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Results: 344
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Juan Garrido-Maraver, Ivana Celardo, Ana C Costa, Susann Lehmann, Samantha HY Loh, L Miguel Martins
Feb 27, 2019
Deep Video Portraits
Hyeongwoo Kim, Pablo Garrido, Ayush Tewari, Weipeng Xu, Justus Thies, Matthias Nießner, Patrick Perez, Christian Richardt, Michael Zollhöfer, Christian Theobalt
Aug 31, 2018
We present a novel approach that enables photo-realistic re-animation of portrait videos using only an input video. In contrast to existing approaches that are restricted to manipulations of facial expressions only, we are the...
Deep Video Portraits
Hyeongwoo Kim, Pablo Garrido, Ayush Tewari, Weipeng Xu, Justus Thies, Matthias Nießner, Patrick Perez, Christian Richardt, Michael Zollhöfer, Christian Theobalt
Aug 31, 2018
We present a novel approach that enables photo-realistic re-animation of portrait videos using only an input video. In contrast to existing approaches that are restricted to manipulations of facial expressions only, we are the...
Very long O-antigen chains of Salmonella Paratyphi A inhibit inflammasome activation and pyroptotic cell death.
Elli Mylona, Julia Sanchez-Garrido, Trang Nguyen Hoang Thu, Sabina Dongol, Abhilasha Karkey, Stephen Baker, Avinash R Shenoy, Gad Frankel
Jan 22, 2021
Salmonella Paratyphi A (SPtA) remains one of the leading causes of enteric (typhoid) fever. Yet, despite the recent increased rate of isolation from patients in Asia, our understanding of its pathogenesis is incomplete. Here we...
FepE O-antigen Salmonella paratyphi A Salmonella typhimurium caspase-4 enteric fever Inflammasomes pyroptosis Bacterial Proteins Caspases HeLa Cells Humans Inflammasomes Intracellular Signaling Peptides and Proteins MACROPHAGES O Antigens Paratyphoid Fever Phosphate-Binding Proteins pyroptosis Salmonella paratyphi A THP-1 Cells Type III Secretion Systems Virulence Virulence Factors
Dictyostelium transcriptional responses to Pseudomonas aeruginosa
Sergio Carilla-Latorre, Javier Calvo-Garrido, Gareth Bloomfield, Jason Skelton, Robert R Kay, Alasdair Ivens, José L Martinez, Ricardo Escalante
Jun 14, 2011
A roadmap for STEP-NC-enabled interoperable manufacturing
M. Hardwick, Y.F. Zhao, F.M. Proctor, A. Nassehi, X. Xu, S. Venkatesh, D. Odendahl, L. Xu, M. Hedlind, M. Lundgren, L. Maggiano, D. Loffredo, J. Fritz, B. Olsson, J. Garrido, A. Brail
Sep 01, 2013
The STEP-NC-AP 238 and ISO 14649 standard is the result of a 10-year international effort to replace the RS274D (ISO 6983) G and M code standard with a modern associative language that connects the CAD design data used to...
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Anna K Uryga, Mandy OJ Grootaert, Abel M Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d'Adda di Fagagna, Dimitra Aravani, Helle F Jorgensen, Martin R Bennett
Apr 15, 2021
Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic...
Animals Atherosclerosis Cell Proliferation Cells Cultured Cellular Senescence DNA Damage Disease Models Animal Humans Inflammation Male Mice Mice Inbred C57BL Mice Knockout Microfilament Proteins Muscle Proteins Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Telomere Telomeric Repeat Binding Protein 2
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Anna K Uryga, Mandy O J Grootaert, Abel M Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d'Adda di Fagagna, Dimitra Aravani, Helle F Jorgensen, Martin R Bennett
Jun 22, 2021
Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced atherosclerotic...
Published by: Communications biology
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
Xhenti Ferhati, Marina Salas-Cubero, Pablo Garrido, Josune García-Sanmartín, Ana Guerreiro, Alberto Avenoza, Jesús H Busto, Jesús M Peregrina, Alfredo Martínez, Ester Jiménez-Moreno, Goncalo Lopes Bernardes, Francisco Corzana
Nov 02, 2021
A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media....
Synthetic mimetics of the endogenous gastrointestinal nanomineral
Laetitia C Pele, Carolin T Haas, Rachel E Hewitt, Jack Robertson, Jeremy Skepper, Andy Brown, Juan Carlos Hernandez-Garrido, Paul A Midgley, Nuno Faria, Helen Chappell, Jonathan J Powell
Jan 16, 2018
Amorphous magnesium-substituted calcium phosphate (AMCP) nanoparticles (75-150nm) form constitutively in large numbers in the mammalian gut. Collective evidence indicates that they trap and deliver luminal macromolecules to...
