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Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition
The paucity of currently available therapies for glioblastoma multiforme requires novel approaches to the treatment of this brain tumour. Disrupting cyclic nucleotide-signalling through phosphodiesterase (PDE) inhibition may be...
Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition.
The paucity of currently available therapies for glioblastoma multiforme requires novel approaches to the treatment of this brain tumour. Disrupting cyclic nucleotide-signalling through phosphodiesterase (PDE) inhibition may be...
Proliferation Glioblastoma drug combination phosphodiesterase inhibitor multidrug resistance-associated protein 1
Published by: International journal of molecular sciences
Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition.
The paucity of currently available therapies for glioblastoma multiforme requires novel approaches to the treatment of this brain tumour. Disrupting cyclic nucleotide-signalling through phosphodiesterase (PDE) inhibition may be...
drug combination Glioblastoma multidrug resistance-associated protein 1 phosphodiesterase inhibitor Proliferation Antineoplastic Agents Cell Line Tumor Cell Proliferation Cell Survival Cyclic AMP Cyclic GMP Drug Synergism Glioblastoma Humans Multidrug Resistance-Associated Proteins Phosphodiesterase Inhibitors Phosphoric Diester Hydrolases Pyrazoles Quinolines
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.
Matthew J Broadhead, Mathew H Horrocks, Fei Zhu, Leila Muresan, Ruth Benavides-Piccione, Javier DeFelipe, David Fricker, Maksym V Kopanitsa, Rory R Duncan, David Klenerman, Noboru H Komiyama, Steven F Lee, Seth GN Grant
Apr 19, 2016
A Role for RAS in V-CRK Transformation
Heidi Greulich
Jan 01, 0001
The v-Crk oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src...
Published by: Rockefeller University
LITTLE v IN INUKTITUT
Bettina Spreng
Jul 30, 2013
This paper provides an in-depth examination of the distribution of the Antipassive morpheme -si- in Mittimatalik, a dialect of !nuktitut spoken in North Baffin. It is demonstrated that the occurrence of the overt Antipassive...
Published by: Atlantic Provinces Linguistic Association
LITTLE v IN INUKTITUT
Bettina Spreng
Jul 30, 2013
This paper provides an in-depth examination of the distribution of the Antipassive morpheme -si- in Mittimatalik, a dialect of !nuktitut spoken in North Baffin. It is demonstrated that the occurrence of the overt Antipassive...
Published by: Atlantic Provinces Linguistic Association
Structure and metallicity of phase V of hydrogen
B Monserrat, Neil D Drummond, Philip Dalladay-Simpson, Ross T Howie, Pablo Lopez Rios, Eugene Gregoryanz, Chris J Pickard, Richard J Needs
Oct 08, 2018
A new phase V of hydrogen was recently claimed in experiments above 325 GPa and 300 K. Due to the extremely small sample size at such record pressures the measurements were limited to Raman spectroscopy. The experimental data on...
Photovoltage detection of spin excitation of a ferromagnetic stripe and disk at low temperature
Najla Almulhem, Maksym Stebliy, J C Portal, Alexander Samardak, Harvey Beere, D Ritchie, Alain Nogaret
Jan 30, 2020
Photovoltage spectroscopy is a beneficial technique to investigate the dynamic properties of the spin excitations of ferromagnetic elements fabricated at the surface of a GaAs/Al 0.33Ga 0.67As...
Photovoltage detection of spin excitation of a ferromagnetic stripe and disk at low temperature
Najla Almulhem, Maksym Stebliy, J C Portal, Alexander Samardak, Harvey Beere, D Ritchie, Alain Nogaret
Jan 30, 2020
Photovoltage spectroscopy is a beneficial technique to investigate the dynamic properties of the spin excitations of ferromagnetic elements fabricated at the surface of a GaAs/Al 0.33Ga 0.67As...
Patel v Mirza
G Virgo
Nov 17, 2016
The decision of the Supreme Court in Patel v Mirza is now the leading case on the application of the defence of illegality to private law claims, which has resolved a controversy among the Justices of the Supreme Court as to...
Novel rhenium(V) nitride complexes with dithiocarbimate ligands
Joanne Perils, Fernando Cortezon-Tamarit, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Jonathan R Dilworth, Sofia I. Pascu
Apr 24, 2018
The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based...
Amphoteric Colloids. V. The Influence of the Valency of Anions Upon the Physical Properties of Gelatin
Jacques Loeb
Jan 01, 0001
Jacques Loeb. Amphoteric colloids. V. The influence of the valency of anions upon the physical properties of gelatin
Reprinted from J. Gen.Physiol., 1919, 1(5):559-580
Published by: Rockefeller University
Professor Steven V Ley CBE FRS FMedSci
Steven V Ley
Sep 10, 2018
Professor Steven Ley is currently Professor of Chemistry and Director of Research at at the University of Cambridge. He is also a Fellow of Trinity College and was BP 1702 Professor of Chemistry for 21 years. Steve obtained his...
