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Results: 319
Achieving climate justice, safeguarding planetary health
Renzo R Guinto, Thilagawathi Abi Deivanayagam, Paccha Turner Chuji, Azmal Hossan, Anpotowin Jensen, Laura Jung, Eric Njuguna, Rhiannon Osborne, Melvine Anyango Otieno, Ayisha Siddiqa, Amiteshwar Singh, Bernard Kato Ewekia Taomia
Apr 17, 2023
Published by: PLOS global public health
Villous Tree Model with Active Contractions for Estimating Blood Flow Conditions in the Human Placenta
$\textit{Background:}$ In the human placenta, maternal and fetal bloods exchange substances through the surface of the villous trees: the fetal blood circulates in the villous trees, around which the maternal blood circulates....
Label-free single-particle imaging of the influenza virus by objective-type total internal reflection dark-field microscopy.
Sawako Enoki, Ryota Iino, Nobuhiro Morone, Kunihiro Kaihatsu, Shouichi Sakakihara, Nobuo Kato, Hiroyuki Noji
May 28, 2019
Here we report label-free optical imaging of single particles of the influenza virus attached on a glass surface with a simple objective-type total internal reflection dark-field microscopy (TIRDFM). The capability of TIRDFM for...
Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania
Humphrey D Mazigo, Fred Nuwaha, David W Dunne, Godfrey M Kaatano, Tekla Angelo, Stella Kepha, Safari M Kinung'hi
Sep 05, 2018
Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and infected. To justify the inclusion...
Mara Schistosoma mansoni Tanzania Adult organomegaly Ultrasonography Adolescent Adult Aged Aged 80 and over Animals Cross-Sectional Studies Feces Female Fibrosis Hepatomegaly Humans Male Middle Aged Morbidity prevalence Rural Population Schistosoma mansoni Schistosomiasis mansoni Sex Factors Splenomegaly Tanzania Young Adult
Relationship between atomic structure and excellent glass forming ability in Pd42.5Ni7.5Cu30P20 metallic glass
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf-Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Nov 15, 2022
To understand the relation of the glass-forming ability (GFA) to the local atomic configurations of a
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Glass-forming ability Icosahedral arrangement Partial structure Persistent homology analysis Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
Wei Jiao, Rosa Karlic, Edwin Cuppen, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P. Lolkema, Neeltje Steeghs, Quaid Morris, Fatima Al-Shahrour, Gurnit Atwal, Peter J. Bailey, Andrew V. Biankin, Paul C. Boutros, Peter J. Campbell, David K. Chang, Susanna L. Cooke, Vikram Deshpande, Bishoy M. Faltas, William C. Faquin, Levi Garraway, Gad Getz, Sean M. Grimmond, Syed Haider, Katherine A. Hoadley, Vera B. Kaiser, Rosa Karlić, Mamoru Kato, Kirsten Kübler, Alexander J. Lazar, Constance H. Li, David N. Louis, Adam Margolin, Sancha Martin, Hardeep K. Nahal-Bose, G. Petur Nielsen, Serena Nik-Zainal, Larsson Omberg, Christine P’ng, Marc D. Perry, Paz Polak, Esther Rheinbay, Mark A. Rubin, Colin A. Semple, Dennis C. Sgroi, Tatsuhiro Shibata, Reiner Siebert, Jaclyn Smith, Lincoln D. Stein, Miranda D. Stobbe, Ren X. Sun, Kevin Thai, Derek W. Wright, Chin-Lee Wu, Ke Yuan, Junjun Zhang
Feb 04, 2021
Abstract: In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary....
Detailed structural analysis of amorphous Pd<sub>40</sub>Cu<sub>40</sub>P<sub>20</sub>
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Mar 01, 2021
To clarify the relationship between the glass-forming ability (GFA) and local atomic structure of Pd-based metallic glasses, the structures of an amorphous Pd40Cu40P20 (PCP) were investigated...
Anomalous X-ray scattering Glass-forming ability Hyper-ordered structures metallic glasses neutron diffraction Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
A combination of anomalous x-ray scattering and neutron diffraction for structural characterizations of Zr63Ni25Al12 metallic glass
Shinja Hosokawa, J.-F. Berar, N. Boudet, Shinji Kohara, J. Stellhorn, W.-C. Pilgrim, A Zeidler, H. Kato, Y. Kawakita, T. Otomo
Apr 11, 2014
Zr63Ni25Al12 bulk metallic glass was investigated using neutron diffraction and
anomalous x-ray scattering close to the Zr and Ni K edges. The experimental results were analyzed using reverse Monte Carlo modeling (RMC) to...
anomalous x-ray scattering close to the Zr and Ni K edges. The experimental results were analyzed using reverse Monte Carlo modeling (RMC) to...
Detailed structural analysis of amorphous Pd<sub>40</sub>Cu<sub>40</sub>P<sub>20</sub>
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Mar 01, 2021
To clarify the relationship between the glass-forming ability (GFA) and local atomic structure of Pd-based metallic glasses, the structures of an amorphous Pd40Cu40P20 (PCP) were investigated...
