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Results: 102
3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices.
Janko Kajtez, Sebastian Buchmann, Shashank Vasudevan, Marcella Birtele, Stefano Rocchetti, Christian Jonathan Pless, Arto Heiskanen, Roger A Barker, Alberto Martínez-Serrano, Malin Parmar, Johan Ulrik Lind, Jenny Emnéus
Jul 16, 2020
Compartmentalized microfluidic platforms are an invaluable tool in neuroscience research. However, harnessing the full potential of this technology remains hindered by the lack of a simple fabrication approach for the creation...
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Oct 24, 2022
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's...
Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain.
Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
Jennifer Zuckerman Malin
Jan 01, 0001
Cell death is a major cell fate that promotes tissue sculpting and morphogenesis during animal development. Many developmental cell-culling events cannot be accounted for solely by caspase-dependent apoptosis, yet, alternate...
Published by: Rockefeller University
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
Janelle Drouin-Ouellet, Shong Lau, Per Ludvik Brattås, Daniella Rylander Ottosson, Karolina Pircs, Daniela A Grassi, Lucy M Collins, Romina Vuono, Annika Andersson Sjöland, Gunilla Westergren-Thorsson, Caroline Graff, Lennart Minthon, Håkan Toresson, Roger A Barker, Johan Jakobsson, Malin Parmar
Nov 27, 2017
Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This technology offers a promising shortcut for obtaining patient- and...
Out of the Mouth of Babes
Marine mammal behavior and cognition researchers often face a number of challenges, including the research subjects’ lack of interest and verbal abilities, as well as choosing a paradigm with appropriate stimuli for the...
Infant cognition Marine mammal cognition Cognition paradigms Dolphin cognition Marine mammal behavior Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
The search for active learning
This article suggests that the concept of ‘active learning’ has different meanings. These meanings are created in the dynamic and variable relationships between the uses of learning technologies and approaches to pedagogy....
The search for active learning
This article suggests that the concept of ‘active learning’ has different meanings. These meanings are created in the dynamic and variable relationships between the uses of learning technologies and approaches to pedagogy....
Seasonality of Social Behaviour Among Immature Belugas (Delphinapterus leucas) in Managed Care
Belugas ( Delphinapterus leucas ) in managed care have been reported to show seasonal variation in socio-sexual behaviour, hormone levels and respiration rates; however, little is known about the social interactions of wild...
Juvenile behaviour sociality white whales socio-sexual behaviour agonistic behaviour affiliative behaviour Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
Seasonality of Social Behaviour Among Immature Belugas (Delphinapterus leucas) in Managed Care
Belugas ( Delphinapterus leucas ) in managed care have been reported to show seasonal variation in socio-sexual behaviour, hormone levels and respiration rates; however, little is known about the social interactions of wild...
Juvenile behaviour sociality white whales socio-sexual behaviour agonistic behaviour affiliative behaviour Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
Out of the Mouth of Babes
Marine mammal behavior and cognition researchers often face a number of challenges, including the research subjects’ lack of interest and verbal abilities, as well as choosing a paradigm with appropriate stimuli for the...
Infant cognition Marine mammal cognition Cognition paradigms Dolphin cognition Marine mammal behavior Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
Out of the Mouth of Babes
Marine mammal behavior and cognition researchers often face a number of challenges, including the research subjects’ lack of interest and verbal abilities, as well as choosing a paradigm with appropriate stimuli for the...
Infant cognition Marine mammal cognition Cognition paradigms Dolphin cognition Marine mammal behavior Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
A LINE-1 insertion situated in the promoter of IMPG2 is associated with autosomal recessive progressive retinal atrophy in Lhasa Apso dogs
Do Pinnipeds Have Personality? Broad Dimensions and Contextual Consistency of Behavior in Harbor Seals (Phoca vitulina) and California Sea Lions (Zalophus californianus)
Personality has now been studied in species as diverse as chimpanzees and cuttlefish, but marine mammals remain vastly underrepresented in this area. A broad range of traits have been assessed only once in each of bottlenose...