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
Xhenti Ferhati, Marina Salas-Cubero, Pablo Garrido, Josune García-Sanmartín, Ana Guerreiro, Alberto Avenoza, Jesús H Busto, Jesús M Peregrina, Alfredo Martínez, Ester Jiménez-Moreno, Gonçalo JL Bernardes, Francisco Corzana
Jan 06, 2022
A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media....
Stem cell function and stress response are controlled by protein synthesis.
Sandra Blanco, Roberto Bandiera, Martyna Popis, Shobbir Hussain, Patrick Lombard, Jelena Aleksic, Abdulrahim Sajini, Hinal Tanna, Rosana Cortés-Garrido, Nikoletta Gkatza, Sabine Dietmann, Michaela Frye
May 05, 2016
A roadmap for STEP-NC-enabled interoperable manufacturing
M. Hardwick, Y.F. Zhao, F.M. Proctor, A. Nassehi, X. Xu, S. Venkatesh, D. Odendahl, L. Xu, M. Hedlind, M. Lundgren, L. Maggiano, D. Loffredo, J. Fritz, B. Olsson, J. Garrido, A. Brail
Sep 01, 2013
The STEP-NC-AP 238 and ISO 14649 standard is the result of a 10-year international effort to replace the RS274D (ISO 6983) G and M code standard with a modern associative language that connects the CAD design data used to...
Efficacy and limitations of senolysis in atherosclerosis.
Abel Martin Garrido, Anuradha Kaistha, Anna K Uryga, Sebnem Oc, Kirsty Foote, Aarti Shah, Alison Finigan, Nichola Figg, Lina Dobnikar, Helle Jørgensen, Martin Bennett
Jun 07, 2021
AIMS: Traditional markers of cell senescence including p16, Lamin B1, and senescence-associated beta galactosidase (SAβG) suggest very high frequencies of senescent cells in atherosclerosis, while their removal via 'senolysis'...
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
Anna K. Uryga, Mandy O. J. Grootaert, Abel M. Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d’Adda di Fagagna, Dimitra Aravani, Helle F. Jorgensen, Martin R. Bennett
May 21, 2021
Abstract: Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies, including following neointimal formation after injury and atherosclerosis. However, human VSMCs in advanced...
Effective therapeutic strategies in a preclinical mouse model of Charcot-Marie-Tooth disease.
Cristina Nuevo-Tapioles, Fulvio Santacatterina, Brenda Sánchez-Garrido, Cristina Núñez de Arenas, Adrián Robledo-Bérgamo, Paula Martínez-Valero, Lara Cantarero, Beatriz Pardo, Janet Hoenicka, Michael P Murphy, Jorgina Satrústegui, Francesc Palau, José M Cuezva
Aug 02, 2021
Charcot-Marie-Tooth (CMT) disease is a neuropathy that lacks effective therapy. CMT patients show degeneration of peripheral nerves, leading to muscle weakness and loss of proprioception. Loss of mitochondrial oxidative...
Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry.
Xhenti Ferhati, Ester Jiménez-Moreno, Emily A Hoyt, Giulia Salluce, Mar Cabeza-Cabrerizo, Claudio D Navo, Ismael Compañón, Padma Akkapeddi, Maria J Matos, Noelia Salaverri, Pablo Garrido, Alfredo Martínez, Víctor Laserna, Thomas V Murray, Gonzalo Jiménez-Osés, Peter Ravn, Gonçalo JL Bernardes, Francisco Corzana
Apr 19, 2022
An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.
Jonathan J Powell, Emma Thomas-McKay, Vinay Thoree, Jack Robertson, Rachel E Hewitt, Jeremy N Skepper, Andy Brown, Juan Carlos Hernandez-Garrido, Paul A Midgley, Inmaculada Gomez-Morilla, Geoffrey W Grime, Karen J Kirkby, Neil A Mabbott, David S Donaldson, Ifor R Williams, Daniel Rios, Stephen E Girardin, Carolin T Haas, Sylvaine FA Bruggraber, Jon D Laman, Yakup Tanriver, Giovanna Lombardi, Robert Lechler, Richard PH Thompson, Laetitia C Pele
Aug 08, 2017
In humans and other mammals it is known that calcium and phosphate ions are secreted from the distal small intestine into the lumen. However, why this secretion occurs is unclear. Here, we show that the process leads to the...
