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Results: 25
A risk-informed decision support tool for the strategic asset management of railway track infrastructure
The provision of safe, efficient, reliable and affordable railway transport requires the railway track infrastructure to be maintained to an appropriate condition. Given the constrained budgets under which the...
Continuous Indexing of Fibrosis (CIF)
Hosuk Ryou, Korsuk Sirinukunwattana, Alan Aberdeen, Gillian Grindstaff, Bernadette J Stolz, Helen Byrne, Heather A Harrington, Nikolaos Sousos, Anna L Godfrey, Claire N Harrison, Bethan Psaila, Adam J Mead, Gabrielle Rees, Gareth DH Turner, Jens Rittscher, Daniel Royston
Feb 09, 2023
The grading of fibrosis in myeloproliferative neoplasms (MPN) is an important component of disease classification, prognostication and monitoring. However, current fibrosis grading systems are only semi-quantitative and fail to...
Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis.
Jeanne F Rivera, April J Baral, Fatima Nadat, Grace Boyd, Rachael Smyth, Hershna Patel, Emma L Burman, Ghadah Alameer, Sally A Boxall, Brian R Jackson, E Joanna Baxter, Peter Laslo, Anthony R Green, David G Kent, Ann Mullally, Edwin Chen
Apr 09, 2021
Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALRdel52) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation...
Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.
Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T Prchal, Katarzyna Piwocka, Alison R Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R Green, Radek C Skoda, Tomasz Skorski
May 31, 2018
Myeloproliferative neoplasms (MPNs) often carry JAK2(V617F), MPL(W515L), or CALR(del52) mutations. Current treatment options for MPNs include cytoreduction by hydroxyurea and JAK1/2 inhibition by ruxolitinib, both of which are...
1.3-W Ripple-Free Superluminescent Diode
This letter presents the experimental characterization of tapered and stripe superluminescent diodes fabricated from 980-nm high-power triple quantum-well InGaAs–AlGaAs semiconductor material. Record output powers in excess of...
Ripple-free high-power super-luminescent diode arrays
This paper presents the experimental and theoretical characterisation of arrays of tapered super-luminescent diodes to achieve very high, broad-band, ripple-free optical output. These arrays were fabricated from 980-nm...
Ripple-free high-power super-luminescent diode arrays
This paper presents the experimental and theoretical characterisation of arrays of tapered super-luminescent diodes to achieve very high, broad-band, ripple-free optical output. These arrays were fabricated from 980-nm...
Methylation age as a correlate for allele burden, disease status, and clinical response in myeloproliferative neoplasm patients treated with vorinostat.
Suzanne McPherson, Graeme Greenfield, Christen Andersen, Jacob Grinfeld, Hans C Hasselbalch, Jyoti Nangalia, Ken I Mills, Mary F McMullin
Oct 04, 2019
The myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal neoplastic disorders. Driver mutations in JAK2, CALR, and MPL genes have been identified in the majority of cases. Alongside these, an increasing number...
1.3-W Ripple-Free Superluminescent Diode
This letter presents the experimental characterization of tapered and stripe superluminescent diodes fabricated from 980-nm high-power triple quantum-well InGaAs–AlGaAs semiconductor material. Record output powers in excess of...
A review of techniques to mitigate jamming in electromechanical actuators for safety critical applications
This paper presents a review of techniques to mitigate jamming in Electromechanical Actuators (EMA) for safety critical applications in aerospace. Published progress to date is evaluated, with the remaining challenges...
aerospace Ballscrew Electromechanical actuators Health monitoring jamming Prognostics /dk/atira/pure/subjectarea/asjc/1700/1701 name=Computer Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2213 name=Safety, Risk, Reliability and Quality /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
The Lantern Vol. 66, No. 1, Fall 1998
Jennifer Herbst, Amanda Chiampi, Lou Nemphos, Geoffrey Mills, Jeffrey Church, Oana Nechita, Tom Howard, Rebecca Class, Andrew Gerchak, Chris Cocca, Monica Stahl, Daniel Tavares
Jan 01, 0001
Curled Bruised Accident Prone Bob or Beatrice or Something Burrow The French Door Before the War: On Earth as it is in Texas Love Seat Delusionus Prime Delineate The Color of Coffee A Memory August...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
A review of techniques to mitigate jamming in electromechanical actuators for safety critical applications
This paper presents a review of techniques to mitigate jamming in Electromechanical Actuators (EMA) for safety critical applications in aerospace. Published progress to date is evaluated, with the remaining challenges...
