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An 8.22 Mb Assembly and Annotation of the Alpaca (Vicugna pacos) Y Chromosome.
Matthew J Jevit, Brian W Davis, Caitlin Castaneda, Andrew Hillhouse, Rytis Juras, Vladimir A Trifonov, Ahmed Tibary, Jorge C Pereira, Malcolm A Ferguson-Smith, Terje Raudsepp
Apr 12, 2021
The unique evolutionary dynamics and complex structure make the Y chromosome the most diverse and least understood region in the mammalian genome, despite its undisputable role in sex determination, development, and male...
An 8.22 Mb Assembly and Annotation of the Alpaca ( Vicugna pacos ) Y Chromosome
Matthew J. Jevit, Brian W. Davis, Caitlin Castaneda, Andrew Hillhouse, Rytis Juras, Vladimir A. Trifonov, Ahmed Tibary, Jorge C. Pereira, Malcolm A. Ferguson-Smith, Terje Raudsepp
Jan 17, 2021
The unique evolutionary dynamics and complex structure make the Y chromosome the most diverse and least understood region in the mammalian genome, despite its undisputable role in sex determination, development, and male...
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
PJ Brown, KK Wong, SL Felce, L Lyne, H Spearman, EJ Soilleux, LM Pedersen, MB Møller, TM Green, DM Gascoyne, AH Banham
Dec 17, 2018
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune...
Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antigens Differentiation B-Lymphocyte Antineoplastic Combined Chemotherapy Protocols B-Lymphocytes cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Regulation Neoplastic Germinal Center HLA-DR alpha-Chains Histocompatibility Antigens Class II Humans Lymphocyte Activation Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Staging Nuclear Proteins prednisone RNA Small Interfering Repressor Proteins Rituximab Signal Transduction Survival Analysis Trans-Activators Vincristine
High-resolution array CGH clarifies events occurring on 8p in carcinogenesis.
Susanna L Cooke, Jessica CM Pole, Suet-Feung Chin, Ian O Ellis, Carlos Caldas, Paul AW Edwards
Jun 16, 2011
BACKGROUND: Rearrangement of the short arm of chromosome 8 (8p) is very common in epithelial cancers such as breast cancer. Usually there is an unbalanced translocation breakpoint in 8p12 (29.7 Mb - 38.5 Mb) with loss of distal...
Breast Neoplasms Chi-Square Distribution Chromosome Aberrations Chromosome Deletion Chromosome Painting Chromosomes Human Pair 8 Cytogenetic Analysis Female Genes Tumor Suppressor Humans hybridization Genetic In Situ Hybridization Fluorescence Loss of Heterozygosity Oligonucleotide Array Sequence Analysis Polymorphism Genetic Reverse Transcriptase Polymerase Chain Reaction
The connectome of the adult Drosophila mushroom body provides insights into function.
Feng Li, Jack W Lindsey, Elizabeth C Marin, Nils Otto, Marisa Dreher, Georgia Dempsey, Ildiko Stark, Alexander S Bates, Markus William Pleijzier, Philipp Schlegel, Aljoscha Nern, Shin-Ya Takemura, Nils Eckstein, Tansy Yang, Audrey Francis, Amalia Braun, Ruchi Parekh, Marta Costa, Louis K Scheffer, Yoshinori Aso, Gregory SXE Jefferis, Larry F Abbott, Ashok Litwin-Kumar, Scott Waddell, Gerald M Rubin
Dec 23, 2020
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such...
Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry.
Isabel Quiros-Gonzalez, Michal R Tomaszewski, Sarah J Aitken, Laura Ansel-Bollepalli, Leigh-Ann McDuffus, Michael Gill, Lina Hacker, Joanna Brunker, Sarah E Bohndiek
Mar 08, 2018
BACKGROUND: Optoacoustic tomography (OT) of breast tumour oxygenation is a promising new technique, currently in clinical trials, which may help to determine disease stage and therapeutic response. However, the ability of OT to...
Animals Biological Mimicry Breast Neoplasms Cell Line Tumor Drug Monitoring Female Humans MCF-7 Cells Mammary Neoplasms Experimental Mice Mice Inbred BALB C Mice Nude Neoplasm Staging Neovascularization Pathologic Oxygen Consumption Photoacoustic Techniques Sensitivity and Specificity Tomography Tumor Hypoxia Xenograft Model Antitumor Assays
Does adiposity mediate the relationship between physical activity and biological risk factors in youth?
BACKGROUND/OBJECTIVES: To model the association between accumulating 60 daily minutes of moderate-to-vigorous physical activity and a composite score of biological risk factors into a direct and an indirect effect, using...
Pressure-induced Anderson-Mott transition in elemental tellurium
Abstract Elemental tellurium is a small band-gap semiconductor, which is always p-doped due to the natural occurrence of vacancies. Its chiral non-centrosymmetric structure, characterized by...
JF Oliveira, MB Fontes, M Moutinho, SE Rowley, E Baggio-Saitovitch, MB Silva Neto, C Enderlein
Jan 04, 2021
The formation of three-grain junctions during solidification. Part I
Abstract: The thermodynamic equilibrium dihedral angle at grain junctions in crystalline rocks is set by the grain boundary interfacial surface energies, but the long times required to attain equilibrium mean that the observed...
The formation of three-grain junctions during solidification. Part II
Abstract We provide a simple geometric theory of crystal growth which predicts the shape and final dihedral angle of three-grain junctions of an augite crystal with two plagioclase grains. The...
Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information.
Hui-Su Kim, Sungwon Jeon, Changjae Kim, Yeon Kyung Kim, Yun Sung Cho, Jungeun Kim, Asta Blazyte, Andrea Manica, Semin Lee, Jong Bhak
Jan 06, 2020
BACKGROUND:Long DNA reads produced by single-molecule and pore-based sequencers are more suitable for assembly and structural variation discovery than short-read DNA fragments. For de novo assembly, Pacific Biosciences (PacBio)...
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.
John A Halsall, Simon Andrews, Felix Krueger, Charlotte E Rutledge, Gabriella Ficz, Wolf Reik, Bryan M Turner
Apr 12, 2021
Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long. Post-translational modifications (PTM) of core histones seem to be involved...
Exact properties of an integrated correlator in N = 4 SU(N) SYM
Abstract
We present a novel expression for an integrated correlation function of four superconformal primaries in SU(N )...
The formation of three-grain junctions during solidification. Part I
Abstract The thermodynamic equilibrium dihedral angle at grain junctions in crystalline rocks is set by the grain boundary interfacial surface energies, but the long times required to attain...
Cyanogenesis in Arthropods
Chemical defences are key components in insect⁻plant interactions, as insects continuously learn to overcome plant defence systems by, e.g., detoxification, excretion or sequestration. Cyanogenic glucosides are natural products...
A bias towards natural rewards away from gambling cues in gamblers undergoing active treatment.
Casper Schmidt, Carsten Gleesborg, Hema Schmidt, Timo L Kvamme, Torben E Lund, Valerie Voon, Arne Møller
Apr 20, 2021
BACKGROUND: Disorders of substance and behavioral addiction are believed to be associated with a myopic bias towards the incentive salience of addiction-related cues away from general rewards in the environment. In non-treatment...
gambling disorder MID task orbitofrontal cortex Reward dissociation Striatum fMRI Adult Anticipation Psychological Brain Mapping Cognitive Behavioral Therapy Cues dorsolateral prefrontal cortex echo-planar imaging Erotica Female Gambling Gyrus Cinguli Humans Male motivation Reward Treatment Outcome Ventral Striatum Young Adult
Reverse iontophoresis of L-lactate
This work investigates the reverse iontophoretic extraction of lactate, a widely used marker of tissue distress in critically ill patients and of sports performance. In vitro experiments were performed to establish the...
Reverse iontophoresis of L-lactate
This work investigates the reverse iontophoretic extraction of lactate, a widely used marker of tissue distress in critically ill patients and of sports performance. In vitro experiments were performed to establish the...
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