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Eigenvalue repulsions and quasinormal mode spectra of Kerr-Newman
The frequency spectra of the gravito-electromagnetic perturbations of the
Kerr-Newman (KN) black hole with the slowest decay rate have been computed
recently. It has been found that KN has two families $-$ the photon sphere...
Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.
Vítor Mendes, Marta Acebrón-García-de-Eulate, Nupur Verma, Michal Blaszczyk, Márcio V B Dias, Tom L Blundell
Jan 03, 2020
Trehalose is an essential disaccharide for mycobacteria and a key constituent of several cell wall glycolipids with fundamental roles in pathogenesis. Mycobacteria possess two pathways for trehalose biosynthesis. However, only...
The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family.
Fernanda CR de Paiva, Karen Chan, Markiyan Samborskyy, Ariel M Silber, Peter F Leadlay, Marcio VB Dias
Dec 07, 2020
Adenylate-forming enzymes (AFEs) are a mechanistic superfamily of proteins that are involved in many cellular roles. In the biosynthesis of benzoxazole antibiotics, an AFE has been reported to play a key role in the condensation...
Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
Marcio VB Dias, Fanglu Huang, Dimitri Y Chirgadze, Manuela Tosin, Dieter Spiteller, Emily FV Dry, Peter F Leadlay, Jonathan B Spencer, Tom L Blundell
Mar 12, 2021
The thioesterase FlK from the fluoroacetate-producing Streptomyces cattleya catalyzes the hydrolysis of fluoroacetyl-coenzyme A. This provides an effective self-defense mechanism, preventing any fluoroacetyl-coenzyme A formed...
Acetyl Coenzyme A Biocatalysis Catalytic Domain Crystallography X-Ray Hydrophobic and Hydrophilic Interactions Models Molecular Mutagenesis Site-Directed Mutant Proteins Mutation Protein Structure Quaternary Protein Structure Secondary Streptomyces Substrate Specificity Thiolester Hydrolases Threonine
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.
Daniel Shiu-Hin Chan, Jeannine Hess, Elen Shaw, Christina Spry, Robert Starley, Claudio Dagostin, Marcio VB Dias, Ramesh Kale, Vitor Mendes, Tom L Blundell, Anthony G Coyne, Chris Abell
Sep 13, 2019
CoaBC, part of the vital coenzyme A biosynthetic pathway in bacteria, has recently been validated as a promising antimicrobial target. In this work, we employed native ion mobility-mass spectrometry to gain structural insights...
Computational Analysis of Vertebral Body for Compression Fracture Using Texture and Shape Features
The primary goal in this paper is to automate radiological measurements of Vertebral Body (VB) in Magnetic Resonance Imaging (MRI) spinal scans. It starts by preprocessing the images, then detect and localize the VB regions...
Published by: IGI Global Scientific Publishing
Material property calibration is more important than element size and number of different materials on the finite element modelling of vertebral bodies
Finite element (FE) modelling of a vertebral body (VB) is considered challenging due to the many parameters involved such as element size and type, and material properties. Previous studies have reported how these parameters...
Material property calibration is more important than element size and number of different materials on the finite element modelling of vertebral bodies
Finite element (FE) modelling of a vertebral body (VB) is considered challenging due to the many parameters involved such as element size and type, and material properties. Previous studies have reported how these parameters...
Sequestration and biosynthesis of cyanogenic glucosides in passion vine butterflies and consequences for the diversification of their host plants.
Érika C Pinheiro de Castro, Mika Zagrobelny, Juan Pablo Zurano, Márcio Zikan Cardoso, René Feyereisen, Søren Bak
Jan 20, 2020
The colorful heliconiine butterflies are distasteful to predators due to their content of defense compounds called cyanogenic glucosides (CNglcs), which they biosynthesize from aliphatic amino acids. Heliconiine larvae feed...
Longitudinal associations between prepubertal childhood total energy and macronutrient intakes and subsequent puberty timing in UK boys and girls.
Tuck Seng Cheng, Stephen J Sharp, Soren Brage, Pauline M Emmett, Nita Forouhi, Kenneth Ong
Jul 12, 2021
PURPOSE: Early puberty is associated with adverse health outcomes. To identify potential modifiable factors for puberty timing, we examined the associations of prepubertal childhood macronutrient intakes with puberty timing in...
Analysis of Emigration and Social Demographic Conditions on Divorce and Economic Levels in East Java
Economic development is one of the essential pillars for the attainment of people’s wellbeing. Indonesia is one of the largest migrant worker contributors in southeast Asia, where East Java is its biggest supplier. However, the...
Published by: Indonesia Strategic Sustainability
Anatomy and behavior of Laternula elliptica, a keystone species of the Antarctic benthos (Bivalvia: Anomalodesmata
Laternula elliptica (P. P. King, 1832) is the sole representative of the anomalodesmatan family Laternulidae and the largest bivalve in the Antarctic and Subantarctic. A keystone species of the regional benthic communities, it...
The Impacts of Financial Compensation of Student-Athletes in NCAA Division I Men's Basketball on the Labor Market
Gabriel Boscardin Dias
Jan 01, 0001
The purpose of this study is to identify the impacts that financial compensation of men's basketball student-athletes in the NCAA Division I will have on the market of collegiate athletics. As the NCAA is facing issues involving...
Published by: Winthrop University
Single-site glycine-specific labeling of proteins.
Landa Purushottam, Srinivasa Rao Adusumalli, Usha Singh, VB Unnikrishnan, Dattatraya Gautam Rawale, Mansi Gujrati, Ram Kumar Mishra, Vishal Rai
Jan 25, 2021
Labeling of native proteins invites interest from diverse segments of science. However, there remains the significant unmet challenge in precise labeling at a single site of a protein. Here, we report the site-specific labeling...
Reproducibility of compartmental modelling of 18 F-FDG PET/CT to evaluate lung inflammation
Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan, Ian Wilkinson
Dec 22, 2020
Abstract: Introduction: Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models...
Reproducibility of compartmental modelling of 18F-FDG PET/CT to evaluate lung inflammation.
Laurence D Vass, Sarah Lee, Frederick J Wilson, Marie Fisk, Joseph Cheriyan, Ian Wilkinson
Jan 27, 2020
INTRODUCTION:Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains...
Business Intelligence for Human Capital Management
This article presents the results of an exploratory study of the use of business intelligence (BI) tools to help to make decisions about human resources management in Portuguese organizations. The purpose of this article is to...
Published by: IGI Global Scientific Publishing
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