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Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.
Pham Thanh Duy, Nga Tran Vu Thieu, To Nguyen Thi Nguyen, Ho Ngoc Dan Thanh, Sabina Dongol, Abhilasha Karkey, Megan Carey, Buddha Basnyat, Gordon Dougan, Maia A Rabaa, Stephen Baker
Oct 27, 2020
Despite recent advances in typhoid fever control, asymptomatic carriage of Salmonella Typhi in the gallbladder remains poorly understood. Aiming to understand if S. Typhi becomes genetically adapted for long-term colonisation in...
Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi
Pham Thanh Duy, Nga Tran Vu Thieu, To Nguyen Thi Nguyen, Ho Ngoc Dan Thanh, Sabina Dongol, Abhilasha Karkey, Megan Carey, Buddha Basnyat, Gordon Dougan, Maia A. Rabaa, Stephen Baker
Nov 02, 2020
Despite recent advances in typhoid fever control, asymptomatic carriage of Salmonella Typhi in the gallbladder remains poorly understood. Aiming to understand if S. Typhi becomes genetically adapted for long-term colonisation in...
Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi
Pham Thanh Duy, Nga Tran Vu Thieu, To Nguyen Thi Nguyen, Ho Ngoc Dan Thanh, Sabina Dongol, Abhilasha Karkey, Megan Carey, Buddha Basnyat, Gordon Dougan, Maia A. Rabaa, Stephen Baker
Nov 03, 2020
Despite recent advances in typhoid fever control, asymptomatic carriage of Salmonella Typhi in the gallbladder remains poorly understood. Aiming to understand if S. Typhi becomes genetically adapted for long-term colonisation in...
The emergence of azithromycin-resistant Salmonella Typhi in Nepal.
Pham Thanh Duy, Sabina Dongol, Abhishek Giri, Nguyen Thi Nguyen To, Ho Ngoc Dan Thanh, Nguyen Pham Nhu Quynh, Pham Duc Trung, Guy E Thwaites, Buddha Basnyat, Stephen Baker, Maia A Rabaa, Abhilasha Karkey
May 17, 2021
BACKGROUND: Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs...
Occupational Animal Contact in Southern and Central Vietnam.
Nguyen Thi Kha Tu, Ngo Tri Tue, Olli Vapalahti, Anna-Maija K Virtala, Le Van Tan, Maia A Rabaa, Juan Carrique-Mas, Guy E Thwaites, Stephen Baker, VIZIONS consortium
Nov 12, 2020
Despite the global zoonotic disease burden, the underlying exposures that drive zoonotic disease emergence are not understood. Here, we aimed to assess exposures to potential sources of zoonotic disease and investigate the...
Animal health workers cohort Emerging infections Exposure risk Slaughterers Vietnam zoonosis Abattoirs Adolescent Adult Aged Aged 80 and over Animals Cross-Sectional Studies Farmers Female Humans Male Meat Products Middle Aged occupational exposure Risk Assessment Socioeconomic Factors Surveys and Questionnaires Vietnam Young Adult Zoonoses
Genomic epidemiology, antimicrobial resistance and virulence factors of Enterobacter cloacae complex causing potential community-onset bloodstream infections in a tertiary care hospital of Nepal.
Sulochana Manandhar, Quynh Nguyen, To Nguyen Thi Nguyen, Duy Thanh Pham, Maia A Rabaa, Sabina Dongol, Buddha Basnyat, Sameer M Dixit, Stephen Baker, Abhilasha Karkey
Jul 07, 2022
OBJECTIVES: Community-onset bloodstream infections (BSIs) caused by carbapenemase-producing Enterobacter cloacae complex (ECC) species are increasing internationally. This observation suggests that ECC are emerging pathogens...
A universal genome sequencing method for rotavirus A from human fecal samples which identifies segment reassortment and multi-genotype mixed infection.
Tran Thi Ngoc Dung, Pham Thanh Duy, October M Sessions, Uma K Sangumathi, Voong Vinh Phat, Pham Thi Thanh Tam, Nguyen Thi Nguyen To, Tran My Phuc, Tran Thi Hong Chau, Nguyen Ngoc Minh Chau, Ngoc Nguyen Minh, Guy E Thwaites, Maia A Rabaa, Stephen Baker
Apr 10, 2019
BACKGROUND: Genomic characterization of rotavirus (RoV) has not been adopted at large-scale due to the complexity of obtaining sequences for all 11 segments, particularly when feces are used as starting material. METHODS: To...
Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children.
Hao Chung The, Paola Florez de Sessions, Song Jie, Duy Pham Thanh, Corinne N Thompson, Chau Nguyen Ngoc Minh, Collins Wenhan Chu, Tuan-Anh Tran, Nicholas R Thomson, Guy E Thwaites, Maia A Rabaa, Martin Hibberd, Stephen Baker
Apr 10, 2019
Diarrheal diseases remain the second most common cause of mortality in young children in developing countries. Efforts have been made to explore the impact of diarrhea on bacterial communities in the human gut, but a thorough...
Bifidobacterium Fusobacterium developing country Diarrhea enterotype Microbiome Oral microbiome Bacteria Bacterial Physiological Phenomena Biodiversity Cluster Analysis Diarrhea Infantile Dysbiosis dysentery Feces Female Gastrointestinal Microbiome Gastrointestinal Tract Humans Infant Male RNA Ribosomal 16S Risk Factors Vietnam
Genetic diversity and cross-species transmission of kobuviruses in Vietnam.
Lu Lu, Nguyen Van Dung, Alasdair Ivens, Carlijn Bogaardt, Aine O'Toole, Juliet E Bryant, Juan Carrique-Mas, Nguyen Van Cuong, Pham Hong Anh, Maia A Rabaa, Ngo Tri Tue, Guy E Thwaites, Stephen Baker, Peter Simmonds, Mark Ej Woolhouse, VIZIONS consortium
May 17, 2021
Cross-species transmission of viruses poses a sustained threat to public health. Due to increased contact between humans and other animal species the possibility exists for cross-species transmissions and ensuing disease...
Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia.
Hao Chung The, Ladaporn Bodhidatta, Duy Thanh Pham, Carl J Mason, Tuyen Ha Thanh, Phat Voong Vinh, Paul Turner, Sopheak Hem, David AB Dance, Paul N Newton, Rattanaphone Phetsouvanh, Viengmon Davong, Guy E Thwaites, Nicholas R Thomson, Stephen Baker, Maia A Rabaa
Mar 19, 2021
Division of Inclusion and Community Engagement Newsletter, Vol. 1 No. 1, February 2023
A word from our Vice-President MLK Week MLK Week in pictures What's new? In our offices DICE in the community Student spotlight: Maia Peele '23 Who are we? How can I get involved?
inclusion Community engagement Ursinus College Newsletter Martin Luther King Jr. Maia Peele Civic and Community Engagement Higher Education
Published by: Ursinus College
Src and Memory
Visual imprinting is a learning process whereby young animals come to prefer a visual stimulus after exposure to it (training). The available evidence indicates that the intermediate medial mesopallium (IMM) in the domestic...
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei.
Hao Chung The, Christine Boinett, Duy Pham Thanh, Claire Jenkins, Francois-Xavier Weill, Benjamin P Howden, Mary Valcanis, Niall De Lappe, Martin Cormican, Sonam Wangchuk, Ladaporn Bodhidatta, Carl J Mason, To Nguyen Thi Nguyen, Tuyen Ha Thanh, Vinh Phat Voong, Vu Thuy Duong, Phu Huong Lan Nguyen, Paul Turner, Ryan Wick, Pieter-Jan Ceyssens, Guy Thwaites, Kathryn E Holt, Nicholas R Thomson, Maia A Rabaa, Stephen Baker
Dec 18, 2019
Shigella sonnei increasingly dominates the international epidemiological landscape of shigellosis. Treatment options for S. sonnei are dwindling due to resistance to several key antimicrobials, including the fluoroquinolones....
