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Results: 54
Cerebrovascular Pressure Reactivity Monitoring Using Wavelet Analysis in Traumatic Brain Injury Patients
X Liu, J Donnelly, M Czosnyka, MJH Aries, K Brady, D Cardim, C Robba, M Cabeleira, D-J Kim, C Haubrich, PJ Hutchinson, P Smielewski
Jun 27, 2017
Pressure Reactivity-Based Optimal Cerebral Perfusion Pressure in a Traumatic Brain Injury Cohort.
J Donnelly, M Czosnyka, H Adams, C Robba, LA Steiner, D Cardim, B Cabella, X Liu, A Ercole, PJ Hutchinson, DK Menon, MJH Aries, P Smielewski
Mar 16, 2018
OBJECTIVES: Retrospective data from patients with severe traumatic brain injury (TBI) indicate that deviation from the continuously calculated pressure reactivity-based "optimal" cerebral perfusion pressure (CPPopt) is...
autoregulation Cerebral hemodynamics cerebral perfusion pressure Intracranial Pressure Traumatic brain injury Adult Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Disease Management Female Glasgow Outcome Scale Humans Intracranial Pressure Male Monitoring Physiologic Retrospective Studies Trauma Severity Indices
Anti-decubitus bed mattress may interfere with cerebrovascular pressure reactivity measures due to induced ICP and ABP cyclic peaks.
Tas Jeanette, Borg Melisa, Smielewski Peter, Czosnyka Marek, Beqiri Erta, Ercole Ari, Aries Marcel
Jan 29, 2020
Severe traumatic brain injury (TBI) patients are monitored with continuous arterial blood pressure (ABP) and intracranial pressure (ICP). The pressure reactivity index (PRx) is a frequently used correlation coefficient between...
Dynamic cerebral autoregulation estimates derived from near infrared spectroscopy and transcranial Doppler are similar after correction for transit time and blood flow and blood volume oscillations.
We analysed mean arterial blood pressure, cerebral blood flow velocity, oxygenated haemoglobin and deoxygenated haemoglobin signals to estimate dynamic cerebral autoregulation. We compared macrovascular (mean arterial blood...
Dynamic cerebral autoregulation group delay microvascular transit time near infrared spectroscopy Transcranial Doppler Adult Blood Flow Velocity blood pressure Blood Volume Cerebrovascular Circulation Female Hemodynamics Homeostasis Humans Hypercapnia Hypocapnia Male Oxyhemoglobins Rest spectroscopy Near-Infrared Ultrasonography Doppler Transcranial
Visualisation of the 'Optimal Cerebral Perfusion' Landscape in Severe Traumatic Brain Injury Patients.
Ari Ercole, Peter Smielewski, Marcel JH Aries, Robin Wesselink, Jan Willem J Elting, Joseph Donnelly, Marek Czosnyka, Natasha M Maurits
Dec 04, 2017
OBJECTIVE: An 'optimal' cerebral perfusion pressure (CPPopt) can be defined as the point on the CPP scale corresponding to the greatest autoregulatory capacity. This can be established by examining the pressure reactivity index...
Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension.
Chiara Robba, Joseph Donnelly, Rita Bertuetti, Danilo Cardim, Mypinder S Sekhon, Marcel Aries, Peter Smielewski, Hugh Richards, Marek Czosnyka
Aug 10, 2017
BACKGROUND: In many neurological diseases, intracranial pressure (ICP) is elevated and needs to be actively managed. ICP is typically measured with an invasive transducer, which carries risks. Non-invasive techniques for...
Enhanced Visualization of Optimal Cerebral Perfusion Pressure Over Time to Support Clinical Decision Making.
Marcel JH Aries, Robin Wesselink, Jan Willem J Elting, Joseph Donnelly, Marek Czosnyka, Ari Ercole, Natasha M Maurits, Peter Smielewski
Jan 26, 2016
Improving Prediction of Favourable Outcome After 6 Months in Patients with Severe Traumatic Brain Injury Using Physiological Cerebral Parameters in a Multivariable Logistic Regression Model.
Frank C Bennis, Bibi Teeuwen, Frederick A Zeiler, Jan Willem Elting, Joukje van der Naalt, Pietro Bonizzi, Tammo Delhaas, Marcel J Aries
Feb 12, 2021
BACKGROUND/OBJECTIVE: Current severe traumatic brain injury (TBI) outcome prediction models calculate the chance of unfavourable outcome after 6 months based on parameters measured at admission. We aimed to improve current...
Intraoperative non invasive intracranial pressure monitoring during pneumoperitoneum
C Robba, S Bacigaluppi, D Cardim, J Donnelly, MS Sekhon, MJ Aries, G Mancardi, A Booth, NL Bragazzi, M Czosnyka, B Matta
Aug 09, 2017
Intraoperative monitoring Non invasive intracranial pressure Optic nerve sheet diameter Pneumoperitonaeum Adult Aged Brain Mapping Humans Intracranial Hypertension Intracranial Pressure Magnetic Resonance Imaging Male Middle Aged Monitoring Intraoperative Monitoring Physiologic Optic Nerve pneumoperitoneum Prospective Studies Signal Processing Computer-Assisted Ultrasonography Doppler Transcranial
Improving Prediction of Favourable Outcome After 6 Months in Patients with Severe Traumatic Brain Injury Using Physiological Cerebral Parameters in a Multivariable Logistic Regression Model
Frank C. Bennis, Bibi Teeuwen, Frederick A. Zeiler, Jan Willem Elting, Joukje van der Naalt, Pietro Bonizzi, Tammo Delhaas, Marcel J. Aries
Sep 22, 2020
Abstract: Background/Objective: Current severe traumatic brain injury (TBI) outcome prediction models calculate the chance of unfavourable outcome after 6 months based on parameters measured at admission. We aimed to improve...
A kinetic analysis methodology to elucidate the roles of metal, support and solvent for the hydrogenation of 4-phenyl-2-butanone over Pt/TiO<inf>2</inf>
SK Wilkinson, I McManus, H Daly, JM Thompson, C Hardacre, N Sedaie Bonab, J Ten Dam, MJH Simmons, C D'Agostino, J McGregor, LF Gladden, EH Stitt
Jan 22, 2016
Optimal Cerebral Perfusion Pressure in Centers With Different Treatment Protocols.
Tim Howells, Peter Smielewski, Joseph Donnelly, Marek Czosnyka, Peter JA Hutchinson, David K Menon, Per Enblad, Marcel JH Aries
Mar 13, 2018
OBJECTIVES: The three centers in this study have different policies regarding cerebral perfusion pressure targets and use of vasopressors in traumatic brain injury patients. The aim was to determine if the different policies...
Improving Prediction of Favourable Outcome After 6 Months in Patients with Severe Traumatic Brain Injury Using Physiological Cerebral Parameters in a Multivariable Logistic Regression Model
Frank C. Bennis, Bibi Teeuwen, Frederick A. Zeiler, Jan Willem Elting, Joukje van der Naalt, Pietro Bonizzi, Tammo Delhaas, Marcel J. Aries
Feb 08, 2021
Abstract: Background/Objective: Current severe traumatic brain injury (TBI) outcome prediction models calculate the chance of unfavourable outcome after 6 months based on parameters measured at admission. We aimed to improve...
Continuous cerebrovascular reactivity monitoring in moderate/severe traumatic brain injury
Frederick A Zeiler, Ari Ercole, Marek Czosnyka, Peter Smielewski, Gregory Hawryluk, Peter JA Hutchinson, David K Menon, Marcel Aries
Nov 27, 2019
Impaired cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI) is known to be associated with worse global outcome at 6-12 months. As technology has improved over the past decades, monitoring of...
A Significance Test for Inferring Affiliation Networks from Spatio-Temporal Data.
Scientists have long been interested in studying social structures within groups of gregarious animals. However, obtaining evidence about interactions between members of a group is difficult. Recent technologies, such as Global...
Cerebral multimodality monitoring in adult neurocritical care patients with acute brain injury
Jeanette Tas, Marek Czosnyka, Iwan CC van der Horst, Soojin Park, Caroline van Heugten, Mypinder Sekhon, Chiara Robba, David K Menon, Frederick A Zeiler, Marcel JH Aries
Jan 22, 2023
Cerebral multimodality monitoring (MMM) is, even with a general lack of Class I evidence, increasingly recognized as a tool to support clinical decision-making in the neuroscience intensive care unit (NICU). However, literature...
Optimal Cerebral Perfusion Pressure Assessed with a Multi-Window Weighted Approach Adapted for Prospective Use
Erta Beqiri, Ari Ercole, Marcel J Aries, Manuel Cabeleira, Andras Czigler, Annalisa Liberti, Jeanette Tas, Joseph Donnelly, Xiuyun Liu, Marta Fedriga, Ka Hing Chu, Frederick A Zeiler, Marek Czosnyka, Peter Smielewski
Apr 16, 2020
BACKGROUND: Pressure reactivity index (PRx)-cerebral perfusion pressure (CPP) relationships over a given time period can be used to detect a value of CPP at which PRx shows the best autoregulation (optimal CPP, or CPPopt)....
Feasibility of individualised severe traumatic brain injury management using an automated assessment of optimal cerebral perfusion pressure
Erta Beqiri, Peter Smielewski, Chiara Robba, Marek Czosnyka, Manuel Teixeira Cabeleira, Jeanette Tas, Joseph Donnelly, Joanne G Outtrim, Peter Hutchinson, David Menon, Geert Meyfroidt, Bart Depreitere, Marcel J Aries, Ari Ercole
Aug 28, 2019
INTRODUCTION: Individualising therapy is an important challenge for intensive care of patients with severe traumatic brain injury (TBI). Targeting a cerebral perfusion pressure (CPP) tailored to optimise cerebrovascular...
COGiTATE Optimal CPP autoregulation individualised TBI management Intensive Care Precision Medicine Brain Injuries Traumatic Cerebrovascular Circulation Clinical Trials Phase II as Topic Feasibility Studies Humans Injury Severity Score Multicenter Studies as Topic Neurophysiological Monitoring Prospective Studies Randomized Controlled Trials as Topic
Monitoring of Optimal Cerebral Perfusion Pressure in Traumatic Brain Injured Patients Using a Multi-Window Weighting Algorithm.
Xiuyun Liu, Natasha M Maurits, Marcel JH Aries, Marek Czosnyka, Ari Ercole, Joseph Donnelly, Danilo Cardim, Dong-Joo Kim, Celeste Dias, Manuel Cabeleira, Peter Smielewski
Nov 23, 2017
Methods to identify an autoregulation guided "optimal" cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is...
CPPopt TBI cerebral autoregulation multi-window algorithm pressure reactivity index Adult Algorithms Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Data Interpretation Statistical Female Glasgow Coma Scale Glasgow Outcome Scale Humans Intracranial Pressure Male Middle Aged Neurophysiological Monitoring Outcome Assessment Health Care Reproducibility of Results Retrospective Studies Young Adult
Patient's Clinical Presentation and CPPopt Availability
Annalisa Liberti, Erta Beqiri, Ari Ercole, Manuel Cabeleira, Jeanette Tas, Frederick A Zeiler, Marek Czosnyka, Peter Smielewski, Marcel J Aries, CENTER-TBI High Resolution Substudy Participants and Investigators
Apr 17, 2020
BACKGROUND: The 'optimal' CPP (CPPopt) concept is based on the vascular pressure reactivity index (PRx). The feasibility and effectiveness of CPPopt guided therapy in severe traumatic brain injury (TBI) patients is currently...
Sheep recognize familiar and unfamiliar human faces from two-dimensional images.
© 2017 The Authors. One of the most important human social skills is the ability to recognize faces. Humans recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly presented images. Sheep are...
Published by: Royal Society open science
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
Jun 29, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
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