Anomalous X-ray scattering Glass-forming ability Hyper-ordered structures metallic glasses neutron diffraction Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Relationship between atomic structure and excellent glass forming ability in Pd42.5Ni7.5Cu30P20 metallic glass
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf-Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Nov 15, 2022
To understand the relation of the glass-forming ability (GFA) to the local atomic configurations of a
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Glass-forming ability Icosahedral arrangement Partial structure Persistent homology analysis Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Building primary care in Japan
Daisuke Kato, Hikohaku Ryu, Tomoki Matsumoto, Kazuhiro Abe, Makoto Kaneko, Mezhen Ko, Greg Irving, Robin Ramsay, Masatoshi Kondo
Feb 24, 2020
Japan's health system is well known for achieving one of the world's highest life expectancy with universal health coverage. However, the country now faces challenges of a rapidly aging population and changes in patterns and...
A combination of anomalous x-ray scattering and neutron diffraction for structural characterizations of Zr63Ni25Al12 metallic glass
Shinja Hosokawa, J.-F. Berar, N. Boudet, Shinji Kohara, J. Stellhorn, W.-C. Pilgrim, A Zeidler, H. Kato, Y. Kawakita, T. Otomo
Apr 11, 2014
Zr63Ni25Al12 bulk metallic glass was investigated using neutron diffraction and
anomalous x-ray scattering close to the Zr and Ni K edges. The experimental results were analyzed using reverse Monte Carlo modeling (RMC) to...
anomalous x-ray scattering close to the Zr and Ni K edges. The experimental results were analyzed using reverse Monte Carlo modeling (RMC) to...
Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses.
Moses Egesa, Lawrence Lubyayi, Edridah M Tukahebwa, Bernard S Bagaya, Iain W Chalmers, Shona Wilson, Cornelis H Hokke, Karl F Hoffmann, David W Dunne, Maria Yazdanbakhsh, Lucja A Labuda, Stephen Cose
Nov 22, 2018
Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets, although cellular immune responses against schistosomula antigens in endemic human...
Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania
Safari M Kinung'hi, Humphrey D Mazigo, David W Dunne, Stella Kepha, Godfrey Kaatano, Coleman Kishamawe, Samuel Ndokeji, Teckla Angelo, Fred Nuwaha
Jan 24, 2018
BACKGROUND: Schistosomiasis represents a major public health problem in Tanzania despite ongoing national control efforts. This study examined whether intestinal schistosomiasis is associated with malaria and assessed the...
Partial structure investigation of the traditional bulk metallic glass Pd40Ni40 P20
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Kenji Maruyama, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Aug 28, 2019
Local structures of Pd40Ni40P20 bulk metallic glass were investigated by combining anomalous x-ray scattering close to the Pd and Ni K absorption edges, x-ray diffraction, neutron diffraction, and reverse Monte Carlo...
Human embryo research, stem cell-derived embryo models and in vitro gametogenesis
Amander T Clark, Ali Brivanlou, Jianping Fu, Kazuto Kato, Debra Mathews, Kathy K Niakan, Nicolas Rivron, Mitinori Saitou, Azim Surani, Fuchou Tang, Janet Rossant
Jun 07, 2021
The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in 2016. Since then, rapid progress has been made in research areas related to in vitro culture of human embryos, creation of stem cell-based...
Partial structure investigation of the traditional bulk metallic glass Pd40Ni40 P20
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Kenji Maruyama, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Aug 28, 2019
Local structures of Pd40Ni40P20 bulk metallic glass were investigated by combining anomalous x-ray scattering close to the Pd and Ni K absorption edges, x-ray diffraction, neutron diffraction, and reverse Monte Carlo...
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.
Kosuke Yusa, S Tamir Rashid, Helene Strick-Marchand, Ignacio Varela, Pei-Qi Liu, David E Paschon, Elena Miranda, Adriana Ordóñez, Nicholas RF Hannan, Foad J Rouhani, Sylvie Darche, Graeme Alexander, Stefan J Marciniak, Noemi Fusaki, Mamoru Hasegawa, Michael C Holmes, James P Di Santo, David A Lomas, Allan Bradley, Ludovic Vallier
Oct 22, 2020
Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited quantities of cells for autologous transplantation, with potential...
Structural insights into μ-opioid receptor activation
Weijiao Huang, Aashish Manglik, A. J. Venkatakrishnan, Toon Laeremans, Evan N. Feinberg, Adrian L. Sanborn, Hideaki E. Kato, Kathryn E. Livingston, Thor S. Thorsen, Ralf C. Kling, Sébastien Granier, Peter Gmeiner, Stephen M. Husbands, John R. Traynor, William I. Weis, Jan Steyaert, Ron O. Dror, Brian K. Kobilka
Aug 20, 2015
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X-ray crystal structure of the...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 14, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Mar 27, 2020
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important...
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
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