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EHA evaluation of the ESMO—Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for haematological malignancies
Barbara Kiesewetter, Nathan I Cherny, Nicolas Boissel, Francesco Cerisoli, Urania Dafni, Elisabeth G E de Vries, Paolo Ghia, Nicola Gökbuget, Verónica González-Calle, Brian Huntly, Ulrich Jäger, Nicola Jane Latino, Jean-Yves Douillard, Luca Malcovati, María-Victoria Mateos, Gert J Ossenkoppele, Kimmo Porkka, Markus Raderer, Josep-Maria Ribera, Lydia Scarfò, Ruth Wester, Panagiota Zygoura, Pieter Sonneveld
Feb 10, 2020
Objective: Value frameworks in oncology have not been validated for the assessment of treatments in haematological malignancies, but to avoid overlaps and duplications it appears reasonable to build up experience on existing...
fMRI evidence for areas that process surface gloss in the human visual cortex.
The Ethics of Astrobiology and the Cosmic Bet Argument
Luca Lo Sapio
Jan 01, 2024
Stephen Weinberg posited in 1977 that as the universe becomes more comprehensible, it appears more meaningless owing to a strict division between facts and values. He seemingly overlooked the consideration of the purposes and...
Published by: IGI Global Scientific Publishing
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment
Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment
Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...
Impact of spliceosome mutations on RNA splicing in myelodysplasia
Andrea Pellagatti, Richard N Armstrong, Violetta Steeples, Eshita Sharma, Emmanouela Repapi, Shalini Singh, Andrea Sanchi, Aleksandar Radujkovic, Patrick Horn, Hamid Dolatshad, Swagata Roy, John Broxholme, Helen Lockstone, Stephen Taylor, Aristoteles Giagounidis, Paresh Vyas, Anna Schuh, Angela Hamblin, Elli Papaemmanuil, Sally Killick, Luca Malcovati, Marco L Hennrich, Anne-Claude Gavin, Anthony D Ho, Thomas Luft, Eva Hellström-Lindberg, Mario Cazzola, Christopher WJ Smith, Stephen Smith, Jacqueline Boultwood
Mar 19, 2019
SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the effect of these commonly mutated...
Coherent backscattering of light by an anisotropic biological network.
Gianni Jacucci, Olimpia D Onelli, Antonio De Luca, Jacopo Bertolotti, Riccardo Sapienza, Silvia Vignolini
Jan 07, 2019
The scattering strength of a random medium relies on the geometry and spatial distribution of its components as well as on their refractive index. Anisotropy can, therefore, play a major role in the optimization of the...
SOI CMOS MEMS infra-red thermal source with carbon nanotubes coating
This abstract presents the development of a Silicon-on-Insulator (SOI) CMOS micro-electro-mechanical (MEMS) micro-hotplate based infra-red (IR) light source employing a vertically aligned multi-walled carbon nanotubes...
A Semantic Framework Supporting Multilayer Networks Analysis for Rare Diseases
Understanding the role played by genetic variations in diseases, exploring genomic variants and discovering disease-associated loci are among the most pressing challenges of genomic medicine. A huge and ever-increasing amount of...
Published by: IGI Global Scientific Publishing
Digital Evidence in Crime
This research was conducted to analyze the risk factors of online violent video games, relationship between these games and social media in terms of conducting crime, and techniques that might be used to prevent crime on social...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Convergence of Prognostic Gene Signatures Suggests Underlying Mechanisms of Human Prostate Cancer Progression.
Bogdan-Alexandru Luca, Vincent Moulton, Christopher Ellis, Shea P Connell, Daniel S Brewer, Colin S Cooper
Oct 02, 2020
The highly heterogeneous clinical course of human prostate cancer has prompted the development of multiple RNA biomarkers and diagnostic tools to predict outcome for individual patients. Biomarker discovery is often unstable...
aggressive cancer Biomarkers cancer progression diagnostic signature prognostic signature prostate cancer Biomarkers Tumor Cohort Studies Datasets as Topic Disease Progression Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Microarray Analysis Neoplasm Invasiveness Prognosis Prostatic Neoplasms Transcriptome
Differential processing of binocular and monocular gloss cues in human visual cortex.
Hua-Chun Sun, Massimiliano Di Luca, Hiroshi Ban, Alexander Muryy, Roland W Fleming, Andrew E Welchman
Mar 07, 2016
LoRaWAN Battery-Free Wireless Sensors Network Designed for Structural Health Monitoring in the Construction Domain.
Gaël Loubet, Alexandru Takacs, Ethan Gardner, Andrea De Luca, Florin Udrea, Daniela Dragomirescu
Jun 20, 2019
This paper addresses the practical implementation of a wireless sensors network designed to actualize cyber-physical systems that are dedicated to structural health monitoring applications in the construction domain. This...
Internet of Things (IoT) communicating material cyber-physical systems (CPS) simultaneous wireless information and power transfer (SWIPT) Structural health monitoring (SHM) wireless power transmission (WPT) wireless sensor network (WSN) Electric Power Supplies Environment Design Humans humidity Monitoring Physiologic SUPERCONDUCTIVITY Temperature Transducers Wireless Technology
Effects of Ketogenic Diet on Cardiac Ischemia-Reperfusion Injury in Mice
Luca Walborn
Jan 01, 0001
Ketone bodies have been identified as an important fuel source during physiological and pathological stress. During exercise, augmenting ketone body metabolism in the skeletal muscle may enhance exercise performance while...
ketogenic diet Cardiac Function Ischemia Ischemia reperfusion Heart Biology Circulatory and Respiratory Physiology Life Sciences Medical Anatomy Medical Nutrition
Published by: Ursinus College
EHA evaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for haematological malignancies.
Barbara Kiesewetter, Nathan I Cherny, Nicolas Boissel, Francesco Cerisoli, Urania Dafni, Elisabeth GE de Vries, Paolo Ghia, Nicola Gökbuget, Verónica González-Calle, Brian Huntly, Ulrich Jäger, Nicola Jane Latino, Jean-Yves Douillard, Luca Malcovati, María-Victoria Mateos, Gert J Ossenkoppele, Kimmo Porkka, Markus Raderer, Josep-Maria Ribera, Lydia Scarfò, Ruth Wester, Panagiota Zygoura, Pieter Sonneveld
Mar 25, 2020
OBJECTIVE: Value frameworks in oncology have not been validated for the assessment of treatments in haematological malignancies, but to avoid overlaps and duplications it appears reasonable to build up experience on existing...
Dissection of Neurons and Circuits Involved in Regulating Innate Behaviors, Movement and Higher Cognitive Functions in Mice
Luca Parolari
Jan 01, 0001
Elucidating the mechanisms through which brain circuits influence behavior is a fundamental tenet of Systems Neuroscience. Advancements in this field are critical to help us understand the inner workings of our brains, and...
Published by: Rockefeller University
Categorical and Dimensional Diagnoses of Dyslexia
Dyslexia is often assessed using categorical diagnoses, and subtypes of dyslexia are also recognized in a categorical fashion. Children may meet the criteria for dyslexia, and they may more specifically meet the criteria for a...
Pair correlation function of charge-stabilized colloidal systems under sheared conditions
Abstract: The pair correlation function of charge stabilized colloidal particles under strongly sheared conditions is studied using the analytical intermediate asymptotics method recently developed in Banetta and Zaccone (Phys....
Targeting Mitochondrial Metabolism in Neuroinflammation
The lack of effective treatment options for chronic neurological conditions, such as multiple sclerosis (MS), highlights the need to re-evaluate disease pathophysiology in the process of identifying novel therapeutic targets....
immune metabolism MACROPHAGES Microglia Mitochondria Neuroinflammation progressive multiple sclerosis Central Nervous System Crotonates Dimethyl Fumarate Electron Transport Glymphatic System Humans Hydroxybutyrates Immunity Innate Metabolic Networks and Pathways Microglia Mitochondria Molecular Targeted Therapy Mononuclear Phagocyte System Multiple Sclerosis Chronic Progressive Neurodegenerative Diseases Nitriles Signal Transduction Stem Cell Transplantation Toluidines
Non-coding genetic variation in regulatory elements determines thrombosis and hemostasis phenotypes.
Since the early inception of genome-wide association studies (GWAS), it became clear that, in all diseases or traits studied, most genetic variants are likely to exert their effect on gene expression mainly by altering the...
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