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In Vivo Cell Tracking Using PET
Cell therapy is a rapidly evolving field involving a wide spectrum of therapeutic cells for personalised medicine in cancer. In vivo imaging and tracking of cells can provide useful information for improving the accuracy...
Published by: Cancers
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.
Active targeting by means of drug encapsulated nanoparticles decorated with targeting bioactive moieties represents the next frontier in drug delivery; it reduces drug side effects and increases the therapeutic index. Peptides...
In Vivo Cell Tracking Using PET
Cell therapy is a rapidly evolving field involving a wide spectrum of therapeutic cells for personalised medicine in cancer. In vivo imaging and tracking of cells can provide useful information for improving the accuracy...
Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors.
Antonella Accardo, Filippo Galli, Rosalba Mansi, Luigi Del Pozzo, Michela Aurilio, Anna Morisco, Paola Ringhieri, Alberto Signore, Giancarlo Morelli, Luigi Aloj
Dec 18, 2018
BACKGROUND: Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabeled...
Lymphoscintigraphy defines new lymphatic pathways from cutaneous melanoma site
Sentinel lymph node biopsy is commonly applied as staging procedure of regional lymph nodes in patients with cutaneous melanoma. Dynamic lymphoscintigraphy defines the lymphatic pathways from a primary melanoma site and allows...
In Vivo Cell Tracking Using PET
Cell therapy is a rapidly evolving field involving a wide spectrum of therapeutic cells for personalised medicine in cancer. In vivo imaging and tracking of cells can provide useful information for improving the accuracy...
Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes
Syafiq Ramlee, David Hulse, Kinga Bernatowicz, Raquel Pérez-López, Evis Sala, Luigi Aloj
Jul 28, 2022
The tumour immune microenvironment influences the efficacy of immune checkpoint inhibitors. Within this microenvironment are CD8-expressing tumour-infiltrating lymphocytes (CD8+ TILs), which are an important mediator and marker...
Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes
Syafiq Ramlee, David Hulse, Kinga Bernatowicz, Raquel Pérez-López, Evis Sala, Luigi Aloj
Sep 11, 2022
The tumour immune microenvironment influences the efficacy of immune checkpoint inhibitors. Within this microenvironment are CD8-expressing tumour-infiltrating lymphocytes (CD8+ TILs), which are an important mediator and marker...
Use of neoadjuvant electrochemotherapy to treat a large metastatic lesion of the cheek in a patient with melanoma.
Nicola Mozzillo, Corrado Caracò, Stefano Mori, Gianluca Di Monta, Gerardo Botti, Paolo A Ascierto, Corradina Caracò, Luigi Aloj
Dec 21, 2018
BACKGROUND: Approximately 200,000 new cases of melanoma are diagnosed worldwide each year. Skin metastases are a frequent event, occurring in 18.2% of cases. This can be distressing for the patient, as the number and size of...
Evaluation of Tumor Response after Short-Course Radiotherapy and Delayed Surgery for Rectal Cancer.
Daniela Rega, Biagio Pecori, Dario Scala, Antonio Avallone, Ugo Pace, Antonella Petrillo, Luigi Aloj, Fabiana Tatangelo, Paolo Delrio
Dec 18, 2018
PURPOSE: Neoadjuvant therapy is able to reduce local recurrence in rectal cancer. Immediate surgery after short course radiotherapy allows only for minimal downstaging. We investigated the effect of delayed surgery after...
3D printing 18 F radioactive phantoms for PET imaging
Daniel Gillett, Daniel Marsden, Safia Ballout, Bala Attili, Nick Bird, Sarah Heard, Mark Gurnell, Iosif A. Mendichovszky, Luigi Aloj
Apr 28, 2021
Abstract: Purpose: Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by...
Influence of a novel, versatile bifunctional chelator on theranostic properties of a minigastrin analogue.
