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Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
Jonathan Pansieri, Igor A Iashchishyn, Hussein Fakhouri, Lucija Ostojić, Mantas Malisauskas, Greta Musteikyte, Vytautas Smirnovas, Matthias M Schneider, Tom Scheidt, Catherine K Xu, Georg Meisl, Tuomas PJ Knowles, Ehud Gazit, Rodolphe Antoine, Ludmilla A Morozova-Roche
Jul 28, 2021
The mechanism of amyloid co-aggregation and its nucleation process are not fully understood in spite of extensive studies. Deciphering the interactions between proinflammatory S100A9 protein and Aβ42 peptide in Alzheimer's...
Behavioural coordination of dogs in a cooperative problem-solving task with a conspecific and a human partner.
The process of domestication has arguably provided dogs (Canis familiaris) with decreased emotional reactivity (reduced fear and aggression) and increased socio-cognitive skills adaptive for living with humans. It has been...
The hidden side of animal cognition research
Animal cognition research aims to understand animal minds by using a diverse range of methods across an equally diverse range of species. Throughout its history, the field has sought to mitigate various biases that occur when...
Published by: PLOS ONE
Testing two competing hypotheses for Eurasian jays’ caching for the future
Abstract: Previous research reported that corvids preferentially cache food in a location where no food will be available or cache more of a specific food in a location where this food will not be available. Here, we consider...
Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific's desire and visual perspective.
Piero Amodio, Benjamin G Farrar, Christopher Krupenye, Ljerka Ostojić, Nicola S Clayton
Sep 13, 2021
Eurasian jays have been reported to protect their caches by responding to cues about either the visual perspective or current desire of an observing conspecific, similarly to other corvids. Here, we used established paradigms to...
It's not just the animals that are STRANGE.
A "STRANGE" framework has been proposed to mitigate the effects of sampling biases in animal experiments (Webster & Rutz, Nature, 582, 337-340, 2020). While sampling biases are likely a major cause of poor replicability and...
Electron Microscopy Characterization of P3 Lines and Laser Scribing-Induced Perovskite Decomposition in Perovskite Solar Modules.
Hybrid metal halide perovskites have emerged as a potential photovoltaic material for low-cost thin film solar cells due to their excellent optoelectronic properties. However, high efficiencies obtained with lab-scale cells are...
The hidden side of animal cognition research
Animal cognition research aims to understand animal minds by using a diverse range of methods across an equally diverse range of species. Throughout its history, the field has sought to mitigate various biases that occur when...
Difficulties when using video playback to investigate social cognition in California scrub-jays (Aphelocoma californica).
Previous research has suggested that videos can be used to experimentally manipulate social stimuli. In the present study, we used the California scrub-jays' cache protection strategies to assess whether video playback can be...
Can male Eurasian jays disengage from their own current desire to feed the female what she wants?
Ljerka Ostojić, Edward W Legg, Rachael C Shaw, Lucy G Cheke, Michael Mendl, Nicola S Clayton
Mar 02, 2020
Humans' predictions of another person's behaviour are regularly influenced by what they themselves might know or want. In a previous study, we found that male Eurasian jays (Garrulus glandarius) could cater for their female...
Desire-state attribution
In recent years, we have investigated the possibility that Eurasian jay food sharing might rely on desire-state attribution. The female's desire for a particular type of food can be decreased by sating her on it (specific...
Experimenter expectancy bias does not explain Eurasian jays' (Garrulus glandarius) performance in a desire-state attribution task.
Ljerka Ostojić, Edward W Legg, Arne Dits, Natalie Williams, Katharina F Brecht, Michael Mendl, Nicola S Clayton
Sep 06, 2016
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Feb 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Jan 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Genetic mechanisms of critical illness in COVID-19.
Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D Bretherick, Konrad Rawlik, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alexandre C Pereira, Alessandra Renieri, GenOMICC Investigators, ISARIC4C investigators, COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Xia Shen, Chris P Ponting, Angie Fawkes, Albert Tenesa, Mark Caulfield, Richard Scott, Kathy Rowan, Lee Murphy, Peter JM Openshaw, Malcolm G Semple, Andrew Law, Veronique Vitart, James F Wilson, J Kenneth Baillie
Dec 01, 2020
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets...
2' 5'-Oligoadenylate Synthetase covid-19 Chromosomes Human Pair 12 Chromosomes Human Pair 19 Chromosomes Human Pair 21 Critical Care Critical Illness Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Drug Repositioning Female Genome-Wide Association Study Humans Inflammation Lung Male Multigene Family Receptor Interferon alpha-beta Receptors CCR2 TYK2 Kinase United Kingdom
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey, Christopher A Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Sean Keating, Bo Wang, Daniel Rhodes, Lucija Klaric, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David Maslove, Alistair Nichol, Malcolm G Semple, Tala Zainy, Fiona Maleady-Crowe, Linda Todd, Shahla Salehi, Julian Knight, Greg Elgar, Georgia Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A Kosmicki, Julie E Horowitz, Aris Baras, Goncalo R Abecasis, Manuel AR Ferreira, Anne Justice, Tooraj Mirshahi, Matthew Oetjens, Daniel J Rader, Marylyn D Ritchie, Anurag Verma, Tom A Fowler, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter JM Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, GenOMICC Investigators, 23andMe Investigators, COVID-19 Human Genetics Initiative, Angie Fawkes, Lee Murphy, Kathy Rowan, Chris P Ponting, Veronique Vitart, James F Wilson, Jian Yang, Andrew D Bretherick, Richard H Scott, Sara Clohisey Hendry, Loukas Moutsianas, Andy Law, Mark J Caulfield, J Kenneth Baillie
Jul 07, 2022
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC...
ATP-Binding Cassette Transporters covid-19 Cell Adhesion Molecules Critical Care Critical Illness E-Selectin Factor VIII Fucosyltransferases Genome Human Genome-Wide Association Study Host-Pathogen Interactions Humans Interleukin-10 Receptor beta Subunit Lectins C-Type Mucin-1 Nerve Tissue Proteins Phospholipid Transfer Proteins Receptors Cell Surface Repressor Proteins SARS-CoV-2 whole genome sequencing
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