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Ambulatory Thoracoscopic Pleurodesis Combined With Indwelling Pleural Catheter in Malignant Pleural Effusion
Background and Objective: Malignant pleural effusion (MPE) often results in debilitating symptoms. Relief of dyspnoea and improvement in quality of life can be achieved with either talc pleurodesis or insertion of an indwelling...
Ambulatory Thoracoscopic Pleurodesis Combined With Indwelling Pleural Catheter in Malignant Pleural Effusion.
Background and Objective: Malignant pleural effusion (MPE) often results in debilitating symptoms. Relief of dyspnoea and improvement in quality of life can be achieved with either talc pleurodesis or insertion of an indwelling...
Identification of functional long non-coding RNAs in C. elegans.
Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P Ponting, Eric A Miska, Wilfried Haerty
May 09, 2019
BACKGROUND: Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the...
Oxygen regulation of TET enzymes.
Hypoxia has a significant impact on many physiological and pathological processes. Over the recent years, its role in modulation of epigenetic remodelling has also become clearer. In cancer, low oxygen environments and aberrant...
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
Isabela Cunha Navarro, Francesca Tuorto, David Jordan, Carine Legrand, Jonathan Price, Fabian Braukmann, Alan G Hendrick, Alper Akay, Annika Kotter, Mark Helm, Frank Lyko, Eric A Miska
Nov 12, 2020
Methylation of carbon-5 of cytosines (m5 C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m5 C-methyltransferases have been studied, the impact of the global cytosine-5...
Caenorhabditis elegans 5-Methylcytosine NSUN RNA modifications translation efficiency 5-Methylcytosine Adaptation Physiological Animals CRISPR-Cas Systems Caenorhabditis elegans Cytosine Gene Editing Heat-Shock Response Hot Temperature Leucine Methyltransferases Mitochondria Proline Protein Biosynthesis RNA RNA processing Post-Transcriptional Ribosomes
Oxygen regulation of TET enzymes.
Hypoxia has a significant impact on many physiological and pathological processes. Over the recent years, its role in modulation of epigenetic remodelling has also become clearer. In cancer, low oxygen environments and aberrant...
A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly.
Eyal Maori, Isabela Cunha Navarro, Humberto Boncristiani, David J Seilly, Konrad Ludwig Moritz Rudolph, Alexandra Sapetschnig, Chi-Chuan Lin, John Edward Ladbury, Jay Daniel Evans, Jonathan Luke Heeney, Eric Alexander Miska
Apr 26, 2019
Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages
Milos Gojkovic, Pedro P Cunha, Gabriella S Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S Johnson
Jun 10, 2021
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence...
HIF Nitric oxide prolyl hydroxylase inhibitors Hypoxia immunosuppression Myeloid Cells von Hippel-Lindau. Adaptive Immunity Animals CD8-Positive T-Lymphocytes Cell Hypoxia Cell Line Tumor Cell Proliferation Coculture Techniques Glycine Humans Hypoxia-Inducible Factor 1 alpha Subunit Isoquinolines MACROPHAGES Mice Mice Transgenic Oxygen Von Hippel-Lindau Tumor Suppressor Protein
Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses.
David Bargiela, Pedro P Cunha, Pedro Veliça, Iosifina P Foskolou, Laura Barbieri, Helene Rundqvist, Randall S Johnson
Apr 06, 2022
Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages
Milos Gojkovic, Pedro P. Cunha, Gabriella S. Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S. Johnson
May 26, 2021
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence...
Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses.
David Bargiela, Pedro P Cunha, Pedro Veliça, Iosifina Foskolou, Laura Barbieri, Helene Rundqvist, Randall Johnson
Mar 03, 2022
Targeting T cell metabolism is an established method of immunomodulation. Following activation, T cells engage distinct metabolic programs leading to the uptake and processing of nutrients that determine cell proliferation and...
Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells.
Laura Barbieri, Pedro Veliça, Paulo A Gameiro, Pedro P Cunha, Iosifina P Foskolou, Eric Rullman, David Bargiela, Randall S Johnson, Helene Rundqvist
Mar 13, 2023
Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells.
Laura Barbieri, Pedro Veliça, Paulo A Gameiro, Pedro P Cunha, Iosifina P Foskolou, Eric Rullman, David Bargiela, Randall S Johnson, Helene Rundqvist
Apr 15, 2023
metabolism Oxygen lactate Transcriptome CD8+ T cells CD8-Positive T-Lymphocytes T-Lymphocytes Cytotoxic Animals Humans Mice Lactic Acid Sodium Lactate
Published by: Frontiers in immunology
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
Ludimila Dias Almeida, Ali Salim Faraj Silva, Daniel Calixto Mota, Adrielle Ayumi Vasconcelos, Antônio Pedro Camargo, Gabriel Silva Pires, Monique Furlan, Helena Martins Ribeiro da Cunha Freire, Angélica Hollunder Klippel, Suélen Fernandes Silva, Cleslei Fernando Zanelli, Marcelo Falsarella Carazzolle, Stephen G Oliver, Elizabeth Bilsland
Jan 28, 2022
Saccharomyces cerevisiae drug efflux drug transport drug uptake genetic interactions nonessential transporter double-deletion library plasma membrane transporter xenobiotics Yeast ATP-Binding Cassette Transporters Antifungal Agents Biological Transport Gene Deletion Gene Library High-Throughput Screening Assays Monosaccharide Transport Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins xenobiotics
The impact of modes of administration on self-reports of offending
Hugo S Gomes, David P Farrington, Marvin D Krohn, Ana Cunha, Julia Jurdi, Bárbara Sousa, Diogo Morgado, Joseph Hoft, Elizabeth Hartsell, Leigh Kassem, Ângela Maia
Oct 28, 2022
OBJECTIVES: Current knowledge about the causes of offending behavior is heavily reliant on self-reports of offending (SRO). However, methodological research on the impact of modes of administration on SRO is very scarce....