Joachim Pfister, Dominik Summer, Christine Rangger, Milos Petrik, Elisabeth von Guggenberg, Paolo Minazzi, Giovanni B Giovenzana, Luigi Aloj, Clemens Decristoforo
Dec 18, 2018
BACKGROUND: 6-[Bis(carboxymethyl)amino]-1,4-bis(carboxymethyl)-6-methyl-1,4-diazepane (AAZTA ) is a promising chelator with potential advantages over 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) for...
Sequential PET/CT with [18F]-FDG Predicts Pathological Tumor Response to Preoperative Short Course Radiotherapy with Delayed Surgery in Patients with Locally Advanced Rectal Cancer Using Logistic Regression Analysis.
Biagio Pecori, Secondo Lastoria, Corradina Caracò, Marco Celentani, Fabiana Tatangelo, Antonio Avallone, Daniela Rega, Giampaolo De Palma, Maria Mormile, Alfredo Budillon, Paolo Muto, Francesco Bianco, Luigi Aloj, Antonella Petrillo, Paolo Delrio
Dec 18, 2018
UNLABELLED: Previous studies indicate that FDG PET/CT may predict pathological response in patients undergoing neoadjuvant chemo-radiotherapy for locally advanced rectal cancer (LARC). Aim of the current study is evaluate if...
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells
Antonella Accardo, Giuseppina Salsano, Anna Morisco, Michela Aurilio, Antonio Parisi, Francesco Maione, Carla Cicala, Diego Tesauro, Luigi Aloj, Giuseppe De Rosa, Giancarlo Morelli
Dec 21, 2018
OBJECTIVES: Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This...
PC-3 Cells bombesin peptide doxorubicin delivery gastrin-releasing peptide receptors theranostic applications Animals Antineoplastic Agents Bombesin Cell Line Tumor Doxorubicin Drug Carriers Drug Delivery Systems Female Humans Liposomes Male Mice Mice Inbred BALB C Mice Nude nanomedicine Pentetic Acid Peptide Fragments Phosphatidylcholines Prostatic Neoplasms Receptors Bombesin Surface-Active Agents Xenograft Model Antitumor Assays
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model
Doreen Lau, Fabien Garçon, Anita Chandra, Laura M. Lechermann, Luigi Aloj, Edwin R. Chilvers, Pippa G. Corrie, Klaus Okkenhaug, Ferdia A. Gallagher
Aug 05, 2020
Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell behavior within tumors, as well as...
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model.
Doreen Lau, Fabien Garçon, Anita Chandra, Laura M Lechermann, Luigi Aloj, Edwin R Chilvers, Pippa G Corrie, Klaus Okkenhaug, Ferdia A Gallagher
Jun 12, 2020
adoptive T-cell therapy Immune Checkpoint Inhibitors immunocompetent intravital imaging Melanoma Adoptive Transfer Animals Antigens Neoplasm Cell Line Tumor Cell Movement Combined Modality Therapy Disease Models Animal Fluorescent Antibody Technique Image Processing Computer-Assisted Immune Checkpoint Inhibitors Immunotherapy Adoptive Lymphocyte Activation Melanoma Experimental Mice Molecular Imaging T-Cell Antigen Receptor Specificity T-Lymphocytes
Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas.
Gaetano Corazzelli, Ferdinando Frigeri, Manuela Arcamone, Luigi Aloj, Gaetana Capobianco, Cristina Becchimanzi, Emanuela Morelli, Francesco Volzone, Gianpaolo Marcacci, Filippo Russo, Rosaria De Filippi, Secondo Lastoria, Antonio Pinto
Dec 21, 2018
Patients with recurring T-cell non-Hodgkin lymphoma (T-NHL) are incurable and candidate for investigational agents. Here, we report on five patients with T-NHL refractory to multiple chemotherapy lines, including in all cases...
Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides.