Pinnipeds personality harbor seals Phoca vitulina California sea lions Zalophus californianus Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
A LINE-1 insertion situated in the promoter of IMPG2 is associated with autosomal recessive progressive retinal atrophy in Lhasa Apso dogs.
Rebekkah J Hitti-Malin, Louise M Burmeister, Sally L Ricketts, Thomas W Lewis, Louise Pettitt, Mike Boursnell, Ellen C Schofield, David Sargan, Cathryn S Mellersh
Sep 14, 2020
BACKGROUND: Canine progressive retinal atrophies are a group of hereditary retinal degenerations in dogs characterised by depletion of photoreceptor cells in the retina, which ultimately leads to blindness. PRA in the Lhasa Apso...
Canine Canine retinal degeneration Dog IMPG2 Inherited PRA Photoreceptor degeneration progressive retinal atrophy Animals Atrophy Breeding Dog Diseases Dogs Gene Frequency Genetic Association Studies Genotype High-Throughput Nucleotide Sequencing Long Interspersed Nucleotide Elements Mutagenesis Insertional Promoter Regions Genetic Proteoglycans Retina Retinal Degeneration Exome Sequencing
Seasonality of Social Behaviour Among Immature Belugas (Delphinapterus leucas) in Managed Care
Belugas ( Delphinapterus leucas ) in managed care have been reported to show seasonal variation in socio-sexual behaviour, hormone levels and respiration rates; however, little is known about the social interactions of wild...
Juvenile behaviour; sociality; white whales; socio-sexual behaviour; agonistic behaviour; affiliative behaviour Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
Economic Impact of Information Industry Development and Investment Strategy for Information Industry
The information industry leads the digital revolution and innovation. With regards to what economic impact the development of the industry will bring about, there has been minimal focus from literature. This paper fills the...
Published by: IGI Global Scientific Publishing
Do Pinnipeds Have Personality? Broad Dimensions and Contextual Consistency of Behavior in Harbor Seals (Phoca vitulina) and California Sea Lions (Zalophus californianus)
Personality has now been studied in species as diverse as chimpanzees and cuttlefish, but marine mammals remain vastly underrepresented in this area. A broad range of traits have been assessed only once in each of bottlenose...
Pinnipeds personality harbor seals Phoca vitulina California sea lions Zalophus californianus Animal Studies Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
QSAR Study of N-((3-Benzamido-4-oxo-3,4-Dihydroquinazolin 2-yl)methyl)-N-(Substituted) Phenyl Benzamide as Antiulcer Agents
Suppression of gastric acid secretion by use of proton pump inhibitors is an efficient way to control hyperacidity complications. An inhibitory activity of N-((3-Benzamido-4-oxo-3, 4 dihydro quinazolin -2-yl)...
Published by: IGI Global Scientific Publishing
Laterality of Eye Use by Bottlenose (Tursiops truncatus) and Rough-toothed (Steno bredanensis) Dolphins While Viewing Predictable and Unpredictable Stimuli
Laterality of eye use has been increasingly studied in cetaceans. Research supports that many cetacean species keep prey on the right side while feeding and preferentially view unfamiliar objects with the right eye. In contrast...
Published by: Digital Commons @ Texas A&M University-San Antonio
Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease.
Daniel F Burgos, Lorena Cussó, Gentzane Sánchez-Elexpuru, Daniel Calle, Max Bautista Perpinyà, Manuel Desco, José M Serratosa, Marina P Sánchez
Oct 21, 2020
Mutations in the EPM2A and EPM2B genes, encoding laforin and malin proteins respectively, are responsible for Lafora disease, a fatal form of progressive myoclonus epilepsy with autosomal recessive inheritance. Neuroimaging...
1H-HRMAS MRS FDG PET Lafora disease MRI brain metabolites Mouse models Volumetry Animals Atrophy basal ganglia Brain Brain Diseases cerebellum Cerebral Cortex Disease Models Animal Glucose Hippocampus Humans Lafora Disease Magnetic Resonance Imaging Mice Knockout Mutation Positron-Emission Tomography Protein Tyrosine Phosphatases Non-Receptor Ubiquitin-Protein Ligases
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