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Biopolymer‐based Carriers for DNA Vaccine Design
Christoph O. Franck, Luise Fanslau, Andrea Bistrovic Popov, Puneet Tyagi, Ljiljana Fruk
Jun 04, 2021
Abstract: Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers....
Published by: Angewandte Chemie International Edition
Nutritional status and clinical outcome in postterm neonates undergoing surgery for congenital heart disease.
Rebecca Mitting, Luise Marino, Duncan Macrae, Nitin Shastri, Rosan Meyer, Nazima Pathan
Apr 02, 2015
Biopolymer‐based Carriers for DNA Vaccine Design
Abstract: Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers....
Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars.
Luise Krüger, Milena Stillfried, Carolin Prinz, Vanessa Schröder, Lena Katharina Neubert, Joachim Denner
Apr 09, 2020
Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in...
Biopolymer-based Carriers for DNA Vaccine Design.
Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, the...
Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa
Ilka Boehm, Esther Walton, Nina Alexander, Victoria-Luise Batury, Maria Seidel, Daniel Geisler, Joseph A. King, Kerstin Weidner, Veit Roessner, Stefan Ehrlich
Jul 31, 2020
Background: Epigenetic variation in the serotonin transporter gene (SLC6A4) has been shown to modulate the functioning of brain circuitry associated with the salience network and may heighten the risk for mental illness. This...
PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies
Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder.
Nico Bast, Luke Mason, Christine M Freitag, Tim Smith, Ana Maria Portugal, Luise Poustka, Tobias Banaschewski, Mark Johnson, EU-AIMS LEAP group
Apr 12, 2021
BACKGROUND: Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during...
Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Luise Eckardt, Maria Prange-Barczynska, Emma J Hodson, James W Fielding, Xiaotong Cheng, Joanna DCC Lima, Samvid Kurlekar, Gillian Douglas, Peter J Ratcliffe, Tammie Bishop
Nov 22, 2021
Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway, including PHD2, PHD1, EPAS1 (encoding HIF-2α) are highly...
Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa
Ilka Boehm, Esther Walton, Nina Alexander, Victoria-Luise Batury, Maria Seidel, Daniel Geisler, Joseph A. King, Kerstin Weidner, Veit Roessner, Stefan Ehrlich
Jul 31, 2020
Background: Epigenetic variation in the serotonin transporter gene (SLC6A4) has been shown to modulate the functioning of brain circuitry associated with the salience network and may heighten the risk for mental illness. This...
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Maik Pietzner, Beatrice Engelmann, Tim Kacprowski, Janine Golchert, Anna-Luise Dirk, Elke Hammer, K Alexander Iwen, Matthias Nauck, Henri Wallaschofski, Dagmar Führer, Thomas F Münte, Nele Friedrich, Uwe Völker, Georg Homuth, Georg Brabant
Nov 16, 2020
BACKGROUND: Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize...
The genetic diversity, phylogeography and morphology of Elphidiidae (Foraminifera) in the Northeast Atlantic
Kate F. Darling, Magali Schweizer, Karen Luise Knudsen, Katharine M. Evans, Clare Bird, Angela Roberts, Helena L. Filipsson, Jung-Hyun Kim, Gudmundur Gudmundsson, Christopher M. Wade, Martin D.J. Sayer, William E.N. Austin
Dec 01, 2016
Genetic characterisation (SSU rRNA genotyping) and Scanning Electron Microscope (SEM) imaging of individual tests were used in tandem to determine the modern species richness of the foraminiferal family Elphidiidae (Elphidium...
Nutritional support for children during critical illness
Lyvonne N. Tume, Frederic V. Valla, Koen Joosten, Corinne Jotterand Chaparro, Lynne Latten, Luise V. Marino, Isobel Macleod, Clémence Moullet, Nazima Pathan, Shancy Rooze, Joost van Rosmalen, Sascha C. A. T. Verbruggen
Jun 06, 2020
Abstract: Background: Nutritional support is considered essential for the outcome of paediatric critical illness. There is a lack of methodologically sound trials to provide evidence-based guidelines leading to diverse practices...
Nutritional support for children during critical illness
Lyvonne N. Tume, Frederic V. Valla, Koen Joosten, Corinne Jotterand Chaparro, Lynne Latten, Luise V. Marino, Isobel Macleod, Clémence Moullet, Nazima Pathan, Shancy Rooze, Joost van Rosmalen, Sascha C. A. T. Verbruggen
Feb 19, 2021
Abstract: Background: Nutritional support is considered essential for the outcome of paediatric critical illness. There is a lack of methodologically sound trials to provide evidence-based guidelines leading to diverse practices...
The genetic diversity, phylogeography and morphology of Elphidiidae (Foraminifera) in the Northeast Atlantic
Kate F. Darling, Magali Schweizer, Karen Luise Knudsen, Katharine M. Evans, Clare Bird, Angela Roberts, Helena L. Filipsson, Jung-Hyun Kim, Gudmundur Gudmundsson, Christopher M. Wade, Martin D.J. Sayer, William E.N. Austin
Dec 01, 2016
Genetic characterisation (SSU rRNA genotyping) and Scanning Electron Microscope (SEM) imaging of individual tests were used in tandem to determine the modern species richness of the foraminiferal family Elphidiidae (Elphidium...
Neural correlates of three types of negative life events during angry face processing in adolescents.
Fanny Gollier-Briant, Marie-Laure Paillère-Martinot, Hervé Lemaitre, Ruben Miranda, Hélène Vulser, Robert Goodman, Jani Penttilä, Maren Struve, Tahmine Fadai, Viola Kappel, Luise Poustka, Yvonne Grimmer, Uli Bromberg, Patricia Conrod, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Herta Flor, Juergen Gallinat, Hugh Garavan, Andreas Heinz, Claire Lawrence, Karl Mann, Frauke Nees, Tomas Paus, Zdenka Pausova, Vincent Frouin, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Gunter Schumann, IMAGEN Consortium+, Jean-Luc Martinot, Eric Artiges
May 21, 2018
Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate...
Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.
Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor W Robbins, Jianfeng Feng, IMAGEN consortium
Mar 08, 2021
Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol...
Trajectories of cortical structures associated with stress across adolescence
Tochukwu Nweze, Tobias Banaschewski, Cyracius Ajaelu, Chukwuemeka Okoye, Michael Ezenwa, Robert Whelan, Dimitri Papadopoulos Orfanos, Arun LW Bokde, Sylvane Desrivières, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Gunter Schumann, Jamie L Hanson, IMAGEN consortium
Mar 29, 2023
Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition.
Wanlu Deng, Edmund T Rolls, Xiaoxi Ji, Trevor W Robbins, Tobias Banaschewski, Arun LW Bokde, Uli Bromberg, Christian Buechel, Sylvane Desrivières, Patricia Conrod, Herta Flor, Vincent Frouin, Juergen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Herve Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jianfeng Feng
Apr 12, 2018
To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709...
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis
Alessandra Bettiol, Maria Letizia Urban, Lorenzo Dagna, Vincent Cottin, Franco Franceschini, Stefano Del Giacco, Franco Schiavon, Thomas Neumann, Giuseppe Lopalco, Pavel Novikov, Chiara Baldini, Carlo Lombardi, Alvise Berti, Federico Alberici, Marco Folci, Simone Negrini, Renato Alberto Sinico, Luca Quartuccio, Claudio Lunardi, Paola Parronchi, Frank Moosig, Georgina Espígol-Frigolé, Jan Schroeder, Anna Luise Kernder, Sara Monti, Ettore Silvagni, Claudia Crimi, Francesco Cinetto, Paolo Fraticelli, Dario Roccatello, Angelo Vacca, Aladdin J Mohammad, Bernhard Hellmich, Maxime Samson, Elena Bargagli, Jan Willem Cohen Tervaert, Camillo Ribi, Davide Fiori, Federica Bello, Filippo Fagni, Luca Moroni, Giuseppe Alvise Ramirez, Mouhamad Nasser, Chiara Marvisi, Paola Toniati, Davide Firinu, Roberto Padoan, Allyson Egan, Benjamin Seeliger, Florenzo Iannone, Carlo Salvarani, David Jayne, Domenico Prisco, Augusto Vaglio, Giacomo Emmi, European EGPA Study Group
Nov 15, 2021
OBJECTIVE: Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported...
Association between childhood trauma and risk for obesity
Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W. Kanen, Qi Zhao, Ye Yao, Erin B. Quinlan, Tianye Jia, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Barbara J. Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W. Robbins
Oct 15, 2020
Association between childhood trauma and risk for obesity
Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W. Kanen, Qi Zhao, Ye Yao, Erin B. Quinlan, Tianye Jia, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Barbara J. Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W. Robbins
Oct 18, 2021
Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis
Alessandra Bettiol, Maria Letizia Urban, Lorenzo Dagna, Vincent Cottin, Franco Franceschini, Stefano Del Giacco, Franco Schiavon, Thomas Neumann, Giuseppe Lopalco, Pavel Novikov, Chiara Baldini, Carlo Lombardi, Alvise Berti, Federico Alberici, Marco Folci, Simone Negrini, Renato Alberto Sinico, Luca Quartuccio, Claudio Lunardi, Paola Parronchi, Frank Moosig, Georgina Espígol-Frigolé, Jan Schroeder, Anna Luise Kernder, Sara Monti, Ettore Silvagni, Claudia Crimi, Francesco Cinetto, Paolo Fraticelli, Dario Roccatello, Angelo Vacca, Aladdin J Mohammad, Bernhard Hellmich, Maxime Samson, Elena Bargagli, Jan Willem Cohen Tervaert, Camillo Ribi, Davide Fiori, Federica Bello, Filippo Fagni, Luca Moroni, Giuseppe Alvise Ramirez, Mouhamad Nasser, Chiara Marvisi, Paola Toniati, Davide Firinu, Roberto Padoan, Allyson Egan, Benjamin Seeliger, Florenzo Iannone, Carlo Salvarani, David Jayne, Domenico Prisco, Augusto Vaglio, Giacomo Emmi, European EGPA Study Group
Jan 07, 2022
OBJECTIVE: Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported...
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents.
Christian Büchel, Jan Peters, Tobias Banaschewski, Arun LW Bokde, Uli Bromberg, Patricia J Conrod, Herta Flor, Dimitri Papadopoulos, Hugh Garavan, Penny Gowland, Andreas Heinz, Henrik Walter, Bernd Ittermann, Karl Mann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, Frauke Nees, Tomas Paus, Zdenka Pausova, Luise Poustka, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Juergen Gallinat, Gunter Schumann, Brian Knutson, IMAGEN consortium
Mar 26, 2018
Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated...
Structural brain correlates of adolescent resilience.
Keith B Burt, Robert Whelan, Patricia J Conrod, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Uli Bromberg, Christian Büchel, Mira Fauth-Bühler, Herta Flor, André Galinowski, Juergen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Karl Mann, Frauke Nees, Dimitri Papadopoulos-Orfanos, Tomas Paus, Zdenka Pausova, Luise Poustka, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Andreas Ströhle, Gunter Schumann, Hugh Garavan, IMAGEN consortium
Apr 11, 2018
BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim...
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