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Genomic insights into the causes of type 2 diabetes.
Genome-wide association studies have implicated around 250 genomic regions in predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for several of these regions. Understanding of the underlying...
Prioritising Risk Factors for Type 2 Diabetes
PURPOSE OF THE REVIEW: Causality has been demonstrated for few of the many putative risk factors for type 2 diabetes (T2D) emerging from observational epidemiology. Genetic approaches are increasingly being used to infer...
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M Lindgren, Jian'an Luan, Luca A Lotta, Claudia Langenberg, Peter Arner, Rona J Strawbridge, Ingrid Dahlman
Apr 17, 2020
OBJECTIVES:Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes. The goal of this...
Published by: Molecular metabolism
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression.
Roberto Bonelli, Brendan RE Ansell, Luca Lotta, Thomas Scerri, Traci E Clemons, Irene Leung, MacTel Consortium, Tunde Peto, Alan C Bird, Ferenc B Sallo, Claudia Langenberg, Melanie Bahlo
Mar 26, 2021
BACKGROUND: Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend retinal vascular calibre and glycine/serine/threonine...
GWAS Mendelian randomisation Metabolomics Retinal disease Serine Biosynthetic Pathways Diabetes mellitus Type 2 Disease Progression Endophenotypes Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Metabolome Polymorphism Single Nucleotide Retinal Telangiectasis Retinal Vessels Serine
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M Lindgren, Jian'an Luan, Luca A Lotta, Claudia Langenberg, Peter Arner, Rona J Strawbridge, Ingrid Dahlman
Apr 01, 2020
OBJECTIVES: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes. The goal of this...
Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes.
Zhifen Chen, Haojie Yu, Xu Shi, Curtis R Warren, Luca A Lotta, Max Friesen, Torsten B Meissner, Claudia Langenberg, Martin Wabitsch, Nick Wareham, Mark D Benson, Rob E Gerszten, Chad A Cowan
Nov 25, 2019
Rationale: Genome-wide association studies have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To identify candidate causal genes...
Adipocytes Adipogenesis Diabetes mellitus Type 2 Insulin Resistance lipid metabolis Adaptor Proteins Signal Transducing Adipocytes Cell Line Dipeptidases Follistatin Genome-Wide Association Study Humans Insulin Receptor Substrate Proteins Insulin Resistance Loss of Function Mutation Lymphokines MAP Kinase Kinase Kinase 1 PPAR gamma Platelet-Derived Growth Factor Quantitative Trait Loci
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.
Adil Mardinoglu, Silvia Gogg, Luca A Lotta, Alena Stančáková, Annika Nerstedt, Jan Boren, Matthias Blüher, Ele Ferrannini, Claudia Langenberg, Nicholas J Wareham, Markku Laakso, Ulf Smith
Mar 02, 2018
Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if...
3-Hydroxyisobutyric acid (3-HIB) Branched-chain amino acids (BCAAs) Insulin Resistance Insulin Secretion T2D Adipose Tissue Amino Acids Branched-Chain Biological Transport Body Mass Index Diabetes mellitus Type 2 Endothelial Cells Fatty Acids Humans Hydroxybutyrates Incidence Metabolome Microvessels
Targeting the CD4 Binding Site of HIV
Lotta von Boehmer
Jan 01, 0001
The immunologic obstacles to develop a broadly neutralizing antibody (bNAb) against HIV by vaccine mandate for methodical testing in order to understand and direct the immune response. A mouse model with the predicted human...
Published by: Rockefeller University
Genome-wide association study for risk taking propensity indicates shared pathways with body mass index.
Emma Ad Clifton, John RB Perry, Fumiaki Imamura, Luca A Lotta, Soren Brage, Nita G Forouhi, Simon J Griffin, Nicholas J Wareham, Ken K Ong, Felix R Day
Jun 12, 2018
Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide association study of self-reported risk-taking propensity among 436,236 white...
Circulating Selenium and Prostate Cancer Risk
James Yarmolinsky, Carolina Bonilla, Philip C Haycock, Ryan JQ Langdon, Luca A Lotta, Claudia Langenberg, Caroline L Relton, Sarah J Lewis, David M Evans, PRACTICAL Consortium, George Davey Smith, Richard M Martin
Sep 18, 2018
In the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade...
