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Results: 55
Achieving integrated self-directed Cancer aftercare (ASICA) for melanoma
Felicity Reilly, Lynda Contstable, William Brant, Kaz Rahman, Amer Durrani, Nigel Burrows, Charlotte Proby, Julia Allan, Marie Johnston, Derek Johnston, Fiona Walter, Peter Murchie
Nov 22, 2021
BACKGROUND: Melanoma incidence has quadrupled since 1970 and melanoma is now the second most common cancer in individuals under 50. Targeted immunotherapies for melanoma now potentially enable long-term remission even in...
Cancer Melanoma PRIMARY CARE randomised controlled trial Self-directed care Survivorship e-Health Aftercare Cancer Survivors Computers Handheld Feasibility Studies Female Humans Male Melanoma Middle Aged Mobile Applications Neoplasm Recurrence Local Nurse Practitioners Oncology Nursing Photography Pilot Projects Self Care Self-Examination Skin Skin Neoplasms United Kingdom
US Equity Crowdfunding
Recently developed SEC guidelines provide the regulatory framework for Title II of the Jump Start our Business (JOBS) Act of 2012, which legalizes interstate equity crowdfunding in the United States. Concurrently, eighteen...
crowdfunding equity crowdfunding intrastate equity crowdfunding Business Administration management and Operations Entrepreneurial and Small Business Operations
Published by: Digital Commons @ Texas A&M University-San Antonio
US Equity Crowdfunding
Recently developed SEC guidelines provide the regulatory framework for Title II of the Jump Start our Business (JOBS) Act of 2012, which legalizes interstate equity crowdfunding in the United States. Concurrently, eighteen...
crowdfunding equity crowdfunding intrastate equity crowdfunding Business Administration, Management, and Operations Entrepreneurial and Small Business Operations
Published by: Digital Commons @ Texas A&M University-San Antonio
FURTHER MANUSCRIPTS OF HIGDEN'S POLYCHRONICON
In 1999 Lynda Dennison and Nicholas Rogers noted the existence of 132 copies of Ranulf Higden’s Polychronicon. We note below a further fifteen manuscripts, or fragments of once complete manuscripts, previously unrecorded. A...
US Equity Crowdfunding
Recently developed SEC guidelines provide the regulatory framework for Title II of the Jump Start our Business (JOBS) Act of 2012, which legalizes interstate equity crowdfunding in the United States. Concurrently, eighteen...
crowdfunding equity crowdfunding intrastate equity crowdfunding Business Administration management and Operations Entrepreneurial and Small Business Operations
Published by: Digital Commons @ Texas A&M University-San Antonio
Forecasting the prevalence of overweight and obesity in India to 2040
Shammi Luhar, Ian M. Timæus, Rebecca Jones, Solveig Cunningham, Shivani A. Patel, Sanjay Kinra, Lynda Clarke, Rein Houben
Feb 24, 2020
Background: In India, the prevalence of overweight and obesity has increased rapidly in recent decades. Given the association between overweight and obesity with many non-communicable diseases, forecasts of the future prevalence...
Hyperacute Stroke Thrombolysis via Telemedicine – A Multicentre Study of Performance, Safety, and Clinical Efficacy
Nicholas Evans, Lynda Sibson, Diana Day, Smriti Agarwal, Raj Shekhar, Elizabeth Warburton
Jan 28, 2022
Objectives: Timely thrombolysis of ischaemic stroke improves functional recovery, yet its delivery nationally is challenging due to shortages in the stroke specialist workforce and large geographical areas. One solution is...
MICE or NICE? An economic evaluation of clinical decision rules in the diagnosis of heart failure in primary care.
Mark Monahan, Pelham Barton, Clare J Taylor, Andrea K Roalfe, FD Richard Hobbs, REFER investigators, Martin Cowie, Russell Davis, Jon Deeks, Jonathan Mant, Deborah McCahon, Theresa McDonagh, George Sutton, Lynda Tait
May 02, 2018
BACKGROUND: Detection and treatment of heart failure (HF) can improve quality of life and reduce premature mortality. However, symptoms such as breathlessness are common in primary care, have a variety of causes and not all...
Cost benefit analysis Economic model General Practice Medical economics Natriuretic Peptide Aged Clinical Decision-Making Cost-Benefit Analysis Edema England Female Follow-Up Studies Heart Failure Humans Male Myocardial Infarction Practice Guidelines as Topic Primary Health Care Prospective Studies State Medicine
The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice.
Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi, Lynda Zeboudj, Andreas Giraud, Xavier Loyer, Marie Vandestienne, Julien Wain-Hobson, Bruno Esposito, Stephane Potteaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat, Soraya Taleb
Jun 21, 2018
RATIONALE: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between...
Lifetime risk of diabetes in metropolitan cities in India.
Shammi Luhar, Dimple Kondal, Rebecca Jones, Ranjit M Anjana, Shivani A Patel, Sanjay Kinra, Lynda Clarke, Mohammed K Ali, Dorairaj Prabhakaran, M Masood Kadir, Nikhil Tandon, Viswanathan Mohan, KM Venkat Narayan
Feb 05, 2021
AIMS/HYPOTHESIS: We aimed to estimate the lifetime risk of diabetes and diabetes-free life expectancy in metropolitan cities in India among the population aged 20 years or more, and their variation by sex, age and BMI. METHODS...
Body Mass Index Diabetes Diabetes-free life expectancy india lifetime risk Metropolitan cities urban Adult Age Distribution Diabetes mellitus Disease-Free Survival Female Humans Incidence india Life Expectancy Male Markov Chains Middle Aged Models Theoretical obesity prevalence Risk Assessment Risk Factors Sex Distribution Time Factors Urban Health Young Adult
Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.
