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Repurposing hyperpolarization-activated cyclic nucleotide-gated channels as a novel therapy for breast cancer.
Ka-Chun Mok, Ho Tsoi, Ellen PS Man, Man-Hong Leung, Ka Man Chau, Lai-San Wong, Wing-Lok Chan, Sum-Yin Chan, Mai-Yee Luk, Jessie YW Chan, Jackie KM Leung, Yolanda HY Chan, Sellma Batalha, Virginia Lau, David CW Siu, Terence KW Lee, Chun Gong, Ui-Soon Khoo
Nov 04, 2021
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated cation channel family known to be expressed in the heart and central nervous system. Ivabradine, a small molecule HCN...
Can Volunteering Buffer the Negative Impacts of Unemployment and Economic Inactivity on Mental Health? Longitudinal Evidence from the United Kingdom.
Previous research suggests that volunteering can mitigate the negative mental health impacts of unemployment but has yielded mixed results. This study extends the previous literature by examining whether volunteering can buffer...
Rock Hill Man Charged with Five Burglaries of Campus Buildings
Winthrop University
Jan 01, 0001
Zedric Barr, 24, arrested for trespassing and now charged with several burglaries. Campus Police charged a second man for possessing property from the burglaries.
Published by: Winthrop University
Rock Hill Man Arrested for March 26 Assault on Student
Winthrop University
Jan 01, 0001
Winthrop University police have arrested a Rock Hill man in connection with a March 26 assault of a student outside of Kinard Hall.
Published by: Winthrop University
AI-Powered Tracking for Sustainable Marine Ecosystem Resource Management Projects
Ecosystems are our planet's life-support systems that facilitate sustainable development. Within the marine ecosystem, oysters serve as a keystone species. Numerous oyster restoration projects have been launched with a crucial...
Published by: IGI Global Scientific Publishing
Program for the Stage Production The Man Who Came to Dinner
Curtain Club
Jan 01, 0001
This eleven-page program details the Curtain Club of Ursinus College's production of The Man Who Came to Dinner, held May 10, 1947 in Thompson-Gay Gymnasium. It includes information about the directors, cast, production of the...
Moss Hart George S. Kaufman V-12 Dramatur Alpha Psi Omega Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
Program for the Stage Production The Man Who Came to Dinner
Curtain Club
Jan 01, 0001
This twenty-four-page program details the Curtain Club of Ursinus College's production of The Man Who Came to Dinner, held May 6, 7, and 8, 1954 in Thompson-Gay Gymnasium. It includes information about the directors, cast...
George S. Kaufman Moss Hart Donald L. Helfferich Curtain Club Ursinus College theater program Thompson-Gay Gymnasium Theatre and Performance Studies Theatre History
Published by: Ursinus College
Blind Man Who Survived 9/11 Attack to Tell His Story at United Way Event
Winthrop University
Jan 01, 0001
Blind since birth, Hingson wrote "Thunder Dog: A Blind Man, His Guide Dog, and the Triumph of Trust at Ground Zero," to encourage the importance of teamwork and trust. The United Way event is invitation-only. It begins at 8 a.m....
Published by: Winthrop University
A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2.
Man-Hong Leung, Ho Tsoi, Chun Gong, Ellen PS Man, Stefania Zona, Shang Yao, Eric W-F Lam, Ui-Soon Khoo
Feb 27, 2020
Breast cancer is the most common type of female cancer. Reactive oxygen species (ROS) are vital in regulating signaling pathways that control cell survival and cell proliferation. Chemotherapeutic drugs such as anthracyclines...
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man
Inaba, K., Steinman, R.M., Van Voorhis, W.C., and Muramatsu, S. Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc. Natl. Acad. Sci. USA. 80: 6041-6045, 1983
Published by: The National Academy of Sciences
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man
We report that dendritic cells (DC) are necessary and potent accessory cells for anti-sheep erythrocyte responses in both mouse and man. In mice, a small number of DC (0.3-1% of the culture) restores the response of...
antibody production blood and hemopoietic system Endocrine System langerhans cell Lymphatic System macrophage monocyte
Published by: Rockefeller University
Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.