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes.
Nicholas Bowker, Rupal L Shah, Stephen J Sharp, Jian'an Luan, Isobel D Stewart, Eleanor Wheeler, Manuel AR Ferreira, Aris Baras, Nicholas J Wareham, Claudia Langenberg, Luca A Lotta
Oct 07, 2020
Genetic Interleukin-6 Trans-ethnic Type 2 diabetes Adiposity Biomarkers Blood Glucose Body Weights and Measures Cytokines Diabetes mellitus Type 2 Disease Susceptibility Genetic Predisposition to Disease Humans Inflammation Inflammation Mediators Interleukin-6 Odds Ratio Receptors Interleukin-6 Risk Factors Signal Transduction
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression
Roberto Bonelli, Brendan R. E. Ansell, Luca Lotta, Thomas Scerri, Traci E. Clemons, Irene Leung, Tunde Peto, Alan C. Bird, Ferenc B. Sallo, Claudia Langenberg, Melanie Bahlo
Mar 09, 2021
Abstract: Background: Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend retinal vascular calibre and...
Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes.
Luca A Lotta, Isobel D Stewart, Stephen J Sharp, Felix R Day, Stephen Burgess, Jian'an Luan, Nicholas Bowker, Lina Cai, Chen Li, Laura BL Wittemans, Nicola D Kerrison, Kay-Tee Khaw, Mark I McCarthy, Stephen O'Rahilly, Robert A Scott, David B Savage, John RB Perry, Claudia Langenberg, Nicholas J Wareham
Nov 05, 2018
Aged Angiopoietin-Like Protein 4 Cholesterol LDL Coronary Artery Disease Diabetes mellitus Type 2 Female Genetic Association Studies Genetic Predisposition to Disease Humans Hydroxymethylglutaryl CoA Reductases Lipolysis Lipoprotein Lipase Male Membrane Proteins Membrane Transport Proteins Middle Aged Odds Ratio Proprotein Convertase 9
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
Luca A Lotta, Jacek Mokrosiński, Edson Mendes de Oliveira, Chen Li, Stephen J Sharp, Jian'an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D Stewart, Eleanor Wheeler, Felix R Day, John RB Perry, Claudia Langenberg, Nicholas J Wareham, I Sadaf Farooqi
Apr 12, 2019
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations...
GPCRs MC4R UK Biobank biased signaling Genetics melanocortin obesity β-Arrestin Adult Aged Body Mass Index Coronary Artery Disease Cyclic AMP Databases Factual Diabetes mellitus Type 2 Female GTP-Binding Protein alpha Subunits Gs Gain of Function Mutation Genetic Predisposition to Disease Genotype Humans Male Middle Aged obesity Polymorphism Single Nucleotide Receptor Melanocortin Type 4 Signal Transduction beta-Arrestins
Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.
Luca A Lotta, Laura BL Wittemans, Verena Zuber, Isobel D Stewart, Stephen J Sharp, Jian'an Luan, Felix R Day, Chen Li, Nicholas Bowker, Lina Cai, Emanuella De Lucia Rolfe, Kay-Tee Khaw, John RB Perry, Stephen O'Rahilly, Robert A Scott, David B Savage, Stephen Burgess, Nicholas J Wareham, Claudia Langenberg
Jan 07, 2019
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease
Søren D Østergaard, Shubhabrata Mukherjee, Stephen J Sharp, Petroula Proitsi, Luca A Lotta, Felix Day, John RB Perry, Kevin L Boehme, Stefan Walter, John S Kauwe, Laura E Gibbons, Alzheimer’s Disease Genetics Consortium, GERAD1 Consortium, EPIC-InterAct Consortium, Eric B Larson, John F Powell, Claudia Langenberg, Paul K Crane, Nicholas J Wareham, Robert A Scott
Jun 09, 2015
fMRI evidence for areas that process surface gloss in the human visual cortex.
The Ethics of Astrobiology and the Cosmic Bet Argument
Luca Lo Sapio
Jan 01, 2024
Stephen Weinberg posited in 1977 that as the universe becomes more comprehensible, it appears more meaningless owing to a strict division between facts and values. He seemingly overlooked the consideration of the purposes and...
Published by: IGI Global Scientific Publishing
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Jan 04, 2023
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment
Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment
Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...
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