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Results: 249
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma.
Natalie Cook, Bristi Basu, Donna-Michelle Smith, Aarthi Gopinathan, Jeffry Evans, William P Steward, Daniel Palmer, David Propper, Balaji Venugopal, Mirela Hategan, D Alan Anthoney, Lisa V Hampson, Michael Nebozhyn, David Tuveson, Hayley Farmer-Hall, Helen Turner, Robert McLeod, Sarah Halford, Duncan Jodrell
Sep 20, 2018
BACKGROUND: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase inhibitors has been shown to be effective in pre-clinical models of pancreatic cancer, in combination with gemcitabine. METHODS...
Adult Aged Amyloid Precursor Protein Secretases Antineoplastic Combined Chemotherapy Protocols Bayes Theorem Benzene Derivatives Carcinoma Pancreatic Ductal Deoxycytidine Drug Administration Schedule Female Humans Infusions Intravenous Male Middle Aged Pancreatic Neoplasms Propionates Receptors Notch Signal Transduction Sulfones Gemcitabine
A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain.
A Ranger, A Dunlop, K Hutchinson, H Convery, MK Maclennan, H Chantler, N Twyman, C Rose, D McQuaid, RA Amos, C Griffin, NM deSouza, E Donovan, E Harris, CE Coles, A Kirby
Jun 05, 2018
AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be...
High resolution soft x-ray spectroscopy and the quest for the hot (5-10 MK) plasma in solar active regions
We discuss the diagnostics available to study the 5-10 MK plasma in the solar
corona, which is key to understanding the heating in the cores of solar active
regions. We present several simulated spectra, and show that...
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.
Fizzah A Choudry, Frederik O Bagger, Iain C Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F Martin, Anthony Mathur, Willem H Ouwehand, Elisa Laurenti, Sarah A Teichmann, Mattia Frontini
Mar 15, 2021
BACKGROUND: Megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release...
Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.
Jingyuan Tong, Ting Sun, Shihui Ma, Yanhong Zhao, Mankai Ju, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen J Loughran, Juan Li, Anthony R Green, Emery H Bresnick, Dong Wang, Tao Cheng, Lei Zhang, Lihong Shi
Feb 24, 2021
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse...
Mafic tiers and transient mushes
J Maclennan
Jan 17, 2019
It is well established that magmatism is trans-crustal, with melt storage and processing occurring over a range of depths. Development of this conceptual model was based on observations of the products of magmatism at spreading...
Analysis of microbial keratitis incidence, isolates and in-vitro antimicrobial susceptibility in the East of England
Malik Moledina, Harry W Roberts, Achyut Mukherjee, David Spokes, Dimitris Pimenides, Christopher Stephenson, Ramy Bassily, Madhavan S Rajan, James Myerscough
Feb 28, 2023
BACKGROUND/OBJECTIVES: To report the incidence, microbiological profile and in-vitro antimicrobial susceptibilities of microbial keratitis (MK) in the East of England (EoE) over a 6-year period. SUBJECTS/METHODS: A retrospective...
The Prevention and Nursing Care of Common Injuries in Long-Distance Running of College Students
As a favorite sport of teachers and students, long-distance running can enhance physical fitness. However, due to nonstandard movements in sports, teachers and students get injured psysically. Taking the prevention of...
Published by: IGI Global Scientific Publishing
Microstructural constraints on magmatic mushes under Kīlauea Volcano, Hawai'i.
Distorted olivines of enigmatic origin are ubiquitous in erupted products from a wide range of volcanic systems (e.g., Hawai'i, Iceland, Andes). Investigation of these features at Kīlauea Volcano, Hawai'i, using an integrative...
Published by: Nature Communications
Clinopyroxene Dissolution Records Rapid Magma Ascent
Magma ascent rates control volcanic eruption styles. However, the rates at which basaltic magmas ascend through the crust remain highly uncertain. Although recent studies have successfully exploited records of decompression...
Microstructural constraints on magmatic mushes under Kīlauea Volcano, Hawai'i.
Distorted olivines of enigmatic origin are ubiquitous in erupted products from a wide range of volcanic systems (e.g., Hawai'i, Iceland, Andes). Investigation of these features at Kīlauea Volcano, Hawai'i, using an integrative...
Global influence of mantle temperature and plate thickness on intraplate volcanism
Abstract: The thermochemical structure of lithospheric and asthenospheric mantle exert primary controls on surface topography and volcanic activity. Volcanic rock compositions and mantle seismic velocities provide indirect...
Monoclonal Antibodies of a Diverse Isotype Induced by an O-Antigen Glycoconjugate Vaccine Mediate In Vitro and In Vivo Killing of African Invasive Nontyphoidal Salmonella.
Yun Shan Goh, Simon Clare, Francesca Micoli, Allan Saul, Pietro Mastroeni, Calman A MacLennan
Jul 14, 2015
Millennial storage of near-Moho magma.
The lower crust plays a critical role in the processing of mantle melts and the triggering of volcanic eruptions by supply of magma from greater depth. Our understanding of the deeper parts of magmatic systems is obscured by...
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