Peter Laverman, Lieke Joosten, Annemarie Eek, Susan Roosenburg, Petra Kolenc Peitl, Theodosia Maina, Helmut Mäcke, Luigi Aloj, Elisabeth von Guggenberg, Jane K Sosabowski, Marion de Jong, Jean-Claude Reubi, Wim JG Oyen, Otto C Boerman
Dec 21, 2018
PURPOSE: Cholecystokinin 2 (CCK-2) receptor overexpression has been demonstrated in various tumours such as medullary thyroid carcinomas and small-cell lung cancers. Due to this high expression, CCK-2 receptors might be suitable...
Standardized Index of Shape (DCE-MRI) and Standardized Uptake Value (PET/CT)
Antonella Petrillo, Roberta Fusco, Mario Petrillo, Vincenza Granata, Paolo Delrio, Francesco Bianco, Biagio Pecori, Gerardo Botti, Fabiana Tatangelo, Corradina Caracò, Luigi Aloj, Antonio Avallone, Secondo Lastoria
May 03, 2019
PURPOSE: To investigate dynamic contrast enhanced-MRI (DCE-MRI) in the preoperative chemo-radiotherapy (CRT) assessment for locally advanced rectal cancer (LARC) compared to18F-fluorodeoxyglucose positron emission...
neoadjuvant chemo-radiotherapy rectal cancer treatment response assessment Adult Aged Area Under Curve Chemoradiotherapy Adjuvant Contrast Media Digestive System Surgical Procedures Female Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Magnetite Nanoparticles Male Middle Aged Neoadjuvant Therapy Perfusion Imaging Positron Emission Tomography Computed Tomography Predictive Value of Tests ROC Curve Radiopharmaceuticals Rectal Neoplasms Regional Blood Flow Remission Induction Reproducibility of Results Siloxanes Treatment Outcome
Imaging and treatment of brain tumors through molecular targeting
Fulvio Zaccagna, James T Grist, Natale Quartuccio, Frank Riemer, Francesco Fraioli, Corradina Caracò, Richard Halsey, Yazeed Aldalilah, Charles H Cunningham, Tarik F Massoud, Luigi Aloj, Ferdia A Gallagher
Jul 23, 2021
Molecular imaging techniques have rapidly progressed over recent decades providing unprecedented in vivo characterization of metabolic pathways and molecular biomarkers. Many of these new techniques have been successfully...
Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction.
Daniel Gillett, Russell Senanayake, James MacFarlane, Merel van der Meulen, Olympia Koulouri, Andrew S Powlson, Rosy Crawford, Bethany Gillett, Nick Bird, Sarah Heard, Angelos Kolias, Richard Mannion, Luigi Aloj, Iosif A Mendichovszky, Heok Cheow, Waiel A Bashari, Mark Gurnell
Jun 07, 2022
BACKGROUND: Pituitary adenomas (PA) affect ~ 1:1200 of the population and can cause a wide range of symptoms due to hormone over-secretion, loss of normal pituitary gland function and/or compression of visual pathways, resulting...
Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer
Antonio Avallone, Biagio Pecori, Franco Bianco, Luigi Aloj, Fabiana Tatangelo, Carmela Romano, Vincenza Granata, Pietro Marone, Alessandra Leone, Gerardo Botti, Antonella Petrillo, Corradina Caracò, Vincenzo R Iaffaioli, Paolo Muto, Giovanni Romano, Pasquale Comella, Alfredo Budillon, Paolo Delrio
Jul 01, 2019
adjuvant chemotherapy Bevacizumab locally advanced rectal cancer preoperative chemo-radiotherapy vessel normalization Adult Aged Angiogenesis Inhibitors Antineoplastic Combined Chemotherapy Protocols Bevacizumab Chemoradiotherapy Adjuvant Disease Progression Disease-Free Survival Drug Administration Schedule Early Termination of Clinical Trials Female Fluorouracil Humans Italy Kaplan-Meier Estimate Leucovorin Magnetic Resonance Imaging Male Middle Aged Neoadjuvant Therapy Neoplasm Recurrence Local Organoplatinum Compounds Oxaliplatin Predictive Value of Tests Quinazolines Rectal Neoplasms Risk Factors Thiophenes Time Factors Treatment Outcome
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