Novel rhenium(V) nitride complexes with dithiocarbimate ligands
Joanne Perils, Fernando Cortezon-Tamarit, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Jonathan R Dilworth, Sofia I. Pascu
Apr 24, 2018
The application of rhenium complexes as therapeutic agents in nuclear medicine has propelled research into the chemistry of these compounds. In our effort to develop and investigate new therapeutic radiopharmaceuticals based...
Nanocrystals of cesium lead halide perovskites (CsPbX3, X=Cl, Br, and I)
Loredana Protesescu, Sergii Yakunin, Maryna I. Bodnarchuk, Franziska Krieg, Riccarda Caputo, Christopher Holman Hendon, Ruoxi Yang, Aron Walsh, Maksym V. Kovalenko
Jun 10, 2015
Metal halides perovskites, such as hybrid organic-inorganic CH3NH3PbI3, are newcomer optoelectronic materials that have attracted enormous attention as solution-deposited absorbing layers in solar cells with power conversion...
Spatiotemporal continuum generation in polariton waveguides.
Paul M Walker, Charles E Whittaker, Dmitry V Skryabin, Emiliano Cancellieri, Ben Royall, Maksym Sich, Ian Farrer, David A Ritchie, Maurice S Skolnick, Dmitry N Krizhanovskii
Mar 19, 2019
We demonstrate the generation of a spatiotemporal optical continuum in a highly nonlinear exciton-polariton waveguide using extremely low excitation powers (2-ps, 100-W peak power pulses) and a submillimeter device suitable for...
An Improved Firefly Algorithm-Based 2-D Image Thresholding for Brain Image Fusion
In this article, an attempt is made to diagnose brain diseases like neoplastic, cerebrovascular, Alzheimer's, and sarcomas by the effective fusion of two images. The two images are fused in three steps. Step 1. Segmentation: The...
Published by: IGI Global Scientific Publishing
A 2D Histogram-Based Image Thresholding Using Hybrid Algorithms for Brain Image Fusion
In this article an effort is made to identify brain tumor disease such as neoplastic, cerebrovascular, Alzheimer's, lethal, sarcoma diseases by successful fusion of images from magnetic resonance imaging (MRI) and computed...
Published by: IGI Global Scientific Publishing
ERIC-PCR Analysis of the Clinical and Environmental strains of V. cholerae during 2013 Epidemic in Nigeria
Smith Stella, Nwaokorie Francisca, Awoderu Oluwatoyin, Bamidele Tajudeen, Akinsinde Kehinde, Ochoga Michael, Oladele David, Bamidele Moses, Fesobi Toun, Afocha Eberechukwu, Amoo Samuel, Ajayi Morakinyo, Atat Prince, Ogbonna Francisca, Nduaga Samuel, Idika Nneoma, Oparaugo Chinedu, Musa Adesola, Adeneye Adeniyi, Ijeh Margaret, Ujah Innocent
Nov 21, 2015
Background: Molecular markers are important tools in the monitoring of toxigenic strains of Vibrio cholerae in environmental and clinical samples.
Objectives: The study was aimed at determining the clinical and environmental...
Published by: IJHS Medical Association
Experimental analysis of the V-Charge variable drive supercharger system on a 1.0 L GTDI engine
Bo Hu, Sam Akehurst, Andrew G.J. Lewis, Pengfei Lu, Darren Millwood, Colin Copeland, Edward Chappell, Andrew De Freitas, James Shawe, Dave Burtt
Mar 01, 2018
A compound charging system that pairs a turbocharger with a supercharger seems to be a potential trend for future passenger car gasoline engines, as the strength of both could be enhanced and the deficiencies of each could be...
Delimiting the Continental Shelf Beyond 200 Nautical Miles at the International Court of Justice
M Lando
Aug 21, 2017
In both $\textit{Nicaragua v. Colombia}$ cases, the International Court of Justice upheld that international tribunals may delimit the continental shelf beyond 200 nautical miles prior to the establishment of the continental...
Impact of Ujjwala Yojana Scheme and Its Effect on Behavioural Changes Among Rural Women
Delivering multiple roles every single day, women are undoubtedly the backbone of any society. However, they have also been an ignored segment of the society in many parts of the world. To re-establish their rightful and...
Published by: IGI Global Scientific Publishing
Polymorphism in M(H2PO2)3 (M = V, Al, Ga) compounds with the perovskite-related ReO3 structure.
Hayden A Evans, Zeyu Deng, Ines E Collings, Yue Wu, Jessica L Andrews, Kartik Pilar, Joshua M Tuffnell, Guang Wu, John Wang, Siân E Dutton, Paul D Bristowe, Ram Seshadri, Anthony K Cheetham
Feb 18, 2019
Trivalent metal hypophosphites with the general formula M(H2PO2)3 (M = V, Al, Ga) adopt the ReO3 structure, with each compound displaying two structural polymorphs. High-pressure synchrotron X-ray studies reveal a...
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