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Results: 160
The Effects of Bisphenol A Structural Analogs on the Metastasis and Cathepsin Activity of MCF-7 Breast Cancer Cells
Jake C Lachowicz
Jan 01, 0001
Although different in practical use, water bottles, thermal receipts, and food cans all have one thing in common. All of these items have the possibility of containing bisphenols. Bisphenols are synthetic chemicals used in the...
bisphenols Breast Cancer Cathepsins metastasis Migration Estrogen Biochemistry, Biophysics, and Structural Biology Life Sciences
Published by: Ursinus College
Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions
Milad Rouhimoghadam, Shahrokh Safarian, Jason S Carroll, Nader Sheibani, Gholamreza Bidkhori
Apr 25, 2019
Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast cancer. It benefits nearly 75% of patients with estrogen receptor (ER)-positive breast cancer that receive this drug. Its...
Ultrafast laser inscription of a 121-waveguide fan-out for astrophotonics
Using ultrafast laser inscription, we report the fabrication of a prototype three-dimensional 121-waveguide fan-out device capable of reformatting the output of a 120-core multicore fiber (MCF) into a one-dimensional linear...
Is vigorous-intensity physical activity required for improving bone mass in adolescence? Findings from a Brazilian birth cohort.
RM Bielemann, VV Ramires, FC Wehrmeister, H Gonçalves, MCF Assunção, U Ekelund, BL Horta
Mar 11, 2019
Ultrafast laser inscription of a 121-waveguide fan-out for astrophotonics
Using ultrafast laser inscription, we report the fabrication of a prototype three-dimensional 121-waveguide fan-out device capable of reformatting the output of a 120-core multicore fiber (MCF) into a one-dimensional linear...
The Impact of BPA, BPS, and BPF on Cathepsin Activity and Metastasis of MCF-7 Breast Cancer Cells
Jake C Lachowicz
Jan 01, 0001
In the twenty-first century, plastic is a major product we use throughout our daily lives. One of the main components that is used to create and harden some plastics is a compound called bisphenol A (BPA). It is found widely in...
Cathepsins metastasis Breast Cancer BPF BPS BPA plastic Biochemistry Biochemistry, Biophysics, and Structural Biology Life Sciences Molecular Biology
Published by: Ursinus College
Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry.
Isabel Quiros-Gonzalez, Michal R Tomaszewski, Sarah J Aitken, Laura Ansel-Bollepalli, Leigh-Ann McDuffus, Michael Gill, Lina Hacker, Joanna Brunker, Sarah E Bohndiek
Mar 08, 2018
BACKGROUND: Optoacoustic tomography (OT) of breast tumour oxygenation is a promising new technique, currently in clinical trials, which may help to determine disease stage and therapeutic response. However, the ability of OT to...
Animals Biological Mimicry Breast Neoplasms Cell Line Tumor Drug Monitoring Female Humans MCF-7 Cells Mammary Neoplasms Experimental Mice Mice Inbred BALB C Mice Nude Neoplasm Staging Neovascularization Pathologic Oxygen Consumption Photoacoustic Techniques Sensitivity and Specificity Tomography Tumor Hypoxia Xenograft Model Antitumor Assays
Full-field quantitative phase and polarisation-resolved imaging through an optical fibre bundle.
George SD Gordon, James Joseph, Travis Sawyer, Alexander J Macfaden, Calum Williams, Timothy D Wilkinson, Sarah E Bohndiek
Jul 17, 2019
Flexible optical fibres, used in conventional medical endoscopy and industrial inspection, scramble phase and polarisation information, restricting users to amplitude-only imaging. Here, we exploit the near-diagonality of the...
The Effects of Estrogen, BPA, and BPA Structural Analogs on the MCF-7 Breast Cancer Cell Line
Saloni Parikh
Jan 01, 0001
Cancer results from genetic mutations that lead to a harmful uncontrollable cell division and differentiation. Once the cancer cells amass to a large amount, angiogenesis can turn this group of cells into a malignant tumor. The...
Breast Cancer bisphenols metastasis BPA Cathepsins endocrine disrupting compounds (EDCs) Biochemistry Biochemistry, Biophysics, and Structural Biology Chemicals and Drugs Environmental Public Health Enzymes and Coenzymes Hormones, Hormone Substitutes, and Hormone Antagonists Life Sciences Maternal and Child Health Medical Sciences Medicine and Health Sciences Molecular Biology Other Chemicals and Drugs Public Health Women's Health
Published by: Ursinus College
The Effects of Estrogen (E2), Bisphenol A (BPA), Bisphenol S (BPS), and Bisphenol F (BPF) on the Proliferation of MCF-7 Cells
Colleen Leahy
Jan 01, 0001
Endocrine disrupting compounds (EDCs) are chemicals that disturb the endocrine system and exhibit adverse effects throughout the body. EDCs exert their effects by displaying hormone-like activity and can act as agonists or...
Published by: Ursinus College
Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines.
Lavinia-Lorena Pruteanu, Cornelia Braicu, Dezső Módos, Maria-Ancuţa Jurj, Lajos-Zsolt Raduly, Oana Zănoagă, Lorand Magdo, Roxana Cojocneanu, Sergiu Paşca, Cristian Moldovan, Alin Iulian Moldovan, Adrian Bogdan Ţigu, Eugen Gurzău, Lorentz Jäntschi, Andreas Bender, Ioana Berindan-Neagoe
Jun 14, 2022
Triple negative breast cancer (TNBC) is currently associated with a lack of treatment options. Arsenic derivatives have shown antitumoral activity both in vitro and in vivo; however, their mode of action is not completely...
Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines.
Lavinia-Lorena Pruteanu, Cornelia Braicu, Dezső Módos, Maria-Ancuţa Jurj, Lajos-Zsolt Raduly, Oana Zănoagă, Lorand Magdo, Roxana Cojocneanu, Sergiu Paşca, Cristian Moldovan, Alin Iulian Moldovan, Adrian Bogdan Ţigu, Eugen Gurzău, Lorentz Jäntschi, Andreas Bender, Ioana Berindan-Neagoe
Apr 27, 2022
Triple negative breast cancer (TNBC) is currently associated with a lack of treatment options. Arsenic derivatives have shown antitumoral activity both in vitro and in vivo; however, their mode of action is not completely...
Computational optical imaging with a photonic lantern
Tim Birks, Debaditya Choudhury, Duncan McNicholl, Audrey Repetti, Itandehui Gris Sanchez, Shuhui Li, David Phillips, Graeme Whyte, Yves Wiaux, Robert Thomson
Oct 15, 2020
The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to...
Computational optical imaging with a photonic lantern
Tim Birks, Debaditya Choudhury, Duncan McNicholl, Audrey Repetti, Itandehui Gris Sanchez, Shuhui Li, David Phillips, Graeme Whyte, Yves Wiaux, Robert Thomson
Oct 15, 2020
The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to...
Pathogenic correlation between mosaic variegated aneuploidy 1 (MVA1) and a novel BUB1B variant
Piero Pavone, Xena Giada Pappalardo, Naira Mustafa, Raffaele Falsaperla, Simona Domenica Marino, Giovanni Corsello, Sebastiano Bianca, Enrico Parano, Martino Ruggieri
Oct 28, 2022
Optimized inducible shRNA and CRISPR/Cas9 platforms for $\textit{in vitro}$ studies of human development using hPSCs
A Bertero, M Pawlowski, D Ortmann, K Snijders, L Yiangou, M Cardoso de Brito, S Brown, WG Bernard, JD Cooper, E Giacomelli, L Gambardella, NRF Hannan, D Iyer, F Sampaziotis, F Serrano, MCF Zonneveld, S Sinha, M Kotter, L Vallier
Dec 14, 2016
Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors.
Fung-Wei Chang, Hueng-Chuen Fan, Jui-Ming Liu, Tai-Ping Fan, Jin Jing, Chia-Ling Yang, Ren-Jun Hsu
Mar 22, 2018
BACKGROUND: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding...
ATP-binding cassette sub-family G member 2 (ABCG2) Breast Cancer Estrogen estrogen receptor α (ERα) mitoxantrone (MX) ATP Binding Cassette Transporter Subfamily G Member 2 Adenosine Triphosphate Breast Neoplasms Cell Death Cell Hypoxia Drug Resistance Neoplasm Estrogens Female Gene Expression Regulation Neoplastic Genes Mitochondrial Humans MCF-7 Cells Models Biological Oligonucleotide Array Sequence Analysis Reactive Oxygen Species Receptors Estrogen
Alternating Hemiplegia of Childhood
Piero Pavone, Xena Giada Pappalardo, Naira Mustafa, Sung Yoon Cho, Dong Kyu Jin, Gemma Incorpora, Raffaele Falsaperla, Simona Domenica Marino, Giovanni Corsello, Enrico Parano, Martino Ruggieri
Feb 17, 2022
BACKGROUND: Alternating of Childhood (AHC) is an uncommon and complex disorder characterized by age of onset before 18 months with recurrent hemiplegia of one or either sides of the body or quadriplegia. The disorder is mainly...
Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele.
JA Jaffey, M Pavlick, CR Webster, GE Moore, KA McDaniel, SL Blois, EM Brand, CF Reich, L Motschenbacher, ET Hostnik, D Su, JA Lidbury, O Raab, SV Carr, KE Mabry, W Fox-Alvarez, S Townsend, S Palermo, Y Nakazono, K Ohno, E VanEerde, H Fieten, AH Hulsman, K Cooley-Lock, M Dunning, C Kisielewicz, A Zoia, M Caldin, A Conti-Patara, L Ross, C Mansfield, O Lynn, MA Claus, PJ Watson, A Swallow, DA Yool, K Gommeren, M Knops, V Ceplecha, H de Rooster, R Lobetti, O Dossin, F Jolivet, LG Papazoglou, MCF Pappalardo, F Manczur, Z Dudás-Györki, EJ O'Neill, C Martinez, A Gal, RL Owen, E Gunn, K Brown, LK Harder, C Griebsch, KP Anfinsen, TK Gron, V Marchetti, RM Heilmann, P Pazzi, AE DeClue
Oct 21, 2019
Gallbladder mucocele (GBM) is a common extra-hepatic biliary syndrome in dogs with death rates ranging from 7 to 45%. Therefore, the aim of this study was to identify the association of survival with variables that could be...
BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer.
C Gong, S Yao, AR Gomes, EPS Man, HJ Lee, G Gong, S Chang, S-B Kim, K Fujino, S-W Kim, SK Park, JW Lee, MH Lee, KOHBRA study group, US Khoo, EW-F Lam
Jan 08, 2019
BRCA1 mutation or depletion correlates with basal-like phenotype and poor prognosis in breast cancer but the underlying reason remains elusive. RNA and protein analysis of a panel of breast cancer cell lines revealed that BRCA1...
DSCAM-AS1-Driven Proliferation of Breast Cancer Cells Involves Regulation of Alternative Exon Splicing and 3′-End Usage
Jamal Elhasnaoui, Valentina Miano, Giulio Ferrero, Elena Doria, Antonette E. Leon, Aline S. C. Fabricio, Laura Annaratone, Isabella Castellano, Anna Sapino, Michele De Bortoli
Jun 04, 2020
DSCAM-AS1 is a cancer-related long noncoding RNA with higher expression levels in Luminal A, B, and HER2-positive Breast Carcinoma (BC), where its expression is strongly dependent on Estrogen Receptor Alpha (ERα). DSCAM-AS1...
Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam).
Fatemeh Farjadian, Somayeh Rezaeifard, Mahsa Naeimi, Sahar Ghasemi, Soliman Mohammadi-Samani, Mark E Welland, Lobat Tayebi
Oct 28, 2019
BACKGROUND: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating...
DOX PVCL Raft Cancer Drug delivery Lysine Caprolactam Cell Death Doxorubicin Drug Carriers Drug Delivery Systems Drug Liberation Humans Hydrogels Hydrogen-Ion Concentration Lysine MCF-7 Cells Molecular Weight Nanoparticles Phase Transition Polymers Proton Magnetic Resonance Spectroscopy spectroscopy Fourier Transform Infrared Temperature Toxicity Tests
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia.
Carme Camps, Harpreet K Saini, David R Mole, Hani Choudhry, Martin Reczko, José Afonso Guerra-Assunção, Ya-Min Tian, Francesca M Buffa, Adrian L Harris, Artemis G Hatzigeorgiou, Anton J Enright, Jiannis Ragoussis
Jan 23, 2018
BACKGROUND: In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide....
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