The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.
Ahmet C Berkyurek, Giulia Furlan, Lisa Lampersberger, Toni Beltran, Eva-Maria Weick, Emily Nischwitz, Isabela Cunha Navarro, Fabian Braukmann, Alper Akay, Jonathan Price, Falk Butter, Peter Sarkies, Eric A Miska
Mar 19, 2021
PIWI-interacting RNAs (piRNAs) are genome-encoded small RNAs that regulate germ cell development and maintain germline integrity in many animals. Mature piRNAs engage Piwi Argonaute proteins to silence complementary transcripts...
Cardiovascular and enjoyment comparisons after active videogame and running in type 1 diabetes patients
Jorge Luiz de Brito Gomes, Denise Maria Martins Vancea, Rodrigo Cappato de Araújo, Pooya Soltani, Fernando José de Sá Pereira Guimarães, Manoel da Cunha Costa
Oct 31, 2021
Background: Active videogames (AVGs) have been primarily studied in healthy individuals. To use the technology in type 1 diabetes mellitus (T1DM) patients, cardiovascular and enjoyment responses should be studied and compared...
cardiovascular system Diabetes mellitus Exercise motivation Running Videogames /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2742 name=Rehabilitation /dk/atira/pure/subjectarea/asjc/1700/1706 name=Computer Science Applications /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Cardiovascular and enjoyment comparisons after active videogame and running in type 1 diabetes patients
Jorge Luiz de Brito Gomes, Denise Maria Martins Vancea, Rodrigo Cappato de Araújo, Pooya Soltani, Fernando José de Sá Pereira Guimarães, Manoel da Cunha Costa
Oct 31, 2021
Background: Active videogames (AVGs) have been primarily studied in healthy individuals. To use the technology in type 1 diabetes mellitus (T1DM) patients, cardiovascular and enjoyment responses should be studied and compared...
cardiovascular system Diabetes mellitus Exercise motivation Running Videogames /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2742 name=Rehabilitation /dk/atira/pure/subjectarea/asjc/1700/1706 name=Computer Science Applications /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.
Baroj Abdulkarim, Marc Nicolino, Mariana Igoillo-Esteve, Mathilde Daures, Sophie Romero, Anne Philippi, Valérie Senée, Miguel Lopes, Daniel A Cunha, Heather P Harding, Céline Derbois, Nathalie Bendelac, Andrew T Hattersley, Décio L Eizirik, David Ron, Miriam Cnop, Cécile Julier
Aug 09, 2017
A massive galaxy in its core formation phase three billion years after the Big Bang
E. Nelson, P. van Dokkum, M. Franx, G. Brammer, I. Momcheva, N. F. Schreiber, E. Da Cunha, L. Tacconi, R. Bezanson, A. Kirkpatrick, J. Leja, H.-W. Rix, R. Skelton, A. van der Wel, K. Whitaker, S. Wuyts
Sep 18, 2014
Most massive galaxies are thought to have formed their dense stellar cores in early cosmic epochs1, 2, 3. Previous studies have found galaxies with high gas velocity dispersions4 or small apparent sizes5, 6, 7, but so far no...
The Lived Experience of Paradox
Camille Pradies, Ina Aust, Rebecca Bednarek, Julia Brandl, Simone Carmine, Joe Cheal, Miguel Pina e Cunha, Medhanie Gaim, Anne Keegan, Jane K. Lê, Ella Miron-Spektor, Rikke Kristine Nielsen, Vanessa Pouthier, Garima Sharma, Jennifer L. Sparr, Russ Vince, Joshua Keller
Apr 01, 2021
Organizational life has always been filled with tensions, but the COVID-19 pandemic is amplifying this experience in fundamental ways. Across the globe, employees have had to quickly adjust to working from home, striving to...
The Lived Experience of Paradox
Camille Pradies, Ina Aust, Rebecca Bednarek, Julia Brandl, Simone Carmine, Joe Cheal, Miguel Pina e Cunha, Medhanie Gaim, Anne Keegan, Jane K. Lê, Ella Miron-Spektor, Rikke Kristine Nielsen, Vanessa Pouthier, Garima Sharma, Jennifer L. Sparr, Russ Vince, Joshua Keller
Apr 01, 2021
Organizational life has always been filled with tensions, but the COVID-19 pandemic is amplifying this experience in fundamental ways. Across the globe, employees have had to quickly adjust to working from home, striving to...
A massive galaxy in its core formation phase three billion years after the Big Bang
E. Nelson, P. van Dokkum, M. Franx, G. Brammer, I. Momcheva, N. F. Schreiber, E. Da Cunha, L. Tacconi, R. Bezanson, A. Kirkpatrick, J. Leja, H.-W. Rix, R. Skelton, A. van der Wel, K. Whitaker, S. Wuyts
Sep 18, 2014
Most massive galaxies are thought to have formed their dense stellar cores in early cosmic epochs1, 2, 3. Previous studies have found galaxies with high gas velocity dispersions4 or small apparent sizes5, 6, 7, but so far no...
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