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Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.
Inge MM Lakeman, Mar Rodríguez-Girondo, Andrew Lee, Rikje Ruiter, Bruno H Stricker, Sara RA Wijnant, Maryam Kavousi, Antonis C Antoniou, Marjanka K Schmidt, André G Uitterlinden, Jeroen van Rooij, Peter Devilee
Jun 05, 2020
PURPOSE: We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score...
Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort
Inge M. M. Lakeman, Mar Rodríguez-Girondo, Andrew Lee, Rikje Ruiter, Bruno H. Stricker, Sara R. A. Wijnant, Maryam Kavousi, Antonis C. Antoniou, Marjanka K. Schmidt, André G. Uitterlinden, Jeroen van Rooij, Peter Devilee
Oct 29, 2020
Abstract: Purpose: We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic...
Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort
Inge M. M. Lakeman, Mar Rodríguez-Girondo, Andrew Lee, Rikje Ruiter, Bruno H. Stricker, Sara R. A. Wijnant, Maryam Kavousi, Antonis C. Antoniou, Marjanka K. Schmidt, André G. Uitterlinden, Jeroen van Rooij, Peter Devilee
Jul 07, 2021
Abstract: Purpose: We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic...
Addition of a 161-SNP polygenic risk score to family history-based risk prediction
Inge MM Lakeman, Florentine S Hilbers, Mar Rodríguez-Girondo, Andrew Lee, Maaike PG Vreeswijk, Antoinette Hollestelle, Caroline Seynaeve, Hanne Meijers-Heijboer, Jan C Oosterwijk, Nicoline Hoogerbrugge, Edith Olah, Hans FA Vasen, Christi J van Asperen, Peter Devilee
Jun 20, 2019
Cancer: breast Clinical genetics Genetic epidemiology Genetic screening/counselling polygenic risk score Adult Aged Aged 80 and over Alleles Biomarkers Tumor Breast Neoplasms Case-Control Studies Clinical Decision-Making Disease Management Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Middle Aged Pedigree Polymorphism Single Nucleotide Prognosis Proportional Hazards Models Risk Assessment Young Adult
Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.
Inge MM Lakeman, Mar DM Rodríguez-Girondo, Andrew Lee, Nandi Celosse, Merel E Braspenning, Klaartje van Engelen, Irma van de Beek, Annemiek H van der Hout, Encarna B Gómez García, Arjen R Mensenkamp, Margreet Gem Ausems, Maartje J Hooning, Muriel A Adank, Antoinette Hollestelle, Marjanka K Schmidt, Christi J van Asperen, Peter Devilee
Sep 27, 2022
Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.
Inge MM Lakeman, Mar DM Rodríguez-Girondo, Andrew Lee, Nandi Celosse, Merel E Braspenning, Klaartje van Engelen, Irma van de Beek, Annemiek H van der Hout, Encarna B Gómez García, Arjen R Mensenkamp, Margreet Gem Ausems, Maartje J Hooning, Muriel A Adank, Antoinette Hollestelle, Marjanka K Schmidt, Christi J van Asperen, Peter Devilee
Oct 26, 2022
Utilizing MAR for Remedial Teaching of Compound-Cube-Surface Area at Elementary School in Taiwan
In this paper, the development of the MAR (mobile augmented reality) remedial teaching program is described. It allowed students to manipulate augmented objects through AURASMA app via internet and find leads to solve geometry...
Published by: IGI Global Scientific Publishing
Evaluation of a weighting approach for performing sensitivity analysis after multiple imputation.
BACKGROUND: Multiple imputation (MI) is a well-recognised statistical technique for handling missing data. As usually implemented in standard statistical software, MI assumes that data are 'Missing at random' (MAR); an...
Desgarraduras del cuerpo y degolladuras de la voz
B Epps
Aug 24, 2017
El mismo mar de todos los veranos de Esther Tusquets narra la tormentosa relación erótica y emocional de una mujer de la alta burguesía catalana, casada y desencantada, que ejerce de profesora de literatura, con una joven...
Linear Increments with Non-monotone Missing Data and Measurement Error.
Linear increments (LI) are used to analyse repeated outcome data with missing values. Previously, two LI methods have been proposed, one allowing non-monotone missingness but not independent measurement error and one allowing...
Teachers as Augmented Reality Designers
Martina Manna
Feb 02, 2023
As an emergent technology augmented reality (AR) demonstrated a plethora of advantages in foreign language education, promoting motivation, memorization of contents, as well as contextualized learning. However, the majority of...
Published by: IGI Global Scientific Publishing
Teaching clinicians shared decision making and risk communication online
Objectives: To describe the development and initial evaluation of a brief e-learning course as a means of teaching shared decision making and risk communication skills to clinicians of all specialties. Design: Comparison...
Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells.
Analyses of Sensitivity to the Missing-at-Random Assumption Using Multiple Imputation With Delta Adjustment
Multiple imputation with delta adjustment provides a flexible and transparent means to impute univariate missing data under general missing-not-at-random mechanisms. This facilitates the conduct of analyses assessing sensitivity...
causal mediation analysis incomplete data nonignorable nonresponse sensitivity analysis AIDS-Related Opportunistic Infections Adolescent Adult Data Interpretation Statistical Epidemiologic Methods Female HIV Infections Humans Logistic Models Male Middle Aged Models Statistical Odds Ratio prevalence Risk Factors Tuberculosis Young Adult
Comparing the effects of subchronic phencyclidine and medial prefrontal cortex dysfunction on cognitive tests relevant to schizophrenia.
animal model associative learning discrimination Glutamate Learning and memory object recognition Phencyclidine Prefrontal Cortex rat Schizophrenia Animals Behavior Animal Brain Diseases Cognition Excitatory Amino Acid Agonists Hallucinogens Ibotenic Acid Injections Intraperitoneal learning Limbic System Male Memory Phencyclidine Prefrontal Cortex Rats RECOGNITION psychology Schizophrenic Psychology
Movement seasonality in a desert-dwelling bat revealed by miniature GPS loggers.
BACKGROUND: Bats are among the most successful desert mammals. Yet, our understanding of their spatio-temporal dynamics in habitat use associated with the seasonal oscillation of resources is still limited. In this study, we...
Design Principles of Mobile Learning Frameworks
Numerous studies show positive cognitive and affective results regarding the adoption of mobile learning; however, adoption levels are low, and when mobile learning occurs, it is not always based on innovative pedagogies. The...
Published by: IGI Global Scientific Publishing
Parasite-associated mortality in a long-lived mammal
Parasites can cause severe host morbidity and threaten survival. As parasites are generally aggregated within certain host demographics, they are likely to affect a small proportion of the entire population, with specific hosts...
A general method for elicitation, imputation, and sensitivity analysis for incomplete repeated binary data.
We develop and demonstrate methods to perform sensitivity analyses to assess sensitivity to plausible departures from missing at random in incomplete repeated binary outcome data. We use multiple imputation in the not at random...
Safety signals as instrumental reinforcers during free-operant avoidance.
Anushka BP Fernando, Gonzalo P Urcelay, Adam C Mar, Anthony Dickinson, Trevor W Robbins
Jul 14, 2014
Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia.
Opsonins are soluble, extracellular proteins, released by activated immune cells, and when bound to a target cell, can induce phagocytes to phagocytose the target cell. There are three known classes of opsonin: antibodies...
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