Detection of Atherosclerotic Inflammation by $^{68}$Ga-DOTATATE PET Compared to [$^{18}$F]FDG PET Imaging
JM Tarkin, FR Joshi, NR Evans, MM Chowdhury, NL Figg, AV Shah, LT Starks, A Martin-Garrido, R Manavaki, E Yu, RE Kuc, L Grassi, R Kreuzhuber, MA Kostadima, M Frontini, PJ Kirkpatrick, PA Coughlin, D Gopalan, TD Fryer, JR Buscombe, AM Groves, WH Ouwehand, MR Bennett, EA Warburton, AP Davenport, JHF Rudd
Apr 06, 2017
The intrusive nature of the Châtelperronian in the Iberian Peninsula.
Joseba Rios-Garaizar, Eneko Iriarte, Lee J Arnold, Laura Sánchez-Romero, Ana B Marín-Arroyo, Aixa San Emeterio, Asier Gómez-Olivencia, Carflos Pérez-Garrido, Martina Demuro, Isidoro Campaña, Laurence Bourguignon, Alfonso Benito-Calvo, María J Iriarte, Arantza Aranburu, Amaia Arranz-Otaegi, Diego Garate, María Silva-Gago, Christelle Lahaye, Illuminada Ortega
Mar 31, 2022
Multiple factors have been proposed to explain the disappearance of Neandertals between ca. 50 and 40 kyr BP. Central to these discussions has been the identification of new techno-cultural complexes that overlap with the period...
Using nonhuman culture in conservation requires careful and concerted action
Susana Carvalho, Erin G Wessling, Ekwoge E Abwe, Katarina Almeida‐Warren, Mimi Arandjelovic, Christophe Boesch, Emmanuel Danquah, Mamadou Saliou Diallo, Catherine Hobaiter, Kimberley Hockings, Tatyana Humle, Rachel Ashegbofe Ikemeh, Ammie K Kalan, Lydia Luncz, Gaku Ohashi, Alejandra Pascual‐Garrido, Alex Piel, Liran Samuni, Serge Soiret, Crickette Sanz, Kathelijne Koops
Jan 10, 2022
Abstract: Discussions of how animal culture can aid the conservation crisis are burgeoning. As scientists and conservationists working to protect endangered species, we call for reflection on how the culture concept may be...
The international experience of in-situ recovery of the DCD heart
John Louca, Marco Öchsner, Ashish Shah, Jordan Hoffman, Francisco González Vilchez, Iris Garrido, Mario Royo-Villanova, Beatriz Domínguez-Gil, Deane Smith, Leslie James, Nader Moazami, Filip Rega, Janne Brouckaert, Johan Van Cleemput, Katrien Vandendriessche, Vincent Tchana-Sato, Diawara Bandiougou, Marian Urban, Alex Manara, Marius Berman, Simon Messer, Stephen Large
Apr 12, 2023
Background
Heart transplantation is an effective treatment offering the best recovery in both quality and quantity of life in those affected by refractory, severe heart failure. However, transplantation is limited by...
Cold storage Donation After Circulatory Determination Of Death Esmp Cs Dbd Dcd donation after brain death Non Heart Beating Donation Thoraco-Abdominal Nromothermic Regional Perfusion Donation After Neurological Death Heart Beating Donation Tanrp In-situ Perfusion Ex-situ Machine Perfusion
Published by: EClinicalMedicine
A comparison of optimisation algorithms for high-dimensional particle and astrophysics applications
C Balázs, M van Beekveld, S Caron, BM Dillon, B Farmer, A Fowlie, EC Garrido-Merchán, W Handley, L Hendriks, G Jóhannesson, A Leinweber, J Mamužić, GD Martinez, S Otten, RR de Austri, P Scott, Z Searle, B Stienen, J Vanschoren, M White
Sep 03, 2021
Optimisation problems are ubiquitous in particle and astrophysics, and
involve locating the optimum of a complicated function of many parameters that
may be computationally expensive to evaluate. We describe a number of...
A comparison of optimisation algorithms for high-dimensional particle and astrophysics applications
Csaba Balázs, Melissa van Beekveld, Sascha Caron, Barry M. Dillon, Ben Farmer, Andrew Fowlie, Eduardo C. Garrido-Merchán, Will Handley, Luc Hendriks, Guðlaugur Jóhannesson, Adam Leinweber, Judita Mamužić, Gregory D. Martinez, Sydney Otten, Roberto Ruiz de Austri, Pat Scott, Zachary Searle, Bob Stienen, Joaquin Vanschoren, Martin White
May 20, 2021
Abstract: Optimisation problems are ubiquitous in particle and astrophysics, and involve locating the optimum of a complicated function of many parameters that may be computationally expensive to evaluate. We describe a number...
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