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Anxiety cancer risk intervention Personalised risk provision risk perception Systematic review Worry Anxiety Humans Neoplasms Perception risk

L.A. graphic designer Shepard Fairey will speak at the 2006 Portfolio Show April 7. Fairey is the grandsom of former Winthrop president Charles Davis.

Little is known about the types of intestinal parasites that infected people living in prehistoric Britain. The Late Bronze Age archaeological site of Must Farm was a pile-dwelling settlement located in a wetland, consisting of...

Dioctophyma Diphyllobothrium Echinostoma Late Bronze Age fish tapeworm helminth palaeoparasitology Animals Archaeology England Helminths Humans Intestinal Diseases Parasitic

Microbial community metabolomics, particularly in the human gut, are beginning to provide a new route to identify functions and ecology disrupted in disease. However, these data can be costly and difficult to obtain at scale...

Algorithms Colitis Ulcerative Crohn Disease Gastrointestinal Microbiome Humans Metabolomics Metagenomics Microbiota Models Genetic

The classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however there is a low conversion rate from success in animals to humans. Non-alcoholic fatty...

RESEARCH ARTICLE Medicine Fatty Liver meta-research randomisation Bias Insulin Resistance MOUSE rat

Animals Animals Genetically Modified Cholesterol Dietary Diet Diet High-Fat Dietary Sucrose Dietary Sugars Disease Models Animal Dyslipidemias Female Fructose Humans Liver Male Metabolic Syndrome Mice non-alcoholic fatty liver disease obesity Rats Reproducibility of Results

Background and Aims: Animal models of human disease are a key component of translational hepatology research, yet there is no consensus on which model is optimal for NAFLD. Approach and Results: We generated a database of 3,920...

Original Article Original Articles

Bias Fatty Liver Insulin Resistance Medicine meta-research MOUSE randomisation rat Animals Disease Models Animal Insulin Resistance Liver Mice non-alcoholic fatty liver disease Rats Treatment Outcome Triglycerides Weight Loss

INTRODUCTION: Detection and monitoring of circulating tumor DNA (ctDNA) is rapidly becoming a diagnostic, prognostic and predictive tool in cancer patient care. A growing number of gene targets have been identified as diagnostic...

Adult Alleles Biomarkers Tumor Cell-Free Nucleic Acids Circulating Tumor DNA DNA Mutational Analysis DNA Neoplasm Female High-Throughput Nucleotide Sequencing Humans Liquid biopsy Male Mutation Neoplasms Neoplastic Cells Circulating Polymerase Chain Reaction Reproducibility of Results Sensitivity and Specificity

Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations...

Carcinoma Non-Small-Cell Lung Circulating Tumor DNA Cohort Studies Humans Liquid biopsy Mutation Polymerase Chain Reaction Reproducibility of Results Sensitivity and Specificity Sequence Analysis DNA

ALSPAC Diabetes Fibrosis MBOAT7 NAFLD triglyceride Acyltransferases Alanine Transaminase Drug Discovery Genetic Predisposition to Disease Humans Liver Liver Cirrhosis Membrane Proteins non-alcoholic fatty liver disease Polymorphism Single Nucleotide