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Results: 1053
Pathogenic variants in MT-ATP6
Yi Shiau Ng, Mika H Martikainen, Gráinne S Gorman, Alasdair Blain, Enrico Bugiardini, Apphia Bunting, Andrew M Schaefer, Charlotte L Alston, Emma L Blakely, Sunil Sharma, Imelda Hughes, Albert Lim, Christian de Goede, Meriel McEntagart, Stefan Spinty, Iain Horrocks, Mark Roberts, Cathy E Woodward, Patrick F Chinnery, Rita Horvath, Victoria Nesbitt, Carl Fratter, Joanna Poulton, Michael G Hanna, Robert DS Pitceathly, Robert W Taylor, Doug M Turnbull, Robert McFarland
Jun 28, 2019
Distinct clinical syndromes have been associated with pathogenic MT-ATP6 variants. In this cohort study, we identified 125 individuals (60 families) including 88 clinically affected individuals and 37 asymptomatic carriers....
MT-HESS
Alex Lewin, Habib Saadi, James E Peters, Aida Moreno-Moral, James C Lee, Kenneth GC Smith, Enrico Petretto, Leonardo Bottolo, Sylvia Richardson
Sep 05, 2018
MOTIVATION: Analysing the joint association between a large set of responses and predictors is a fundamental statistical task in integrative genomics, exemplified by numerous expression Quantitative Trait Loci (eQTL) studies. Of...
Algorithms Animals Bayes Theorem Diabetes mellitus Type 1 Gene Expression Regulation Gene Regulatory Networks Genomics Humans Inflammation Inflammatory Bowel Diseases Models Theoretical Organ Specificity Polymorphism Single Nucleotide Programming Languages Quantitative Trait Loci Rats Software Tissue Distribution
Next steps in the footprint project
Abstract: Reduction of the carbon footprint of historic buildings is urgent, given their exceptionally large energy demand. In this study, the performance and cost of a roof mounted photovoltaic system has been simulated for...
Faraday pilot-wave dynamics
A millimetric droplet bouncing on the surface of a vibrating fluid bath can self-propel by virtue of a resonant interaction with its own wave field. This system represents the first known example of a pilot-wave system of the...
Faraday pilot-wave dynamics
A millimetric droplet bouncing on the surface of a vibrating fluid bath can self-propel by virtue of a resonant interaction with its own wave field. This system represents the first known example of a pilot-wave system of the...
Designing Controlled Chinese Rules for MT Pre-Editing of Product Description Text
The study aims to investigate how pre-editing based on controlled Chinese rules can be an effective approach to improving Chinese-to-English machine translation (MT) output. Based on the analysis of comparable texts, and by...
Published by: IGI Global Scientific Publishing
GRAPPA 2021 Pilot Grant Award Reports
Fazira R Kasiem, Daisuke Yamada, Josefina Marin, Marijn Vis, William Tillett, Samuel T Hwang, Enrique R Soriano, Oliver FitzGerald, April W Armstrong
Nov 30, 2023
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot grant awards help support young researchers starting their careers while also encouraging them to develop a focus on psoriatic disease....
GRAPPA 2021 Pilot Grant Award Reports
Fazira R Kasiem, Daisuke Yamada, Josefina Marin, Marijn Vis, William Tillett, Samuel T Hwang, Enrique R Soriano, Oliver FitzGerald, April W Armstrong
Nov 30, 2023
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot grant awards help support young researchers starting their careers while also encouraging them to develop a focus on psoriatic disease....
Pilot Evaluation Report
Neil Howard
Mar 01, 2020
The SaVa pilot partners Ecobank, Terre des Hommes (TdH), the African Movement of Working Children and Youth (AMWCY), and the University of Bath (UoB). Its primary aim has been to offer street-connected working and migrant...
street children microbanking mobile banking child participation financial inclusion Action Research /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Pilot study
In an attempt to improve attention bias modification (ABM), we tested whether an attentional training protocol which featured monetary operant conditioning of eye-gaze to avoid alcohol stimuli in alcohol-dependent patients could...
