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Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia.
Luke W Thomas, Cinzia Esposito, Rachel E Morgan, Stacey Price, Jamie Young, Steven P Williams, Lucas A Maddalena, Ultan McDermott, Margaret Ashcroft
Jun 22, 2021
Mitochondria are typically essential for the viability of eukaryotic cells, and utilize oxygen and nutrients (e.g. glucose) to perform key metabolic functions that maintain energetic homeostasis and support proliferation. Here...
Published by: Communications biology
Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy
Maddalena Ardissino, Eric AW Slob, Skanda Rajasundaram, Rohin K Reddy, Benjamin Woolf, Joanna Girling, Mark R Johnson, Fu Siong Ng, Dipender Gill
Sep 06, 2022
BACKGROUND: Beta-blocker (BB) and calcium channel blocker (CCB) antihypertensive drugs are commonly used in pregnancy. However, data on their relative impact on maternal and foetal outcomes are limited. We leveraged genetic...
Prognostic Relevance of Neutrophil to Lymphocyte Ratio (NLR) in Luminal Breast Cancer
Antonino Grassadonia, Vincenzo Graziano, Laura Iezzi, Patrizia Vici, Maddalena Barba, Laura Pizzuti, Giuseppe Cicero, Eriseld Krasniqi, Marco Mazzotta, Daniele Marinelli, Antonella Amodio, Clara Natoli, Nicola Tinari
Sep 08, 2021
The neutrophil to lymphocyte ratio (NLR) is a promising predictive and prognostic factor in breast cancer. We investigated its ability to predict disease-free survival (DFS) and overall survival (OS) in patients with luminal A-...
Luminal breast cancer neoadjuvant chemotherapy neutrophil to lymphocyte ratio (NLR) predictive/prognostic biomarkers Adult Aged Breast Neoplasms Disease-Free Survival Female Humans Ki-67 Antigen Lymphocytes Middle Aged Multivariate Analysis Neoadjuvant Therapy Neutrophils Prognosis Retrospective Studies Treatment Outcome
Sleep Disordered Breathing, Obesity and Atrial Fibrillation
Maddalena Ardissino, Rohin K Reddy, Eric AW Slob, Kiran HK Patel, David K Ryan, Dipender Gill, Fu Siong Ng
Feb 20, 2022
Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy
Maddalena Ardissino, Eric AW Slob, Skanda Rajasundaram, Rohin K Reddy, Benjamin Woolf, Joanna Girling, Mark R Johnson, Fu Siong Ng, Dipender Gill
Oct 06, 2022
Beta-blocker blood pressure Calcium channel blocker Mendelian randomization Pregnancy Adrenergic beta-Antagonists Antihypertensive Agents Birth Weight Calcium Channel Blockers Child Diabetes Gestational Eclampsia Female Genome-Wide Association Study Humans Hypertension Mendelian Randomization Analysis pre-eclampsia Pregnancy Pregnancy Complications
Prognostic Relevance of Neutrophil to Lymphocyte Ratio (NLR) in Luminal Breast Cancer
Antonino Grassadonia, Vincenzo Graziano, Laura Iezzi, Patrizia Vici, Maddalena Barba, Laura Pizzuti, Giuseppe Cicero, Eriseld Krasniqi, Marco Mazzotta, Daniele Marinelli, Antonella Amodio, Clara Natoli, Nicola Tinari
Jul 07, 2021
The neutrophil to lymphocyte ratio (NLR) is a promising predictive and prognostic factor in breast cancer. We investigated its ability to predict disease-free survival (DFS) and overall survival (OS) in patients with luminal A-...
Video feedback parent-infant intervention for mothers experiencing enduring difficulties in managing emotions and relationships
Kirsten Barnicot, Morgan Welsh, Sarah Kalwarowsky, Eloise Stevens, Jane Iles, Jennie Parker, Maddalena Miele, Tara Lawn, Laura O'Hanlon, Sushma Sundaresh, Ola Ajala, Paul Bassett, Christina Jones, Paul Ramchandani, Mike Crawford
Oct 10, 2022
OBJECTIVES: Parents experiencing mental health difficulties consistent with "personality disorder", often related to a history of complex trauma, may face increased challenges in parent-child relationships and child...
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
May 21, 2021
Sleep Disordered Breathing, Obesity and Atrial Fibrillation
Maddalena Ardissino, Rohin K Reddy, Eric Slob, Kiran HK Patel, David K Ryan, Dipender Gill, Fu Siong Ng
Jan 10, 2022
It remains unclear whether the association between obstructive sleep apnoea (OSA), a form of sleep-disordered breathing (SDB), and atrial fibrillation (AF) is causal or mediated by shared co-morbidities such as obesity. Existing...
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia.
Luke W Thomas, Cinzia Esposito, Rachel E Morgan, Stacey Price, Jamie Young, Steven P Williams, Lucas A Maddalena, Ultan McDermott, Margaret Ashcroft
Apr 07, 2021
Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.
Katie A O'Brien, Ben D McNally, Alice P Sowton, Antonio Murgia, James Armitage, Luke W Thomas, Fynn N Krause, Lucas A Maddalena, Ian Francis, Stefan Kavanagh, Dominic P Williams, Margaret Ashcroft, Julian L Griffin, Jonathan J Lyon, Andrew J Murray
Jan 28, 2022
Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.
Katie O'Brien, Ben D McNally, Alice P Sowton, Antonio Murgia, James Armitage, Luke W Thomas, Fynn N Krause, Lucas A Maddalena, Ian Francis, Stefan Kavanagh, Dominic P Williams, Margaret Ashcroft, Julian L Griffin, Jonathan J Lyon, Andrew Murray
Jan 05, 2022
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.
Concetta D'Ambrosio, Jessica Erriquez, Maddalena Arigoni, Sonia Capellero, Gloria Mittica, Eleonora Ghisoni, Fulvio Borella, Dionyssios Katsaros, Silvana Privitera, Marisa Ribotta, Elena Maldi, Giovanna Di Nardo, Enrico Berrino, Tiziana Venesio, Riccardo Ponzone, Marco Vaira, Douglas Hall, Mercedes Jimenez-Linan, Anna L Paterson, Raffaele A Calogero, James D Brenton, Giorgio Valabrega, Maria Flavia Di Renzo, Martina Olivero
Mar 10, 2020
Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation. We fully characterized 43 lines of...
PDX derived tumour cells PI3K PIK3R1 Patient-Derived xenografts ovarian cancer Animals Carcinoma Ovarian Epithelial Cell Line Tumor Class Ia Phosphatidylinositol 3-Kinase Cystadenocarcinoma Serous Female Heterografts Humans Mice Mice Inbred NOD Mice SCID Molecular Targeted Therapy Mutation Neoplasm Grading Ovarian Neoplasms Random Allocation
VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.
Thomas Briston, Jenna M Stephen, Luke W Thomas, Cinzia Esposito, Yuen-Li Chung, Saiful E Syafruddin, Mark Turmaine, Lucas A Maddalena, Basma Greef, Gyorgy Szabadkai, Patrick H Maxwell, Sakari Vanharanta, Margaret Ashcroft
Nov 16, 2018
Evaluation of Methodologies for Assessing Self-Healing Performance of Concrete with Mineral Expansive Agents
Chrysoula Litina, Girts Bumanis, Giovanni Anglani, Marta Dudek, Riccardo Maddalena, Maria Amenta, Stamatoula Papaioannou, Gloria Pérez, José Luis García Calvo, Eloy Asensio, Rubén Beltrán Cobos, Fabiano Tavares Pinto, Algirdas Augonis, Robert Davies, Ana Guerrero, Mercedes Sánchez Moreno, Teresa Stryszewska, Ioannis Karatasios, Jean-Marc Tulliani, Paola Antonaci, Diana Bajare, Abir Al-Tabbaa
Apr 15, 2021
Evaluation of Methodologies for Assessing Self-Healing Performance of Concrete with Mineral Expansive Agents
Chrysoula Litina, Girts Bumanis, Giovanni Anglani, Marta Dudek, Riccardo Maddalena, Maria Amenta, Stamatoula Papaioannou, Gloria Pérez, José Luis García García Calvo, Eloy Asensio, Rubén Beltrán Cobos, Fabiano Tavares Pinto, Algirdas Augonis, Robert Davies, Ana Guerrero, Mercedes Sánchez Moreno, Teresa Stryszewska, Ioannis Karatasios, Jean-Marc Tulliani, Paola Antonaci, Diana Bajare, Abir Al-Tabbaa
Apr 18, 2021
Self-healing concrete has the potential to optimise traditional design approaches; however, commercial uptake requires the ability to harmonize against standardized frameworks. Within EU SARCOS COST Action, different...
Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria.
Silverio Perrotta, Domenico Roberti, Debora Bencivenga, Paola Corsetto, Katie A O'Brien, Martina Caiazza, Emanuela Stampone, Leanne Allison, Roland A Fleck, Saverio Scianguetta, Immacolata Tartaglione, Peter A Robbins, Maddalena Casale, James A West, Clara Franzini-Armstrong, Julian L Griffin, Angela M Rizzo, Antonio A Sinisi, Andrew J Murray, Adriana Borriello, Federico Formenti, Fulvio Della Ragione
Mar 03, 2020
Mutations in VHL, which encodes von Hippel-Lindau tumor suppressor (VHL), are associated with divergent diseases. We describe a patient with marked erythrocytosis and prominent mitochondrial alterations associated with a severe...
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