaoting Gao, Jeffrey M. Gerold, Pierre Gestraud, Samik Ghosh, Jussi Gillberg, Antonia Godoy-Lorite, Lizzy Godynyuk, Adam Godzik, Anna Goldenberg, David Gomez-Cabrero, Mehmet Gonen, Chris de Graaf, Harry Gray, Maxim Grechkin, Roger Guimera, Emre Guney, Benjamin Haibe-Kains, Younghyun Han, Takeshi Hase, Di He, Liye He, Lenwood S. Heath, Kristoffer H. Hellton, Manuela Helmer-Citterich, Marta R. Hidalgo, Daniel Hidru, Steven M. Hill, Sepp Hochreiter, Seungpyo Hong, Eivind Hovig, Ya-Chih Hsueh, Zhiyuan Hu, Justin K Huang, R. Stephanie Huang, László Hunyady, Jinseub Hwang, Tae Hyun Hwang, Woochang Hwang, Yongdeuk Hwang, Olexandr Isayev, Oliver Bear Don’t Walk, John Jack, Samad Jahandideh, Jiadong Ji, Yousang Jo, Piotr J. Kamola, Georgi K. Kanev, Loukia Karacosta, Mostafa Karimi, Samuel Kaski, Marat Kazanov, Abdullah M Khamis, Suleiman Ali Khan, Narsis A. Kiani, Allen Kim, Jinhan Kim, Juntae Kim, Kiseong Kim, Kyung Kim, Sunkyu Kim, Yongsoo Kim, Yunseong Kim, Paul D. W. Kirk, Hiroaki Kitano, Gunter Klambauer, David Knowles, Melissa Ko, Alvaro Kohn-Luque, Albert J. Kooistra, Melaine A. Kuenemann, Martin Kuiper, Christoph Kurz, Mijin Kwon, Twan van Laarhoven, Astrid Laegreid, Simone Lederer, Heewon Lee, Jeon Lee, Yun Woo Lee, Eemeli Lepp_aho, Richard Lewis, Jing Li, Lang Li, James Liley, Weng Khong Lim, Chieh Lin, Yiyi Liu, Yosvany Lopez, Joshua Low, Artem Lysenko, Daniel Machado, Neel Madhukar, Dries De Maeyer, Ana Belen Malpartida, Hiroshi Mamitsuka, Francesco Marabita, Kathleen Marchal, Pekka Marttinen, Daniel Mason, Alireza Mazaheri, Arfa Mehmood, Ali Mehreen, Magali Michaut, Ryan A. Miller, Costas Mitsopoulos, Dezso Modos, Marijke Van Moerbeke, Keagan Moo, Alison Motsinger-Reif, Rajiv Movva, Sebastian Muraru, Eugene Muratov, Mushthofa Mushthofa, Niranjan Nagarajan, Sigve Nakken, Aritro Nath, Pierre Neuvial, Richard Newton, Zheng Ning, Carlos De Niz, Baldo Oliva, Catharina Olsen, Antonio Palmeri, Bhawan Panesar, Stavros Papadopoulos, Jaesub Park, Seonyeong Park, Sungjoon Park, Yudi Pawitan, Daniele Peluso, Sriram Pendyala, Jian Peng, Livia Perfetto, Stefano Pirro, Sylvia Plevritis, Regina Politi, Hoifung Poon, Eduard Porta, Isak Prellner, Kristina Preuer, Miguel Angel Pujana, Ricardo Ramnarine, John E. Reid, Fabien Reyal, Sylvia Richardson, Camir Ricketts, Linda Rieswijk, Miguel Rocha, Carmen Rodriguez-Gonzalvez, Kyle Roell, Daniel Rotroff, Julian R. de Ruiter, Ploy Rukawa, Benjamin Sadacca, Zhaleh Safikhani, Fita Safitri, Marta Sales-Pardo, Sebastian Sauer, Moritz Schlichting, Jose A. Seoane, Jordi Serra, Ming-Mei Shang, Alok Sharma, Hari Sharma, Yang Shen, Motoki Shiga, Moonshik Shin, Ziv Shkedy, Kevin Shopsowitz, Sam Sinai, Dylan Skola, Petr Smirnov, Izel Fourie Soerensen, Peter Soerensen, Je-Hoon Song, Sang Ok Song, Othman Soufan, Andreas Spitzmueller, Boris Steipe, Chayaporn Suphavilai, Sergio Pulido Tamayo, David Tamborero, Jing Tang, Zia-ur-Rehman Tanoli, Marc Tarres-Deulofeu, Jesper Tegner, Liv Thommesen, Seyed Ali Madani Tonekaboni, Hong Tran, Ewoud De Troyer, Amy Truong, Tatsuhiko Tsunoda, Gábor Turu, Guang-Yo Tzeng, Lieven Verbeke, Santiago Videla, Daniel Vis, Andrey Voronkov, Konstantinos Votis, Ashley Wang, Hong-Qiang Horace Wang, Po-Wei Wang, Sheng Wang, Wei Wang, Xiaochen Wang, Xin Wang, Krister Wennerberg, Lorenz Wernisch, Lodewyk Wessels, Gerard J. P. van Westen, Bart A. Westerman, Simon Richard White, Egon Willighagen, Tom Wurdinger, Lei Xie, Shuilian Xie, Hua Xu, Bhagwan Yadav, Christopher Yau, Huwate Yeerna, Jia Wei Yin, Michael Yu, MinHwan Yu, So Jeong Yun, Alexey Zakharov, Alexandros Zamichos, Massimiliano Zanin, Li Zeng, Hector Zenil, Frederick Zhang, Pengyue Zhang, Wei Zhang, Hongyu Zhao, Lan Zhao, Wenjin Zheng, AZEDINE Zoufir, Manuela Zucknick
Jun 16, 2020
Abstract: The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating...