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Results: 395
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma.
Natalie Cook, Bristi Basu, Donna-Michelle Smith, Aarthi Gopinathan, Jeffry Evans, William P Steward, Daniel Palmer, David Propper, Balaji Venugopal, Mirela Hategan, D Alan Anthoney, Lisa V Hampson, Michael Nebozhyn, David Tuveson, Hayley Farmer-Hall, Helen Turner, Robert McLeod, Sarah Halford, Duncan Jodrell
Sep 20, 2018
BACKGROUND: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase inhibitors has been shown to be effective in pre-clinical models of pancreatic cancer, in combination with gemcitabine. METHODS...
Adult Aged Amyloid Precursor Protein Secretases Antineoplastic Combined Chemotherapy Protocols Bayes Theorem Benzene Derivatives Carcinoma Pancreatic Ductal Deoxycytidine Drug Administration Schedule Female Humans Infusions Intravenous Male Middle Aged Pancreatic Neoplasms Propionates Receptors Notch Signal Transduction Sulfones Gemcitabine
High resolution soft x-ray spectroscopy and the quest for the hot (5-10 MK) plasma in solar active regions
We discuss the diagnostics available to study the 5-10 MK plasma in the solar
corona, which is key to understanding the heating in the cores of solar active
regions. We present several simulated spectra, and show that...
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.
Fizzah A Choudry, Frederik O Bagger, Iain C Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F Martin, Anthony Mathur, Willem H Ouwehand, Elisa Laurenti, Sarah A Teichmann, Mattia Frontini
Mar 15, 2021
BACKGROUND: Megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release...
Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.
Jingyuan Tong, Ting Sun, Shihui Ma, Yanhong Zhao, Mankai Ju, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen J Loughran, Juan Li, Anthony R Green, Emery H Bresnick, Dong Wang, Tao Cheng, Lei Zhang, Lihong Shi
Feb 24, 2021
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse...
Analysis of microbial keratitis incidence, isolates and in-vitro antimicrobial susceptibility in the East of England
Malik Moledina, Harry W Roberts, Achyut Mukherjee, David Spokes, Dimitris Pimenides, Christopher Stephenson, Ramy Bassily, Madhavan S Rajan, James Myerscough
Feb 28, 2023
BACKGROUND/OBJECTIVES: To report the incidence, microbiological profile and in-vitro antimicrobial susceptibilities of microbial keratitis (MK) in the East of England (EoE) over a 6-year period. SUBJECTS/METHODS: A retrospective...
Variance reduction for Metropolis–Hastings samplers
Abstract We introduce a general framework that constructs estimators with reduced variance for random walk Metropolis and Metropolis-adjusted Langevin algorithms. The resulting estimators require...
Revealing the Drag Instability in One-fluid Nonideal Magnetohydrodynamic Simulations of a 1D Isothermal C-shock
Abstract
C-type shocks are believed to be ubiquitous in turbulent molecular clouds thanks to ambipolar diffusion. We investigate whether the drag instability in 1D isothermal...
The Domestication of the Seasons
Discussions of domestication and its associated genetic traits has focused upon dispersal mechanisms, for example in the rachis structure of cereals. Here we consider another trait of importance to domesticated crops –...
A Retrospective Study Comparing Crossed and Lateral Wire Configurations in Paediatric Supracondylar Fractures
BACKGROUND: Supracondylar fractures are common in children and are associated with significant morbidity. The purpose of our study was to assess and compare the clinical and radiological outcome of management of supracondylar...
Variance reduction for Metropolis–Hastings samplers
Abstract We introduce a general framework that constructs estimators with reduced variance for random walk Metropolis and Metropolis-adjusted Langevin algorithms. The resulting estimators require...
Cooling low-dimensional electron systems into the microkelvin regime.
Lev V Levitin, Harriet van der Vliet, Terje Theisen, Stefanos Dimitriadis, Marijn Lucas, Antonio D Corcoles, Ján Nyéki, Andrew J Casey, Graham Creeth, Ian Farrer, David Ritchie, James T Nicholls, John Saunders
Feb 03, 2022
Two-dimensional electron gases (2DEGs) with high mobility, engineered in semiconductor heterostructures host a variety of ordered phases arising from strong correlations, which emerge at sufficiently low temperatures. The 2DEG...
Cooling low-dimensional electron systems into the microkelvin regime.
Lev V Levitin, Harriet van der Vliet, Terje Theisen, Stefanos Dimitriadis, Marijn Lucas, Antonio D Corcoles, Ján Nyéki, Andrew J Casey, Graham Creeth, Ian Farrer, David A Ritchie, James T Nicholls, John Saunders
Mar 07, 2022
Two-dimensional electron gases (2DEGs) with high mobility, engineered in semiconductor heterostructures host a variety of ordered phases arising from strong correlations, which emerge at sufficiently low temperatures. The 2DEG...
Insights into the Control of Drug Release from Complex Immediate Release Formulations
Runqiao Dong, James C. DiNunzio, Brian P. Regler, Walter Wasylaschuk, Adam Socia, J. Axel Zeitler
Jun 25, 2021
The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release...
Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task.
RATIONALE: Maladaptive impulsivity is symptomatic of several neuropsychiatric disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and substance abuse disorders; paradigms designed to assess the...
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
Modelling the potential ecological niche of domesticated buckwheat in China
Abstract We present a species distribution model (SDM) of Fagopyrum esculentum (buckwheat) in China using present distribution data and estimates for the past based on...
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