aerospace Ballscrew Electromechanical actuators Health monitoring jamming Prognostics /dk/atira/pure/subjectarea/asjc/1700/1701 name=Computer Science (miscellaneous) /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2213 name=Safety, Risk, Reliability and Quality /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Using Probabilistic Fault Tree Analysis and Monte Carlo Simulation to Examine the Likelihood of Risks Associated with Ballasted Railway Drainage Failure
Inadequate track drainage can lead to a variety of issues, including flooding, accelerated track degradation, and progressive or sudden failure of railway track, slope, or embankment. These can result in unplanned track...
Kristianto Usman, Michael Peter Nicholas Burrow, Gurmel Singh Ghataora, Manu Sasidharan
Apr 30, 2021
Pathogenesis of Myeloproliferative Disorders.
Myeloproliferative neoplasms (MPNs) are a set of chronic hematopoietic neoplasms with overlapping clinical and molecular features. Recent years have witnessed considerable advances in our understanding of their pathogenetic...
'Getting to Know Me'
Ruth Elvish, Simon Burrow, Rosanne Cawley, Kathryn Harney, Pat Graham, Mark Pilling, Julie Gregory, Pamela Roach, Jane Fossey, John Keady
Jun 08, 2018
Synthesis of unprotected glyco-alkynones via molybdenum-catalyzed carbonylative Sonogashira cross-coupling reaction.
Mariana P Darbem, Henrique A Esteves, Robert A Burrow, Antônio A Soares-Paulino, Daniel C Pimenta, Hélio A Stefani
May 17, 2022
Herein we report a novel Mo-catalyzed carbonylative Sonogashira cross-coupling between 2-iodoglycals and terminal alkynes. The reaction displays major improvements compared to a related Pd-catalyzed procedure previously...
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J Farady, Simón Méndez-Ferrer, Radek C Skoda
Oct 15, 2022
Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels...
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J Farady, Simón Méndez-Ferrer, Radek C Skoda
Sep 13, 2022
Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels...
Eliglustat maintains long-term clinical stability in patients with Gaucher disease type 1 stabilized on enzyme therapy
TM Cox, G Drelichman, R Cravo, M Balwani, TA Burrow, AM Martins, E Lukina, B Rosenbloom, O Goker-Alpan, N Watman, A El-Beshlawy, PS Kishnani, ML Pedroso, SJM Gaemers, R Tayag, MJ Peterschmitt
Apr 20, 2017
Occurrence of <em>Vibrio</em> and <em>Salmonella</em> species in mussels (<em>Mytilus</em> <em>galloprovincialis</em>) collected along the Moroccan Atlantic coast
Hasna Mannas, Rachida Mimouni, Noureddine Chaouqy, Fatima Hamadi, Jaime Martinez-Urtaza
May 24, 2014
This study reports the occurrence of different Vibrio and Salmonella species in 52 samples of Mytilus galloprovincialis collected from four sites along the Atlantic coast between Agadir and...
Mutant Calreticulin in the Myeloproliferative Neoplasms.
Mutations in the gene for calreticulin (CALR) were identified in the myeloproliferative neoplasms (MPNs) essential thrombocythaemia (ET) and primary myelofibrosis (MF) in 2013; in combination with previously described mutations...
Mutant Calreticulin in the Myeloproliferative Neoplasms.
Daniel Prins, Carlos González Arias, Thorsten Klampfl, Jacob Grinfeld, Anthony R. Green
Mar 25, 2020
AbstractMutations in the gene for calreticulin (CALR) were identified in the myeloproliferative neoplasms (MPNs) essential thrombocythaemia (ET) and primary myelofibrosis (MF) in 2013; in combination with previously described...
Published by: HemaSphere
Occurrence of <em>Vibrio</em> and <em>Salmonella</em> species in mussels (<em>Mytilus</em> <em>galloprovincialis</em>) collected along the Moroccan Atlantic coast
Hasna Mannas, Rachida Mimouni, Noureddine Chaouqy, Fatima Hamadi, Jaime Martinez-Urtaza
May 24, 2014
This study reports the occurrence of different Vibrio and Salmonella species in 52 samples of Mytilus galloprovincialis collected from four sites along the Atlantic coast between Agadir and...
JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics.