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Results: 28
A QTL analysis of host plant effects on fungal endophyte biomass and alkaloid expression in perennial ryegrass.
Marty J Faville, Lyn Briggs, Mingshu Cao, Albert Koulman, MZ Zulfi Jahufer, John Koolaard, David E Hume
Nov 17, 2017
The association between perennial ryegrass (Loliumperenne L.) and its Epichloë fungal endophyte symbiont, Epichloëfestucae var. lolii, supports the persistence of ryegrass-based pastures principally by producing bioactive...
Synthetic scaffolds help airway cells reach maturity
Transplanting bioengineered human lung organoids into mice could lead to a humanized model for pre-clinical studies of lung disease.
Early life affects late-life health through determining DNA methylation across the lifespan
Shuai Li, Zhoufeng Ye, Karen A Mather, Tuong L Nguyen, Gillian S Dite, Nicola J Armstrong, Ee Ming Wong, Anbupalam Thalamuthu, Graham G Giles, Jeffrey M Craig, Richard Saffery, Melissa C Southey, Qihua Tan, Perminder S Sachdev, John L Hopper
Apr 19, 2022
BACKGROUND: Previous findings for the genetic and environmental contributions to DNA methylation variation were for limited age ranges only. We investigated the lifespan contributions and their implications for human health for...
Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk.
Tuong L Nguyen, Shuai Li, James G Dowty, Gillian S Dite, Zhoufeng Ye, Tu Nguyen-Dumont, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, Melissa C Southey, John L Hopper
Jun 07, 2022
Cumulus, Cumulus-percent, Altocumulus, Cirrocumulus, and Cumulus-white are mammogram risk scores (MRSs) for breast cancer based on mammographic density defined in effect by different levels of pixel brightness and adjusted for...
Concordance for clonal hematopoiesis is limited in elderly twins.
Margarete A Fabre, Thomas McKerrell, Maximillian Zwiebel, MS Vijayabaskar, Naomi Park, Philippa M Wells, Roland Rad, Panagiotis Deloukas, Kerrin Small, Claire J Steves, George S Vassiliou
Dec 17, 2019
Although acquisition of leukemia-associated somatic mutations by 1 or more hematopoietic stem cells is inevitable with advancing age, its consequences are highly variable, ranging from clinically silent clonal hematopoiesis (CH)...
Collider constraints on Z ′ models for neutral current B-anomalies
Abstract: We examine current collider constraints on some simple Z′ models that fit neutral current B-anomalies, including constraints coming from measurements of Standard Model (SM) signatures at the LHC. The ‘MDM’ simplified...
Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk.
Tuong L Nguyen, Shuai Li, James G Dowty, Gillian S Dite, Zhoufeng Ye, Tu Nguyen-Dumont, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, Melissa C Southey, John L Hopper
Apr 24, 2022
Cumulus, Cumulus-percent, Altocumulus, Cirrocumulus, and Cumulus-white are mammogram risk scores (MRSs) for breast cancer based on mammographic density defined in effect by different levels of pixel brightness and adjusted for...
Genetic influence is linked to cortical morphology in category-selective areas of visual cortex.
Human visual cortex contains discrete areas that respond selectively to specific object categories such as faces, bodies, and places. A long-standing question is whether these areas are shaped by genetic or environmental...
Genetic influence is linked to cortical morphology in category-selective areas of visual cortex.
Human visual cortex contains discrete areas that respond selectively to specific object categories such as faces, bodies, and places. A long-standing question is whether these areas are shaped by genetic or environmental...
Published by: Nature Communications
Nanoscale residual stress depth profiling by Focused Ion Beam milling and eigenstrain analysis
AM Korsunsky, E Salvati, AGJ Lunt, Tan Sui, MZ Mughal, R Daniel, J Keckes, E Bemporad, M Sebastiani
Feb 21, 2018
Residual stresses play a crucial role in determining material properties and behaviour, in terms of structural integrity under monotonic and cyclic loading, and for functional performance, in terms of capacitance, conductivity...
Nanoscale residual stress depth profiling by Focused Ion Beam milling and eigenstrain analysis
AM Korsunsky, E Salvati, AGJ Lunt, Tan Sui, MZ Mughal, R Daniel, J Keckes, E Bemporad, M Sebastiani
Feb 21, 2018
Residual stresses play a crucial role in determining material properties and behaviour, in terms of structural integrity under monotonic and cyclic loading, and for functional performance, in terms of capacitance, conductivity...
Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity
DS Fernandez Twinn, G Gascoin, B Musial, S Carr, D Duque-Guimaraes, HL Blackmore, MZ Alfaradhi, E Loche, AN Sferruzzi-Perri, AL Fowden, SE Ozanne
May 01, 2017
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease.
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Dec 12, 2020
BACKGROUND AND AIMS: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT...
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Jun 06, 2020
Abstract: Background and aims: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of...
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
LA Hurst, BJ Dunmore, L Long, A Crosby, R Al-Lamki, J Deighton, M Southwood, X Yang, MZ Nikolic, B Herrera, GJ Inman, JR Bradley, AA Rana, PD Upton, NW Morrell
Feb 20, 2017
ADAM10 Protein Animals Bone Morphogenetic Protein 6 Bone Morphogenetic Protein Receptors Type II Familial Primary Pulmonary Hypertension Female Humans Male Mice Mice Inbred C57BL Myocytes Smooth Muscle Pulmonary Artery Rats Receptor Notch2 Receptor Notch3 Signal Transduction Tumor Necrosis Factor-alpha
Natural priors, CMSSM fits and LHC weather forecasts
Previous LHC forecasts for the constrained minimal supersymmetric standard
model (CMSSM), based on current astrophysical and laboratory measurements, have
used priors that are flat in the parameter tan beta, while being...
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey, John L. Hopper
Oct 22, 2020
Abstract: Background: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of...
Genetic and environmental causes of variation in epigenetic aging across the lifespan.
Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper
Oct 22, 2021
BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variation....
aging Biological age DNA Methylation Epigenetic aging Epigenetic clock Twin study Adolescent Adult Aged Aged 80 and over aging Case-Control Studies Child Child Preschool DNA Methylation Epigenesis Genetic Epigenomics Female Gene-Environment Interaction genetic variation Genome-Wide Association Study Humans Infant Infant Newborn longevity Male Middle Aged Twins Dizygotic Twins Monozygotic Young Adult
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Shuai Li, Tuong L. Nguyen, Ee Ming Wong, Pierre-Antoine Dugué, Gillian S. Dite, Nicola J. Armstrong, Jeffrey M. Craig, Karen A. Mather, Perminder S. Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L. Milne, Graham G. Giles, Melissa C. Southey, John L. Hopper
Jan 23, 2021
Abstract: Background: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of...
Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.
Malin Fromme, Carolin V Schneider, Vitor Pereira, Karim Hamesch, Monica Pons, Matthias C Reichert, Federica Benini, Paul Ellis, Katrine H Thorhauge, Mattias Mandorfer, Barbara Burbaum, Vivien Woditsch, Joanna Chorostowska-Wynimko, Jef Verbeek, Frederik Nevens, Joan Genesca, Marc Miravitlles, Alexa Nuñez, Benedikt Schaefer, Heinz Zoller, Sabina Janciauskiene, Nélia Abreu, Luís Jasmins, Rui Gaspar, Rodrigo Liberal, Guilherme Macedo, Ravi Mahadeva, Catarina Gomes, Kai Markus Schneider, Michael Trauner, Aleksander Krag, Bibek Gooptu, Douglas Thorburn, Aileen Marshall, John R Hurst, David A Lomas, Frank Lammert, Nadine T Gaisa, Virginia Clark, William Griffiths, Christian Trautwein, Alice M Turner, Noel G McElvaney, Pavel Strnad
Mar 02, 2021
OBJECTIVE: Alpha-1 antitrypsin deficiency (AATD) is a common, potentially lethal inborn disorder caused by mutations in alpha-1 antitrypsin (AAT). Homozygosity for the 'Pi*Z' variant of AAT (Pi*ZZ genotype) causes lung and liver...
U ( 1 ) B 3 - L 2 explanation of the neutral current B - anomalies
B. C. Allanach
Mar 25, 2021
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Naturalising the third family hypercharge model for neutral current B - anomalies
Abstract: We consider a deformation of the Third Family Hypercharge Model, which arguably makes the model more natural. Additional non-zero charges of the spontaneously broken, family-dependent U(1)F gauge symmetry are assigned...
U ( 1 ) B 3 - L 2 explanation of the neutral current B - anomalies
B. C. Allanach
Apr 16, 2021
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
U ( 1 ) B 3 - L 2 explanation of the neutral current B - anomalies
B. C. Allanach
Jan 20, 2021
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
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