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Results: 66
Structure of a 13-fold superhelix (almost) determined from first principles.
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor...
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De novo metatranscriptomic exploration of gene function in the millipede holobiont.
Invertebrate-microbial associations are widespread in the biosphere and are often related to the function of novel genes, fitness advantages, and even speciation events. Despite ~ 13,000 species of millipedes identified across...
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Moderators of treatment effects in a child maltreatment prevention programme in South Africa.
BACKGROUND: Previous research has found mixed results on whether the most disadvantaged families benefit as much as less disadvantaged families from parenting interventions designed to reduce child maltreatment, and little in...
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De novo metatranscriptomic exploration of gene function in the millipede holobiont.
Invertebrate-microbial associations are widespread in the biosphere and are often related to the function of novel genes, fitness advantages, and even speciation events. Despite ~ 13,000 species of millipedes identified across...
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Buckling and strength analysis of panels with discrete stiffness tailoring

Continuous variation of stiffness across flat plates has been shown, theoretically, to improve buckling performance by up to 60%. However, steered fibre manufacturing methods cannot achieve the minimum radius of curvature...

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Discrete Stiffness Tailoring
Discrete Stiffness Tailoring (DST) is a novel manufacturing concept where stiffness tailoring is achieved using discrete changes in ply angle to favourably redistribute stresses. Resulting performance increases can be exploited...
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Buckling and strength analysis of panels with discrete stiffness tailoring

Continuous variation of stiffness across flat plates has been shown, theoretically, to improve buckling performance by up to 60%. However, steered fibre manufacturing methods cannot achieve the minimum radius of curvature...

Published by:
Discrete Stiffness Tailoring
Discrete Stiffness Tailoring (DST) is a novel manufacturing concept where stiffness tailoring is achieved using discrete changes in ply angle to favourably redistribute stresses. Resulting performance increases can be exploited...
Published by:
How common are Depression and Anxiety in adolescents with Chronic Fatigue Syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study
Adolescents with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) appear to be more likely to experience anxiety and/or depression using Patient Reported Outcome Measures (PROMs). However, we do not know how accurate...
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How common are Depression and Anxiety in adolescents with Chronic Fatigue Syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study
Adolescents with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) appear to be more likely to experience anxiety and/or depression using Patient Reported Outcome Measures (PROMs). However, we do not know how accurate...
Published by:
Defining the challenges for ecodesign implementation in companies
This study addresses the problem of the slow take-up of ecodesign in industry by identifying and categorising the implementation challenges faced by practitioners. Case studies from nine manufacturing companies from five...
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Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues.
A novel assay procedure has been developed to allow simultaneous activity discrimination in crude tissue extracts of the three known mammalian nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1) isozymes. These...
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Mechanism-based traps enable protease and hydrolase substrate discovery.
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases-especially...
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Mechanism-based traps enable protease and hydrolase substrate discovery.
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases-especially...
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Evaluating pain in survivors of critical illness
INTRODUCTION: Pain is a common and debilitating symptom in survivors of critical illness. The 'Core Outcome Set for Survivors of Acute Respiratory Failure' proposes that the pain and discomfort question of the EuroQol 5...
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Defining the challenges for ecodesign implementation in companies
This study addresses the problem of the slow take-up of ecodesign in industry by identifying and categorising the implementation challenges faced by practitioners. Case studies from nine manufacturing companies from five...
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The molecular signatures of compatible and incompatible pollination in Arabidopsis.
BACKGROUND: Fertilization in flowering plants depends on the early contact and acceptance of pollen grains by the receptive papilla cells of the stigma. Deciphering the specific transcriptomic response of both pollen and...
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Mechanistic insights into the genetics of affective psychosis from Prader-Willi syndrome.
Schizophrenia and bipolar disorder are common, severe, and disabling psychotic disorders, which are difficult to research. We argue that the genetically determined neurodevelopmental disorder Prader-Willi syndrome (PWS), which...
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