Anti-Bacterial Agents Asia Southeastern Asia Western Bayes Theorem ciprofloxacin DNA Gyrase DNA Topoisomerase IV Directed Molecular Evolution Drug Resistance Bacterial dysentery Bacillary Europe evolution Molecular Fluoroquinolones Genome Bacterial Humans molecular epidemiology Mutation Phylogeny Polymorphism Single Nucleotide Shigella sonnei
High-flow nasal oxygen vs. standard oxygen therapy for patients undergoing transcatheter aortic valve replacement with conscious sedation
S Scheuermann, A Tan, P Govender, M Mckie, J Pack, G Martinez, F Falter, S George, A A. Klein
Apr 14, 2023
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei
Hao Chung The, Christine Boinett, Duy Pham Thanh, Claire Jenkins, Francois-Xavier Weill, Benjamin P. Howden, Mary Valcanis, Niall De Lappe, Martin Cormican, Sonam Wangchuk, Ladaporn Bodhidatta, Carl J. Mason, To Nguyen Thi Nguyen, Tuyen Ha Thanh, Vinh Phat Voong, Vu Thuy Duong, Phu Huong Lan Nguyen, Paul Turner, Ryan Wick, Pieter-Jan Ceyssens, Guy Thwaites, Kathryn E. Holt, Nicholas R. Thomson, Maia A. Rabaa, Stephen Baker
Oct 22, 2020
Abstract: Shigella sonnei increasingly dominates the international epidemiological landscape of shigellosis. Treatment options for S. sonnei are dwindling due to resistance to several key antimicrobials, including the...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.
Alison E Mather, Tu Le Thi Phuong, Yunfeng Gao, Simon Clare, Subhankar Mukhopadhyay, David A Goulding, Nhu Tran Do Hoang, Ha Thanh Tuyen, Nguyen Phu Huong Lan, Corinne N Thompson, Nguyen Hoang Thu Trang, Juan Carrique-Mas, Ngo Tri Tue, James I Campbell, Maia A Rabaa, Duy Pham Thanh, Katherine Harcourt, Ngo Thi Hoa, Nguyen Vinh Trung, Constance Schultsz, Gabriel G Perron, John E Coia, Derek J Brown, Chinyere Okoro, Julian Parkhill, Nicholas R Thomson, Nguyen Van Vinh Chau, Guy E Thwaites, Duncan J Maskell, Gordon Dougan, Linda J Kenney, Stephen Baker
Nov 21, 2018
Nontyphoidal Salmonella (NTS), particularly Salmonella enterica serovar Typhimurium, is among the leading etiologic agents of bacterial enterocolitis globally and a well-characterized cause of invasive disease (iNTS) in...
Salmonella typhimurium Antimicrobial resistance Genomics Invasive salmonellosis Animals Bacteremia Carrier State Chickens Disease Transmission Infectious Drug Resistance Multiple Bacterial Ducks Gastroenteritis genetic variation Genotype HIV Infections Humans Immunocompromised Host molecular epidemiology Salmonella Infections Salmonella Infections Animal Salmonella typhimurium Swine Vietnam whole genome sequencing Zoonoses
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Associations between meeting combinations of 24-hour movement recommendations and dietary patterns of children
David Thivel, Mark S. Tremblay, Peter T. Katzmarzyk, Mikael Fogelholm, Gang Hu, Carol Maher, José A R Maia, Timothy Olds, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Jean-Philippe Chaput
Jan 01, 2019
The purpose of this study was to examine whether meeting movement behavior recommendations (i.e., ≥60 min of moderate-to-vigorous physical activity [MVPA] per day, ≤2 h of recreational screen time per day, and between 9 and 11 h...
Chicken cognin interactome and the memory of filial imprinting
Lela Chitadze, Giorgi Margvelani, Maia Meparishvili, Lia Tsverava, Ekaterine Mikautadze, Marine Kikvidze, Vincenzo Lagani, Brian J McCabe, Revaz Solomonia
Mar 02, 2020
A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression
KB Meyer, A-T Maia, M O'Reilly, M Ghoussaini, R Prathalingam, P Porter-Gill, S Ambs, L Prokunina-Olsson, J Carroll, BAJ Ponder
Apr 26, 2017
Alleles Base Sequence Binding Sites Breast Neoplasms Cell Line Tumor Chromosomes Human Pair 8 Colonic Neoplasms Consensus Sequence Female Gene Expression Regulation Neoplastic Genetic Loci Genetic Predisposition to Disease Genotype HCT116 Cells Humans Male Models Biological Polymorphism Single Nucleotide Prostatic Neoplasms RNA Untranslated Transcriptional Activation YY1 Transcription Factor
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