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Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.
Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction...
A capped optimal stopping problem for the maximum process
This paper concerns an optimal stopping problem driven by the running maximum of a spectrally negative Lévy process X. More precisely, we are interested in capped versions of the American lookback optimal stopping problem...
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Louise Thisted, Mette V. Østergaard, Annemarie A. Pedersen, Philip J. Pedersen, Ross T. Lindsay, Andrew J. Murray, Lisbeth N. Fink, Tanja X. Pedersen, Thomas Secher, Thea T. Johansen, Sebastian T. Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B. Thomsen, Nora E. Zois
Oct 01, 2021
Abstract: Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models...
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Louise Thisted, Mette V. Østergaard, Annemarie A. Pedersen, Philip J. Pedersen, Ross T. Lindsay, Andrew J. Murray, Lisbeth N. Fink, Tanja X. Pedersen, Thomas Secher, Thea T. Johansen, Sebastian T. Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B. Thomsen, Nora E. Zois
Sep 30, 2020
Abstract: Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models...
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy.
Louise Thisted, Mette V Østergaard, Annemarie A Pedersen, Philip J Pedersen, Ross T Lindsay, Andrew J Murray, Lisbeth N Fink, Tanja X Pedersen, Thomas Secher, Thea T Johansen, Sebastian T Thrane, Torben Skarsfeldt, Jacob Jelsing, Morten B Thomsen, Nora E Zois
Dec 04, 2020
Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models...
Human-Mouse Chimerism Validates Human Stem Cell Pluripotency.
A capped optimal stopping problem for the maximum process
This paper concerns an optimal stopping problem driven by the running maximum of a spectrally negative Lévy process X. More precisely, we are interested in capped versions of the American lookback optimal stopping problem...
Impulsivity traits and addiction-related behaviors in youth.
Kristine Rømer Thomsen, Mette Buhl Callesen, Morten Hesse, Timo Lehmann Kvamme, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Valerie Voon
Jun 21, 2018
A theoretical analysis of taxonomic binning accuracy.
Many metagenomic and environmental DNA studies require the taxonomic assignment of individual reads or sequences by aligning reads to a reference database, known as taxonomic binning. When a read aligns to more than one...
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
Criterion validity of the Physical Activity Scale (PAS2) in Danish adults.
BACKGROUND: The Physical Activity Scale (PAS2) was developed to measure physical activity (PA) during work, transportation and leisure time, in the Danish adult population. The objective of this study was to assess the criterion...
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
Azad Farzadfard, Jannik Nedergaard Pedersen, Georg Meisl, Arun Kumar Somavarapu, Parvez Alam, Louise Goksøyr, Morten Agertoug Nielsen, Adam Frederik Sander, Tuomas Knowles, Jan Skov Pedersen, Daniel Erik Otzen
Feb 10, 2022
Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of Parkinson's disease. Although the intensely anionic C-terminal domain (CTD) of αSN does not form part of the amyloid core region or...
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
Azad Farzadfard, Jannik Nedergaard Pedersen, Georg Meisl, Arun Kumar Somavarapu, Parvez Alam, Louise Goksøyr, Morten Agertoug Nielsen, Adam Frederik Sander, Tuomas PJ Knowles, Jan Skov Pedersen, Daniel Erik Otzen
Mar 14, 2022
Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of Parkinson's disease. Although the intensely anionic C-terminal domain (CTD) of αSN does not form part of the amyloid core region or...
Pilot study
In an attempt to improve attention bias modification (ABM), we tested whether an attentional training protocol which featured monetary operant conditioning of eye-gaze to avoid alcohol stimuli in alcohol-dependent patients could...
Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure
Nicolas Hernandez Norager, Markus Harboe Olsen, Sarah Hornshoej Pedersen, Casper Schwartz Riedel, Marek Czosnyka, Marianne Juhler
Apr 13, 2021
Pupillary reactivity to alcohol cues as a predictive biomarker of alcohol relapse following treatment in a pilot study.
Timo L Kvamme, Mads Uffe Pedersen, Morten Overgaard, Kristine Rømer Thomsen, Valerie Voon
Jan 17, 2019
RATIONALE: Identifying the predictors of relapse in detoxified alcohol-dependent patients is crucial for effective surveillance procedures and the optimization of treatment. Physiological measures such as functional MRI activity...
Effect of particle size and deformation behaviour on water ingress into tablets.
Anne Linnet Skelbæk-Pedersen, Mohammed Al-Sharabi, Thomas Kvistgaard Vilhelmsen, Jukka Rantanen, J Axel Zeitler
Aug 24, 2020
Drug release performance of tablets is often highly dependent on disintegration, and water ingress is typically the rate-limiting step of the disintegration process. Water ingress into tablets is known to be highly influenced by...
Non-destructive quantification of fragmentation within tablets after compression from scattering analysis of terahertz transmission measurements.
Anne Linnet Skelbæk-Pedersen, Moritz Anuschek, Thomas Kvistgaard Vilhelmsen, Jukka Rantanen, J Axel Zeitler
Aug 24, 2020
Material deformation behaviour has a critical impact on tablet formation. Fragmentation is one of the key mechanisms affecting the strength of a final compact, however, quantitative methods for estimating fragmentation are often...
The causal effects of serum lipids and apolipoproteins on kidney function
Humaira Rasheed, Jie Zheng, Jessica Rees, Eleanor Sanderson, Laurent Thomas, Tom G Richardson, Si Fang, Ole-Jørgen Bekkevold, Endre Bakken Stovner, Maiken Elvestad Gabrielsen, Anne Heidi Skogholt, Solfrid Romundstad, Ben Brumpton, Stein Hallan, Cristen Willer, Stephen Burgess, Kristian Hveem, George Davey Smith, Tom R Gaunt, Bjørn Olav Åsvold
Feb 16, 2021
WGS of 1058 <i>Enterococcus faecium</i> from Copenhagen, Denmark, reveals rapid clonal expansion of vancomycin-resistant clone ST80 combined with widespread dissemination of a vanA-containing plasmid and acquisition of a heterogeneous accessory genome
Mette Pinholt, Sion C. Bayliss, Heidi Gumpert, Peder Worning, Veronika V.S. Jensen, Michael Pedersen, Edward J. Feil, Henrik Westh
Jul 01, 2019
Objectives: From 2012 to 2015, a sudden significant increase in vancomycin-resistant (vanA) Enterococcus faecium (VREfm) was observed in the Capital Region of Denmark. Clonal relatedness of VREfm and vancomycinsusceptible E....
/dk/atira/pure/subjectarea/asjc/3000/3004 name=Pharmacology /dk/atira/pure/subjectarea/asjc/2700/2726 name=Microbiology (medical) /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/subjectarea/asjc/2700/2725 name=Infectious Diseases /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
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