Rhiannon S Morris, P Simon Jones, Josef A Alawneh, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, Elizabeth A Warburton, Jean-Claude Baron
Nov 06, 2018
Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of...
Case 267
History A 28-year-old man presented with lifelong anejaculation, which had become an issue because of family planning. The patient had a history of normal erections and experienced the sensation of orgasm without ever...
Educating China on the Move
The landscape of global higher education is changing rapidly in response to and alongside the geopolitical and geosocial global transformations and China and East Asia are becoming key players in higher education. As China’s...
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.
Timothy Barkham, Ruth N Zadoks, Mohammad Noor Amal Azmai, Stephen Baker, Vu Thi Ngoc Bich, Victoria Chalker, Man Ling Chau, David Dance, Rama Narayana Deepak, H Rogier van Doorn, Ramona A Gutierrez, Mark A Holmes, Lan Nguyen Phu Huong, Tse Hsien Koh, Elisabete Martins, Kurosh Mehershahi, Paul Newton, Lee Ching Ng, Nguyen Ngoc Phuoc, Ornuma Sangwichian, Pongpun Sawatwong, Uraiwan Surin, Thean Yen Tan, Wen Ying Tang, Nguyen Vu Thuy, Paul Turner, Manivanh Vongsouvath, Defeng Zhang, Toni Whistler, Swaine L Chen
Jul 09, 2019
BACKGROUND: In 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis...
Adolescent Adult Aged Aged 80 and over Animals Asia Southeastern Child Child Preschool Female Fish Diseases Foodborne Diseases Genotype Humans Infant Infant Newborn Male Middle Aged molecular epidemiology Multilocus Sequence Typing Phylogeny Pregnancy Streptococcal Infections Streptococcus Agalactiae Tilapia whole genome sequencing Young Adult
Educating China on the Move
The landscape of global higher education is changing rapidly in response to and alongside the geopolitical and geosocial global transformations and China and East Asia are becoming key players in higher education. As China’s...
Differential prevalence and geographic distribution of hepatitis C virus genotypes in acute and chronic hepatitis C patients in Vietnam.
Chau Le Ngoc, Thanh Tran Thi Thanh, Phuong Tran Thi Lan, Trinh Nguyen Mai, Trang Nguyen Hoa, Ngoc Nghiem My, Tan Le Van, Hung Le Manh, Phuong Le Thanh, Chau Nguyen Van Vinh, Guy Thwaites, Graham Cooke, Gabrielle M Heilek, Cecilia Shikuma, Thuy Le, Stephen Baker, Motiur Rahman, VIZIONS consortium
Apr 10, 2019
BACKGROUND: The highest burden of disease from hepatitis C virus (HCV) is found in Southeast Asia, but our understanding of the epidemiology of infection in many heavily burdened countries is still limited. In particular, there...
‘The most remarkable man’
Kevin J Edwards
Apr 04, 2022
ABSTRACT: The year 2021 marked the bicentenary of the birth of James Croll (1821–1890), the self‐educated son of a crofter‐stonemason, whose life was characterised by a dizzying range of occupations and homes, poor health and...
Engaging in English Speaking Teaching Based on a Task-Based Approach
Ling Ding
Dec 20, 2018
In this article, the author reports, in a narrative style, details of teaching speaking in experiential learning with a Syrian woman, and the author’s perceptions of applying a role play task-based approach. It has been widely...
Published by: The Morning Watch: Educational and Social Analysis
The potential of immune biomarkers to advance personalized medicine approaches for schizophrenia.
2018 Real Estate Finance & Investment Symposium
Abstract In October 2018, the Real Estate Finance & Investment Symposium, sponsored and organized by the University of Cambridge, the University of Florida, and the National University of...
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