The BARCODE1 Pilot
Sarah Benafif, Holly Ni Raghallaigh, Eva McGrowder, Edward J Saunders, Mark N Brook, Sibel Saya, Reshma Rageevakumar, Sarah Wakerell, Denzil James, Anthony Chamberlain, Natalie Taylor, Matthew Hogben, Barbara Benton, Lucia D'Mello, Kathryn Myhill, Christos Mikropoulos, Hywel Bowen-Perkins, Imran Rafi, Michelle Ferris, Andre Beattie, Shophia Kuganolipava, Tamsin Sevenoaks, Juliet Bower, Pardeep Kumar, Steven Hazell, Nandita M deSouza, Antonis Antoniou, Elizabeth Bancroft, Zsofia Kote-Jarai, Rosalind Eeles
Jul 21, 2021
OBJECTIVES: To assess the feasibility and uptake of a community-based prostate cancer (PCa) screening programme selecting men according to their genetic risk of PCa. To assess the uptake of PCa screening investigations by men...
Pilot Evaluation Report
Neil Howard
Mar 01, 2020
The SaVa pilot partners Ecobank, Terre des Hommes (TdH), the African Movement of Working Children and Youth (AMWCY), and the University of Bath (UoB). Its primary aim has been to offer street-connected working and migrant...
street children microbanking mobile banking child participation financial inclusion Action Research /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions
Faraday pilot-wave dynamics in a circular corral
A millimetric droplet of silicone oil may bounce and self-propel on the free surface of a vertically vibrating fluid bath due to the droplet's interaction with its accompanying Faraday wave field. This hydrodynamic pilot-wave...
Faraday pilot-wave dynamics in a circular corral
A millimetric droplet of silicone oil may bounce and self-propel on the free surface of a vertically vibrating fluid bath due to the droplet's interaction with its accompanying Faraday wave field. This hydrodynamic pilot-wave...
Results of a single-arm pilot study of 32P microparticles in unresectable locally advanced pancreatic adenocarcinoma with gemcitabine/nab-paclitaxel or FOLFIRINOX chemotherapy.
PJ Ross, HS Wasan, D Croagh, M Nikfarjam, N Nguyen, M Aghmesheh, AM Nagrial, D Bartholomeusz, A Hendlisz, T Ajithkumar, C Iwuji, NE Wilson, DM Turner, DC James, E Young, MT Harris
Jan 28, 2022
BACKGROUND: Unresectable locally advanced pancreatic cancer (LAPC) is generally managed with chemotherapy or chemoradiotherapy, but prognosis is poor with a median survival of ∼13 months (or up to 19 months in some studies). We...
(32)P microparticles Brachytherapy local disease control rate locally advanced pancreatic cancer safety profile Adenocarcinoma Adult Albumins Antineoplastic Combined Chemotherapy Protocols Deoxycytidine Fluorouracil Humans Irinotecan Leucovorin Oxaliplatin Paclitaxel Pancreatic Neoplasms Pilot Projects Gemcitabine
Identification and evaluation of risk of generalizability biases in pilot versus efficacy/effectiveness trials
Michael W. Beets, R. Glenn Weaver, John P. A. Ioannidis, Marco Geraci, Keith Brazendale, Lindsay Decker, Anthony D. Okely, David Lubans, Esther van Sluijs, Russell Jago, Gabrielle Turner-McGrievy, James Thrasher, Xiaming Li, Andrew J. Milat
Feb 10, 2021
Abstract: Background: Preliminary evaluations of behavioral interventions, referred to as pilot studies, predate the conduct of many large-scale efficacy/effectiveness trial. The ability of a pilot study to inform an...
Identification and evaluation of risk of generalizability biases in pilot versus efficacy/effectiveness trials
Michael W Beets, R Glenn Weaver, John P A Ioannidis, Marco Geraci, Keith Brazendale, Lindsay Decker, Anthony D Okely, David Lubans, Esther van Sluijs, Russell Jago, Gabrielle Turner-McGrievy, James Thrasher, Xiaming Li, Andrew J Milat
Mar 14, 2020
BACKGROUND:Preliminary evaluations of behavioral interventions, referred to as pilot studies, predate the conduct of many large-scale efficacy/effectiveness trial. The ability of a pilot study to inform an efficacy/effectiveness...
Deadzone compensation control based on detection of micro flow rate in pilot stage of proportional directional valve
The pilot operated proportional directional valves (POPDVs) with a flow rate ranging from 100 to 1000 L/min are widely used in electro-hydraulic systems (EHSs). The deadzone of the pilot stage valve and its control compensation...
Deadzone compensation Deadzone detection Micro flow rate Pilot operated Position control Proportional directional valve /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/1700/1706 name=Computer Science Applications /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
Development and testing of an intervention to increase staff knowledge and confidence in responding to health anxiety in the context of cognitive decline
Background: Memory complaint in the absence of organic pathology is a common phenomenon accounting for up to one third of patients presenting to memory clinics. Health anxiety has been specifically linked to dementia worry and...
Development and testing of an intervention to increase staff knowledge and confidence in responding to health anxiety in the context of cognitive decline
Background: Memory complaint in the absence of organic pathology is a common phenomenon accounting for up to one third of patients presenting to memory clinics. Health anxiety has been specifically linked to dementia worry and...
Identification and evaluation of risk of generalizability biases in pilot versus efficacy/effectiveness trials
Michael W. Beets, R. Glenn Weaver, John P. A. Ioannidis, Marco Geraci, Keith Brazendale, Lindsay Decker, Anthony D. Okely, David Lubans, Esther van Sluijs, Russell Jago, Gabrielle Turner-McGrievy, James Thrasher, Xiaming Li, Andrew J. Milat
Jun 06, 2020
Abstract: Background: Preliminary evaluations of behavioral interventions, referred to as pilot studies, predate the conduct of many large-scale efficacy/effectiveness trial. The ability of a pilot study to inform an...
Deadzone compensation control based on detection of micro flow rate in pilot stage of proportional directional valve
The pilot operated proportional directional valves (POPDVs) with a flow rate ranging from 100 to 1000 L/min are widely used in electro-hydraulic systems (EHSs). The deadzone of the pilot stage valve and its control compensation...
Deadzone compensation Deadzone detection Micro flow rate Pilot operated Position control Proportional directional valve /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/1700/1706 name=Computer Science Applications /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics
UK Lung Cancer RCT Pilot Screening Trial
JK Field, SW Duffy, DR Baldwin, DK Whynes, A Devaraj, KE Brain, T Eisen, J Gosney, BA Green, JA Holemans, T Kavanagh, KM Kerr, M Ledson, KJ Lifford, FE McRonald, A Nair, RD Page, MKB Parmar, DM Rassl, RC Rintoul, NJ Screaton, NJ Wald, D Weller, PR Williamson, G Yadegarfar, DM Hansell
Sep 05, 2018
BACKGROUND: Lung cancer screening using low-dose CT (LDCT) was shown to reduce lung cancer mortality by 20% in the National Lung Screening Trial. METHODS: The pilot UK Lung Cancer Screening (UKLS) is a randomised controlled...
Integrated Care in England - what can we Learn from a Decade of National Pilot Programmes?
Richard Q Lewis, Kath Checkland, Mary Alison Durand, Tom Ling, Nicholas Mays, Martin Roland, Judith A Smith
Jan 07, 2022
INTRODUCTION: For more than a decade the English NHS has pursued integrated care through three national pilot programmes. The independent evaluators of these programmes here identify several common themes that inform the...
Sono-photo-degradation of Carbamazepine in a thin falling film reactor
The photo-Fenton degradation of carbamazepine (CBZ) assisted with ultrasound radiation (US/UV/H2O2/Fe) was tested in a lab thin film reactor allowing high TOC removals (89% in 35 minutes). The synergism between the UV process...
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