Padmapriya Ponnuswamy, Jeremie Joffre, Olivier Herbin, Bruno Esposito, Ludivine Laurans, Christoph J Binder, Thomas F Tedder, Lynda Zeboudj, Xavier Loyer, Andreas Giraud, Yujiao Zhang, Alain Tedgui, Ziad Mallat, Hafid Ait-Oufella
Jun 21, 2018
Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B...
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Group, PCAWG Consortium
Feb 04, 2021
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating...
Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis.
Jeremie Joffre, Stephane Potteaux, Lynda Zeboudj, Xavier Loyer, Amir Boufenzer, Ludivine Laurans, Bruno Esposito, Marie Vandestienne, Saskia CA de Jager, Carole Hénique, Ivana Zlatanova, Soraya Taleb, Patrick Bruneval, Alain Tedgui, Ziad Mallat, Sebastien Gibot, Hafid Ait-Oufella
Jun 21, 2018
BACKGROUND: Innate immune responses activated through myeloid cells contribute to the initiation, progression, and complications of atherosclerosis in experimental models. However, the critical upstream pathways that link innate...
apolipoprotein foam cells Inflammation macrophage Toll-like receptor Animals Apoptosis Carotid Arteries Carotid Artery Diseases Cells Cultured Disease Models Animal Enzyme-Linked Immunosorbent Assay Genetic Therapy Humans Immunity Innate Lauric Acids MACROPHAGES Male Membrane Glycoproteins Mice Mice Inbred C57BL Mice Transgenic Oligopeptides Plaque Atherosclerotic Receptors Immunologic Rhodamines Triggering Receptor Expressed on Myeloid Cells-1
Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production.
Andreas Giraud, Lynda Zeboudj, Marie Vandestienne, Jérémie Joffre, Bruno Esposito, Stéphane Potteaux, José Vilar, Daniela Cabuzu, Johannes Kluwe, Sylvie Seguier, Alain Tedgui, Ziad Mallat, Antoine Lafont, Hafid Ait-Oufella
Apr 09, 2019
AIMS: Abdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix destruction. Despite improvement...
abdominal aortic aneurysm Cell therapy Gingival fibroblasts Metalloproteases Remodelling Angiotensin II Animals Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Disease Models Animal Extracellular Matrix FIBROBLASTS Gingiva Mice Inbred C57BL Mice Knockout Protective Agents Tissue Inhibitor of Metalloproteinase-1 Transforming Growth Factor beta
Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis-Brief Report.
Lynda Zeboudj, Andréas Giraud, Lea Guyonnet, Yujiao Zhang, Ludivine Laurans, Bruno Esposito, Jose Vilar, Anna Chipont, Nikolina Papac-Milicevic, Christoph J Binder, Alain Tedgui, Ziad Mallat, Pierre-Louis Tharaux, Hafid Ait-Oufella
Apr 09, 2019
OBJECTIVE: To determine the consequences of specific inhibition of EGFR (epidermal growth factor receptor) in myeloid cells in atherosclerosis development. APPROACH AND RESULTS: Atherosclerotic lesion size was significantly...
Atherosclerosis foam cells Inflammation MACROPHAGES Mice Animals Atherosclerosis Bone Marrow Transplantation CD36 Antigens Cytoskeleton Diet High-Fat Disease Models Animal ErbB Receptors Gene Deletion Interleukin-6 MACROPHAGES Male Mice Knockout Necrosis Plaque Atherosclerotic Receptors LDL Tumor Necrosis Factor-alpha Whole-Body Irradiation
Impaired Bone Architecture in Peripubertal Children With HIV, Despite Treatment With Antiretroviral Therapy
Cynthia Mukwasi-Kahari, Andrea M Rehman, Mícheál Ó Breasail, Ruramayi Rukuni, Tafadzwa Madanhire, Joseph Chipanga, Lynda Stranix-Chibanda, Lisa K Micklesfield, Rashida A Ferrand, Kate A Ward, Celia L Gregson
Dec 10, 2022
HIV infection has multi-system adverse effects in children, including on the growing skeleton. We aimed to determine the association between chronic HIV infection and bone architecture (density, size, strength) in peripubertal...
Measurement of antibodies to pneumococcal, meningococcal and haemophilus polysaccharides, and tetanus and diphtheria toxoids using a 19-plexed assay
Alison M E Whitelegg, Jane Birtwistle, Alex Richter, John Campbell, James E Turner, Tarana M Ahmed, Lynda J Giles, Mark Fellows, Tim Plant, Alastair J Ferraro, Mark Cobbold, Mark T Drayson, Calman A MacLennan
Mar 30, 2012
The measurement of antibody responses to vaccination is useful in the assessment of immune status in suspected immune deficiency. Previous reliance on enzyme-linked immunoabsorbent assays (ELISA) has been cumbersome...
Genetic Depletion or Hyperresponsiveness of Natural Killer Cells Do Not Affect Atherosclerosis Development.
Wared Nour-Eldine, Jérémie Joffre, Kazem Zibara, Bruno Esposito, Andréas Giraud, Lynda Zeboudj, José Vilar, Megumi Terada, Patrick Bruneval, Eric Vivier, Hafid Ait-Oufella, Ziad Mallat, Sophie Ugolini, Alain Tedgui
Jun 21, 2018
RATIONALE: Chronic inflammation is central in the development of atherosclerosis. Both innate and adaptive immunities are involved. Although several studies have evaluated the functions of natural killer (NK) cells in...
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